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The map label for this gene is degU [H]

Identifier: 222525026

GI number: 222525026

Start: 2226130

End: 2226870

Strand: Reverse

Name: degU [H]

Synonym: Chy400_1761

Alternate gene names: 222525026

Gene position: 2226870-2226130 (Counterclockwise)

Preceding gene: 222525027

Following gene: 222525016

Centisome position: 42.26

GC content: 54.25

Gene sequence:

>741_bases
ATGGCCAACCCAACCGTAAAGCTGTTGATCGTCGATGACCATCCACTCTTCCGGCAAGGAGTGCGGTGGGCATTATCGAA
TGAACCGGGCATTCAGATTGTTGGTGAAGCAGCCAATGGTGAAGAGGCATTGCGCTGGTTGGCCCAGGTCGATGCCGGTT
CTGAGCCAAATGTGATGCTGGTTGATCTGAATTTGCCGGGAATGAGTGGGTTGGAGTTGACACGCCAGATTCGTCGGCAG
TACACGAGTATCGCTGTGGTGATGCTGAGCATGCACGAGAATGATGAGGCAGCCTTTAATGCTTTGCGCGCCGGTGCTGC
TGCCTATCGCTCGAAGGATATTAAACCCGCTGCCCTGGCCGATATTCTGCGACGAGTAGCCCACGGCGAGTATGTGATTA
ACGATGTCTTGCTGGAAGAGCCACGGGTGGCGAGTCGCATTCTGTCGCAATTTCGCAATTTGCCCGAAGTGCAGATGTTG
GTCGGTGATCCGTCGATACAGGTCTTCACGCCACTCAGTGAGCGCGAGATCGAAGTGCTTGAACGGATCGCAGCCGGTAA
CAGCAATAAAGAGATTGCCGATGCCCTGGGGATTAGTACACAAACGGTGAAGAATCATATCTCCTCAATCCTGCGCAAGC
TGTCGCTCAATGATCGTACTCAGGCGGTGATTTTTGCACTACGCCGCGGCTGGATCGAGACGCCGCAGCAGATTCAACCC
GGTTCCGGCGAGGAAGATTGA

Upstream 100 bases:

>100_bases
CAGTGGCCCGGCTCTTGCGCGCTGTCGGCATTGAACCACCCGTTGACCCGATGAAAGCATACGACGAATGGCTACGCAGT
CAGGGAAAGGAACCGGCACC

Downstream 100 bases:

>100_bases
TGGTGTCAGGCCCGAAACCTGATACTCCTGAGTGAGTCGTCGCCCTCGCGAGTACGCTGGTTCAGTGCATCTGCGACCAG
GTGCAGCGCCAGGACGACGA

Product: LuxR family two component transcriptional regulator

Products: NA

Alternate protein names: Protease production enhancer protein [H]

Number of amino acids: Translated: 246; Mature: 245

Protein sequence:

>246_residues
MANPTVKLLIVDDHPLFRQGVRWALSNEPGIQIVGEAANGEEALRWLAQVDAGSEPNVMLVDLNLPGMSGLELTRQIRRQ
YTSIAVVMLSMHENDEAAFNALRAGAAAYRSKDIKPAALADILRRVAHGEYVINDVLLEEPRVASRILSQFRNLPEVQML
VGDPSIQVFTPLSEREIEVLERIAAGNSNKEIADALGISTQTVKNHISSILRKLSLNDRTQAVIFALRRGWIETPQQIQP
GSGEED

Sequences:

>Translated_246_residues
MANPTVKLLIVDDHPLFRQGVRWALSNEPGIQIVGEAANGEEALRWLAQVDAGSEPNVMLVDLNLPGMSGLELTRQIRRQ
YTSIAVVMLSMHENDEAAFNALRAGAAAYRSKDIKPAALADILRRVAHGEYVINDVLLEEPRVASRILSQFRNLPEVQML
VGDPSIQVFTPLSEREIEVLERIAAGNSNKEIADALGISTQTVKNHISSILRKLSLNDRTQAVIFALRRGWIETPQQIQP
GSGEED
>Mature_245_residues
ANPTVKLLIVDDHPLFRQGVRWALSNEPGIQIVGEAANGEEALRWLAQVDAGSEPNVMLVDLNLPGMSGLELTRQIRRQY
TSIAVVMLSMHENDEAAFNALRAGAAAYRSKDIKPAALADILRRVAHGEYVINDVLLEEPRVASRILSQFRNLPEVQMLV
GDPSIQVFTPLSEREIEVLERIAAGNSNKEIADALGISTQTVKNHISSILRKLSLNDRTQAVIFALRRGWIETPQQIQPG
SGEED

Specific function: Regulating factor for the production of extracellular proteases. The N-terminal region acts as an inhibitor, whereas the C-terminal region carries enhancing activity [H]

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788521, Length=223, Percent_Identity=36.7713004484305, Blast_Score=131, Evalue=4e-32,
Organism=Escherichia coli, GI1788222, Length=226, Percent_Identity=31.858407079646, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1787473, Length=218, Percent_Identity=33.9449541284404, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1790102, Length=213, Percent_Identity=30.9859154929577, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI87082052, Length=121, Percent_Identity=32.2314049586777, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1788546, Length=236, Percent_Identity=24.5762711864407, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 27147; Mature: 27016

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANPTVKLLIVDDHPLFRQGVRWALSNEPGIQIVGEAANGEEALRWLAQVDAGSEPNVML
CCCCEEEEEEECCCHHHHHCCHHHCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCEEE
VDLNLPGMSGLELTRQIRRQYTSIAVVMLSMHENDEAAFNALRAGAAAYRSKDIKPAALA
EEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHH
DILRRVAHGEYVINDVLLEEPRVASRILSQFRNLPEVQMLVGDPSIQVFTPLSEREIEVL
HHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEECCCCEEEECCCCHHHHHHH
ERIAAGNSNKEIADALGISTQTVKNHISSILRKLSLNDRTQAVIFALRRGWIETPQQIQP
HHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHCCC
GSGEED
CCCCCC
>Mature Secondary Structure 
ANPTVKLLIVDDHPLFRQGVRWALSNEPGIQIVGEAANGEEALRWLAQVDAGSEPNVML
CCCEEEEEEECCCHHHHHCCHHHCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCEEE
VDLNLPGMSGLELTRQIRRQYTSIAVVMLSMHENDEAAFNALRAGAAAYRSKDIKPAALA
EEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHH
DILRRVAHGEYVINDVLLEEPRVASRILSQFRNLPEVQMLVGDPSIQVFTPLSEREIEVL
HHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHCCCCEEEEECCCCEEEECCCCHHHHHHH
ERIAAGNSNKEIADALGISTQTVKNHISSILRKLSLNDRTQAVIFALRRGWIETPQQIQP
HHHHCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHCCC
GSGEED
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3136143; 3141378; 3141377; 9384377 [H]