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The map label for this gene is dapA

Identifier: 222525376

GI number: 222525376

Start: 2695980

End: 2696879

Strand: Reverse

Name: dapA

Synonym: Chy400_2121

Alternate gene names: 222525376

Gene position: 2696879-2695980 (Counterclockwise)

Preceding gene: 222525378

Following gene: 222525375

Centisome position: 51.18

GC content: 60.0

Gene sequence:

>900_bases
ATGGCAGAGCCTCGTGGGATTATCAGCGCAATGCTTACCCCCTTCACCAGTGATGTTGGCCCGGTGGATTACGAGTGGTT
GCCGGGATACCTGCGCTTTCTGGCTGATGGCGGACTCCACGGTGTGCTGGCGCTGGGCACCACCGGTGAGGGGCCGTCGA
TGAGTGTGGCCGAGCGAATCCGCACCCTTGAGATCATAATGGCGCACCGGGGGGAGTTGAGCGTGATTGCCGGTACCGGC
TGTGCTGCGCTTACCGATACGATTGCGCTGAGCCGGGCAGCGATTGATCTGGGTGTTGATGCGATTCTGGTCATGCCGCC
GTTCTACATCAAGCAACCGGACGAAACCGGCATTCTGGCCTACTTCCGGGCACTGTGCGATGCGTTACCGGCCGATGCGC
GCGTGATGCTGTACCATATTCCGCAGGTGACCGGGGTGCCGATCACGAGGACTATCATCGATGGCTTGCTGGCGAGCCAC
GGCACCCAGTTTTACGGTTTGAAAGACAGTAGTGGCGATTGGGAACACTCTAAGATGCTCATTGACAGCTACCCGCAATT
ACGCATCTTCACCGGTAGTGATCGCCTGATTGCCCGTGCTCTGGCCGGTGGCGCTGCCGGCGCTATTACGGCGCTCTCCA
GTGCGTTTCCGAAACTGGCCCGTGCAGTGTTCGATGCGTTCCATCAGGGTGGTGATGTAGCGGCAGCCCAGGCTCGCCTA
AGCGCTGTACGCGATCTGGTGAACCCGATCAACACACCACCAGCGCTCAAAGCGGCATTAACCTGGACAAGTGACTTGCC
GGAAACGGCGCTGCGGCTTCCGTTGCTGCCCTTGAGTAACGAGGAGGTCGCTGCTCTCCGTGCTGCTTACGAGCGGATCA
TGGCCGGTACAACGCCCTGA

Upstream 100 bases:

>100_bases
CTGATCACGCTTGCTGCTGCTTGATTCTACACCATGTCGCGGAAACGGCAACTTATGGTAGAGTCAACGGAGGACATGAG
AACAGGAAGGAGACATTCAT

Downstream 100 bases:

>100_bases
CCTGCCGGTCAGCCGGACAGCAGCCGAATGAGGCAAGCCAACCCTTGACTCGCGTTATACTACCTGTAACGAGAACACAT
TGAGAACTGGCAACGGTATG

Product: dihydrodipicolinate synthetase

Products: NA

Alternate protein names: DHDPS

Number of amino acids: Translated: 299; Mature: 298

Protein sequence:

>299_residues
MAEPRGIISAMLTPFTSDVGPVDYEWLPGYLRFLADGGLHGVLALGTTGEGPSMSVAERIRTLEIIMAHRGELSVIAGTG
CAALTDTIALSRAAIDLGVDAILVMPPFYIKQPDETGILAYFRALCDALPADARVMLYHIPQVTGVPITRTIIDGLLASH
GTQFYGLKDSSGDWEHSKMLIDSYPQLRIFTGSDRLIARALAGGAAGAITALSSAFPKLARAVFDAFHQGGDVAAAQARL
SAVRDLVNPINTPPALKAALTWTSDLPETALRLPLLPLSNEEVAALRAAYERIMAGTTP

Sequences:

>Translated_299_residues
MAEPRGIISAMLTPFTSDVGPVDYEWLPGYLRFLADGGLHGVLALGTTGEGPSMSVAERIRTLEIIMAHRGELSVIAGTG
CAALTDTIALSRAAIDLGVDAILVMPPFYIKQPDETGILAYFRALCDALPADARVMLYHIPQVTGVPITRTIIDGLLASH
GTQFYGLKDSSGDWEHSKMLIDSYPQLRIFTGSDRLIARALAGGAAGAITALSSAFPKLARAVFDAFHQGGDVAAAQARL
SAVRDLVNPINTPPALKAALTWTSDLPETALRLPLLPLSNEEVAALRAAYERIMAGTTP
>Mature_298_residues
AEPRGIISAMLTPFTSDVGPVDYEWLPGYLRFLADGGLHGVLALGTTGEGPSMSVAERIRTLEIIMAHRGELSVIAGTGC
AALTDTIALSRAAIDLGVDAILVMPPFYIKQPDETGILAYFRALCDALPADARVMLYHIPQVTGVPITRTIIDGLLASHG
TQFYGLKDSSGDWEHSKMLIDSYPQLRIFTGSDRLIARALAGGAAGAITALSSAFPKLARAVFDAFHQGGDVAAAQARLS
AVRDLVNPINTPPALKAALTWTSDLPETALRLPLLPLSNEEVAALRAAYERIMAGTTP

Specific function: Important in N-acetylneuraminate lyase reaction [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family

Homologues:

Organism=Homo sapiens, GI13540533, Length=287, Percent_Identity=29.2682926829268, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI31543060, Length=294, Percent_Identity=25.8503401360544, Blast_Score=72, Evalue=8e-13,
Organism=Escherichia coli, GI1789620, Length=295, Percent_Identity=28.135593220339, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1786463, Length=238, Percent_Identity=30.2521008403361, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI87082415, Length=243, Percent_Identity=27.5720164609054, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1788823, Length=294, Percent_Identity=23.8095238095238, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DAPA_CHLAA (A9WE23)

Other databases:

- EMBL:   CP000909
- RefSeq:   YP_001635571.1
- ProteinModelPortal:   A9WE23
- SMR:   A9WE23
- GeneID:   5826418
- GenomeReviews:   CP000909_GR
- KEGG:   cau:Caur_1967
- HOGENOM:   HBG358848
- OMA:   GCITATS
- ProtClustDB:   CLSK974852
- GO:   GO:0005737
- HAMAP:   MF_00418
- InterPro:   IPR013785
- InterPro:   IPR002220
- InterPro:   IPR020624
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR12128
- PRINTS:   PR00146

Pfam domain/function: PF00701 DHDPS

EC number: =4.2.1.52

Molecular weight: Translated: 31677; Mature: 31546

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: PS00665 DHDPS_1; PS00666 DHDPS_2

Important sites: ACT_SITE 168-168

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEPRGIISAMLTPFTSDVGPVDYEWLPGYLRFLADGGLHGVLALGTTGEGPSMSVAERI
CCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHH
RTLEIIMAHRGELSVIAGTGCAALTDTIALSRAAIDLGVDAILVMPPFYIKQPDETGILA
HHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCEEEECCCHHEECCCCCHHHH
YFRALCDALPADARVMLYHIPQVTGVPITRTIIDGLLASHGTQFYGLKDSSGDWEHSKML
HHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHH
IDSYPQLRIFTGSDRLIARALAGGAAGAITALSSAFPKLARAVFDAFHQGGDVAAAQARL
HCCCCCEEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
SAVRDLVNPINTPPALKAALTWTSDLPETALRLPLLPLSNEEVAALRAAYERIMAGTTP
HHHHHHHHCCCCCHHHHEEEEECCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AEPRGIISAMLTPFTSDVGPVDYEWLPGYLRFLADGGLHGVLALGTTGEGPSMSVAERI
CCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHH
RTLEIIMAHRGELSVIAGTGCAALTDTIALSRAAIDLGVDAILVMPPFYIKQPDETGILA
HHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCEEEECCCHHEECCCCCHHHH
YFRALCDALPADARVMLYHIPQVTGVPITRTIIDGLLASHGTQFYGLKDSSGDWEHSKML
HHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHH
IDSYPQLRIFTGSDRLIARALAGGAAGAITALSSAFPKLARAVFDAFHQGGDVAAAQARL
HCCCCCEEEEECCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
SAVRDLVNPINTPPALKAALTWTSDLPETALRLPLLPLSNEEVAALRAAYERIMAGTTP
HHHHHHHHCCCCCHHHHEEEEECCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA