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The map label for this gene is ydgK [H]

Identifier: 222524691

GI number: 222524691

Start: 1800573

End: 1801805

Strand: Reverse

Name: ydgK [H]

Synonym: Chy400_1418

Alternate gene names: 222524691

Gene position: 1801805-1800573 (Counterclockwise)

Preceding gene: 222524693

Following gene: 222524690

Centisome position: 34.2

GC content: 56.85

Gene sequence:

>1233_bases
ATGTCATCGTCAAAACTCACACACGGCCCGCAAACCGGCGAATTTATCGCCATGATGGCTCTAATGACCTCGCTGGTCGC
TATGTCGATTGATCTGATGTTACCCGCCCTGGCCGATATTGGCGCCGATCTCGGCTCCCCCCACGAGAATGCCAACCAGC
TTGTCGTCACGATGGTCTTTCTCGGCCTGGCGATTGGTCAGCTTCTCTACGGCCCGCTTTCGGACAGCATCGGGCGTAAA
CCGGCGATTTACCTGGGATACGCCATGTTTGGTGTTGGCTCACTGCTGGCTATCTTCGCCATCAATTTTCCCATGATGCT
GATCGGGCGTCTGCTTCAGGGGTTGGGCGTGGCCGGGCCACGTGGGGTCTCAATGGCGCTCATTCGGGATCGCTTTGCCG
GGAGAGCGATGGCGCGGGTGATGTCATTTATTATGGTTGTCTTCATCGTGGTACCTATCATTGCGCCGGCTATCGGCCAG
GCTATCCTGTTTGTGGCTGCCTGGCGCATCATCTTCGTCATCCTGCTGGTGCTGGGGGTAGTATCACTGATCTGGTTTGC
GCTCCGTCAGCCGGAGACACTTCCATCCGAGCGCAGGGTGCCGTTGTCGGCACGCCGAATGATTGGTGCGCTCCGCGAAG
TACTGGCGAACGCCACCACGCTCGGTTACACCCTCATGGCCGGAGCAGTGTCGGCCATCCTGCAAGCGTATCTGAATTCG
TCACAGCAGATTTTTCAGCAGCAATACGGTTTAGGTGCACTGTTTCCACTATTTTTTGCGATCAATGCCCTGGCGATTGG
CCTCGCTTCATTCGTGAATGGCCGCCTCGTCATGCGCTACGGCATGCGTCCGCTGGTAAAAATTGCGCTGTTTGCGTTGT
GCAGCATAGCCCTGCTCTTTGTCGGGATCGCTCTGATCACCGCCGGGCAACCGCCGTTGTGGAAGTTGATGGCGTACCTG
ATCCCGTGTTTCTTCTGTCTGGGCATTCTCTTCGGCAATATGAATGCACTGGCGATGGAACCACTCGGTCATATTGCCGG
TGTAGGTTCGGCAGTAGTTGGCTCGCTTTCCACCTTCGTCGCGATTCCGCTCGGTGCGGTTATTGGGCAGGCGTACAACG
GCACAGTGACGCCACTGGCGATGGGGTTCGCTGTACTGGCCTTTAGTGCGCTGGTCTTGATGTATTGGGCCAATCGCGAT
CAACCTGAGCCGGTAGTTGTGAGCGAAGAGTAG

Upstream 100 bases:

>100_bases
AAAACTCTTTGACAAAGCGAAGATTGTCTTGTCAAGATTGCGCAAAGAGGGCATAATACGACGAAAACCTATCAGATAGC
GTAAAGGAACTGGAAACGTC

Downstream 100 bases:

>100_bases
CACCTGGCTGCTGGTCATTCCGCAAGTATGCTGTGAAATCTAACAAGTACTGGTAGGGCAACCGCTGTAGGAGCGTGGGT
CGGGCTGGAACGCCTGTGTC

Product: Bcr/CflA subfamily drug resistance transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 410; Mature: 409

Protein sequence:

>410_residues
MSSSKLTHGPQTGEFIAMMALMTSLVAMSIDLMLPALADIGADLGSPHENANQLVVTMVFLGLAIGQLLYGPLSDSIGRK
PAIYLGYAMFGVGSLLAIFAINFPMMLIGRLLQGLGVAGPRGVSMALIRDRFAGRAMARVMSFIMVVFIVVPIIAPAIGQ
AILFVAAWRIIFVILLVLGVVSLIWFALRQPETLPSERRVPLSARRMIGALREVLANATTLGYTLMAGAVSAILQAYLNS
SQQIFQQQYGLGALFPLFFAINALAIGLASFVNGRLVMRYGMRPLVKIALFALCSIALLFVGIALITAGQPPLWKLMAYL
IPCFFCLGILFGNMNALAMEPLGHIAGVGSAVVGSLSTFVAIPLGAVIGQAYNGTVTPLAMGFAVLAFSALVLMYWANRD
QPEPVVVSEE

Sequences:

>Translated_410_residues
MSSSKLTHGPQTGEFIAMMALMTSLVAMSIDLMLPALADIGADLGSPHENANQLVVTMVFLGLAIGQLLYGPLSDSIGRK
PAIYLGYAMFGVGSLLAIFAINFPMMLIGRLLQGLGVAGPRGVSMALIRDRFAGRAMARVMSFIMVVFIVVPIIAPAIGQ
AILFVAAWRIIFVILLVLGVVSLIWFALRQPETLPSERRVPLSARRMIGALREVLANATTLGYTLMAGAVSAILQAYLNS
SQQIFQQQYGLGALFPLFFAINALAIGLASFVNGRLVMRYGMRPLVKIALFALCSIALLFVGIALITAGQPPLWKLMAYL
IPCFFCLGILFGNMNALAMEPLGHIAGVGSAVVGSLSTFVAIPLGAVIGQAYNGTVTPLAMGFAVLAFSALVLMYWANRD
QPEPVVVSEE
>Mature_409_residues
SSSKLTHGPQTGEFIAMMALMTSLVAMSIDLMLPALADIGADLGSPHENANQLVVTMVFLGLAIGQLLYGPLSDSIGRKP
AIYLGYAMFGVGSLLAIFAINFPMMLIGRLLQGLGVAGPRGVSMALIRDRFAGRAMARVMSFIMVVFIVVPIIAPAIGQA
ILFVAAWRIIFVILLVLGVVSLIWFALRQPETLPSERRVPLSARRMIGALREVLANATTLGYTLMAGAVSAILQAYLNSS
QQIFQQQYGLGALFPLFFAINALAIGLASFVNGRLVMRYGMRPLVKIALFALCSIALLFVGIALITAGQPPLWKLMAYLI
PCFFCLGILFGNMNALAMEPLGHIAGVGSAVVGSLSTFVAIPLGAVIGQAYNGTVTPLAMGFAVLAFSALVLMYWANRDQ
PEPVVVSEE

Specific function: Involved In Sulfonamide (Sulfathiazole) And Bicyclomycin Resistance. Probable Membrane Translocase. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI1788509, Length=389, Percent_Identity=28.0205655526992, Blast_Score=144, Evalue=8e-36,
Organism=Escherichia coli, GI48994889, Length=351, Percent_Identity=27.3504273504274, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1790794, Length=190, Percent_Identity=28.9473684210526, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI87082312, Length=335, Percent_Identity=26.2686567164179, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1790146, Length=221, Percent_Identity=26.6968325791855, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1787065, Length=255, Percent_Identity=28.2352941176471, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43629; Mature: 43498

Theoretical pI: Translated: 9.71; Mature: 9.71

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSSKLTHGPQTGEFIAMMALMTSLVAMSIDLMLPALADIGADLGSPHENANQLVVTMVF
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
LGLAIGQLLYGPLSDSIGRKPAIYLGYAMFGVGSLLAIFAINFPMMLIGRLLQGLGVAGP
HHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCC
RGVSMALIRDRFAGRAMARVMSFIMVVFIVVPIIAPAIGQAILFVAAWRIIFVILLVLGV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSLIWFALRQPETLPSERRVPLSARRMIGALREVLANATTLGYTLMAGAVSAILQAYLNS
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SQQIFQQQYGLGALFPLFFAINALAIGLASFVNGRLVMRYGMRPLVKIALFALCSIALLF
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHH
VGIALITAGQPPLWKLMAYLIPCFFCLGILFGNMNALAMEPLGHIAGVGSAVVGSLSTFV
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AIPLGAVIGQAYNGTVTPLAMGFAVLAFSALVLMYWANRDQPEPVVVSEE
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCC
>Mature Secondary Structure 
SSSKLTHGPQTGEFIAMMALMTSLVAMSIDLMLPALADIGADLGSPHENANQLVVTMVF
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
LGLAIGQLLYGPLSDSIGRKPAIYLGYAMFGVGSLLAIFAINFPMMLIGRLLQGLGVAGP
HHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCC
RGVSMALIRDRFAGRAMARVMSFIMVVFIVVPIIAPAIGQAILFVAAWRIIFVILLVLGV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VSLIWFALRQPETLPSERRVPLSARRMIGALREVLANATTLGYTLMAGAVSAILQAYLNS
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
SQQIFQQQYGLGALFPLFFAINALAIGLASFVNGRLVMRYGMRPLVKIALFALCSIALLF
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHH
VGIALITAGQPPLWKLMAYLIPCFFCLGILFGNMNALAMEPLGHIAGVGSAVVGSLSTFV
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AIPLGAVIGQAYNGTVTPLAMGFAVLAFSALVLMYWANRDQPEPVVVSEE
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 9202461 [H]