Click here to switch to the map view.

The map label for this gene is uvrB [H]

Identifier: 222524438

GI number: 222524438

Start: 1473570

End: 1475564

Strand: Direct

Name: uvrB [H]

Synonym: Chy400_1162

Alternate gene names: 222524438

Gene position: 1473570-1475564 (Clockwise)

Preceding gene: 222524437

Following gene: 222524439

Centisome position: 27.97

GC content: 58.1

Gene sequence:

>1995_bases
ATGTCATTCCGGATCGAAGCGCCTTATCAGCCCACCGGCGACCAACCGCGTGCCATTGAGCAACTGGTGGCCGGCCTGCG
TGCCGGTTACCGTCATCAAACCCTGCTCGGTGCCACCGGAACCGGTAAGACGTTTGTCATGGCGCACATCTTCGCGCAGA
TGCAGCGCCCAACCCTGGTTCTTGCCCATAATAAAACCCTCGTCTCGCAGCTTTGGGCTGAGTTCCGCGAGTTTCTGCCT
GATGCTGCGGTTGAGATGTTTATCTCGTACTACGATGAGTACACGCCCGAAGCCTACGTGCCCTCGAAAGACCTCTACAT
TGAAAAAGAGGCCAGCATCAACGAAGAGATTGATCGCTTGCGCCACGCCGCAACCCAGGCCCTGCTCAGCCGGCGCGATG
TGCTGATCGTGGCGTCAGTATCGGCGATCTTCGGTCTCGGTTCACCGCACGACTACGGGCAAGAGAAGGTCACGCTGCGC
GTCGGTGAGGTACGCAACCGCGATAAGCTCATGCGCCAGTTGATCGATTTGCAGTTCGAGCGCAAGGATATGGATTTTCA
GCGCGGCACGTTTCGCGTGCGCGGTGATACGCTCGATATTATTCCGGCCAACGCCGAAACCGCGATCCGGGTGGAGTTTT
GGGGTGATGAGATTGAGCGGATTGTCGAACTTGATCCGCTCACCGGCGAGGTGTTGTGTAAGCACGCGGTGGTTGAGATT
TATCCGGCCAAACACTTCGTTACCACCAAAGAGAAGTTGCAGCTTGCGATTGCCAGCATTCAAGACGAGCTGGCCGAACG
GGTGCGCGAACTGGAGGCTGCCGGCAAATTGCTGGAAGCCCAACGGCTGAAGCAACGCACTCTGTACGACATCGAGATGC
TCAGTGAGGTAGGCTACTGTAGTGGCATTGAGAACTATTCCCGCCATCTCGATGGCCGGGCGCCCGGCCAGACGCCCTGG
ACGTTGCTTGACTATTTTCCCGATGATTTTCTGATCTTTATTGACGAGAGCCACATTACGCTTCCGCAGTTGCGCGGGAT
GTACAACGGTGACCGTCAGCGCAAGCAGACGCTGGTTGATTTCGGTTTTCGCCTGCCCTCAGCGCTCGATAACCGCCCGC
TGCGCTTTGAAGAGTTCGAGCAGCATGTCTACCAGGTCATTTATGTCTCGGCGACCCCCGGCCCTTACGAACGCGAGAAG
AGCGAGCAGATTGTAGAGCAGATTATTCGGCCAACCGGCCTGCTCGACCCGGAGATCGAGGTGCGGCCAACCCGTGGTCA
GATTGATGATCTGCTCGGTGAGATTCGGCGGCGGGTGGAGCGTAAACAGCGCGTGTTGGTGACCACGCTGACCAAGCGCA
TGGCCGAAGATTTGGCCGACTATCTGAAAGAGATGGGGGTACGCACAATGTACCTCCACGCCGACATTGATACGATTGAG
CGGGTGGAGATTCTGCGCGACCTGCGGCTGGGGGTTTACGATGTGGTGGTGGGAATTAACCTGTTGCGCGAGGGGCTTGA
TCTGCCGGAGGTGAGCCTGGTGGCGATCCTGGACGCGGATAAAGAGGGGTATCTGCGCTCAGAGACCTCACTGATCCAGA
TCATTGGGCGGGCGGCTCGCCACATTGAGGGCAAGGTGATCATGTACGCCGATACGATCACCCGCTCGATGGAGGCGGCC
ATCCGCGAGACGCAGCGCCGGCGCGATATTCAGATGGCCCACAACCTGCGCTACAACATCAAACCGCAGGGGATTGCCAA
GGGGGTGCGCGATCTGACCGACCGGATTCGCAAGATGGCAGAAGAGCGCGGCGAGTATGTGGCGACGCCAACCACCGCCG
TTGCGGTCGATCTGCCCCGCGATGAAGTGCTGAAGTTAATCAAAGACCTGGAAAAGCAGATGAAGCAGGCCGCGAAAGAG
CTTGCCTTCGAGAAGGCGGCTGCATTACGCGACCAGATCGTTGAGTTGCGCAAAACACTGGCGCTGAGTGAGTGA

Upstream 100 bases:

>100_bases
AACCCAACCATCGGCGCGGCGTTGTGGCCCTCTCCGCCCTGGAGCGGTGACACAACCCGCGCTGTTGCGTCTCTACACCG
CAGAAACACGCGAGCATCGT

Downstream 100 bases:

>100_bases
AAAATGGCCGTTCAAGTCTGGATTGGCGAGAAACCGGAACACCCCCAGGAACGCCGGGCGATCCTGGGGGTTGCCCAGGC
ACTCGAAAAACTGGAGGGCC

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 664; Mature: 663

Protein sequence:

>664_residues
MSFRIEAPYQPTGDQPRAIEQLVAGLRAGYRHQTLLGATGTGKTFVMAHIFAQMQRPTLVLAHNKTLVSQLWAEFREFLP
DAAVEMFISYYDEYTPEAYVPSKDLYIEKEASINEEIDRLRHAATQALLSRRDVLIVASVSAIFGLGSPHDYGQEKVTLR
VGEVRNRDKLMRQLIDLQFERKDMDFQRGTFRVRGDTLDIIPANAETAIRVEFWGDEIERIVELDPLTGEVLCKHAVVEI
YPAKHFVTTKEKLQLAIASIQDELAERVRELEAAGKLLEAQRLKQRTLYDIEMLSEVGYCSGIENYSRHLDGRAPGQTPW
TLLDYFPDDFLIFIDESHITLPQLRGMYNGDRQRKQTLVDFGFRLPSALDNRPLRFEEFEQHVYQVIYVSATPGPYEREK
SEQIVEQIIRPTGLLDPEIEVRPTRGQIDDLLGEIRRRVERKQRVLVTTLTKRMAEDLADYLKEMGVRTMYLHADIDTIE
RVEILRDLRLGVYDVVVGINLLREGLDLPEVSLVAILDADKEGYLRSETSLIQIIGRAARHIEGKVIMYADTITRSMEAA
IRETQRRRDIQMAHNLRYNIKPQGIAKGVRDLTDRIRKMAEERGEYVATPTTAVAVDLPRDEVLKLIKDLEKQMKQAAKE
LAFEKAAALRDQIVELRKTLALSE

Sequences:

>Translated_664_residues
MSFRIEAPYQPTGDQPRAIEQLVAGLRAGYRHQTLLGATGTGKTFVMAHIFAQMQRPTLVLAHNKTLVSQLWAEFREFLP
DAAVEMFISYYDEYTPEAYVPSKDLYIEKEASINEEIDRLRHAATQALLSRRDVLIVASVSAIFGLGSPHDYGQEKVTLR
VGEVRNRDKLMRQLIDLQFERKDMDFQRGTFRVRGDTLDIIPANAETAIRVEFWGDEIERIVELDPLTGEVLCKHAVVEI
YPAKHFVTTKEKLQLAIASIQDELAERVRELEAAGKLLEAQRLKQRTLYDIEMLSEVGYCSGIENYSRHLDGRAPGQTPW
TLLDYFPDDFLIFIDESHITLPQLRGMYNGDRQRKQTLVDFGFRLPSALDNRPLRFEEFEQHVYQVIYVSATPGPYEREK
SEQIVEQIIRPTGLLDPEIEVRPTRGQIDDLLGEIRRRVERKQRVLVTTLTKRMAEDLADYLKEMGVRTMYLHADIDTIE
RVEILRDLRLGVYDVVVGINLLREGLDLPEVSLVAILDADKEGYLRSETSLIQIIGRAARHIEGKVIMYADTITRSMEAA
IRETQRRRDIQMAHNLRYNIKPQGIAKGVRDLTDRIRKMAEERGEYVATPTTAVAVDLPRDEVLKLIKDLEKQMKQAAKE
LAFEKAAALRDQIVELRKTLALSE
>Mature_663_residues
SFRIEAPYQPTGDQPRAIEQLVAGLRAGYRHQTLLGATGTGKTFVMAHIFAQMQRPTLVLAHNKTLVSQLWAEFREFLPD
AAVEMFISYYDEYTPEAYVPSKDLYIEKEASINEEIDRLRHAATQALLSRRDVLIVASVSAIFGLGSPHDYGQEKVTLRV
GEVRNRDKLMRQLIDLQFERKDMDFQRGTFRVRGDTLDIIPANAETAIRVEFWGDEIERIVELDPLTGEVLCKHAVVEIY
PAKHFVTTKEKLQLAIASIQDELAERVRELEAAGKLLEAQRLKQRTLYDIEMLSEVGYCSGIENYSRHLDGRAPGQTPWT
LLDYFPDDFLIFIDESHITLPQLRGMYNGDRQRKQTLVDFGFRLPSALDNRPLRFEEFEQHVYQVIYVSATPGPYEREKS
EQIVEQIIRPTGLLDPEIEVRPTRGQIDDLLGEIRRRVERKQRVLVTTLTKRMAEDLADYLKEMGVRTMYLHADIDTIER
VEILRDLRLGVYDVVVGINLLREGLDLPEVSLVAILDADKEGYLRSETSLIQIIGRAARHIEGKVIMYADTITRSMEAAI
RETQRRRDIQMAHNLRYNIKPQGIAKGVRDLTDRIRKMAEERGEYVATPTTAVAVDLPRDEVLKLIKDLEKQMKQAAKEL
AFEKAAALRDQIVELRKTLALSE

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=664, Percent_Identity=57.078313253012, Blast_Score=730, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 76164; Mature: 76032

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFRIEAPYQPTGDQPRAIEQLVAGLRAGYRHQTLLGATGTGKTFVMAHIFAQMQRPTLV
CCEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHCCCEEE
LAHNKTLVSQLWAEFREFLPDAAVEMFISYYDEYTPEAYVPSKDLYIEKEASINEEIDRL
EECCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCHHHHHHHH
RHAATQALLSRRDVLIVASVSAIFGLGSPHDYGQEKVTLRVGEVRNRDKLMRQLIDLQFE
HHHHHHHHHCCCCEEEEEEHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCHHH
RKDMDFQRGTFRVRGDTLDIIPANAETAIRVEFWGDEIERIVELDPLTGEVLCKHAVVEI
CCCCCCCCCEEEEECCEEEEEECCCCCEEEEEECCHHHHHHHHCCCCCHHHHHHHHHHEE
YPAKHFVTTKEKLQLAIASIQDELAERVRELEAAGKLLEAQRLKQRTLYDIEMLSEVGYC
ECCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGIENYSRHLDGRAPGQTPWTLLDYFPDDFLIFIDESHITLPQLRGMYNGDRQRKQTLVD
CCHHHHHHHCCCCCCCCCCCHHHHCCCCCEEEEEECCCCCHHHHHCCCCCCHHHHHHHHH
FGFRLPSALDNRPLRFEEFEQHVYQVIYVSATPGPYEREKSEQIVEQIIRPTGLLDPEIE
HHCCCCHHHCCCCCCHHHHHHHHHEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCE
VRPTRGQIDDLLGEIRRRVERKQRVLVTTLTKRMAEDLADYLKEMGVRTMYLHADIDTIE
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHH
RVEILRDLRLGVYDVVVGINLLREGLDLPEVSLVAILDADKEGYLRSETSLIQIIGRAAR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHH
HIEGKVIMYADTITRSMEAAIRETQRRRDIQMAHNLRYNIKPQGIAKGVRDLTDRIRKMA
HCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
EERGEYVATPTTAVAVDLPRDEVLKLIKDLEKQMKQAAKELAFEKAAALRDQIVELRKTL
HHCCCEEECCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALSE
CCCC
>Mature Secondary Structure 
SFRIEAPYQPTGDQPRAIEQLVAGLRAGYRHQTLLGATGTGKTFVMAHIFAQMQRPTLV
CEEECCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHCCCEEE
LAHNKTLVSQLWAEFREFLPDAAVEMFISYYDEYTPEAYVPSKDLYIEKEASINEEIDRL
EECCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCHHHHHHHH
RHAATQALLSRRDVLIVASVSAIFGLGSPHDYGQEKVTLRVGEVRNRDKLMRQLIDLQFE
HHHHHHHHHCCCCEEEEEEHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCHHH
RKDMDFQRGTFRVRGDTLDIIPANAETAIRVEFWGDEIERIVELDPLTGEVLCKHAVVEI
CCCCCCCCCEEEEECCEEEEEECCCCCEEEEEECCHHHHHHHHCCCCCHHHHHHHHHHEE
YPAKHFVTTKEKLQLAIASIQDELAERVRELEAAGKLLEAQRLKQRTLYDIEMLSEVGYC
ECCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SGIENYSRHLDGRAPGQTPWTLLDYFPDDFLIFIDESHITLPQLRGMYNGDRQRKQTLVD
CCHHHHHHHCCCCCCCCCCCHHHHCCCCCEEEEEECCCCCHHHHHCCCCCCHHHHHHHHH
FGFRLPSALDNRPLRFEEFEQHVYQVIYVSATPGPYEREKSEQIVEQIIRPTGLLDPEIE
HHCCCCHHHCCCCCCHHHHHHHHHEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCE
VRPTRGQIDDLLGEIRRRVERKQRVLVTTLTKRMAEDLADYLKEMGVRTMYLHADIDTIE
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHH
RVEILRDLRLGVYDVVVGINLLREGLDLPEVSLVAILDADKEGYLRSETSLIQIIGRAAR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHH
HIEGKVIMYADTITRSMEAAIRETQRRRDIQMAHNLRYNIKPQGIAKGVRDLTDRIRKMA
HCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHH
EERGEYVATPTTAVAVDLPRDEVLKLIKDLEKQMKQAAKELAFEKAAALRDQIVELRKTL
HHCCCEEECCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALSE
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA