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The map label for this gene is mutL [H]

Identifier: 222524517

GI number: 222524517

Start: 1577326

End: 1579200

Strand: Direct

Name: mutL [H]

Synonym: Chy400_1241

Alternate gene names: 222524517

Gene position: 1577326-1579200 (Clockwise)

Preceding gene: 222524516

Following gene: 222524519

Centisome position: 29.94

GC content: 58.93

Gene sequence:

>1875_bases
ATGCCCATTCGTCTCCTCGATGAAACCATTGCCGCGCAAATCGCTGCCGGCGAAGTAGTTGAACGACCGGCGTCAGTCGT
CAAAGAGTTGCTCGAAAATGCCATCGACGCCGGTGCGCAACGGATCGTGATCGAGGTACGGGGTGGCGGATTGCGCGAGA
TTCGCGTGCAAGACGATGGCTGTGGTATTCCGGCTGACGAAATTGAACTGGCCTTTGCCCGCCACGCAACCAGCAAATTG
CAATCTGCTGACGATTTGTGGGCTATTCGGACACTGGGGTTCCGCGGCGAAGCCCTGCCCAGCATCGCCAGCGTTGCTCA
GGTCATCTGTATCTCGCGGGTTGCCGATGCTGAACTCGGTGTTGAGTTGCGGATTGCCGGTGGTGAAGTTCAATCCCGAT
TGCCGTGCGGTTGTCCGGTTGGTACGACGATCACGGTACGCAACCTCTTTTACAACACGCCAGTCCGGCGGGAATACCTC
CGTTCTGAAGCGACGGAAACCGGAGCCATCAGCGCAATTGTCCAACAATACGCACTGGCTTACCCGGAAGTGAGCTTTAG
TTTGTTGATCGATGGCCGTATGGCCTTACAGACCAGTGGTGATGGCGATCTCCGGACGGTGGTCGTCGAGCTGTACGGCC
TCGAAGTTGGGCGAGCACTATTGCCGGTACAGGCAGAAGCTGGCGTAGACGAAACATGGGTCGCGGTCAATGGTCTGATT
TCGCCACCTGAATTAACGCGCAGTTCACGGAATTATCTTTCGCTCTTTGCCAACCGCCGTGCGCTGCAACCGCGGGGGGC
ACTGGCTGCGGTGGTCGAGAATGCGTACCATACGATGCTGATGAAGGGACGGTTTCCGATTGCCATCCTCGATGTGCGCG
TCCATCCAGCCGCCATCGATGTCAATGTCCATCCTACCAAGAGTGAAGTGAAGTTTCGCTACGCTGCTCACGTTCACAGT
GTCCTAGGACGTGCCATTCGTGACGCTTTGCTGCGCGGCGCCGATATTCCAACCTGGGATGCCCCTGATCCGGCAACGGC
CCAGCGACGCTTTGAGTTACGTCGGCTGGGTCAGGTAGCAACCACACCCTCCTCTGGCTGGAGTGTTGGAGCCTCGGCGT
GGGATCGTGAACGCTCGCGCTGGGATGTCGGTTCGCCGGCAACTGCGCTGAACACGCCCCTTCCCATTGTGCCCGAAGCA
CCACAGTCACCGCCATCGCCAACGCTTGTGCCCGAACCTGCCCGGCAAACCCCAGGCGAGCCGATAACTCCAGCAGTTCC
GGCAGCGGCACCCTCGGCACTACCCCCGTTACGGGTAGTTGGGCAGGTCGGCCTGACCTACATCGTGGCTGAAGCTCCCG
AAGGGATGTATCTGATCGACCAGCACGCAGCCCACGAACGCATCACCTACGAGAAATTGATGAATCAGTATGCCCAACAC
GCGGTTGAGTCGCAGCAGTTGTTGATTCCACAGGCGGTTGAGGTTAGCCCGGAAGCAAGTGCCTTGTTGTTGGGTAATGC
AGAGCGGCTGGCAGAATGGGGCTTTGTCCTCGAACCGTGGGGCACCGGTGTGCTGGTTCGCGCCATCCCGGCCACCTTAC
CGACCGATGAACTGACGCAAGCTATCCACGAGATAGCCGAAAAGCTGGCCGGACGTGGGGGCAGTGATCCGCTGGAATGG
CGTGAAGCGATGTTGATTACGCTGGCCTGTCACACCTCAGTCCGCGCCGGACAGCCACTTTCCCACGAAGAGATGCGGCA
ATTGTTGCGACAACTTGAACAGTGTGTCAGTCCGCGTACCTGCCCCCACGGTCGTCCGACGATGATCTTGATGACACCGG
CTCAGCTCGAACGCCAGTTTGGGCGACGGGTATAG

Upstream 100 bases:

>100_bases
AATAGCGTTGAACATTTGTTTGTATTATTGGCCTGGCACTCAGTAACGACTCTTCATCAGACACCAGTAGAACTTCGGGA
ATACAGCTCAATGGTGTAAT

Downstream 100 bases:

>100_bases
CCCGGCCTGAAGGCACAACGCCGCAACGGAGCAGTCTCTGCCGGCAGGCAGTGAGCTGCATTTGGGGCTGTATAGTGGTT
GGCTCCATGCCAGAGACGTT

Product: DNA mismatch repair protein MutL

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 624; Mature: 623

Protein sequence:

>624_residues
MPIRLLDETIAAQIAAGEVVERPASVVKELLENAIDAGAQRIVIEVRGGGLREIRVQDDGCGIPADEIELAFARHATSKL
QSADDLWAIRTLGFRGEALPSIASVAQVICISRVADAELGVELRIAGGEVQSRLPCGCPVGTTITVRNLFYNTPVRREYL
RSEATETGAISAIVQQYALAYPEVSFSLLIDGRMALQTSGDGDLRTVVVELYGLEVGRALLPVQAEAGVDETWVAVNGLI
SPPELTRSSRNYLSLFANRRALQPRGALAAVVENAYHTMLMKGRFPIAILDVRVHPAAIDVNVHPTKSEVKFRYAAHVHS
VLGRAIRDALLRGADIPTWDAPDPATAQRRFELRRLGQVATTPSSGWSVGASAWDRERSRWDVGSPATALNTPLPIVPEA
PQSPPSPTLVPEPARQTPGEPITPAVPAAAPSALPPLRVVGQVGLTYIVAEAPEGMYLIDQHAAHERITYEKLMNQYAQH
AVESQQLLIPQAVEVSPEASALLLGNAERLAEWGFVLEPWGTGVLVRAIPATLPTDELTQAIHEIAEKLAGRGGSDPLEW
REAMLITLACHTSVRAGQPLSHEEMRQLLRQLEQCVSPRTCPHGRPTMILMTPAQLERQFGRRV

Sequences:

>Translated_624_residues
MPIRLLDETIAAQIAAGEVVERPASVVKELLENAIDAGAQRIVIEVRGGGLREIRVQDDGCGIPADEIELAFARHATSKL
QSADDLWAIRTLGFRGEALPSIASVAQVICISRVADAELGVELRIAGGEVQSRLPCGCPVGTTITVRNLFYNTPVRREYL
RSEATETGAISAIVQQYALAYPEVSFSLLIDGRMALQTSGDGDLRTVVVELYGLEVGRALLPVQAEAGVDETWVAVNGLI
SPPELTRSSRNYLSLFANRRALQPRGALAAVVENAYHTMLMKGRFPIAILDVRVHPAAIDVNVHPTKSEVKFRYAAHVHS
VLGRAIRDALLRGADIPTWDAPDPATAQRRFELRRLGQVATTPSSGWSVGASAWDRERSRWDVGSPATALNTPLPIVPEA
PQSPPSPTLVPEPARQTPGEPITPAVPAAAPSALPPLRVVGQVGLTYIVAEAPEGMYLIDQHAAHERITYEKLMNQYAQH
AVESQQLLIPQAVEVSPEASALLLGNAERLAEWGFVLEPWGTGVLVRAIPATLPTDELTQAIHEIAEKLAGRGGSDPLEW
REAMLITLACHTSVRAGQPLSHEEMRQLLRQLEQCVSPRTCPHGRPTMILMTPAQLERQFGRRV
>Mature_623_residues
PIRLLDETIAAQIAAGEVVERPASVVKELLENAIDAGAQRIVIEVRGGGLREIRVQDDGCGIPADEIELAFARHATSKLQ
SADDLWAIRTLGFRGEALPSIASVAQVICISRVADAELGVELRIAGGEVQSRLPCGCPVGTTITVRNLFYNTPVRREYLR
SEATETGAISAIVQQYALAYPEVSFSLLIDGRMALQTSGDGDLRTVVVELYGLEVGRALLPVQAEAGVDETWVAVNGLIS
PPELTRSSRNYLSLFANRRALQPRGALAAVVENAYHTMLMKGRFPIAILDVRVHPAAIDVNVHPTKSEVKFRYAAHVHSV
LGRAIRDALLRGADIPTWDAPDPATAQRRFELRRLGQVATTPSSGWSVGASAWDRERSRWDVGSPATALNTPLPIVPEAP
QSPPSPTLVPEPARQTPGEPITPAVPAAAPSALPPLRVVGQVGLTYIVAEAPEGMYLIDQHAAHERITYEKLMNQYAQHA
VESQQLLIPQAVEVSPEASALLLGNAERLAEWGFVLEPWGTGVLVRAIPATLPTDELTQAIHEIAEKLAGRGGSDPLEWR
EAMLITLACHTSVRAGQPLSHEEMRQLLRQLEQCVSPRTCPHGRPTMILMTPAQLERQFGRRV

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=332, Percent_Identity=37.0481927710843, Blast_Score=202, Evalue=6e-52,
Organism=Homo sapiens, GI4505913, Length=331, Percent_Identity=29.3051359516616, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI310128478, Length=331, Percent_Identity=29.3051359516616, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI4505911, Length=311, Percent_Identity=27.3311897106109, Blast_Score=130, Evalue=5e-30,
Organism=Homo sapiens, GI189458898, Length=311, Percent_Identity=27.3311897106109, Blast_Score=129, Evalue=1e-29,
Organism=Homo sapiens, GI189458896, Length=304, Percent_Identity=28.6184210526316, Blast_Score=119, Evalue=9e-27,
Organism=Homo sapiens, GI310128480, Length=288, Percent_Identity=27.4305555555556, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI91992162, Length=342, Percent_Identity=27.7777777777778, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI91992160, Length=342, Percent_Identity=27.7777777777778, Blast_Score=106, Evalue=6e-23,
Organism=Homo sapiens, GI263191589, Length=238, Percent_Identity=31.9327731092437, Blast_Score=103, Evalue=3e-22,
Organism=Escherichia coli, GI1790612, Length=580, Percent_Identity=32.9310344827586, Blast_Score=224, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI71991825, Length=320, Percent_Identity=34.0625, Blast_Score=186, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17562796, Length=361, Percent_Identity=28.808864265928, Blast_Score=144, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6323819, Length=317, Percent_Identity=34.0694006309148, Blast_Score=167, Evalue=5e-42,
Organism=Saccharomyces cerevisiae, GI6325093, Length=723, Percent_Identity=21.8533886583679, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6324247, Length=332, Percent_Identity=25.6024096385542, Blast_Score=111, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6323063, Length=333, Percent_Identity=25.8258258258258, Blast_Score=87, Evalue=7e-18,
Organism=Drosophila melanogaster, GI17136968, Length=337, Percent_Identity=35.3115727002967, Blast_Score=197, Evalue=3e-50,
Organism=Drosophila melanogaster, GI17136970, Length=353, Percent_Identity=28.0453257790368, Blast_Score=137, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 67632; Mature: 67501

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIRLLDETIAAQIAAGEVVERPASVVKELLENAIDAGAQRIVIEVRGGGLREIRVQDDG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEECCCC
CGIPADEIELAFARHATSKLQSADDLWAIRTLGFRGEALPSIASVAQVICISRVADAELG
CCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
VELRIAGGEVQSRLPCGCPVGTTITVRNLFYNTPVRREYLRSEATETGAISAIVQQYALA
EEEEEECCCHHCCCCCCCCCCCEEEEEHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHH
YPEVSFSLLIDGRMALQTSGDGDLRTVVVELYGLEVGRALLPVQAEAGVDETWVAVNGLI
CCCCEEEEEECCEEEEEECCCCCHHHHHHHHHHHHHCCCEECEECCCCCCCEEEEECCCC
SPPELTRSSRNYLSLFANRRALQPRGALAAVVENAYHTMLMKGRFPIAILDVRVHPAAID
CCHHHHHCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCEEEE
VNVHPTKSEVKFRYAAHVHSVLGRAIRDALLRGADIPTWDAPDPATAQRRFELRRLGQVA
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
TTPSSGWSVGASAWDRERSRWDVGSPATALNTPLPIVPEAPQSPPSPTLVPEPARQTPGE
CCCCCCCCCCCHHHHHHHCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PITPAVPAAAPSALPPLRVVGQVGLTYIVAEAPEGMYLIDQHAAHERITYEKLMNQYAQH
CCCCCCCCCCCCCCCHHHHHHHCCEEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHH
AVESQQLLIPQAVEVSPEASALLLGNAERLAEWGFVLEPWGTGVLVRAIPATLPTDELTQ
HHHHHHEECCHHHCCCCCCCEEEECCHHHHHHCCCEECCCCCCEEEEECCCCCCHHHHHH
AIHEIAEKLAGRGGSDPLEWREAMLITLACHTSVRAGQPLSHEEMRQLLRQLEQCVSPRT
HHHHHHHHHHCCCCCCHHHHHHHHEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCC
CPHGRPTMILMTPAQLERQFGRRV
CCCCCCEEEEECHHHHHHHHCCCC
>Mature Secondary Structure 
PIRLLDETIAAQIAAGEVVERPASVVKELLENAIDAGAQRIVIEVRGGGLREIRVQDDG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEECCCC
CGIPADEIELAFARHATSKLQSADDLWAIRTLGFRGEALPSIASVAQVICISRVADAELG
CCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCC
VELRIAGGEVQSRLPCGCPVGTTITVRNLFYNTPVRREYLRSEATETGAISAIVQQYALA
EEEEEECCCHHCCCCCCCCCCCEEEEEHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHH
YPEVSFSLLIDGRMALQTSGDGDLRTVVVELYGLEVGRALLPVQAEAGVDETWVAVNGLI
CCCCEEEEEECCEEEEEECCCCCHHHHHHHHHHHHHCCCEECEECCCCCCCEEEEECCCC
SPPELTRSSRNYLSLFANRRALQPRGALAAVVENAYHTMLMKGRFPIAILDVRVHPAAID
CCHHHHHCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCEEEE
VNVHPTKSEVKFRYAAHVHSVLGRAIRDALLRGADIPTWDAPDPATAQRRFELRRLGQVA
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
TTPSSGWSVGASAWDRERSRWDVGSPATALNTPLPIVPEAPQSPPSPTLVPEPARQTPGE
CCCCCCCCCCCHHHHHHHCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PITPAVPAAAPSALPPLRVVGQVGLTYIVAEAPEGMYLIDQHAAHERITYEKLMNQYAQH
CCCCCCCCCCCCCCCHHHHHHHCCEEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHH
AVESQQLLIPQAVEVSPEASALLLGNAERLAEWGFVLEPWGTGVLVRAIPATLPTDELTQ
HHHHHHEECCHHHCCCCCCCEEEECCHHHHHHCCCEECCCCCCEEEEECCCCCCHHHHHH
AIHEIAEKLAGRGGSDPLEWREAMLITLACHTSVRAGQPLSHEEMRQLLRQLEQCVSPRT
HHHHHHHHHHCCCCCCHHHHHHHHEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCC
CPHGRPTMILMTPAQLERQFGRRV
CCCCCCEEEEECHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA