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The map label for this gene is mtaD [H]

Identifier: 222525258

GI number: 222525258

Start: 2535587

End: 2536924

Strand: Direct

Name: mtaD [H]

Synonym: Chy400_1998

Alternate gene names: 222525258

Gene position: 2535587-2536924 (Clockwise)

Preceding gene: 222525244

Following gene: 222525259

Centisome position: 48.12

GC content: 59.42

Gene sequence:

>1338_bases
ATGTACGATCTTCTTGTTCAACGCGCCGACGTACTTCAGATCGCCAACGGCGTTCCTTCCGTGCTGCCGCAACACGATAT
TGCGATTACCGATAGACGTATCGTCGCCATCGCTCCCGACATCAGCCCCGGTCTTGCTCGTGAAACTCTGGCCGCTGATG
GTCTGCTTGCTATTCCCGGTCTGATCAATAGTCACTCCCACACCGCGATGAGTCTGTTTCGCGGTGTCGCTGAAGATGTT
CCCATCGAAGAGTGGTTCAACGGCATTATCTGGCCGCTGGAGACCAATCTCACCCCTGAAGATGTCTATTGGGGCACATT
GCTCGGTCTAGCTGAGATGATCGAAGCGGGTGTGACCTGCGTCGCCGATCATTACTTTGCTATGGATGCAATTGTCCAGG
CGGTGCAGGAGTCGGGGATGCGTGCACTGCTGGCCTGGACGATCTTTTCGGGGGCTGATGAACACGAACAATTGAGTCAG
GCACGTCAGTTTGTCGAGCAGTGGCACGGTGCTGAGGCAGATCGGATTCGGGTCTGGATGGGGCCGCATTCACCGTATAC
CTGCACACCATCGTTGTTGCGACGGGTGGCCCAGACAGCGCGTGAACTCGGCGTCGGTATTCATATTCACCTTTCCGAAA
CCGCAGCCCAGGTGGCCCAGAGTCTCGCTACCCACGGCTGTTCACCGGTCTCCGTCGCCCGCAACGCCGGCCTGTTCGAC
GTACCGGCCCTGGCAGCGCACGTTGCCCACGTGTCACCAGAGGATATTGCGACCCTGGCAGCCCATGGTGTAGCGGTGGC
CGTTACTCCGAAAACCGAGATGAAACTGGGCATCGGTGTTGCGCCAACGCTGGCAATGCGCGAAGCGGGGGTCACCGTTG
CGCTTGGGAGTGACGGTGCGGCAAGCAATAACACCTACGATATTCTGGAGTCGGCTCGCCTGCTGGCCCTGCTCGAAAAG
CTACGCCAGAGTGATGCCCGTTGTATGCCAATCGGAACTACGCTCGAACTGGCTACCGGCGCCGGTGCCCGCGCGTTGCA
ATGGGACGGGATCGGTGTCTTGCAGGTTGGTGCCCGTGCCGATCTTGCCCTGGTACAATGCGCAACTGCCCATACGCAGC
CGCTGCACAACCCGGCAGCAGCGTTGCTCTACAGTTCGCAGGCTGCCGATGTTGATACAGTGATCGTTGATGGTCGCATC
CTGATGCACAGGCGTACCCTGCTTACCATCGATAAACCGCGAGTGTTACGCGAGGTGGCTGCGCGGATCGAGCGTCTCAC
CCAACGCCAGGGCGAACGACGGATTGCGACGTACCCTGAAGCGCAGGCGAGCCGGTAG

Upstream 100 bases:

>100_bases
GAGACTATTATAGCACAAATGTTCAATTTTTGTCAATCTTGAGATTTCCGGTTACAATGCCCATAATAACCGAAGTGCAA
TATCAATATAGAGAAACGTT

Downstream 100 bases:

>100_bases
CCGAGTAGATGATATCTGATGGCAGAGTCGATATGCCAATTCCCGATTTCCAAACGATCATGCTGCCCATGCTACGGGTG
ATGGCCGATGGTCAAGAGCA

Product: amidohydrolase

Products: NA

Alternate protein names: MTA/SAH deaminase [H]

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
MYDLLVQRADVLQIANGVPSVLPQHDIAITDRRIVAIAPDISPGLARETLAADGLLAIPGLINSHSHTAMSLFRGVAEDV
PIEEWFNGIIWPLETNLTPEDVYWGTLLGLAEMIEAGVTCVADHYFAMDAIVQAVQESGMRALLAWTIFSGADEHEQLSQ
ARQFVEQWHGAEADRIRVWMGPHSPYTCTPSLLRRVAQTARELGVGIHIHLSETAAQVAQSLATHGCSPVSVARNAGLFD
VPALAAHVAHVSPEDIATLAAHGVAVAVTPKTEMKLGIGVAPTLAMREAGVTVALGSDGAASNNTYDILESARLLALLEK
LRQSDARCMPIGTTLELATGAGARALQWDGIGVLQVGARADLALVQCATAHTQPLHNPAAALLYSSQAADVDTVIVDGRI
LMHRRTLLTIDKPRVLREVAARIERLTQRQGERRIATYPEAQASR

Sequences:

>Translated_445_residues
MYDLLVQRADVLQIANGVPSVLPQHDIAITDRRIVAIAPDISPGLARETLAADGLLAIPGLINSHSHTAMSLFRGVAEDV
PIEEWFNGIIWPLETNLTPEDVYWGTLLGLAEMIEAGVTCVADHYFAMDAIVQAVQESGMRALLAWTIFSGADEHEQLSQ
ARQFVEQWHGAEADRIRVWMGPHSPYTCTPSLLRRVAQTARELGVGIHIHLSETAAQVAQSLATHGCSPVSVARNAGLFD
VPALAAHVAHVSPEDIATLAAHGVAVAVTPKTEMKLGIGVAPTLAMREAGVTVALGSDGAASNNTYDILESARLLALLEK
LRQSDARCMPIGTTLELATGAGARALQWDGIGVLQVGARADLALVQCATAHTQPLHNPAAALLYSSQAADVDTVIVDGRI
LMHRRTLLTIDKPRVLREVAARIERLTQRQGERRIATYPEAQASR
>Mature_445_residues
MYDLLVQRADVLQIANGVPSVLPQHDIAITDRRIVAIAPDISPGLARETLAADGLLAIPGLINSHSHTAMSLFRGVAEDV
PIEEWFNGIIWPLETNLTPEDVYWGTLLGLAEMIEAGVTCVADHYFAMDAIVQAVQESGMRALLAWTIFSGADEHEQLSQ
ARQFVEQWHGAEADRIRVWMGPHSPYTCTPSLLRRVAQTARELGVGIHIHLSETAAQVAQSLATHGCSPVSVARNAGLFD
VPALAAHVAHVSPEDIATLAAHGVAVAVTPKTEMKLGIGVAPTLAMREAGVTVALGSDGAASNNTYDILESARLLALLEK
LRQSDARCMPIGTTLELATGAGARALQWDGIGVLQVGARADLALVQCATAHTQPLHNPAAALLYSSQAADVDTVIVDGRI
LMHRRTLLTIDKPRVLREVAARIERLTQRQGERRIATYPEAQASR

Specific function: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MTA/SAH deaminase family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=369, Percent_Identity=21.9512195121951, Blast_Score=89, Evalue=7e-18,
Organism=Escherichia coli, GI87082177, Length=410, Percent_Identity=23.6585365853659, Blast_Score=95, Evalue=9e-21,
Organism=Escherichia coli, GI1789249, Length=362, Percent_Identity=22.9281767955801, Blast_Score=72, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24643849, Length=403, Percent_Identity=23.8213399503722, Blast_Score=85, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.28 [H]

Molecular weight: Translated: 47704; Mature: 47704

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYDLLVQRADVLQIANGVPSVLPQHDIAITDRRIVAIAPDISPGLARETLAADGLLAIPG
CCHHHHHHHHHHHHHCCCCCCCCCCCEEEECCEEEEECCCCCCCHHHHHHHCCCCEECCC
LINSHSHTAMSLFRGVAEDVPIEEWFNGIIWPLETNLTPEDVYWGTLLGLAEMIEAGVTC
CCCCCCHHHHHHHHHHHHCCCHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCHH
VADHYFAMDAIVQAVQESGMRALLAWTIFSGADEHEQLSQARQFVEQWHGAEADRIRVWM
HHHHHHHHHHHHHHHHHCCCCEEEHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEE
GPHSPYTCTPSLLRRVAQTARELGVGIHIHLSETAAQVAQSLATHGCSPVSVARNAGLFD
CCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHCCCCCHHHHHCCCCCC
VPALAAHVAHVSPEDIATLAAHGVAVAVTPKTEMKLGIGVAPTLAMREAGVTVALGSDGA
HHHHHHHHHCCCHHHHHHHHHCCEEEEECCCCCCEECCCCCCHHHHHHCCEEEEECCCCC
ASNNTYDILESARLLALLEKLRQSDARCMPIGTTLELATGAGARALQWDGIGVLQVGARA
CCCCHHHHHHHHHHHHHHHHHHHCCCCEEECCCEEEECCCCCCCEEEECCCEEEEECCCC
DLALVQCATAHTQPLHNPAAALLYSSQAADVDTVIVDGRILMHRRTLLTIDKPRVLREVA
CCHHHHHHHHCCCCCCCHHHHHEECCCCCCCEEEEECCEEEEEECEEEEECCHHHHHHHH
ARIERLTQRQGERRIATYPEAQASR
HHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MYDLLVQRADVLQIANGVPSVLPQHDIAITDRRIVAIAPDISPGLARETLAADGLLAIPG
CCHHHHHHHHHHHHHCCCCCCCCCCCEEEECCEEEEECCCCCCCHHHHHHHCCCCEECCC
LINSHSHTAMSLFRGVAEDVPIEEWFNGIIWPLETNLTPEDVYWGTLLGLAEMIEAGVTC
CCCCCCHHHHHHHHHHHHCCCHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCHH
VADHYFAMDAIVQAVQESGMRALLAWTIFSGADEHEQLSQARQFVEQWHGAEADRIRVWM
HHHHHHHHHHHHHHHHHCCCCEEEHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEE
GPHSPYTCTPSLLRRVAQTARELGVGIHIHLSETAAQVAQSLATHGCSPVSVARNAGLFD
CCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHCCCCCHHHHHCCCCCC
VPALAAHVAHVSPEDIATLAAHGVAVAVTPKTEMKLGIGVAPTLAMREAGVTVALGSDGA
HHHHHHHHHCCCHHHHHHHHHCCEEEEECCCCCCEECCCCCCHHHHHHCCEEEEECCCCC
ASNNTYDILESARLLALLEKLRQSDARCMPIGTTLELATGAGARALQWDGIGVLQVGARA
CCCCHHHHHHHHHHHHHHHHHHHCCCCEEECCCEEEECCCCCCCEEEECCCEEEEECCCC
DLALVQCATAHTQPLHNPAAALLYSSQAADVDTVIVDGRILMHRRTLLTIDKPRVLREVA
CCHHHHHHHHCCCCCCCHHHHHEECCCCCCCEEEEECCEEEEEECEEEEECCHHHHHHHH
ARIERLTQRQGERRIATYPEAQASR
HHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA