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The map label for this gene is hom [H]

Identifier: 222525333

GI number: 222525333

Start: 2638806

End: 2639870

Strand: Direct

Name: hom [H]

Synonym: Chy400_2076

Alternate gene names: 222525333

Gene position: 2638806-2639870 (Clockwise)

Preceding gene: 222525329

Following gene: 222525335

Centisome position: 50.08

GC content: 56.9

Gene sequence:

>1065_bases
ATGGACACCGTTCACACTCTTCTTACCGGTTTAGGGAATATTGGTCGCACCTTCCTTGAGATGTTAATCGCCGATCCTGA
GCGTTTACCGCGTCGCTATGGCTTCCGTCTCAAGATTGTCGGCGTTGCCGACTCTACGGGTGTCGCCCTTGATCCATCTG
GGCTTGATCTGGCAGCGATTGTTGATCTCAAACGACGGCGGCTTGGAGTACGAGAGTTGCCGGCCTTTCGGTCCGATCTC
AATCCGGTTACCCTGGCGCAGACAGCCGAATATGATCTCGTGTTAGAAGCAACGCCAACCAATCTTCGTGATGGTCAGCC
AGGACTTGACATCGTTCGCTCAGCGCTTCAACGCGGCAAAGCTGCGGTTCTGGCCAGTAAAGGCCCGCTGGTGTTGGCAT
TTCAAGAGCTGGCGAGACTTAGCGATTGGGCTGATGATCTTTCACCCCATAGCCAGCGTCCACCGTTGCGCTTTTCTGGT
GCGGTTGGCGGCGCTTTGCCGACGATTAATTTTGGCCGACGTGATCTGGCTGGTGCCCAGATCGAACGCGCAGAACTGGT
GGTGAATGGCACAACCCAGGTCATTCTCGAACAGATGGCTGCCGGTGCCGATTTCGCCACTGCCCTGGCCGAGGCACAGC
GGCAGGGCATCGTCGAACCCGATCCCTCACTTGATGTTGATGGCTGGGATGCCGCGAATAAACTGGTCATCTTCGCCAAT
GCGGTGCTCAATCAGCCGGCAACACTGGCCGATGTACAGGTGCGCGGTATCCGTGAAGTGAGCGCCGACGATCTGGCAGC
GGCCTGGCGTGCCGGTGGACGCATCTCGCTGGTTGCCACTGCCGTGCGTCAAACGGATGGAACGTATACTCTCTCGGTCG
CGCCAACGGTGTTGACAGCCGACCATCCATTGTCCCGACTGGCGCATGGCGAGATGGGTTTTGTCATCTACAGCGATAGT
GCCGGTCGTTCAACGGTCAGCAGTCTCGAAGATGGCCCTCTCGGTACCTGTCAGGCTATGCTACGTGATGTGATTGATAT
TCGTCATCGTCTGAAGCGTCATTAA

Upstream 100 bases:

>100_bases
CATAGGTGCTGCGACGCAAATCTTGATTTGCTTAACTGCTGTGTGTGACTTTATATTATACACGCTCAAGTCATGATTGC
ATAGGAGTACTTAAGTACTT

Downstream 100 bases:

>100_bases
GGAATCAGACCGAGCCGTCGCCCGCGTGCTACCGCTTGCGTGCGCGAGGCGACGCCCAGTTTACTAAAGATGTTGTTAAC
ATGCGATTTTACCGTACTGA

Product: Homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 354; Mature: 354

Protein sequence:

>354_residues
MDTVHTLLTGLGNIGRTFLEMLIADPERLPRRYGFRLKIVGVADSTGVALDPSGLDLAAIVDLKRRRLGVRELPAFRSDL
NPVTLAQTAEYDLVLEATPTNLRDGQPGLDIVRSALQRGKAAVLASKGPLVLAFQELARLSDWADDLSPHSQRPPLRFSG
AVGGALPTINFGRRDLAGAQIERAELVVNGTTQVILEQMAAGADFATALAEAQRQGIVEPDPSLDVDGWDAANKLVIFAN
AVLNQPATLADVQVRGIREVSADDLAAAWRAGGRISLVATAVRQTDGTYTLSVAPTVLTADHPLSRLAHGEMGFVIYSDS
AGRSTVSSLEDGPLGTCQAMLRDVIDIRHRLKRH

Sequences:

>Translated_354_residues
MDTVHTLLTGLGNIGRTFLEMLIADPERLPRRYGFRLKIVGVADSTGVALDPSGLDLAAIVDLKRRRLGVRELPAFRSDL
NPVTLAQTAEYDLVLEATPTNLRDGQPGLDIVRSALQRGKAAVLASKGPLVLAFQELARLSDWADDLSPHSQRPPLRFSG
AVGGALPTINFGRRDLAGAQIERAELVVNGTTQVILEQMAAGADFATALAEAQRQGIVEPDPSLDVDGWDAANKLVIFAN
AVLNQPATLADVQVRGIREVSADDLAAAWRAGGRISLVATAVRQTDGTYTLSVAPTVLTADHPLSRLAHGEMGFVIYSDS
AGRSTVSSLEDGPLGTCQAMLRDVIDIRHRLKRH
>Mature_354_residues
MDTVHTLLTGLGNIGRTFLEMLIADPERLPRRYGFRLKIVGVADSTGVALDPSGLDLAAIVDLKRRRLGVRELPAFRSDL
NPVTLAQTAEYDLVLEATPTNLRDGQPGLDIVRSALQRGKAAVLASKGPLVLAFQELARLSDWADDLSPHSQRPPLRFSG
AVGGALPTINFGRRDLAGAQIERAELVVNGTTQVILEQMAAGADFATALAEAQRQGIVEPDPSLDVDGWDAANKLVIFAN
AVLNQPATLADVQVRGIREVSADDLAAAWRAGGRISLVATAVRQTDGTYTLSVAPTVLTADHPLSRLAHGEMGFVIYSDS
AGRSTVSSLEDGPLGTCQAMLRDVIDIRHRLKRH

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the homoserine dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1790376, Length=242, Percent_Identity=30.5785123966942, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005106
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR022697
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 37870; Mature: 37870

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTVHTLLTGLGNIGRTFLEMLIADPERLPRRYGFRLKIVGVADSTGVALDPSGLDLAAI
CCHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHCCEEEEEEEECCCCCEECCCCCCHHHH
VDLKRRRLGVRELPAFRSDLNPVTLAQTAEYDLVLEATPTNLRDGQPGLDIVRSALQRGK
HHHHHHHCCHHHCCHHHHCCCCEEEEECCCEEEEEEECCCCCCCCCCCHHHHHHHHHCCC
AAVLASKGPLVLAFQELARLSDWADDLSPHSQRPPLRFSGAVGGALPTINFGRRDLAGAQ
EEEEECCCCEEEHHHHHHHHHHHHHHCCCCCCCCCCEECCCCCCCCCCCCCCCCHHCCCC
IERAELVVNGTTQVILEQMAAGADFATALAEAQRQGIVEPDPSLDVDGWDAANKLVIFAN
EEEEEEEECCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEE
AVLNQPATLADVQVRGIREVSADDLAAAWRAGGRISLVATAVRQTDGTYTLSVAPTVLTA
HHHCCCCCEEHHHHHCHHHCCHHHHHHHHHCCCEEEEEEHHHHHCCCCEEEEECCEEEEC
DHPLSRLAHGEMGFVIYSDSAGRSTVSSLEDGPLGTCQAMLRDVIDIRHRLKRH
CCHHHHHCCCCCEEEEEECCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDTVHTLLTGLGNIGRTFLEMLIADPERLPRRYGFRLKIVGVADSTGVALDPSGLDLAAI
CCHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHHCCEEEEEEEECCCCCEECCCCCCHHHH
VDLKRRRLGVRELPAFRSDLNPVTLAQTAEYDLVLEATPTNLRDGQPGLDIVRSALQRGK
HHHHHHHCCHHHCCHHHHCCCCEEEEECCCEEEEEEECCCCCCCCCCCHHHHHHHHHCCC
AAVLASKGPLVLAFQELARLSDWADDLSPHSQRPPLRFSGAVGGALPTINFGRRDLAGAQ
EEEEECCCCEEEHHHHHHHHHHHHHHCCCCCCCCCCEECCCCCCCCCCCCCCCCHHCCCC
IERAELVVNGTTQVILEQMAAGADFATALAEAQRQGIVEPDPSLDVDGWDAANKLVIFAN
EEEEEEEECCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEE
AVLNQPATLADVQVRGIREVSADDLAAAWRAGGRISLVATAVRQTDGTYTLSVAPTVLTA
HHHCCCCCEEHHHHHCHHHCCHHHHHHHHHCCCEEEEEEHHHHHCCCCEEEEECCEEEEC
DHPLSRLAHGEMGFVIYSDSAGRSTVSSLEDGPLGTCQAMLRDVIDIRHRLKRH
CCHHHHHCCCCCEEEEEECCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]