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The map label for this gene is fabG [C]

Identifier: 222151292

GI number: 222151292

Start: 1153093

End: 1153794

Strand: Direct

Name: fabG [C]

Synonym: MCCL_1045

Alternate gene names: 222151292

Gene position: 1153093-1153794 (Clockwise)

Preceding gene: 222151291

Following gene: 222151294

Centisome position: 54.85

GC content: 39.32

Gene sequence:

>702_bases
ATGTCTAAACAAAAAGTAGTTGTGATTACTGGTGATCAGAGTGGTATCGGTAAATGTGTTAAAGAAAGTTTTGAAAAAAA
TGGCGCAATTGTATGTGGTATCGATATACAGGAAGGAAGTTTTTATCACGGTGATATCGCTGATGAGAAGGTGCTGGAAG
CATTTGTGTCGAAAGTAATAACACACTACCAAAAAGTAGATATTATTATTAATAACGCATTACCAGTCATGAAAGGTATT
GATGATTGTACATATGAAGAATTTCAACATGCGCTTTCAGTCGGTGTAACTGCCCCATTCTACCTTGTGAAGTTACTAAA
ACCTCATTTAAGTGAAGGTGCATCAATTGTAAATATCAGCTCTACTCGTGCAATGATGAGCCAAGCTCAGACTGAAAGTT
ACAGCGCAGCAAAAGGCGGTATCCATGCGCTTACCCATGCACTAGCAGTGAGTTTAAGCGGCATTGCGCGTGTAAATGCT
ATCAGTCCGGGGTGGATTGACACTACAAATACAATCTATACAGGTGCAAATGCGTACCAGCACCCTGCAGGTCGTGTTGG
TAAACCTGAAGATATTGCGGAAATGGTCAAATTTCTATGTTCAGAAGAAGCAGCATTTATAACAGGTGAAAACATTACAA
TTGACGGTGGTATGAGTAAATTAATGATTTATCACAATGACCAGGGATGGTCGTTGCAATAA

Upstream 100 bases:

>100_bases
ATGCCCCACTGAAAGAAACGATTGCTTATATCGGAAGTCTCGTTGATGAACTTGAAAAACTAACAGAAGAAATTGAAAAT
TAATAAAGGACTGATATGTA

Downstream 100 bases:

>100_bases
AAAAACGGCTGAAGCAGCCGTTTTTTTATTGATTTAATTTAATTTTATCAGGTTCAATAGTGATGCGCTTACTCTTGTAT
AATCTGCCGATTGCGCGTTT

Product: hypothetical protein

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 233; Mature: 232

Protein sequence:

>233_residues
MSKQKVVVITGDQSGIGKCVKESFEKNGAIVCGIDIQEGSFYHGDIADEKVLEAFVSKVITHYQKVDIIINNALPVMKGI
DDCTYEEFQHALSVGVTAPFYLVKLLKPHLSEGASIVNISSTRAMMSQAQTESYSAAKGGIHALTHALAVSLSGIARVNA
ISPGWIDTTNTIYTGANAYQHPAGRVGKPEDIAEMVKFLCSEEAAFITGENITIDGGMSKLMIYHNDQGWSLQ

Sequences:

>Translated_233_residues
MSKQKVVVITGDQSGIGKCVKESFEKNGAIVCGIDIQEGSFYHGDIADEKVLEAFVSKVITHYQKVDIIINNALPVMKGI
DDCTYEEFQHALSVGVTAPFYLVKLLKPHLSEGASIVNISSTRAMMSQAQTESYSAAKGGIHALTHALAVSLSGIARVNA
ISPGWIDTTNTIYTGANAYQHPAGRVGKPEDIAEMVKFLCSEEAAFITGENITIDGGMSKLMIYHNDQGWSLQ
>Mature_232_residues
SKQKVVVITGDQSGIGKCVKESFEKNGAIVCGIDIQEGSFYHGDIADEKVLEAFVSKVITHYQKVDIIINNALPVMKGID
DCTYEEFQHALSVGVTAPFYLVKLLKPHLSEGASIVNISSTRAMMSQAQTESYSAAKGGIHALTHALAVSLSGIARVNAI
SPGWIDTTNTIYTGANAYQHPAGRVGKPEDIAEMVKFLCSEEAAFITGENITIDGGMSKLMIYHNDQGWSLQ

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI59889578, Length=233, Percent_Identity=30.4721030042918, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI32483357, Length=245, Percent_Identity=28.1632653061224, Blast_Score=91, Evalue=6e-19,
Organism=Homo sapiens, GI5031737, Length=248, Percent_Identity=27.0161290322581, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI19923817, Length=254, Percent_Identity=27.9527559055118, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI31542939, Length=189, Percent_Identity=32.2751322751323, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI66933014, Length=243, Percent_Identity=26.7489711934156, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI15277342, Length=251, Percent_Identity=23.9043824701195, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI4758504, Length=251, Percent_Identity=27.8884462151394, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI40254992, Length=240, Percent_Identity=25, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI1787335, Length=243, Percent_Identity=31.2757201646091, Blast_Score=98, Evalue=5e-22,
Organism=Escherichia coli, GI1789378, Length=247, Percent_Identity=28.3400809716599, Blast_Score=85, Evalue=3e-18,
Organism=Escherichia coli, GI1789208, Length=240, Percent_Identity=25.8333333333333, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI1786812, Length=238, Percent_Identity=26.890756302521, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI1787905, Length=238, Percent_Identity=31.0924369747899, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1790717, Length=244, Percent_Identity=25.4098360655738, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87082100, Length=247, Percent_Identity=25.9109311740891, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI1788459, Length=173, Percent_Identity=28.3236994219653, Blast_Score=72, Evalue=2e-14,
Organism=Escherichia coli, GI2367175, Length=197, Percent_Identity=29.4416243654822, Blast_Score=70, Evalue=9e-14,
Organism=Escherichia coli, GI87082160, Length=243, Percent_Identity=25.9259259259259, Blast_Score=66, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17560332, Length=265, Percent_Identity=29.0566037735849, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17551412, Length=271, Percent_Identity=28.4132841328413, Blast_Score=88, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17562910, Length=260, Percent_Identity=30, Blast_Score=87, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17538480, Length=270, Percent_Identity=28.5185185185185, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17559104, Length=265, Percent_Identity=27.9245283018868, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17562904, Length=261, Percent_Identity=28.735632183908, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17560676, Length=245, Percent_Identity=28.1632653061224, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17561402, Length=246, Percent_Identity=28.4552845528455, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI71994600, Length=247, Percent_Identity=27.1255060728745, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71994604, Length=246, Percent_Identity=25.609756097561, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17538486, Length=265, Percent_Identity=26.0377358490566, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17562990, Length=260, Percent_Identity=27.3076923076923, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI25147288, Length=246, Percent_Identity=27.2357723577236, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17560150, Length=262, Percent_Identity=26.3358778625954, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17562908, Length=271, Percent_Identity=26.1992619926199, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17538182, Length=251, Percent_Identity=25.0996015936255, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17555706, Length=247, Percent_Identity=25.1012145748988, Blast_Score=67, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17536651, Length=248, Percent_Identity=25.8064516129032, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI115534694, Length=243, Percent_Identity=25.1028806584362, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=190, Percent_Identity=28.4210526315789, Blast_Score=63, Evalue=3e-11,
Organism=Drosophila melanogaster, GI23397609, Length=246, Percent_Identity=30.8943089430894, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24644339, Length=245, Percent_Identity=29.7959183673469, Blast_Score=94, Evalue=7e-20,
Organism=Drosophila melanogaster, GI21357041, Length=247, Percent_Identity=27.1255060728745, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24639444, Length=241, Percent_Identity=25.7261410788382, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21355319, Length=244, Percent_Identity=29.0983606557377, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI28571526, Length=247, Percent_Identity=25.5060728744939, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24643142, Length=237, Percent_Identity=25.7383966244726, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24644337, Length=246, Percent_Identity=32.1138211382114, Blast_Score=78, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 25099; Mature: 24968

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKQKVVVITGDQSGIGKCVKESFEKNGAIVCGIDIQEGSFYHGDIADEKVLEAFVSKVI
CCCCEEEEEECCCHHHHHHHHHHHHCCCCEEEEEEECCCCEEECCCCHHHHHHHHHHHHH
THYQKVDIIINNALPVMKGIDDCTYEEFQHALSVGVTAPFYLVKLLKPHLSEGASIVNIS
HHHHHEEEEECCCCHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCEEEEEH
STRAMMSQAQTESYSAAKGGIHALTHALAVSLSGIARVNAISPGWIDTTNTIYTGANAYQ
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCEEEECCCCCC
HPAGRVGKPEDIAEMVKFLCSEEAAFITGENITIDGGMSKLMIYHNDQGWSLQ
CCCCCCCCHHHHHHHHHHHHCCCCEEEECCEEEEECCCEEEEEEECCCCCCCC
>Mature Secondary Structure 
SKQKVVVITGDQSGIGKCVKESFEKNGAIVCGIDIQEGSFYHGDIADEKVLEAFVSKVI
CCCEEEEEECCCHHHHHHHHHHHHCCCCEEEEEEECCCCEEECCCCHHHHHHHHHHHHH
THYQKVDIIINNALPVMKGIDDCTYEEFQHALSVGVTAPFYLVKLLKPHLSEGASIVNIS
HHHHHEEEEECCCCHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCEEEEEH
STRAMMSQAQTESYSAAKGGIHALTHALAVSLSGIARVNAISPGWIDTTNTIYTGANAYQ
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCEEEECCCCCC
HPAGRVGKPEDIAEMVKFLCSEEAAFITGENITIDGGMSKLMIYHNDQGWSLQ
CCCCCCCCHHHHHHHHHHHHCCCCEEEECCEEEEECCCEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8550425; 10360571 [H]