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The map label for this gene is celR [H]

Identifier: 222523702

GI number: 222523702

Start: 482810

End: 483823

Strand: Reverse

Name: celR [H]

Synonym: Chy400_0408

Alternate gene names: 222523702

Gene position: 483823-482810 (Counterclockwise)

Preceding gene: 222523714

Following gene: 222523701

Centisome position: 9.18

GC content: 50.3

Gene sequence:

>1014_bases
ATGAGCAAAAAATCTGTTCAAACACTTGAAGATATTGCACGGCTGGCCAACGTCTCGCGTTCGACCGTTTCACGGGCTTT
GAACAATAGCCCTCTAATTAGCAAGCAGACCAGAGAGCGGATTCAGGCTATTGCTCGTGAGCATAATTTCTGTCTTAATG
TCTCAGGGCGCAATCTCAGATTACGTAGTAGCCGTACCATTGCCTTTGTTGCTCCAATGTGTTTCCCACCCGTAGCTTCA
GCCGAACATCTATTTGGGCTGGAGATGCTGGGTGCTATCTGGAGCGGTCTCCACGAGCTAAATTATGATTGTCTGATTGT
ACACAGTGCCTCACAAGATACTGATTGGGTGCATCGTTATCTGCATAGCGGTCGTGTTGATGGTTTCATTCTCATGGAAT
CAAGTTTCAAGCAAACCCAAATTGAGGCGCTGGTGCAGATGAAGGTGCCATTCATTGTTTGGGGTATGCCGGTGTCACCC
TTTAACTACTGCTCGGTGACGGGTGATAATGTTGCGGGAGGGCGACTGGCAACCGAATACCTGATTCGTACCGGTCGGCA
ACGGATCGCCTTCCTTGGTGGGTTGAAAGGTACTTTAACGGTTGAGAACCGTTTCAAAGGCTACGAGCAGGCATTGCAGC
TCGCCGGACGAGCATTAGACCCCGCGTTGATCGTATACGGTGATTACACGTATGCATCGGGAGCTGCTGGCATGCAACGT
CTCCTTGAACGCGCTCCTGATCTGGATGCGGTCTTTGTCAATAGCGACCTGATGGCGATTGCAGCCATCAATGTGATTCA
GGAGAGCGGGAGAAGTGTTCCAGCGGATATTGCCGTTGTCGGATACGATGATCTGTCGATTGCCGGTTATGCGACTCTCC
CGTTGACCACAATACGGCAGAATATTCCTCTGGCTGGCAAACTTCTCGCTCAGAACTTGATTCAGCATATCGAAACGGGG
CTGGTTACGAATGTGACGGTTCCGGTAGAGCTAGTGATTCGGAAGTCAGCGTAA

Upstream 100 bases:

>100_bases
TTGGAAAACCCTGGCGAATTATTCACAACTCGCTTGACAAAATCTCTTCTGCATACTATTGTAATAGCAGATTGCAATCG
ATTGCAAAATCTGATTACGC

Downstream 100 bases:

>100_bases
GATTATTTTTGTCCGTTGTGCAATCGATTGCATAACATTCGTATGGCGCGACCCTCCCTTGCGTTCGACAGAAAGGTTGT
TCACGATTTATGCCGACGAA

Product: LacI family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 337; Mature: 336

Protein sequence:

>337_residues
MSKKSVQTLEDIARLANVSRSTVSRALNNSPLISKQTRERIQAIAREHNFCLNVSGRNLRLRSSRTIAFVAPMCFPPVAS
AEHLFGLEMLGAIWSGLHELNYDCLIVHSASQDTDWVHRYLHSGRVDGFILMESSFKQTQIEALVQMKVPFIVWGMPVSP
FNYCSVTGDNVAGGRLATEYLIRTGRQRIAFLGGLKGTLTVENRFKGYEQALQLAGRALDPALIVYGDYTYASGAAGMQR
LLERAPDLDAVFVNSDLMAIAAINVIQESGRSVPADIAVVGYDDLSIAGYATLPLTTIRQNIPLAGKLLAQNLIQHIETG
LVTNVTVPVELVIRKSA

Sequences:

>Translated_337_residues
MSKKSVQTLEDIARLANVSRSTVSRALNNSPLISKQTRERIQAIAREHNFCLNVSGRNLRLRSSRTIAFVAPMCFPPVAS
AEHLFGLEMLGAIWSGLHELNYDCLIVHSASQDTDWVHRYLHSGRVDGFILMESSFKQTQIEALVQMKVPFIVWGMPVSP
FNYCSVTGDNVAGGRLATEYLIRTGRQRIAFLGGLKGTLTVENRFKGYEQALQLAGRALDPALIVYGDYTYASGAAGMQR
LLERAPDLDAVFVNSDLMAIAAINVIQESGRSVPADIAVVGYDDLSIAGYATLPLTTIRQNIPLAGKLLAQNLIQHIETG
LVTNVTVPVELVIRKSA
>Mature_336_residues
SKKSVQTLEDIARLANVSRSTVSRALNNSPLISKQTRERIQAIAREHNFCLNVSGRNLRLRSSRTIAFVAPMCFPPVASA
EHLFGLEMLGAIWSGLHELNYDCLIVHSASQDTDWVHRYLHSGRVDGFILMESSFKQTQIEALVQMKVPFIVWGMPVSPF
NYCSVTGDNVAGGRLATEYLIRTGRQRIAFLGGLKGTLTVENRFKGYEQALQLAGRALDPALIVYGDYTYASGAAGMQRL
LERAPDLDAVFVNSDLMAIAAINVIQESGRSVPADIAVVGYDDLSIAGYATLPLTTIRQNIPLAGKLLAQNLIQHIETGL
VTNVTVPVELVIRKSA

Specific function: Binds to the 14-bp operator sequence 5'-TGGGAGCGCTCCCA- 3' in the upstream regions of cellulase genes; these operator sequences are modulated by cellobiose [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=342, Percent_Identity=32.1637426900585, Blast_Score=152, Evalue=3e-38,
Organism=Escherichia coli, GI1790194, Length=316, Percent_Identity=31.0126582278481, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1787948, Length=299, Percent_Identity=29.4314381270903, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1789068, Length=299, Percent_Identity=31.1036789297659, Blast_Score=125, Evalue=5e-30,
Organism=Escherichia coli, GI1789202, Length=299, Percent_Identity=26.4214046822742, Blast_Score=111, Evalue=5e-26,
Organism=Escherichia coli, GI1788474, Length=311, Percent_Identity=29.2604501607717, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI1786540, Length=336, Percent_Identity=29.7619047619048, Blast_Score=104, Evalue=9e-24,
Organism=Escherichia coli, GI1787580, Length=284, Percent_Identity=27.4647887323944, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI48994940, Length=324, Percent_Identity=27.4691358024691, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1787906, Length=344, Percent_Identity=25.5813953488372, Blast_Score=81, Evalue=9e-17,
Organism=Escherichia coli, GI1790715, Length=336, Percent_Identity=29.1666666666667, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1790689, Length=267, Percent_Identity=25.8426966292135, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790192, Length=141, Percent_Identity=30.4964539007092, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1786268, Length=298, Percent_Identity=22.1476510067114, Blast_Score=65, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 36901; Mature: 36770

Theoretical pI: Translated: 8.59; Mature: 8.59

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKSVQTLEDIARLANVSRSTVSRALNNSPLISKQTRERIQAIAREHNFCLNVSGRNLR
CCCHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEECCCEEE
LRSSRTIAFVAPMCFPPVASAEHLFGLEMLGAIWSGLHELNYDCLIVHSASQDTDWVHRY
EECCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHH
LHSGRVDGFILMESSFKQTQIEALVQMKVPFIVWGMPVSPFNYCSVTGDNVAGGRLATEY
HHCCCCCEEEEECCCCHHHHHHHHHHHCCCEEEECCCCCCCCEEEECCCCCCCCHHHHHH
LIRTGRQRIAFLGGLKGTLTVENRFKGYEQALQLAGRALDPALIVYGDYTYASGAAGMQR
HHHCCHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHH
LLERAPDLDAVFVNSDLMAIAAINVIQESGRSVPADIAVVGYDDLSIAGYATLPLTTIRQ
HHHHCCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCEEECCHHHHHH
NIPLAGKLLAQNLIQHIETGLVTNVTVPVELVIRKSA
CCCHHHHHHHHHHHHHHHCCCEEEEEEEEEEEEECCC
>Mature Secondary Structure 
SKKSVQTLEDIARLANVSRSTVSRALNNSPLISKQTRERIQAIAREHNFCLNVSGRNLR
CCHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEECCCEEE
LRSSRTIAFVAPMCFPPVASAEHLFGLEMLGAIWSGLHELNYDCLIVHSASQDTDWVHRY
EECCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHH
LHSGRVDGFILMESSFKQTQIEALVQMKVPFIVWGMPVSPFNYCSVTGDNVAGGRLATEY
HHCCCCCEEEEECCCCHHHHHHHHHHHCCCEEEECCCCCCCCEEEECCCCCCCCHHHHHH
LIRTGRQRIAFLGGLKGTLTVENRFKGYEQALQLAGRALDPALIVYGDYTYASGAAGMQR
HHHCCHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHH
LLERAPDLDAVFVNSDLMAIAAINVIQESGRSVPADIAVVGYDDLSIAGYATLPLTTIRQ
HHHHCCCCCEEEECCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCEEECCHHHHHH
NIPLAGKLLAQNLIQHIETGLVTNVTVPVELVIRKSA
CCCHHHHHHHHHHHHHHHCCCEEEEEEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10224066 [H]