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The map label for this gene is hisB [H]

Identifier: 222525344

GI number: 222525344

Start: 2660300

End: 2660896

Strand: Direct

Name: hisB [H]

Synonym: Chy400_2089

Alternate gene names: 222525344

Gene position: 2660300-2660896 (Clockwise)

Preceding gene: 222525343

Following gene: 222525345

Centisome position: 50.49

GC content: 56.78

Gene sequence:

>597_bases
GTGAATAGAATCCGGCGGGCGACCATTGAGCGGGTGACCGGTGAGACAAACATTACCCTTACCCTCACCATCGATGGTAG
TGGACAGGCTGATGTGCAGACCGGTATCGGTTTTCTTGACCATATGCTGACGTTGTGGGCACGCCATGGCTTGTTCGACC
TTCAGGTGCGGGCGCAGGGCGATCTCCACATTGATGAGCATCACACTGCCGAAGACGTGTGTATTTGCCTGGGTCGGGCC
ATTGATCAGGCGCTCGGTGAGCGGGCCGGCATTGTACGTACCGCACACAGCTTTGTGCCGATGGACGAAGCACTGGCGCT
GGTTGCTGTCGATCTTGGTGGCCGACCGTACTGTGTGGTACAGGCTGATTTTGTTACAATGCGCGTAGGACAGCTCGGTA
CCGATCTGGTGGCCCATTTGTTTGAGAGTGTTGCCTTCAACGGTCGTTTCAATCTCCACGCACAGGTGATGTACGGGCGC
AACGACCATCACAAGATCGAGGCTCTGTTCAAAGCGTTCGGGCGGGCACTCGATGCCGCTACCCGCATTGATGCGCGTTT
AGGGGGAACCATACCGAGCACGAAGGGTGTCCTATGA

Upstream 100 bases:

>100_bases
GCACTTGATGTGCGCTTGAGTACCGTCATGGCGGCCAACATCGAGAAACTGCGACGGCGTTACCCGGAGGGATTTAGCAG
TGAGCGAAGTCAGCAGCGTA

Downstream 100 bases:

>100_bases
TCGGGTTTGTCGCTGCTGCCATCCTCAGCTTTGTACCGGCATTCATCTACGCTGCAATTGCCTACTGGCTCGACCGGTTT
GAGAAAGAGCCACGCCGGTT

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD [H]

Number of amino acids: Translated: 198; Mature: 198

Protein sequence:

>198_residues
MNRIRRATIERVTGETNITLTLTIDGSGQADVQTGIGFLDHMLTLWARHGLFDLQVRAQGDLHIDEHHTAEDVCICLGRA
IDQALGERAGIVRTAHSFVPMDEALALVAVDLGGRPYCVVQADFVTMRVGQLGTDLVAHLFESVAFNGRFNLHAQVMYGR
NDHHKIEALFKAFGRALDAATRIDARLGGTIPSTKGVL

Sequences:

>Translated_198_residues
MNRIRRATIERVTGETNITLTLTIDGSGQADVQTGIGFLDHMLTLWARHGLFDLQVRAQGDLHIDEHHTAEDVCICLGRA
IDQALGERAGIVRTAHSFVPMDEALALVAVDLGGRPYCVVQADFVTMRVGQLGTDLVAHLFESVAFNGRFNLHAQVMYGR
NDHHKIEALFKAFGRALDAATRIDARLGGTIPSTKGVL
>Mature_198_residues
MNRIRRATIERVTGETNITLTLTIDGSGQADVQTGIGFLDHMLTLWARHGLFDLQVRAQGDLHIDEHHTAEDVCICLGRA
IDQALGERAGIVRTAHSFVPMDEALALVAVDLGGRPYCVVQADFVTMRVGQLGTDLVAHLFESVAFNGRFNLHAQVMYGR
NDHHKIEALFKAFGRALDAATRIDARLGGTIPSTKGVL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=196, Percent_Identity=44.8979591836735, Blast_Score=172, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6324776, Length=218, Percent_Identity=38.9908256880734, Blast_Score=154, Evalue=7e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD [H]

EC number: =4.2.1.19 [H]

Molecular weight: Translated: 21612; Mature: 21612

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: PS00954 IGP_DEHYDRATASE_1 ; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRIRRATIERVTGETNITLTLTIDGSGQADVQTGIGFLDHMLTLWARHGLFDLQVRAQG
CCCHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEEECC
DLHIDEHHTAEDVCICLGRAIDQALGERAGIVRTAHSFVPMDEALALVAVDLGGRPYCVV
CEEECCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHEEEEEEECCCCEEEEE
QADFVTMRVGQLGTDLVAHLFESVAFNGRFNLHAQVMYGRNDHHKIEALFKAFGRALDAA
EECCEEEEHHHCCHHHHHHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHH
TRIDARLGGTIPSTKGVL
HHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MNRIRRATIERVTGETNITLTLTIDGSGQADVQTGIGFLDHMLTLWARHGLFDLQVRAQG
CCCHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEEECC
DLHIDEHHTAEDVCICLGRAIDQALGERAGIVRTAHSFVPMDEALALVAVDLGGRPYCVV
CEEECCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHEEEEEEECCCCEEEEE
QADFVTMRVGQLGTDLVAHLFESVAFNGRFNLHAQVMYGRNDHHKIEALFKAFGRALDAA
EECCEEEEHHHCCHHHHHHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHH
TRIDARLGGTIPSTKGVL
HHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA