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The map label for this gene is 222525414

Identifier: 222525414

GI number: 222525414

Start: 2737143

End: 2738183

Strand: Reverse

Name: 222525414

Synonym: Chy400_2159

Alternate gene names: NA

Gene position: 2738183-2737143 (Counterclockwise)

Preceding gene: 222525416

Following gene: 222525402

Centisome position: 51.97

GC content: 61.19

Gene sequence:

>1041_bases
ATGACCATCGTCATTGTCGGTGGGGGGGCAATCGGGTTGTTGCTCCTTTCACGGCTGGCCCAGGCCAGCAACGGGCAGCC
GGTCGCGCTTTTGACCCGCCCAAACGGCGCAGCGGCGTTGCAAGCCACACCGTTACAGGTGAGTGGTATCGGGGCATGTT
CACTAACCGGTTTGACGGTTGCCGGTGCAGTAGCCGATTTACCAGCAGCGTTTCAACAACCGGCGCTGGCAATCTTGTGT
GTCAAAGGCTACGATACGAACGGGGCGATTGCCACCTTACGCGACCTCAATCCTGGATCCATCCTGACGCTGCAAAATGG
GCTGGGCAACGAAGAAGCGCTGGCCCAGGCTTTTGGCGCGGATCGGATTATTGCCGGCGCAATTACAACCTCGGTTGACG
CTACCGGCCCCACGACGATCACTGTGACGAAAGCGGGTGGAATTGGGTTAGCGCCGGTAGGCGGAACAAGTAATCTCACA
CTGGCCGAAACGGCGCTGAGCAATGCAGGCTTTACTGTCCAGCGTTATCACGACTACCGCGCTATGAAATGGTCGAAAGC
GCTGTTGAATATGCTAGGAAATGCGACTGCTGCGATTCTCGATTGGTCGGTTGCGCAGGTCTACGCCGACCGCCGGCTGG
TGGCACTGGAACGGACCGCCGTGCGTGAGGCGCTGGCCGTGATGCAACGCATGGGGATACGACCGGTCAATTTACCCCGC
TATCCGGCGGCACTGCTGGCCTTCGGCATTCGCTGGCTACCACCGATCATCCTCGATCCGATTTTGCGCCAGCGGGTAGC
CGGTGGCCGGGGCGGTAAAGATCCGTCGCTGCTCCGTGATCTGCGCGCGGGACGTAGCCGTTCCGAAGGGGAGTTCTTGT
ACGGCGCGGTGGCCGCAGCCGCCACCGCCCACGGGTTACAGACGCCGGTCAATGCCGGTCTCTGGCAGGTGTTGGGGGGT
ATCGTGCGCGGTGATCTGCGCTGGGACGATTACCGCGGTCAACCTGAACGGTTGCTGGCGGCCTGTGGAATGGCGAAGTG
A

Upstream 100 bases:

>100_bases
AGTTGCACCACGAAGACACGTCACAATACCCTCCTGCTCAATGTCGTAGCAACCAGATTTTCCGCTATACTGAAGGCGAG
TGTGTATAGAGGAGGAATCA

Downstream 100 bases:

>100_bases
GCCTGATATGCATCCACATCCGTCTTCGGCAGACAGTACCCTCACTGCGTCTTGACGTGTGGAAGTCGTGCTGCCAACCA
ATAGCCAATCTGTCAGATAA

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 346; Mature: 345

Protein sequence:

>346_residues
MTIVIVGGGAIGLLLLSRLAQASNGQPVALLTRPNGAAALQATPLQVSGIGACSLTGLTVAGAVADLPAAFQQPALAILC
VKGYDTNGAIATLRDLNPGSILTLQNGLGNEEALAQAFGADRIIAGAITTSVDATGPTTITVTKAGGIGLAPVGGTSNLT
LAETALSNAGFTVQRYHDYRAMKWSKALLNMLGNATAAILDWSVAQVYADRRLVALERTAVREALAVMQRMGIRPVNLPR
YPAALLAFGIRWLPPIILDPILRQRVAGGRGGKDPSLLRDLRAGRSRSEGEFLYGAVAAAATAHGLQTPVNAGLWQVLGG
IVRGDLRWDDYRGQPERLLAACGMAK

Sequences:

>Translated_346_residues
MTIVIVGGGAIGLLLLSRLAQASNGQPVALLTRPNGAAALQATPLQVSGIGACSLTGLTVAGAVADLPAAFQQPALAILC
VKGYDTNGAIATLRDLNPGSILTLQNGLGNEEALAQAFGADRIIAGAITTSVDATGPTTITVTKAGGIGLAPVGGTSNLT
LAETALSNAGFTVQRYHDYRAMKWSKALLNMLGNATAAILDWSVAQVYADRRLVALERTAVREALAVMQRMGIRPVNLPR
YPAALLAFGIRWLPPIILDPILRQRVAGGRGGKDPSLLRDLRAGRSRSEGEFLYGAVAAAATAHGLQTPVNAGLWQVLGG
IVRGDLRWDDYRGQPERLLAACGMAK
>Mature_345_residues
TIVIVGGGAIGLLLLSRLAQASNGQPVALLTRPNGAAALQATPLQVSGIGACSLTGLTVAGAVADLPAAFQQPALAILCV
KGYDTNGAIATLRDLNPGSILTLQNGLGNEEALAQAFGADRIIAGAITTSVDATGPTTITVTKAGGIGLAPVGGTSNLTL
AETALSNAGFTVQRYHDYRAMKWSKALLNMLGNATAAILDWSVAQVYADRRLVALERTAVREALAVMQRMGIRPVNLPRY
PAALLAFGIRWLPPIILDPILRQRVAGGRGGKDPSLLRDLRAGRSRSEGEFLYGAVAAAATAHGLQTPVNAGLWQVLGGI
VRGDLRWDDYRGQPERLLAACGMAK

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 35885; Mature: 35754

Theoretical pI: Translated: 10.18; Mature: 10.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIVIVGGGAIGLLLLSRLAQASNGQPVALLTRPNGAAALQATPLQVSGIGACSLTGLTV
CEEEEECCCHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEECCEEEECCCCCCCCCHHH
AGAVADLPAAFQQPALAILCVKGYDTNGAIATLRDLNPGSILTLQNGLGNEEALAQAFGA
HHHHHHCCHHHCCCCEEEEEEECCCCCCCEEEEEECCCCCEEEEECCCCCHHHHHHHHCC
DRIIAGAITTSVDATGPTTITVTKAGGIGLAPVGGTSNLTLAETALSNAGFTVQRYHDYR
CCEEEHHHCCCCCCCCCEEEEEEECCCCEEECCCCCCCCCHHHHHHCCCCCEEEEHHHHH
AMKWSKALLNMLGNATAAILDWSVAQVYADRRLVALERTAVREALAVMQRMGIRPVNLPR
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
YPAALLAFGIRWLPPIILDPILRQRVAGGRGGKDPSLLRDLRAGRSRSEGEFLYGAVAAA
CHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHH
ATAHGLQTPVNAGLWQVLGGIVRGDLRWDDYRGQPERLLAACGMAK
HHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCC
>Mature Secondary Structure 
TIVIVGGGAIGLLLLSRLAQASNGQPVALLTRPNGAAALQATPLQVSGIGACSLTGLTV
EEEEECCCHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEECCEEEECCCCCCCCCHHH
AGAVADLPAAFQQPALAILCVKGYDTNGAIATLRDLNPGSILTLQNGLGNEEALAQAFGA
HHHHHHCCHHHCCCCEEEEEEECCCCCCCEEEEEECCCCCEEEEECCCCCHHHHHHHHCC
DRIIAGAITTSVDATGPTTITVTKAGGIGLAPVGGTSNLTLAETALSNAGFTVQRYHDYR
CCEEEHHHCCCCCCCCCEEEEEEECCCCEEECCCCCCCCCHHHHHHCCCCCEEEEHHHHH
AMKWSKALLNMLGNATAAILDWSVAQVYADRRLVALERTAVREALAVMQRMGIRPVNLPR
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
YPAALLAFGIRWLPPIILDPILRQRVAGGRGGKDPSLLRDLRAGRSRSEGEFLYGAVAAA
CHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHH
ATAHGLQTPVNAGLWQVLGGIVRGDLRWDDYRGQPERLLAACGMAK
HHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]