Click here to switch to the map view.

The map label for this gene is pyrC [H]

Identifier: 222525302

GI number: 222525302

Start: 2591364

End: 2592824

Strand: Direct

Name: pyrC [H]

Synonym: Chy400_2044

Alternate gene names: 222525302

Gene position: 2591364-2592824 (Clockwise)

Preceding gene: 222525301

Following gene: 222525303

Centisome position: 49.18

GC content: 60.23

Gene sequence:

>1461_bases
ATGCGTTATCTGATTAAAAATGGCACGATTATCGATCCGGCCAATCGTGTAGCCACCATTGGCGATATTCTGGTTGCCAA
CGGTAAAGTTGAGCGGTTGTACGATCTGGCCGATCTGCACACTGATCGCGAACCATTAGCACCTGATGTAGAGGTGATCA
ATGCTCGTGGTTGTGTGGTTGCCCCCGGTTTTACCGATCTCCACACCCACCTGCGCCAACCGGGTGAAGAGCACAAAGAG
ACTATTGCCAGTGTTAGTGCCGCTGCGGCGGTTGGCGGTTTTACCACTCTTTGCGCCCGACCGACGACACGACCAACACC
GGATCATGCGGCGGCCATTCGTCAGTTGCGTGAGCTGGCCGATCAGTACGCCAGAGTGCGGATTGATCTGATCGGCGCAT
TAACCATGGGCAATGAGGGTCAGGTGCTGAGTGAGATGCGAGAGCTGGCCGAAGCCGGTTGTATTGCCTTCAGCGATGGT
GGGCGGACGATTGCCAATACGGCCTTGCTGCGTCATGCCCTCGCCTATGCCGCGGCCCTCAAATTACCGGTGATGGTCAG
TTGTCAGGACCCGTATCTGGCGGCGGGCGGAGTAGCGCACGAAGGTGCCGTCAGTATTCGATTGGGCTTACCCGCTATTC
CGGCGGCTGCCGAAGAGGCGATTGTCGCCCGCGATATTGCCCTTGCCGAAGCGACTGGTGCGCATCTGCATATCAGTCGG
GTCAGTACAGCCGGCAGCGTGGCGCTGATTCGCGCCGCTCGCGCTCGCGGCGTCCATGTCACGGCTGAAGTCACACCACA
CCACCTGACGCTGAGCGACCGCTGGCTGTTGGGATGGCTGGAAGAGCGCAACGAGATTGAGACCGGGCGGCCCGGTGCGC
ATCCCGATCTGAGCCTGCCGTCGTGGCTCAATCCGGCGCTGTTGCCACCCTATGACAGCTCAACCCGGGTTGACCCGCCT
TTACGCAGTATCGAACACGTTGAGGCGTTGGTGGAGGGGCTGCGCGATGGGGTGATTGATGCGATTGCCACCGATCACGC
CCCTCACGCGCTGGTAGACCGGGACTGCGAATATGGGATTGCCCCGCCCGGCATCAGTGGTCTGGAAACGGCCCTGGCCC
TCACCCTGACCCTCGTTCACCGTGGTGAGATGGACATTGTCAACCTGATCGCCAAACTCACCGAAGGACCAGCGCAGGTG
CTCAACCGCTCACCGGCCAATCTCCGCCCAGGCGCTACTGCCGATATTGTCATCTTCGATCCCGAACGCAGTTGGGTGGT
CGACCCAGATCACTTTGCATCGCGTGGTCGCAATACGCCACTGCGTGGTCAGCGCCTGAAGGGGCAGGTGATGCTCACCA
TGGCTGCCGGTAAGATTATCTTTCGCCGTGAGGATTTTGGTCGGCAGGCGCAGGCCGCCCCGCAACCTTCGCGGTTGGAG
GGTATTTTGGGGGCGGAGTAG

Upstream 100 bases:

>100_bases
GGCTACCGCATCACCGGCAGTGATTGAAGAGCAGGTCACCAATGGCGTCGCAGTGCGGATGGCGTTACTCTATCGAATGG
CCGGTTGAGAGGAGATGGCA

Downstream 100 bases:

>100_bases
TGGTTTGCGGGGTGTGGAAATATGGCTTCCGCACCCCTGCCATACATGTGGCACGTGCCTGCCCGCTGCTCGCTGTTGAT
CCAGGCGTCTGACTCAATCC

Product: dihydroorotase, multifunctional complex type

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 486; Mature: 486

Protein sequence:

>486_residues
MRYLIKNGTIIDPANRVATIGDILVANGKVERLYDLADLHTDREPLAPDVEVINARGCVVAPGFTDLHTHLRQPGEEHKE
TIASVSAAAAVGGFTTLCARPTTRPTPDHAAAIRQLRELADQYARVRIDLIGALTMGNEGQVLSEMRELAEAGCIAFSDG
GRTIANTALLRHALAYAAALKLPVMVSCQDPYLAAGGVAHEGAVSIRLGLPAIPAAAEEAIVARDIALAEATGAHLHISR
VSTAGSVALIRAARARGVHVTAEVTPHHLTLSDRWLLGWLEERNEIETGRPGAHPDLSLPSWLNPALLPPYDSSTRVDPP
LRSIEHVEALVEGLRDGVIDAIATDHAPHALVDRDCEYGIAPPGISGLETALALTLTLVHRGEMDIVNLIAKLTEGPAQV
LNRSPANLRPGATADIVIFDPERSWVVDPDHFASRGRNTPLRGQRLKGQVMLTMAAGKIIFRREDFGRQAQAAPQPSRLE
GILGAE

Sequences:

>Translated_486_residues
MRYLIKNGTIIDPANRVATIGDILVANGKVERLYDLADLHTDREPLAPDVEVINARGCVVAPGFTDLHTHLRQPGEEHKE
TIASVSAAAAVGGFTTLCARPTTRPTPDHAAAIRQLRELADQYARVRIDLIGALTMGNEGQVLSEMRELAEAGCIAFSDG
GRTIANTALLRHALAYAAALKLPVMVSCQDPYLAAGGVAHEGAVSIRLGLPAIPAAAEEAIVARDIALAEATGAHLHISR
VSTAGSVALIRAARARGVHVTAEVTPHHLTLSDRWLLGWLEERNEIETGRPGAHPDLSLPSWLNPALLPPYDSSTRVDPP
LRSIEHVEALVEGLRDGVIDAIATDHAPHALVDRDCEYGIAPPGISGLETALALTLTLVHRGEMDIVNLIAKLTEGPAQV
LNRSPANLRPGATADIVIFDPERSWVVDPDHFASRGRNTPLRGQRLKGQVMLTMAAGKIIFRREDFGRQAQAAPQPSRLE
GILGAE
>Mature_486_residues
MRYLIKNGTIIDPANRVATIGDILVANGKVERLYDLADLHTDREPLAPDVEVINARGCVVAPGFTDLHTHLRQPGEEHKE
TIASVSAAAAVGGFTTLCARPTTRPTPDHAAAIRQLRELADQYARVRIDLIGALTMGNEGQVLSEMRELAEAGCIAFSDG
GRTIANTALLRHALAYAAALKLPVMVSCQDPYLAAGGVAHEGAVSIRLGLPAIPAAAEEAIVARDIALAEATGAHLHISR
VSTAGSVALIRAARARGVHVTAEVTPHHLTLSDRWLLGWLEERNEIETGRPGAHPDLSLPSWLNPALLPPYDSSTRVDPP
LRSIEHVEALVEGLRDGVIDAIATDHAPHALVDRDCEYGIAPPGISGLETALALTLTLVHRGEMDIVNLIAKLTEGPAQV
LNRSPANLRPGATADIVIFDPERSWVVDPDHFASRGRNTPLRGQRLKGQVMLTMAAGKIIFRREDFGRQAQAAPQPSRLE
GILGAE

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=418, Percent_Identity=31.8181818181818, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI19923821, Length=492, Percent_Identity=23.9837398373984, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI4503051, Length=486, Percent_Identity=20.7818930041152, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI62422571, Length=485, Percent_Identity=20.8247422680412, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1786722, Length=480, Percent_Identity=26.0416666666667, Blast_Score=129, Evalue=5e-31,
Organism=Escherichia coli, GI87082175, Length=486, Percent_Identity=25.5144032921811, Blast_Score=99, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI193204318, Length=443, Percent_Identity=27.0880361173815, Blast_Score=125, Evalue=7e-29,
Organism=Drosophila melanogaster, GI24642586, Length=419, Percent_Identity=30.5489260143198, Blast_Score=153, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 51930; Mature: 51930

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYLIKNGTIIDPANRVATIGDILVANGKVERLYDLADLHTDREPLAPDVEVINARGCVV
CCEEECCCCEECCCHHHHHHHHEEEECCCHHHHHHHHHHCCCCCCCCCCCEEEECCCCEE
APGFTDLHTHLRQPGEEHKETIASVSAAAAVGGFTTLCARPTTRPTPDHAAAIRQLRELA
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCHHHHHHHHHHHHH
DQYARVRIDLIGALTMGNEGQVLSEMRELAEAGCIAFSDGGRTIANTALLRHALAYAAAL
HHHHHEEEEEEEEEEECCCCHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHH
KLPVMVSCQDPYLAAGGVAHEGAVSIRLGLPAIPAAAEEAIVARDIALAEATGAHLHISR
CCCEEEECCCCCEECCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEE
VSTAGSVALIRAARARGVHVTAEVTPHHLTLSDRWLLGWLEERNEIETGRPGAHPDLSLP
CCCCCCHHHHHHHHCCCEEEEEECCCCEEEECCCHHHHHHHHCCCCCCCCCCCCCCCCCC
SWLNPALLPPYDSSTRVDPPLRSIEHVEALVEGLRDGVIDAIATDHAPHALVDRDCEYGI
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCC
APPGISGLETALALTLTLVHRGEMDIVNLIAKLTEGPAQVLNRSPANLRPGATADIVIFD
CCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCEEEEEEC
PERSWVVDPDHFASRGRNTPLRGQRLKGQVMLTMAAGKIIFRREDFGRQAQAAPQPSRLE
CCCCEEECCHHHHHCCCCCCCCCCCCCCEEEEEEECCEEEEEECCCCCCCCCCCCHHHHC
GILGAE
CCCCCC
>Mature Secondary Structure
MRYLIKNGTIIDPANRVATIGDILVANGKVERLYDLADLHTDREPLAPDVEVINARGCVV
CCEEECCCCEECCCHHHHHHHHEEEECCCHHHHHHHHHHCCCCCCCCCCCEEEECCCCEE
APGFTDLHTHLRQPGEEHKETIASVSAAAAVGGFTTLCARPTTRPTPDHAAAIRQLRELA
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCHHHHHHHHHHHHH
DQYARVRIDLIGALTMGNEGQVLSEMRELAEAGCIAFSDGGRTIANTALLRHALAYAAAL
HHHHHEEEEEEEEEEECCCCHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHH
KLPVMVSCQDPYLAAGGVAHEGAVSIRLGLPAIPAAAEEAIVARDIALAEATGAHLHISR
CCCEEEECCCCCEECCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEE
VSTAGSVALIRAARARGVHVTAEVTPHHLTLSDRWLLGWLEERNEIETGRPGAHPDLSLP
CCCCCCHHHHHHHHCCCEEEEEECCCCEEEECCCHHHHHHHHCCCCCCCCCCCCCCCCCC
SWLNPALLPPYDSSTRVDPPLRSIEHVEALVEGLRDGVIDAIATDHAPHALVDRDCEYGI
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCC
APPGISGLETALALTLTLVHRGEMDIVNLIAKLTEGPAQVLNRSPANLRPGATADIVIFD
CCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCEEEEEEC
PERSWVVDPDHFASRGRNTPLRGQRLKGQVMLTMAAGKIIFRREDFGRQAQAAPQPSRLE
CCCCEEECCHHHHHCCCCCCCCCCCCCCEEEEEEECCEEEEEECCCCCCCCCCCCHHHHC
GILGAE
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA