Click here to switch to the map view.

The map label for this gene is cobB [H]

Identifier: 222151559

GI number: 222151559

Start: 1420448

End: 1421179

Strand: Direct

Name: cobB [H]

Synonym: MCCL_1312

Alternate gene names: 222151559

Gene position: 1420448-1421179 (Clockwise)

Preceding gene: 222151512

Following gene: 222151572

Centisome position: 67.57

GC content: 37.98

Gene sequence:

>732_bases
ATGGAGAAAATTAGTATGCTTGAAAAAGCAATAAAAAAGAGCGAAAAAATAGTATTTTTCGGAGGTGCGGGAGTATCAAC
TGAAAGCGGTATCCCTGACTTTAGAAGCGCTGATGGAATCTTCATGCAGGAAACTAGTATCGAACATTCCCCAGAAGAAA
TTATTTCTATTGATTTCTTTAATAAATATCCAAAACAATATTTCAAGTTTCACTTTGATAAACTCGTGTATCCGCATGCA
AAGCCGAATATAGCACATCGTTTCATCACGAAACTCGAACAACAAGGCAAAGATGTAACCGTCGTAACACAAAATATCGA
TGGTCTACATCAATCAGCCGGCAACAGCAAAGTACTAGAATTGCACGGTAACGTTCAGACAAATTATTGCACGCACTGCA
AGAAAGTCTATCAATTAGAAGACATCTCAATGGATAAAGACGGTATACCAAGATGTCTACATGATGGTCATATTATACGC
CCCGATATCGTAATGTATGGAGAAGCACTTAATTCATCAGTGATTACCGAAGCAATCACTGCTATACAGAATGCTGATAT
GATGATTATCGCTGGGACATCGCTGGTCGTATATCCTGCATCAACCTTTGTAGATTTCTTTAATGGCGAGACGCTTGCAG
TAATCAACAAAACATCTCTACGAACAGTACGCAGTGATGCATTAATCTTTGAAGATTACATCGGAGAAGTGCTCAATGCT
ATAAAGTTATAA

Upstream 100 bases:

>100_bases
TAAATTCATTTATTGTGCAAAGGAGGTAAAACAATATTTTAATATCAGCGTTCAAACATGTTAAAATAGAATAACGACGG
ATAACAAGGAGTAATTGACA

Downstream 100 bases:

>100_bases
AAAAGAACGCTATAGAAAATAAATTTTCTATAGCGTTCTTTTTGATTTTTGAGAGAATATCTAAGTTCTCATCTCATTAG
CGTCCTGGGAGGGATTCGAA

Product: hypothetical protein

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog [H]

Number of amino acids: Translated: 243; Mature: 243

Protein sequence:

>243_residues
MEKISMLEKAIKKSEKIVFFGGAGVSTESGIPDFRSADGIFMQETSIEHSPEEIISIDFFNKYPKQYFKFHFDKLVYPHA
KPNIAHRFITKLEQQGKDVTVVTQNIDGLHQSAGNSKVLELHGNVQTNYCTHCKKVYQLEDISMDKDGIPRCLHDGHIIR
PDIVMYGEALNSSVITEAITAIQNADMMIIAGTSLVVYPASTFVDFFNGETLAVINKTSLRTVRSDALIFEDYIGEVLNA
IKL

Sequences:

>Translated_243_residues
MEKISMLEKAIKKSEKIVFFGGAGVSTESGIPDFRSADGIFMQETSIEHSPEEIISIDFFNKYPKQYFKFHFDKLVYPHA
KPNIAHRFITKLEQQGKDVTVVTQNIDGLHQSAGNSKVLELHGNVQTNYCTHCKKVYQLEDISMDKDGIPRCLHDGHIIR
PDIVMYGEALNSSVITEAITAIQNADMMIIAGTSLVVYPASTFVDFFNGETLAVINKTSLRTVRSDALIFEDYIGEVLNA
IKL
>Mature_243_residues
MEKISMLEKAIKKSEKIVFFGGAGVSTESGIPDFRSADGIFMQETSIEHSPEEIISIDFFNKYPKQYFKFHFDKLVYPHA
KPNIAHRFITKLEQQGKDVTVVTQNIDGLHQSAGNSKVLELHGNVQTNYCTHCKKVYQLEDISMDKDGIPRCLHDGHIIR
PDIVMYGEALNSSVITEAITAIQNADMMIIAGTSLVVYPASTFVDFFNGETLAVINKTSLRTVRSDALIFEDYIGEVLNA
IKL

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI13787215, Length=249, Percent_Identity=32.1285140562249, Blast_Score=130, Evalue=8e-31,
Organism=Homo sapiens, GI6912664, Length=247, Percent_Identity=31.9838056680162, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI6912660, Length=213, Percent_Identity=35.6807511737089, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI300795542, Length=235, Percent_Identity=32.3404255319149, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI63054862, Length=192, Percent_Identity=38.0208333333333, Blast_Score=123, Evalue=2e-28,
Organism=Homo sapiens, GI7657575, Length=215, Percent_Identity=33.953488372093, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI6912662, Length=279, Percent_Identity=27.2401433691756, Blast_Score=108, Evalue=3e-24,
Organism=Homo sapiens, GI13775602, Length=206, Percent_Identity=32.0388349514563, Blast_Score=106, Evalue=1e-23,
Organism=Homo sapiens, GI13775600, Length=206, Percent_Identity=32.0388349514563, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI300797705, Length=197, Percent_Identity=32.48730964467, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI300797577, Length=259, Percent_Identity=27.7992277992278, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI300797597, Length=245, Percent_Identity=28.1632653061224, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI215982798, Length=188, Percent_Identity=30.3191489361702, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI7706712, Length=216, Percent_Identity=28.7037037037037, Blast_Score=79, Evalue=4e-15,
Organism=Escherichia coli, GI308199517, Length=193, Percent_Identity=33.160621761658, Blast_Score=102, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17541892, Length=199, Percent_Identity=32.6633165829146, Blast_Score=104, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI71990482, Length=250, Percent_Identity=28.8, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17567771, Length=226, Percent_Identity=29.646017699115, Blast_Score=97, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI71990487, Length=252, Percent_Identity=28.5714285714286, Blast_Score=94, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI17505510, Length=138, Percent_Identity=29.7101449275362, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6324599, Length=278, Percent_Identity=29.4964028776978, Blast_Score=96, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6325242, Length=213, Percent_Identity=32.8638497652582, Blast_Score=88, Evalue=9e-19,
Organism=Saccharomyces cerevisiae, GI6324504, Length=235, Percent_Identity=28.5106382978723, Blast_Score=87, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320163, Length=237, Percent_Identity=29.535864978903, Blast_Score=83, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24648389, Length=198, Percent_Identity=36.3636363636364, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI17137536, Length=224, Percent_Identity=33.4821428571429, Blast_Score=117, Evalue=5e-27,
Organism=Drosophila melanogaster, GI24645650, Length=259, Percent_Identity=28.1853281853282, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI28571445, Length=219, Percent_Identity=26.4840182648402, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 27210; Mature: 27210

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKISMLEKAIKKSEKIVFFGGAGVSTESGIPDFRSADGIFMQETSIEHSPEEIISIDFF
CCHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCEEEECCCCCCCHHHEEEEHHH
NKYPKQYFKFHFDKLVYPHAKPNIAHRFITKLEQQGKDVTVVTQNIDGLHQSAGNSKVLE
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHCCCCCEEEE
LHGNVQTNYCTHCKKVYQLEDISMDKDGIPRCLHDGHIIRPDIVMYGEALNSSVITEAIT
EECCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHCCCEEECCCCEEECHHHCHHHHHHHHH
AIQNADMMIIAGTSLVVYPASTFVDFFNGETLAVINKTSLRTVRSDALIFEDYIGEVLNA
HHCCCCEEEEECCEEEEEEHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHH
IKL
HCC
>Mature Secondary Structure
MEKISMLEKAIKKSEKIVFFGGAGVSTESGIPDFRSADGIFMQETSIEHSPEEIISIDFF
CCHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCEEEECCCCCCCHHHEEEEHHH
NKYPKQYFKFHFDKLVYPHAKPNIAHRFITKLEQQGKDVTVVTQNIDGLHQSAGNSKVLE
HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHCCCCCEEEE
LHGNVQTNYCTHCKKVYQLEDISMDKDGIPRCLHDGHIIRPDIVMYGEALNSSVITEAIT
EECCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHCCCEEECCCCEEECHHHCHHHHHHHHH
AIQNADMMIIAGTSLVVYPASTFVDFFNGETLAVINKTSLRTVRSDALIFEDYIGEVLNA
HHCCCCEEEEECCEEEEEEHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHH
IKL
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11792842 [H]