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The map label for this gene is adhA [H]

Identifier: 222524494

GI number: 222524494

Start: 1553589

End: 1554635

Strand: Direct

Name: adhA [H]

Synonym: Chy400_1218

Alternate gene names: 222524494

Gene position: 1553589-1554635 (Clockwise)

Preceding gene: 222524493

Following gene: 222524502

Centisome position: 29.49

GC content: 59.12

Gene sequence:

>1047_bases
ATGCGCGCCGTCTATTATGAAGCGTTTGGTCAGATGCCATGGATCGCCACGCTGCCCGATCCAGCCCCAACGCCAGATGG
TGTCGTGCTCGCAGTACGCGCTACCGGCCTGTGTCGTAGCGACTGGCATGGCTGGATGGGGCATGATCCCGATATTAAGC
TGCCGCATGTGCCAGGCCACGAACTGGCCGGCGAGATTGTTGCCGTCGGATCACAGGTTCGGCGCTGGCGAATCGGTGAT
CGGGTCACTGTTCCCTTCGTGTGTGCCTGTGGTTTTTGCCCTCAGTGTCAGGCCGGTCAGCAACAGGTGTGTGACAACCA
GTTTCAACCGGGATTCACGCATTGGGGATCGTTTGCTGAATACGTTGCCATTGATCGCGCCGATCTGAATCTGGTGCGCT
TGCCTGCCGATATGAGCTTCACGACTGCCGCCAGTCTGGGGTGTCGTTTTGCAACTGCCTTTCGCGCCGTCGTTGATTTG
GGCCAGGTACGTGGAGGCGAGTGGGTGGCGGTTTACGGGTGTGGTGGCGTTGGTCTCTCGGCGATTATGTTAGCCTCTGC
CCTCGGTGGACAGGTGATCGGAATCGATATTAACCTGGAACGGCTGGCACTGGCTCGGGCGGTAGGGGCAACGGCGGTGA
TTGATGCCACTACCGAACCGGATGTGGTAAGCGTGGTTCGCGATCTCAGCCGCGGTGGGGTACACCTCGCGATTGATGCG
TTGGGTAGTCCTATGACCTGCGCCAATGCCATTGCCAGTCTGCGGAAGCGCGGGCGCCATGTGCAGGTTGGTCTGCTGCT
GGCCGACCAACGGATGCCTCCGTTGCCGATGGATATCGTGGTTGCGCGTGAGTTGACGATTATGGGAAGCCATGGGATGC
AGGCTTACCGCTATGATGCGATGCTCGACCTCATCCAGTCTGGCAAAGTACAACCGCAGCGCCTGATTGGCCGCACGATT
AGCCTGAGTGAAGCACCGGCGGCGCTGGTCGATCTCGATAGTTTCCGTGGTTCTGGGGTGACGGTGATTACAGAGTTTCA
GGGTTAG

Upstream 100 bases:

>100_bases
CGCTTTTGGGTGCGTAGTGGAGACTGTCGGTATACATAGCAAGATGTGCTAGCATGGGTGAGAGCGAACAAACATTCACC
TGCTACGTAAGGAGACTCCC

Downstream 100 bases:

>100_bases
AGCCGACCAGGCGACTGTAACACTTCGCGCGCTCCCCGCAGGCGAAAACCGAGCTGACGCGCCCGGCTGATGTCGAGCGC
GCAGTTGCGTGGTCGTGGTG

Product: alcohol dehydrogenase GroES domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 348; Mature: 348

Protein sequence:

>348_residues
MRAVYYEAFGQMPWIATLPDPAPTPDGVVLAVRATGLCRSDWHGWMGHDPDIKLPHVPGHELAGEIVAVGSQVRRWRIGD
RVTVPFVCACGFCPQCQAGQQQVCDNQFQPGFTHWGSFAEYVAIDRADLNLVRLPADMSFTTAASLGCRFATAFRAVVDL
GQVRGGEWVAVYGCGGVGLSAIMLASALGGQVIGIDINLERLALARAVGATAVIDATTEPDVVSVVRDLSRGGVHLAIDA
LGSPMTCANAIASLRKRGRHVQVGLLLADQRMPPLPMDIVVARELTIMGSHGMQAYRYDAMLDLIQSGKVQPQRLIGRTI
SLSEAPAALVDLDSFRGSGVTVITEFQG

Sequences:

>Translated_348_residues
MRAVYYEAFGQMPWIATLPDPAPTPDGVVLAVRATGLCRSDWHGWMGHDPDIKLPHVPGHELAGEIVAVGSQVRRWRIGD
RVTVPFVCACGFCPQCQAGQQQVCDNQFQPGFTHWGSFAEYVAIDRADLNLVRLPADMSFTTAASLGCRFATAFRAVVDL
GQVRGGEWVAVYGCGGVGLSAIMLASALGGQVIGIDINLERLALARAVGATAVIDATTEPDVVSVVRDLSRGGVHLAIDA
LGSPMTCANAIASLRKRGRHVQVGLLLADQRMPPLPMDIVVARELTIMGSHGMQAYRYDAMLDLIQSGKVQPQRLIGRTI
SLSEAPAALVDLDSFRGSGVTVITEFQG
>Mature_348_residues
MRAVYYEAFGQMPWIATLPDPAPTPDGVVLAVRATGLCRSDWHGWMGHDPDIKLPHVPGHELAGEIVAVGSQVRRWRIGD
RVTVPFVCACGFCPQCQAGQQQVCDNQFQPGFTHWGSFAEYVAIDRADLNLVRLPADMSFTTAASLGCRFATAFRAVVDL
GQVRGGEWVAVYGCGGVGLSAIMLASALGGQVIGIDINLERLALARAVGATAVIDATTEPDVVSVVRDLSRGGVHLAIDA
LGSPMTCANAIASLRKRGRHVQVGLLLADQRMPPLPMDIVVARELTIMGSHGMQAYRYDAMLDLIQSGKVQPQRLIGRTI
SLSEAPAALVDLDSFRGSGVTVITEFQG

Specific function: Unknown

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI71565152, Length=358, Percent_Identity=26.2569832402235, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI4501939, Length=339, Percent_Identity=25.9587020648968, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI156523966, Length=339, Percent_Identity=25.9587020648968, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI4501933, Length=287, Percent_Identity=28.2229965156794, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI34577061, Length=285, Percent_Identity=28.7719298245614, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI71743840, Length=285, Percent_Identity=28.4210526315789, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI262073058, Length=285, Percent_Identity=28.4210526315789, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI71565154, Length=265, Percent_Identity=28.3018867924528, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI4501929, Length=285, Percent_Identity=27.719298245614, Blast_Score=96, Evalue=5e-20,
Organism=Homo sapiens, GI156627571, Length=354, Percent_Identity=25.4237288135593, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI87082125, Length=256, Percent_Identity=33.203125, Blast_Score=121, Evalue=8e-29,
Organism=Escherichia coli, GI1790045, Length=307, Percent_Identity=29.6416938110749, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1788075, Length=352, Percent_Identity=26.7045454545455, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1786825, Length=268, Percent_Identity=31.3432835820896, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI1787863, Length=339, Percent_Identity=27.4336283185841, Blast_Score=108, Evalue=7e-25,
Organism=Escherichia coli, GI1788073, Length=307, Percent_Identity=28.9902280130293, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI226510992, Length=291, Percent_Identity=29.553264604811, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1786552, Length=336, Percent_Identity=27.9761904761905, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1788407, Length=268, Percent_Identity=31.3432835820896, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI87081918, Length=259, Percent_Identity=32.8185328185328, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1786518, Length=271, Percent_Identity=25.0922509225092, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1790718, Length=319, Percent_Identity=22.257053291536, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI87082401, Length=292, Percent_Identity=26.3698630136986, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71988145, Length=267, Percent_Identity=31.8352059925094, Blast_Score=141, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI17562584, Length=313, Percent_Identity=29.073482428115, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17562582, Length=329, Percent_Identity=28.8753799392097, Blast_Score=121, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI17562876, Length=328, Percent_Identity=28.9634146341463, Blast_Score=100, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI25146526, Length=297, Percent_Identity=27.6094276094276, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17562878, Length=320, Percent_Identity=29.375, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI71997431, Length=284, Percent_Identity=27.8169014084507, Blast_Score=98, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17565904, Length=277, Percent_Identity=27.4368231046931, Blast_Score=95, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6323729, Length=328, Percent_Identity=30.7926829268293, Blast_Score=147, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6324486, Length=319, Percent_Identity=30.4075235109718, Blast_Score=143, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6323961, Length=345, Percent_Identity=30.4347826086957, Blast_Score=143, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6319621, Length=265, Percent_Identity=32.4528301886792, Blast_Score=138, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6320033, Length=361, Percent_Identity=25.4847645429363, Blast_Score=113, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6323099, Length=331, Percent_Identity=25.9818731117825, Blast_Score=96, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6322619, Length=335, Percent_Identity=28.6567164179104, Blast_Score=93, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6319955, Length=335, Percent_Identity=28.6567164179104, Blast_Score=93, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6319258, Length=344, Percent_Identity=23.2558139534884, Blast_Score=80, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6319949, Length=206, Percent_Identity=29.6116504854369, Blast_Score=64, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6323980, Length=215, Percent_Identity=26.5116279069767, Blast_Score=62, Evalue=9e-11,
Organism=Drosophila melanogaster, GI17737895, Length=287, Percent_Identity=28.2229965156794, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI17737897, Length=339, Percent_Identity=30.3834808259587, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17137530, Length=342, Percent_Identity=29.5321637426901, Blast_Score=92, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 37159; Mature: 37159

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAVYYEAFGQMPWIATLPDPAPTPDGVVLAVRATGLCRSDWHGWMGHDPDIKLPHVPGH
CCEEEEEHHCCCCEEEECCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCEECCCCCCH
ELAGEIVAVGSQVRRWRIGDRVTVPFVCACGFCPQCQAGQQQVCDNQFQPGFTHWGSFAE
HHHHHHHHHHHHHHEEECCCCCCCHHHEECCCCCCCCCCHHHHHCCCCCCCHHHHHCHHH
YVAIDRADLNLVRLPADMSFTTAASLGCRFATAFRAVVDLGQVRGGEWVAVYGCGGVGLS
HEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHH
AIMLASALGGQVIGIDINLERLALARAVGATAVIDATTEPDVVSVVRDLSRGGVHLAIDA
HHHHHHHHCCEEEEEECCHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHCCCEEEEEEC
LGSPMTCANAIASLRKRGRHVQVGLLLADQRMPPLPMDIVVARELTIMGSHGMQAYRYDA
CCCCHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCEEEEEEEEEEECCCCCCHHHHHH
MLDLIQSGKVQPQRLIGRTISLSEAPAALVDLDSFRGSGVTVITEFQG
HHHHHHCCCCCHHHHHCCEEECCCCCCCEEEHHCCCCCCEEEEEECCC
>Mature Secondary Structure
MRAVYYEAFGQMPWIATLPDPAPTPDGVVLAVRATGLCRSDWHGWMGHDPDIKLPHVPGH
CCEEEEEHHCCCCEEEECCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCEECCCCCCH
ELAGEIVAVGSQVRRWRIGDRVTVPFVCACGFCPQCQAGQQQVCDNQFQPGFTHWGSFAE
HHHHHHHHHHHHHHEEECCCCCCCHHHEECCCCCCCCCCHHHHHCCCCCCCHHHHHCHHH
YVAIDRADLNLVRLPADMSFTTAASLGCRFATAFRAVVDLGQVRGGEWVAVYGCGGVGLS
HEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHH
AIMLASALGGQVIGIDINLERLALARAVGATAVIDATTEPDVVSVVRDLSRGGVHLAIDA
HHHHHHHHCCEEEEEECCHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHHCCCEEEEEEC
LGSPMTCANAIASLRKRGRHVQVGLLLADQRMPPLPMDIVVARELTIMGSHGMQAYRYDA
CCCCHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCEEEEEEEEEEECCCCCCHHHHHH
MLDLIQSGKVQPQRLIGRTISLSEAPAALVDLDSFRGSGVTVITEFQG
HHHHHHCCCCCHHHHHCCEEECCCCCCCEEEHHCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9659380; 11481432 [H]