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The map label for this gene is hemN [H]

Identifier: 222523979

GI number: 222523979

Start: 865197

End: 866570

Strand: Direct

Name: hemN [H]

Synonym: Chy400_0694

Alternate gene names: 222523979

Gene position: 865197-866570 (Clockwise)

Preceding gene: 222523972

Following gene: 222523980

Centisome position: 16.42

GC content: 56.55

Gene sequence:

>1374_bases
ATGAGTGTTGAGATCACCCGCGAAACCATTGATCGCTACAACCGACCCGGCCCACGCTACACGAGTTATCCAACCGTTCC
CCATTGGAGTAACAGCTTTACCGCAGACGATTACCTGGCCGCGTTAGCCGACATTGCTGTAACACATGACTCGCTCAGCG
TTTATGTTCATCTGCCATTTTGTGCTGAACGCTGCGCCTACTGCGGTTGCAATGCCACCTCAACCCGACGGCCTGACGTT
GTTGATCACTATCTCGACCGGATCGAACGTGAACTAAGTATGGTTATCGCAGCGCTAGGGAGCAATCGTCGAGTGGTGCA
ACTCCATTGGGGAGGCGGGACGCCCAATTTTCTGAATGAAGCGCAGAGCCGGCGGTTAATGGGTATGCTCCGCACAGCAT
TCACGCTCGATCCAGCAGCAGAAGTCGCGCTGGAAGTCGATCCCCGCATCGGCAGCCGTGAACAGATTTTTCTCTTCCGC
GAACTGGGGTTCAACCGCATCAGCTTTGGCGTGCAAGACATTGCGCCCGCAGTCCAGGTCGCCATTGGCCGCATCCAACC
TCTCCACCAGACCGAAACCGTCGTCAAGGCAGCGCGCGACGCCGGCTTTTGCAGTATCAACATCGATCTGGTCTACGGCC
TGCCGTATCAGACACCAACCAGCTTTGCGGCGACACTACAGGCTATGATCGATCTGCGTCCTGATCGCATTGCCTGCTTC
AGCTATGCCCACTTACCCCAGGCCAGACCTAACCAGAAGCGCGTCGATGCCCGGCAGTTGCCAACCGGTTACGAGAAGTT
TCAGCTCTTTCGTCAGGCGATTGACACCTTGACCACCGTTGGTTACGAATGGATCGGGATGGATCACTTTGCGCTGGCGA
GTGATGAATTAGCTGTCGCTGCCCGAGAGCGCCGGTTACAACGCAATTTTATGGGCTACACTGTCTTACCGGCGCCACAC
CAGATCGGGTTCGGGATGAGTGCAATCGGTGATCTGGCCGGGCGCTATGTACAGAATGATGCCGGTTTGGGACGCTATCA
GCGGGCTATTGATGAGGGGCAGCTACCGATCATTCGCGGCATGCGCTTGAGTGACGACGATTTGATGCGTCGGCAGGCGA
TTATGCATCTGATGTGCAACCTCGAAGTACCGTTCGATCTCGCGCTTCCGCCCTACGGCGACCGGTTAGGCGATGTCCTG
GCGCCTGAGATTGAACGAATTGCCGCCTACGCAGCCGATGACCTGGTAGCCATCGAACCACACCGGTTACGTGTCACCGA
GCGCGGGCGCTTCTTTATCCGGAATCTGGCGATGGAACTTGATCGATACCTCCAACAGGCAACAGAACGGCCGGTCTTCT
CGAGCACAGTATGA

Upstream 100 bases:

>100_bases
AAACTATCATGGGCCTGAAAAGAAAAGTGCGGAAGAGGTATTTTGTCTGGTTGCTGTAGTTTGAAAACAGTACTACAATG
AACTATCAAGAGGGGCTGTT

Downstream 100 bases:

>100_bases
GGAGAAACGCACATGATGGCGGGATACGACAGTGTAGTGATTGGCGGTGGCATTGCCGGTTTAGCTGCGGCTTACACGCT
CCACAAGCGTGGTTATCGGG

Product: oxygen-independent coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 457; Mature: 456

Protein sequence:

>457_residues
MSVEITRETIDRYNRPGPRYTSYPTVPHWSNSFTADDYLAALADIAVTHDSLSVYVHLPFCAERCAYCGCNATSTRRPDV
VDHYLDRIERELSMVIAALGSNRRVVQLHWGGGTPNFLNEAQSRRLMGMLRTAFTLDPAAEVALEVDPRIGSREQIFLFR
ELGFNRISFGVQDIAPAVQVAIGRIQPLHQTETVVKAARDAGFCSINIDLVYGLPYQTPTSFAATLQAMIDLRPDRIACF
SYAHLPQARPNQKRVDARQLPTGYEKFQLFRQAIDTLTTVGYEWIGMDHFALASDELAVAARERRLQRNFMGYTVLPAPH
QIGFGMSAIGDLAGRYVQNDAGLGRYQRAIDEGQLPIIRGMRLSDDDLMRRQAIMHLMCNLEVPFDLALPPYGDRLGDVL
APEIERIAAYAADDLVAIEPHRLRVTERGRFFIRNLAMELDRYLQQATERPVFSSTV

Sequences:

>Translated_457_residues
MSVEITRETIDRYNRPGPRYTSYPTVPHWSNSFTADDYLAALADIAVTHDSLSVYVHLPFCAERCAYCGCNATSTRRPDV
VDHYLDRIERELSMVIAALGSNRRVVQLHWGGGTPNFLNEAQSRRLMGMLRTAFTLDPAAEVALEVDPRIGSREQIFLFR
ELGFNRISFGVQDIAPAVQVAIGRIQPLHQTETVVKAARDAGFCSINIDLVYGLPYQTPTSFAATLQAMIDLRPDRIACF
SYAHLPQARPNQKRVDARQLPTGYEKFQLFRQAIDTLTTVGYEWIGMDHFALASDELAVAARERRLQRNFMGYTVLPAPH
QIGFGMSAIGDLAGRYVQNDAGLGRYQRAIDEGQLPIIRGMRLSDDDLMRRQAIMHLMCNLEVPFDLALPPYGDRLGDVL
APEIERIAAYAADDLVAIEPHRLRVTERGRFFIRNLAMELDRYLQQATERPVFSSTV
>Mature_456_residues
SVEITRETIDRYNRPGPRYTSYPTVPHWSNSFTADDYLAALADIAVTHDSLSVYVHLPFCAERCAYCGCNATSTRRPDVV
DHYLDRIERELSMVIAALGSNRRVVQLHWGGGTPNFLNEAQSRRLMGMLRTAFTLDPAAEVALEVDPRIGSREQIFLFRE
LGFNRISFGVQDIAPAVQVAIGRIQPLHQTETVVKAARDAGFCSINIDLVYGLPYQTPTSFAATLQAMIDLRPDRIACFS
YAHLPQARPNQKRVDARQLPTGYEKFQLFRQAIDTLTTVGYEWIGMDHFALASDELAVAARERRLQRNFMGYTVLPAPHQ
IGFGMSAIGDLAGRYVQNDAGLGRYQRAIDEGQLPIIRGMRLSDDDLMRRQAIMHLMCNLEVPFDLALPPYGDRLGDVLA
PEIERIAAYAADDLVAIEPHRLRVTERGRFFIRNLAMELDRYLQQATERPVFSSTV

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=188, Percent_Identity=25, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI87082341, Length=448, Percent_Identity=41.9642857142857, Blast_Score=354, Evalue=6e-99,
Organism=Escherichia coli, GI1789325, Length=240, Percent_Identity=27.9166666666667, Blast_Score=104, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 51485; Mature: 51354

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVEITRETIDRYNRPGPRYTSYPTVPHWSNSFTADDYLAALADIAVTHDSLSVYVHLPF
CCEEEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHEEECCEEEEEECCH
CAERCAYCGCNATSTRRPDVVDHYLDRIERELSMVIAALGSNRRVVQLHWGGGTPNFLNE
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHH
AQSRRLMGMLRTAFTLDPAAEVALEVDPRIGSREQIFLFRELGFNRISFGVQDIAPAVQV
HHHHHHHHHHHHHHCCCCHHHEEEEECCCCCCCCCEEEEHHCCCCHHHCCHHHHHHHHHH
AIGRIQPLHQTETVVKAARDAGFCSINIDLVYGLPYQTPTSFAATLQAMIDLRPDRIACF
HHHCCCCCHHHHHHHHHHHCCCEEEEEEEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEE
SYAHLPQARPNQKRVDARQLPTGYEKFQLFRQAIDTLTTVGYEWIGMDHFALASDELAVA
EHHHCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHCCHHHCCCCHHEECCCHHHHH
ARERRLQRNFMGYTVLPAPHQIGFGMSAIGDLAGRYVQNDAGLGRYQRAIDEGQLPIIRG
HHHHHHHHHHCCEEECCCCHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCEEEC
MRLSDDDLMRRQAIMHLMCNLEVPFDLALPPYGDRLGDVLAPEIERIAAYAADDLVAIEP
CCCCHHHHHHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHCCCEEEECC
HRLRVTERGRFFIRNLAMELDRYLQQATERPVFSSTV
CEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SVEITRETIDRYNRPGPRYTSYPTVPHWSNSFTADDYLAALADIAVTHDSLSVYVHLPF
CEEEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHEEECCEEEEEECCH
CAERCAYCGCNATSTRRPDVVDHYLDRIERELSMVIAALGSNRRVVQLHWGGGTPNFLNE
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHH
AQSRRLMGMLRTAFTLDPAAEVALEVDPRIGSREQIFLFRELGFNRISFGVQDIAPAVQV
HHHHHHHHHHHHHHCCCCHHHEEEEECCCCCCCCCEEEEHHCCCCHHHCCHHHHHHHHHH
AIGRIQPLHQTETVVKAARDAGFCSINIDLVYGLPYQTPTSFAATLQAMIDLRPDRIACF
HHHCCCCCHHHHHHHHHHHCCCEEEEEEEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEE
SYAHLPQARPNQKRVDARQLPTGYEKFQLFRQAIDTLTTVGYEWIGMDHFALASDELAVA
EHHHCCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHCCHHHCCCCHHEECCCHHHHH
ARERRLQRNFMGYTVLPAPHQIGFGMSAIGDLAGRYVQNDAGLGRYQRAIDEGQLPIIRG
HHHHHHHHHHCCEEECCCCHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCEEEC
MRLSDDDLMRRQAIMHLMCNLEVPFDLALPPYGDRLGDVLAPEIERIAAYAADDLVAIEP
CCCCHHHHHHHHHHHHHHHCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHCCCEEEECC
HRLRVTERGRFFIRNLAMELDRYLQQATERPVFSSTV
CEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]