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The map label for this gene is folE2

Identifier: 222152090

GI number: 222152090

Start: 1980776

End: 1981654

Strand: Direct

Name: folE2

Synonym: MCCL_1847

Alternate gene names: 222152090

Gene position: 1980776-1981654 (Clockwise)

Preceding gene: 222152089

Following gene: 222152091

Centisome position: 94.22

GC content: 36.41

Gene sequence:

>879_bases
ATGGATCAATATAATTTAAATACACGTGAAGGTCGATGGAAACATTTCGGTTCGGTAGATCCTATTAAAGGGACTAAACC
TACTGAGAAAGAAAAGATGACAGACCTGCAAAGTTCGAAAAAAGATTTTTTATTTGAAATCGATCATGTAGGTATTAAAA
ATTTAACATATCCCGTCCGACTGGATGGTTATCAAACAGCAGGAACATTTAGCCTATCTACGCATTTAGCTAAAGATGAA
AAAGGCATTAATATGAGCCGTATTTTAGAATCCGTTGAAGCCCATTATGACAATGGTTTATCGCTTGATTTCGATACATT
AAAAACAGTATTAATTACTTTACAGACAGTAATGCATCAAAAAGATGCGACTGTTGATGTAGATGCAAAATGGTTCTTTG
ACCGTTTCAGTCCAGTAACAAACCTACGTGCCATCGGACATGCTGATACACGTTTTTCTATGACAGTTGAAGGTGATACG
ACAGTTAATAAATCGTTAACATTGACTGCAATGGTAACAACACTTTGCCCATGCTCTAAAGAAATCAGCGAATACTCTGC
TCATAACCAACGCGGTATCGTGACAGTTAAAGCTGACTTTGCACCAGAAGGTGAATTACCAGCAAACTTCAAAGAACGCA
TCTTAGAAGCGATGGAAGTTAACGCTAGTTCAATGTTATACCCAATATTAAAACGTACAGATGAAAAATCAGTAACGGAA
CGTGCATATGAAAACCCACGTTTTGTCGAAGATTTATTACGATTAATTGCAGCTGATTTAGTAGAACTTGATTTCGTTAC
AGGTTTTACAATTGAATGTCGCAATGAAGAATCTATTCACCAGCATGATGCGTTTGCGCGTTTGAGCTATAATAAATAA

Upstream 100 bases:

>100_bases
GAAAATTTAGCGGCAAATACACAAGAAGCAGAAGCGGCAAAAGATATGTGGCTTCGAAAAGAACGCTTCTACGAATACGA
AGTTTAATTAGGAGAATGAG

Downstream 100 bases:

>100_bases
TATGCTTACTGAAAAAGAAAAGATGCTACAAGGTGCTATGTATAACCCTTCTGACGTACAACTTGCACACGATAGAATGA
TTGCAAAACTTATGACACGT

Product: GTP cyclohydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MDQYNLNTREGRWKHFGSVDPIKGTKPTEKEKMTDLQSSKKDFLFEIDHVGIKNLTYPVRLDGYQTAGTFSLSTHLAKDE
KGINMSRILESVEAHYDNGLSLDFDTLKTVLITLQTVMHQKDATVDVDAKWFFDRFSPVTNLRAIGHADTRFSMTVEGDT
TVNKSLTLTAMVTTLCPCSKEISEYSAHNQRGIVTVKADFAPEGELPANFKERILEAMEVNASSMLYPILKRTDEKSVTE
RAYENPRFVEDLLRLIAADLVELDFVTGFTIECRNEESIHQHDAFARLSYNK

Sequences:

>Translated_292_residues
MDQYNLNTREGRWKHFGSVDPIKGTKPTEKEKMTDLQSSKKDFLFEIDHVGIKNLTYPVRLDGYQTAGTFSLSTHLAKDE
KGINMSRILESVEAHYDNGLSLDFDTLKTVLITLQTVMHQKDATVDVDAKWFFDRFSPVTNLRAIGHADTRFSMTVEGDT
TVNKSLTLTAMVTTLCPCSKEISEYSAHNQRGIVTVKADFAPEGELPANFKERILEAMEVNASSMLYPILKRTDEKSVTE
RAYENPRFVEDLLRLIAADLVELDFVTGFTIECRNEESIHQHDAFARLSYNK
>Mature_292_residues
MDQYNLNTREGRWKHFGSVDPIKGTKPTEKEKMTDLQSSKKDFLFEIDHVGIKNLTYPVRLDGYQTAGTFSLSTHLAKDE
KGINMSRILESVEAHYDNGLSLDFDTLKTVLITLQTVMHQKDATVDVDAKWFFDRFSPVTNLRAIGHADTRFSMTVEGDT
TVNKSLTLTAMVTTLCPCSKEISEYSAHNQRGIVTVKADFAPEGELPANFKERILEAMEVNASSMLYPILKRTDEKSVTE
RAYENPRFVEDLLRLIAADLVELDFVTGFTIECRNEESIHQHDAFARLSYNK

Specific function: Converts GTP to 7,8-dihydroneopterin triphosphate

COG id: COG1469

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase IV family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCH4_MACCJ (B9E8N6)

Other databases:

- EMBL:   AP009484
- RefSeq:   YP_002561250.1
- GeneID:   7390444
- GenomeReviews:   AP009484_GR
- KEGG:   mcl:MCCL_1847
- OMA:   SLMDYEV
- ProtClustDB:   PRK13674
- HAMAP:   MF_01527_B
- InterPro:   IPR022838
- InterPro:   IPR003801
- InterPro:   IPR002042
- Gene3D:   G3DSA:3.10.270.10
- TIGRFAMs:   TIGR00294

Pfam domain/function: PF02649 DUF198

EC number: =3.5.4.16

Molecular weight: Translated: 33159; Mature: 33159

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQYNLNTREGRWKHFGSVDPIKGTKPTEKEKMTDLQSSKKDFLFEIDHVGIKNLTYPVR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEE
LDGYQTAGTFSLSTHLAKDEKGINMSRILESVEAHYDNGLSLDFDTLKTVLITLQTVMHQ
ECCCCCCCEEEHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEECHHHHHHHHHHHHHHHHC
KDATVDVDAKWFFDRFSPVTNLRAIGHADTRFSMTVEGDTTVNKSLTLTAMVTTLCPCSK
CCCCEECCHHHHHHHHCCHHHHHHCCCCCCEEEEEECCCCCCCCCEEHHHHHHHHCCCHH
EISEYSAHNQRGIVTVKADFAPEGELPANFKERILEAMEVNASSMLYPILKRTDEKSVTE
HHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHH
RAYENPRFVEDLLRLIAADLVELDFVTGFTIECRNEESIHQHDAFARLSYNK
HHCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHEECCCC
>Mature Secondary Structure
MDQYNLNTREGRWKHFGSVDPIKGTKPTEKEKMTDLQSSKKDFLFEIDHVGIKNLTYPVR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEE
LDGYQTAGTFSLSTHLAKDEKGINMSRILESVEAHYDNGLSLDFDTLKTVLITLQTVMHQ
ECCCCCCCEEEHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEECHHHHHHHHHHHHHHHHC
KDATVDVDAKWFFDRFSPVTNLRAIGHADTRFSMTVEGDTTVNKSLTLTAMVTTLCPCSK
CCCCEECCHHHHHHHHCCHHHHHHCCCCCCEEEEEECCCCCCCCCEEHHHHHHHHCCCHH
EISEYSAHNQRGIVTVKADFAPEGELPANFKERILEAMEVNASSMLYPILKRTDEKSVTE
HHHHHHCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCHHHHHH
RAYENPRFVEDLLRLIAADLVELDFVTGFTIECRNEESIHQHDAFARLSYNK
HHCCCCHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA