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The map label for this gene is tdcB [H]

Identifier: 222524643

GI number: 222524643

Start: 1749157

End: 1750149

Strand: Reverse

Name: tdcB [H]

Synonym: Chy400_1368

Alternate gene names: 222524643

Gene position: 1750149-1749157 (Counterclockwise)

Preceding gene: 222524644

Following gene: 222524642

Centisome position: 33.22

GC content: 62.13

Gene sequence:

>993_bases
ATGTCTACCGAGAAAACCATTACCCCTGCCGACATCCTGGCTGCTCGCCGTCGCATCAGCGGTATCGTTCAACCAACTCC
GCTTGAGGTGAGTCGCCCCTTGAGCGCCCTGACCGGTGCCGAGGTCTGGTTGAAGCTGGAACTGGCACAGGTGACCGGCA
GTTTTAAGCTGCGTGGTGCAGCCAATGCTCTGCGCCAGTTACCACCTGCCACGCATGTCGTGGCCTGCTCGGCGGGCAAT
CACGCGCTCGGTGTTGCCCATACCGCCGCGTTGACCGGTACGCCGGCCACCCTGGTGGTGCCGACAACCGCCTCGCCGGC
GAAGGTCACCGCATTGCGACGCTATCCGGTTGAGGTGATATTGCACGGTGCCGGCTACGACGAGGCTGAAACCGAAGCGC
TCCGGCTGGCAGCCCACCACGGCTGGCATTTTGTGTCACCCTACAACGACCCGGCAGTGATTGCCGGGCAGGGAACGCTG
GCAATTGAGGTCTGGGACGCATTGCCCGACGTCGATATGGTGGTAGTCGCGGTCGGTGGCGGTGGGTTAGCCAGCGGCGT
TGGTATCTGGGCCAGAGCGATGAACCCGCGCGTCCGCATCATTGGCGTACAGGCAGCCGCTTCCGCGGCAATGGCGGCGG
CGTTGCGGGCCGGGCGGGTCGTTCCGGCACCTGATGAACCAACGCTGGCCGACGGTCTGGCTGGAGGTATCGCCAGCGAT
ACCATCACGCTCCCGATCCTGCAACAGGTTTTAGACGAGATGATCCTGGTCGAAGAGGCAGCTATTGCCCGCGCTATGCG
CTGGTTAATCGACGAACACCATCTGATTGTAGAAGGGAGTGCTGCGGTGACGGTGGCAGCCCTGCTCGAAGGTCAGATCA
CCCATCTTGTCGGCAAACGGATCGTGGCACTGCTCTGCGGGCGTAATGTTGCCATTTCCACCTTGCACCACATTCTCGCA
GTTCCGCCCAAAGACGGAGCATCATCCCATTGA

Upstream 100 bases:

>100_bases
CCTCGATGTAAAGTTGTCGCCCGAAGAGATTCAGCGTTTAGAGGAACCCTACCGCCCGAAACCGATCCGCGGCCATGCGT
AGCCGGCAGGGAATGAAGCG

Downstream 100 bases:

>100_bases
CAGCAATCCGTTGACGTGCTATGCTGCACGGGCAAGCGGTTCGTATTCGTTCAGAGGAGGACGTTCATGATACTCATCAC
CAACCAGGACATAATGATTG

Product: Pyridoxal-5'-phosphate-dependent protein subunit beta

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 330; Mature: 329

Protein sequence:

>330_residues
MSTEKTITPADILAARRRISGIVQPTPLEVSRPLSALTGAEVWLKLELAQVTGSFKLRGAANALRQLPPATHVVACSAGN
HALGVAHTAALTGTPATLVVPTTASPAKVTALRRYPVEVILHGAGYDEAETEALRLAAHHGWHFVSPYNDPAVIAGQGTL
AIEVWDALPDVDMVVVAVGGGGLASGVGIWARAMNPRVRIIGVQAAASAAMAAALRAGRVVPAPDEPTLADGLAGGIASD
TITLPILQQVLDEMILVEEAAIARAMRWLIDEHHLIVEGSAAVTVAALLEGQITHLVGKRIVALLCGRNVAISTLHHILA
VPPKDGASSH

Sequences:

>Translated_330_residues
MSTEKTITPADILAARRRISGIVQPTPLEVSRPLSALTGAEVWLKLELAQVTGSFKLRGAANALRQLPPATHVVACSAGN
HALGVAHTAALTGTPATLVVPTTASPAKVTALRRYPVEVILHGAGYDEAETEALRLAAHHGWHFVSPYNDPAVIAGQGTL
AIEVWDALPDVDMVVVAVGGGGLASGVGIWARAMNPRVRIIGVQAAASAAMAAALRAGRVVPAPDEPTLADGLAGGIASD
TITLPILQQVLDEMILVEEAAIARAMRWLIDEHHLIVEGSAAVTVAALLEGQITHLVGKRIVALLCGRNVAISTLHHILA
VPPKDGASSH
>Mature_329_residues
STEKTITPADILAARRRISGIVQPTPLEVSRPLSALTGAEVWLKLELAQVTGSFKLRGAANALRQLPPATHVVACSAGNH
ALGVAHTAALTGTPATLVVPTTASPAKVTALRRYPVEVILHGAGYDEAETEALRLAAHHGWHFVSPYNDPAVIAGQGTLA
IEVWDALPDVDMVVVAVGGGGLASGVGIWARAMNPRVRIIGVQAAASAAMAAALRAGRVVPAPDEPTLADGLAGGIASDT
ITLPILQQVLDEMILVEEAAIARAMRWLIDEHHLIVEGSAAVTVAALLEGQITHLVGKRIVALLCGRNVAISTLHHILAV
PPKDGASSH

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=323, Percent_Identity=34.3653250773994, Blast_Score=168, Evalue=6e-42,
Organism=Homo sapiens, GI19923959, Length=297, Percent_Identity=30.6397306397306, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI33469958, Length=306, Percent_Identity=27.1241830065359, Blast_Score=76, Evalue=3e-14,
Organism=Escherichia coli, GI1789505, Length=312, Percent_Identity=37.1794871794872, Blast_Score=184, Evalue=7e-48,
Organism=Escherichia coli, GI1790207, Length=299, Percent_Identity=38.4615384615385, Blast_Score=158, Evalue=5e-40,
Organism=Escherichia coli, GI2367138, Length=201, Percent_Identity=27.8606965174129, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71991565, Length=318, Percent_Identity=35.5345911949685, Blast_Score=168, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17537387, Length=314, Percent_Identity=35.031847133758, Blast_Score=140, Evalue=7e-34,
Organism=Caenorhabditis elegans, GI17508781, Length=316, Percent_Identity=29.746835443038, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI32566674, Length=280, Percent_Identity=26.7857142857143, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17562970, Length=280, Percent_Identity=26.7857142857143, Blast_Score=68, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6322631, Length=310, Percent_Identity=35.4838709677419, Blast_Score=155, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6320930, Length=318, Percent_Identity=33.3333333333333, Blast_Score=142, Evalue=7e-35,
Organism=Saccharomyces cerevisiae, GI6319788, Length=284, Percent_Identity=23.5915492957746, Blast_Score=80, Evalue=5e-16,
Organism=Drosophila melanogaster, GI21355833, Length=321, Percent_Identity=35.8255451713396, Blast_Score=152, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24645328, Length=223, Percent_Identity=34.9775784753363, Blast_Score=104, Evalue=8e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005789 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 34146; Mature: 34015

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTEKTITPADILAARRRISGIVQPTPLEVSRPLSALTGAEVWLKLELAQVTGSFKLRGA
CCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHCCHHHHCCCEEEEEEEEEECCCCEEECHH
ANALRQLPPATHVVACSAGNHALGVAHTAALTGTPATLVVPTTASPAKVTALRRYPVEVI
HHHHHHCCCCCEEEEECCCCCEEEHEEEEEECCCCEEEEEECCCCCHHHHHHHHCCEEEE
LHGAGYDEAETEALRLAAHHGWHFVSPYNDPAVIAGQGTLAIEVWDALPDVDMVVVAVGG
EECCCCCHHHHHHHHHHHHCCEEEECCCCCCEEEECCCEEEEEEECCCCCCCEEEEEECC
GGLASGVGIWARAMNPRVRIIGVQAAASAAMAAALRAGRVVPAPDEPTLADGLAGGIASD
CCHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCC
TITLPILQQVLDEMILVEEAAIARAMRWLIDEHHLIVEGSAAVTVAALLEGQITHLVGKR
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHH
IVALLCGRNVAISTLHHILAVPPKDGASSH
HHHHHHCCCHHHHHHHHHEECCCCCCCCCC
>Mature Secondary Structure 
STEKTITPADILAARRRISGIVQPTPLEVSRPLSALTGAEVWLKLELAQVTGSFKLRGA
CCCCCCCHHHHHHHHHHHCCCCCCCCCCHHCCHHHHCCCEEEEEEEEEECCCCEEECHH
ANALRQLPPATHVVACSAGNHALGVAHTAALTGTPATLVVPTTASPAKVTALRRYPVEVI
HHHHHHCCCCCEEEEECCCCCEEEHEEEEEECCCCEEEEEECCCCCHHHHHHHHCCEEEE
LHGAGYDEAETEALRLAAHHGWHFVSPYNDPAVIAGQGTLAIEVWDALPDVDMVVVAVGG
EECCCCCHHHHHHHHHHHHCCEEEECCCCCCEEEECCCEEEEEEECCCCCCCEEEEEECC
GGLASGVGIWARAMNPRVRIIGVQAAASAAMAAALRAGRVVPAPDEPTLADGLAGGIASD
CCHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCC
TITLPILQQVLDEMILVEEAAIARAMRWLIDEHHLIVEGSAAVTVAALLEGQITHLVGKR
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHHHH
IVALLCGRNVAISTLHHILAVPPKDGASSH
HHHHHHCCCHHHHHHHHHEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA