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The map label for this gene is map [H]

Identifier: 222524852

GI number: 222524852

Start: 2009256

End: 2010056

Strand: Reverse

Name: map [H]

Synonym: Chy400_1579

Alternate gene names: 222524852

Gene position: 2010056-2009256 (Counterclockwise)

Preceding gene: 222524853

Following gene: 222524851

Centisome position: 38.15

GC content: 57.05

Gene sequence:

>801_bases
ATGCTGATCGATGAAAGTACCACTATGGCTATCATTTTAAAATCTCCTGCCCAGATAGAACTCCTACGTGCTGCCGGTCA
ACTGGTGCGGCAGACGTTTCAGGTGCTGCGTGAGCATATTCGGCCAGGGGTAACGACGGCTGAACTCGATGCAATTGCCG
AAGAGTTCATTCGCTCGCACGGGGCCGAGCCGGTATACAAAGGGTATGTACCCGCCGGACGGCGGAACTACATTCCCCCT
TTTCCAGGCACGATCTGCGCTTCGATTAACGACGTGATTTGTCACGGTATTCCGAGCAAGCGTGATCGCCTCCGCCAGGG
TGATATTGTCGGCATCGATATCGGGCTACGCCTCAACGGCTGGATCGGCGATGCGTGCGAGACCTTTGCTGTCGGCGAGG
TTGATGATGAGACGCAACGACTCCTCGACGTGACCCGGCGTTGCCTTGAATTGGGGATTGAGCAGGCACGGGTAGGCAAC
CCCTTGCGGGCAATCGGTGCCGCAATTCAGCGCCACGCTGAAGCGAATGGCTTTTCGGTGGTGCGCGAATATACCGGTCA
TGGCCTGGGGCGTAATCTCCACGAAGAACCGACCATTCTGCATTACGACGATCCCCAGCAGACCCGCAAAATCGTCGCCG
GGATGGTGTTCACAATCGAACCGATGATCAACGCCGGCACAGCCGCAACTAAAGTTGATCGCGATGGCTGGACGGTGCGC
ACTGCTGATGGCAAGCGGTCAGCGCAGTTCGAGCATACGCTGGCTATCACCGAAGAAGGGCCGATTATTCTGACGGCCTG
A

Upstream 100 bases:

>100_bases
CTGGACGCGGGCGATTCCACGGGTCGTGGAACAGGCCGGTCTGTTACCCCGGCCACCGGTACCGTCAACCGAAGAGAATG
TGCTATAACATATGTAGTAC

Downstream 100 bases:

>100_bases
GCAGGAGGGGGATCAACGATGACGCTCGAAGAAGCTTTGATCGCAGCACTCGCTGCCGGTGATCGATCACGTGCCATCGA
GATCGCGACCGAGTTGCATG

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 266; Mature: 266

Protein sequence:

>266_residues
MLIDESTTMAIILKSPAQIELLRAAGQLVRQTFQVLREHIRPGVTTAELDAIAEEFIRSHGAEPVYKGYVPAGRRNYIPP
FPGTICASINDVICHGIPSKRDRLRQGDIVGIDIGLRLNGWIGDACETFAVGEVDDETQRLLDVTRRCLELGIEQARVGN
PLRAIGAAIQRHAEANGFSVVREYTGHGLGRNLHEEPTILHYDDPQQTRKIVAGMVFTIEPMINAGTAATKVDRDGWTVR
TADGKRSAQFEHTLAITEEGPIILTA

Sequences:

>Translated_266_residues
MLIDESTTMAIILKSPAQIELLRAAGQLVRQTFQVLREHIRPGVTTAELDAIAEEFIRSHGAEPVYKGYVPAGRRNYIPP
FPGTICASINDVICHGIPSKRDRLRQGDIVGIDIGLRLNGWIGDACETFAVGEVDDETQRLLDVTRRCLELGIEQARVGN
PLRAIGAAIQRHAEANGFSVVREYTGHGLGRNLHEEPTILHYDDPQQTRKIVAGMVFTIEPMINAGTAATKVDRDGWTVR
TADGKRSAQFEHTLAITEEGPIILTA
>Mature_266_residues
MLIDESTTMAIILKSPAQIELLRAAGQLVRQTFQVLREHIRPGVTTAELDAIAEEFIRSHGAEPVYKGYVPAGRRNYIPP
FPGTICASINDVICHGIPSKRDRLRQGDIVGIDIGLRLNGWIGDACETFAVGEVDDETQRLLDVTRRCLELGIEQARVGN
PLRAIGAAIQRHAEANGFSVVREYTGHGLGRNLHEEPTILHYDDPQQTRKIVAGMVFTIEPMINAGTAATKVDRDGWTVR
TADGKRSAQFEHTLAITEEGPIILTA

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=258, Percent_Identity=44.5736434108527, Blast_Score=202, Evalue=3e-52,
Organism=Homo sapiens, GI40385867, Length=256, Percent_Identity=41.015625, Blast_Score=189, Evalue=2e-48,
Organism=Escherichia coli, GI1786364, Length=261, Percent_Identity=43.6781609195402, Blast_Score=224, Evalue=5e-60,
Organism=Caenorhabditis elegans, GI71996291, Length=247, Percent_Identity=43.3198380566802, Blast_Score=187, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6323273, Length=250, Percent_Identity=43.2, Blast_Score=197, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24583427, Length=253, Percent_Identity=40.7114624505929, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI21355531, Length=248, Percent_Identity=39.9193548387097, Blast_Score=172, Evalue=3e-43,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 29209; Mature: 29209

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIDESTTMAIILKSPAQIELLRAAGQLVRQTFQVLREHIRPGVTTAELDAIAEEFIRSH
CCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHC
GAEPVYKGYVPAGRRNYIPPFPGTICASINDVICHGIPSKRDRLRQGDIVGIDIGLRLNG
CCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHCCCCEEEEEEEEEECC
WIGDACETFAVGEVDDETQRLLDVTRRCLELGIEQARVGNPLRAIGAAIQRHAEANGFSV
CCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHCHHHHHCCCHHHHHHHHHHHHCCCCHHHH
VREYTGHGLGRNLHEEPTILHYDDPQQTRKIVAGMVFTIEPMINAGTAATKVDRDGWTVR
HHHHHCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHEEEECHHCCCCCCEEECCCCCEEE
TADGKRSAQFEHTLAITEEGPIILTA
ECCCCCCCCEEEEEEEECCCCEEEEC
>Mature Secondary Structure
MLIDESTTMAIILKSPAQIELLRAAGQLVRQTFQVLREHIRPGVTTAELDAIAEEFIRSH
CCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHC
GAEPVYKGYVPAGRRNYIPPFPGTICASINDVICHGIPSKRDRLRQGDIVGIDIGLRLNG
CCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHCCCCEEEEEEEEEECC
WIGDACETFAVGEVDDETQRLLDVTRRCLELGIEQARVGNPLRAIGAAIQRHAEANGFSV
CCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHCHHHHHCCCHHHHHHHHHHHHCCCCHHHH
VREYTGHGLGRNLHEEPTILHYDDPQQTRKIVAGMVFTIEPMINAGTAATKVDRDGWTVR
HHHHHCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHEEEECHHCCCCCCEEECCCCCEEE
TADGKRSAQFEHTLAITEEGPIILTA
ECCCCCCCCEEEEEEEECCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192928; 11058132 [H]