Click here to switch to the map view.

The map label for this gene is hutU [H]

Identifier: 222524343

GI number: 222524343

Start: 1355671

End: 1357320

Strand: Reverse

Name: hutU [H]

Synonym: Chy400_1066

Alternate gene names: 222524343

Gene position: 1357320-1355671 (Counterclockwise)

Preceding gene: 222524346

Following gene: 222524342

Centisome position: 25.76

GC content: 65.09

Gene sequence:

>1650_bases
ATGAGTCGCATCGTGCGGGCGCCACGCGGCACAACGTTGACCTGTGCCAACTGGCAGATTGAAGCGGCCTACCGCATGAT
CCAGAACAACCTCGATCCCGATGTCGCCTTCGACCCGGATCATCTGATCGTCTACGGTGGACGCGGGCGAGCGGCCCGCA
ACTGGGAGTGTTTCGACGCCATCCTTGCCACCCTCCGCCGACTCCGTCCCGACGAGACGCTGATTGTGCAATCGGGGAAG
CCGGTCGCTGTCTTCCGTACTCACACCGACGCTCCCCGCGTGCTGATCGCCAATGCCAATCTGGTGCCGGCCTGGGCCAC
GCAGGCCAATTTCGACCGCTGGGAAGCTGCCGGGTTGACGATGTACGGGCAGATGACCGCCGGAAGCTGGATTTATATCG
GTACCCAGGGTATCCTGCAAGGCACCTACGAGACCTTCGGCGCGCTGGCGCGCTCGGCGGGCTGGGGAACGCTCCGCGGC
AGGCTGGTGGTCACTGCCGGTCTCGGTGAGATGGGTGGCGCGCAACCGCTGGCCGTGACCCTGAATGAAGGTGTGCTCAT
CGCAGTCGAGATTGACCGCTGGCGGGCAGAGCGTCGCCTGCGCCTGCGTCAGGTGGATCGCCTGAGCGATGATCTCGAAG
AGGCGATGACCTGGGCCGAAGAGGCACGGGCGAGCGGCACGCCGCTTTCGATTGCGCTGATCGGTAACGCAGCCGAGCTA
CTGCCTGAGATGCTGCGCCGCGGTGTGGTTCCTGATGTGGCAACCGATCAGACCAGCGCCCACGATGTGCGTTACGGCTA
TATCCCTGCCGGATTGTCACTCGCCGAAGCTGCCGAACTACGCGAACGCGACCCCGCCGAGTATGATCGGCGTGCGCTGG
CGTCGATGGCCGAACACGTGCGTACTCTGCTGGAATGGCAGCGCCGCGGCAGCATCGTCTTCGATTACGGCAACAACCTC
CGCCAGCGCGCCTTCGATGCCGGTGTTCACGATGCGTTTAACTATCCCGGCTTCGTCCCGGCCTACATCCGACCTCTCTT
CTGCGAAGGCAAGGGGCCGTTCCGCTGGGTGGCCCTCTCTGGCGACCCCGAAGACATCTACGTCACTGATCGCGCCATCG
CCGAACTCTTCCCCCACGACGAACACCTCGGTCGCTGGTTGCGCCTTGCCCGCGACCACGTCGCCTTCCAGGGTCTCCCC
GCCCGCATCTGCTGGCTGGGCTACGGCGAACGGGCACAAGCCGGCTTGCTTCTGAACGACCTGGTCGCTCGCGGCATCGT
CAAAGCCCCGATTGTCATCGGTCGTGACCATCTCGACGCCGGTTCGGTCGCCAGCCCCAACCGCGAAACCGAAGGTATGC
GCGACGGCTCCGATGCAATCGCCGACTGGCCGCTGCTCAACGCCCTGATCAACGCGGTCGGTGGCGCCACCTGGGTCAGC
ATCCATCACGGTGGTGGCGTCGGGATTGGCTACAGCATCCACGCCGGCCAGGTCATCGTCGCCGACGGCACGCCCGAAGC
CGCCCGCCGCATCGAACGGGTGCTGACCACCGATCCCGGTATGGGAGTCGTCCGCCACGCCGATGCCGGCTATCCCGAAG
CCATCGCGTTTGCCCGCCGTCACGGGATTGATATGCCAATGCTGGAGTGA

Upstream 100 bases:

>100_bases
GGCAACCGACCACCTTTCTCCACTTGTCGAAGCAGCCATTCGGCGCTACTATAGCACCAATCGGCAATGAATGCCATCTA
TCGTACAGGGAGGTACGCCT

Downstream 100 bases:

>100_bases
GCCGGTATTGCCGACGGGGTGACAACGCTCCCGCGGCACCCGGCCCCGGCCCAACCCCGGCCCACCATATGCGAGAGTGC
TGAACGGCGCACGCACGTAT

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase [H]

Number of amino acids: Translated: 549; Mature: 548

Protein sequence:

>549_residues
MSRIVRAPRGTTLTCANWQIEAAYRMIQNNLDPDVAFDPDHLIVYGGRGRAARNWECFDAILATLRRLRPDETLIVQSGK
PVAVFRTHTDAPRVLIANANLVPAWATQANFDRWEAAGLTMYGQMTAGSWIYIGTQGILQGTYETFGALARSAGWGTLRG
RLVVTAGLGEMGGAQPLAVTLNEGVLIAVEIDRWRAERRLRLRQVDRLSDDLEEAMTWAEEARASGTPLSIALIGNAAEL
LPEMLRRGVVPDVATDQTSAHDVRYGYIPAGLSLAEAAELRERDPAEYDRRALASMAEHVRTLLEWQRRGSIVFDYGNNL
RQRAFDAGVHDAFNYPGFVPAYIRPLFCEGKGPFRWVALSGDPEDIYVTDRAIAELFPHDEHLGRWLRLARDHVAFQGLP
ARICWLGYGERAQAGLLLNDLVARGIVKAPIVIGRDHLDAGSVASPNRETEGMRDGSDAIADWPLLNALINAVGGATWVS
IHHGGGVGIGYSIHAGQVIVADGTPEAARRIERVLTTDPGMGVVRHADAGYPEAIAFARRHGIDMPMLE

Sequences:

>Translated_549_residues
MSRIVRAPRGTTLTCANWQIEAAYRMIQNNLDPDVAFDPDHLIVYGGRGRAARNWECFDAILATLRRLRPDETLIVQSGK
PVAVFRTHTDAPRVLIANANLVPAWATQANFDRWEAAGLTMYGQMTAGSWIYIGTQGILQGTYETFGALARSAGWGTLRG
RLVVTAGLGEMGGAQPLAVTLNEGVLIAVEIDRWRAERRLRLRQVDRLSDDLEEAMTWAEEARASGTPLSIALIGNAAEL
LPEMLRRGVVPDVATDQTSAHDVRYGYIPAGLSLAEAAELRERDPAEYDRRALASMAEHVRTLLEWQRRGSIVFDYGNNL
RQRAFDAGVHDAFNYPGFVPAYIRPLFCEGKGPFRWVALSGDPEDIYVTDRAIAELFPHDEHLGRWLRLARDHVAFQGLP
ARICWLGYGERAQAGLLLNDLVARGIVKAPIVIGRDHLDAGSVASPNRETEGMRDGSDAIADWPLLNALINAVGGATWVS
IHHGGGVGIGYSIHAGQVIVADGTPEAARRIERVLTTDPGMGVVRHADAGYPEAIAFARRHGIDMPMLE
>Mature_548_residues
SRIVRAPRGTTLTCANWQIEAAYRMIQNNLDPDVAFDPDHLIVYGGRGRAARNWECFDAILATLRRLRPDETLIVQSGKP
VAVFRTHTDAPRVLIANANLVPAWATQANFDRWEAAGLTMYGQMTAGSWIYIGTQGILQGTYETFGALARSAGWGTLRGR
LVVTAGLGEMGGAQPLAVTLNEGVLIAVEIDRWRAERRLRLRQVDRLSDDLEEAMTWAEEARASGTPLSIALIGNAAELL
PEMLRRGVVPDVATDQTSAHDVRYGYIPAGLSLAEAAELRERDPAEYDRRALASMAEHVRTLLEWQRRGSIVFDYGNNLR
QRAFDAGVHDAFNYPGFVPAYIRPLFCEGKGPFRWVALSGDPEDIYVTDRAIAELFPHDEHLGRWLRLARDHVAFQGLPA
RICWLGYGERAQAGLLLNDLVARGIVKAPIVIGRDHLDAGSVASPNRETEGMRDGSDAIADWPLLNALINAVGGATWVSI
HHGGGVGIGYSIHAGQVIVADGTPEAARRIERVLTTDPGMGVVRHADAGYPEAIAFARRHGIDMPMLE

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family [H]

Homologues:

Organism=Homo sapiens, GI21389467, Length=548, Percent_Identity=35.4014598540146, Blast_Score=303, Evalue=3e-82,
Organism=Homo sapiens, GI260306182, Length=608, Percent_Identity=32.4013157894737, Blast_Score=280, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI71997891, Length=550, Percent_Identity=35.0909090909091, Blast_Score=311, Evalue=6e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000193 [H]

Pfam domain/function: PF01175 Urocanase [H]

EC number: =4.2.1.49 [H]

Molecular weight: Translated: 60170; Mature: 60039

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS01233 UROCANASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRIVRAPRGTTLTCANWQIEAAYRMIQNNLDPDVAFDPDHLIVYGGRGRAARNWECFDA
CCCCCCCCCCCEEEEECCCHHHHHHHHHCCCCCCCEECCCEEEEECCCCCCCCCHHHHHH
ILATLRRLRPDETLIVQSGKPVAVFRTHTDAPRVLIANANLVPAWATQANFDRWEAAGLT
HHHHHHHCCCCCEEEEECCCCEEEEEECCCCCEEEEECCCCCCCCCCCCCCCHHHHCCEE
MYGQMTAGSWIYIGTQGILQGTYETFGALARSAGWGTLRGRLVVTAGLGEMGGAQPLAVT
EEEEECCCCEEEEECHHHHHHHHHHHHHHHHCCCCCEECCEEEEEECCCCCCCCCCEEEE
LNEGVLIAVEIDRWRAERRLRLRQVDRLSDDLEEAMTWAEEARASGTPLSIALIGNAAEL
ECCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHH
LPEMLRRGVVPDVATDQTSAHDVRYGYIPAGLSLAEAAELRERDPAEYDRRALASMAEHV
HHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHH
RTLLEWQRRGSIVFDYGNNLRQRAFDAGVHDAFNYPGFVPAYIRPLFCEGKGPFRWVALS
HHHHHHHHCCCEEEECCCCHHHHHHHCCCHHHCCCCCCCHHHHCEEEECCCCCEEEEEEC
GDPEDIYVTDRAIAELFPHDEHLGRWLRLARDHVAFQGLPARICWLGYGERAQAGLLLND
CCCCEEEEEHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHH
LVARGIVKAPIVIGRDHLDAGSVASPNRETEGMRDGSDAIADWPLLNALINAVGGATWVS
HHHHCHHHCCEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEE
IHHGGGVGIGYSIHAGQVIVADGTPEAARRIERVLTTDPGMGVVRHADAGYPEAIAFARR
EECCCCEEEEEEEECCEEEEECCCHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHH
HGIDMPMLE
CCCCCCCCC
>Mature Secondary Structure 
SRIVRAPRGTTLTCANWQIEAAYRMIQNNLDPDVAFDPDHLIVYGGRGRAARNWECFDA
CCCCCCCCCCEEEEECCCHHHHHHHHHCCCCCCCEECCCEEEEECCCCCCCCCHHHHHH
ILATLRRLRPDETLIVQSGKPVAVFRTHTDAPRVLIANANLVPAWATQANFDRWEAAGLT
HHHHHHHCCCCCEEEEECCCCEEEEEECCCCCEEEEECCCCCCCCCCCCCCCHHHHCCEE
MYGQMTAGSWIYIGTQGILQGTYETFGALARSAGWGTLRGRLVVTAGLGEMGGAQPLAVT
EEEEECCCCEEEEECHHHHHHHHHHHHHHHHCCCCCEECCEEEEEECCCCCCCCCCEEEE
LNEGVLIAVEIDRWRAERRLRLRQVDRLSDDLEEAMTWAEEARASGTPLSIALIGNAAEL
ECCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCHHHH
LPEMLRRGVVPDVATDQTSAHDVRYGYIPAGLSLAEAAELRERDPAEYDRRALASMAEHV
HHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHH
RTLLEWQRRGSIVFDYGNNLRQRAFDAGVHDAFNYPGFVPAYIRPLFCEGKGPFRWVALS
HHHHHHHHCCCEEEECCCCHHHHHHHCCCHHHCCCCCCCHHHHCEEEECCCCCEEEEEEC
GDPEDIYVTDRAIAELFPHDEHLGRWLRLARDHVAFQGLPARICWLGYGERAQAGLLLND
CCCCEEEEEHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHH
LVARGIVKAPIVIGRDHLDAGSVASPNRETEGMRDGSDAIADWPLLNALINAVGGATWVS
HHHHCHHHCCEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEEEEE
IHHGGGVGIGYSIHAGQVIVADGTPEAARRIERVLTTDPGMGVVRHADAGYPEAIAFARR
EECCCCEEEEEEEECCEEEEECCCHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHH
HGIDMPMLE
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA