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The map label for this gene is ribBA [H]

Identifier: 222523680

GI number: 222523680

Start: 453753

End: 454361

Strand: Direct

Name: ribBA [H]

Synonym: Chy400_0386

Alternate gene names: 222523680

Gene position: 453753-454361 (Clockwise)

Preceding gene: 222523679

Following gene: 222523692

Centisome position: 8.61

GC content: 56.32

Gene sequence:

>609_bases
ATGACAACGTTCTTTCCCATCACCCGTGCTGCTATGGCTGACTTACCAACCCGCTTCGGTCACTTTCAGATTGTGGTCTA
TCTCGACGCAGAGCAGAAAGAACAGATAGCGTTGACCTGCGGCCAGCTACACACACCGGAACCGGTTCTGACTCGTCTCC
ATTCCGAATGTTTGACCGGCGACATTTTCGGTTCACACCGTTGCGATTGTGGTGAACAACTGGCAGCGGCGCTCACGGCT
ATTCAACAGGCGGGACGCGGCGTGCTCCTGTACTTACGCCAAGAGGGGCGGGGAATCGGATTGGTAAACAAAATTCGCGC
TTATGCCCTCCAGCAACAAGGACTGGATACCGTTGACGCCAATCGCGCCCTCGGTCTCCCCGACGACATGCGCGATTACC
GCGTGGCCGCTGCCATCCTGACCGATCTTGGGATCAAAAGCGTGCGCCTGCTAACGAACAACCCTGCCAAAATCACCGGC
ATTGAACAGCACGGCATTGCTGTAACCGAGCGCGTACCGCTCCAAATGCCGGCGAACAACTACAGTGCTGCCTACCTGCT
GGCAAAGCAGGTACGGATGGGGCATTTACTCGATAGCCGGTTGTTGTAG

Upstream 100 bases:

>100_bases
TGCTGCTCGGTGCATGGCTGATAACGGTACTAACCTTCGTGCAACCAACGCCGGTTACCACCGGTTCATTGCATCCAGTT
GAAGACTCAGAGGCTTAGAT

Downstream 100 bases:

>100_bases
GATAAAATTGTAGCAGTCATTATAGGTTAGATCAATCAAAAACACAGTAATTGAAACGTGCTACATTACCAAGCCAATAT
GCACTTGGTTTTGGGGTACG

Product: GTP cyclohydrolase II

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 202; Mature: 201

Protein sequence:

>202_residues
MTTFFPITRAAMADLPTRFGHFQIVVYLDAEQKEQIALTCGQLHTPEPVLTRLHSECLTGDIFGSHRCDCGEQLAAALTA
IQQAGRGVLLYLRQEGRGIGLVNKIRAYALQQQGLDTVDANRALGLPDDMRDYRVAAAILTDLGIKSVRLLTNNPAKITG
IEQHGIAVTERVPLQMPANNYSAAYLLAKQVRMGHLLDSRLL

Sequences:

>Translated_202_residues
MTTFFPITRAAMADLPTRFGHFQIVVYLDAEQKEQIALTCGQLHTPEPVLTRLHSECLTGDIFGSHRCDCGEQLAAALTA
IQQAGRGVLLYLRQEGRGIGLVNKIRAYALQQQGLDTVDANRALGLPDDMRDYRVAAAILTDLGIKSVRLLTNNPAKITG
IEQHGIAVTERVPLQMPANNYSAAYLLAKQVRMGHLLDSRLL
>Mature_201_residues
TTFFPITRAAMADLPTRFGHFQIVVYLDAEQKEQIALTCGQLHTPEPVLTRLHSECLTGDIFGSHRCDCGEQLAAALTAI
QQAGRGVLLYLRQEGRGIGLVNKIRAYALQQQGLDTVDANRALGLPDDMRDYRVAAAILTDLGIKSVRLLTNNPAKITGI
EQHGIAVTERVPLQMPANNYSAAYLLAKQVRMGHLLDSRLL

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=194, Percent_Identity=52.0618556701031, Blast_Score=191, Evalue=3e-50,
Organism=Saccharomyces cerevisiae, GI6319438, Length=208, Percent_Identity=41.8269230769231, Blast_Score=130, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 22178; Mature: 22047

Theoretical pI: Translated: 7.99; Mature: 7.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTFFPITRAAMADLPTRFGHFQIVVYLDAEQKEQIALTCGQLHTPEPVLTRLHSECLTG
CCCCCCHHHHHHHHCCCCCCCEEEEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHHHCC
DIFGSHRCDCGEQLAAALTAIQQAGRGVLLYLRQEGRGIGLVNKIRAYALQQQGLDTVDA
CCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCC
NRALGLPDDMRDYRVAAAILTDLGIKSVRLLTNNPAKITGIEQHGIAVTERVPLQMPANN
CCCCCCCCHHHHHHHHHHHHHHCCHHEEEEEECCCCEEEEECCCCEEEECCCCEEECCCC
YSAAYLLAKQVRMGHLLDSRLL
CHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TTFFPITRAAMADLPTRFGHFQIVVYLDAEQKEQIALTCGQLHTPEPVLTRLHSECLTG
CCCCCHHHHHHHHCCCCCCCEEEEEEECCCCCCEEEEECCCCCCCCHHHHHHHHHHHCC
DIFGSHRCDCGEQLAAALTAIQQAGRGVLLYLRQEGRGIGLVNKIRAYALQQQGLDTVDA
CCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCC
NRALGLPDDMRDYRVAAAILTDLGIKSVRLLTNNPAKITGIEQHGIAVTERVPLQMPANN
CCCCCCCCHHHHHHHHHHHHHHCCHHEEEEEECCCCEEEEECCCCEEEECCCCEEECCCC
YSAAYLLAKQVRMGHLLDSRLL
CHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA