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The map label for this gene is ymfI [H]

Identifier: 222151120

GI number: 222151120

Start: 959820

End: 960527

Strand: Direct

Name: ymfI [H]

Synonym: MCCL_0871

Alternate gene names: 222151120

Gene position: 959820-960527 (Clockwise)

Preceding gene: 222151119

Following gene: 222151121

Centisome position: 45.66

GC content: 39.12

Gene sequence:

>708_bases
ATGGGTAAATATATGGTTATTGGAGCGAGCGGAGATATCGGCAGTCAGATTACACGGGATTTGTTATTGGATGGACATGA
AGTCATCGCGCAGTACTTTAGTGCAGATATTAGAGGCTTAAAAGAACAGTTTAGTGGTCAGGCAATTTCTTTTTTACACC
TTGACTTATCGGTTCCTCTGCAGAAGAATCCTTTTGAAACATGGATGACAGCACATCTTGATGGTTTAATCTATGTTGCT
GGTAAGTCCTATTTTTCAGAACTTCGCGATGTCACAGATGATAAAATTCACGAACAGTACGCGATTCATTTCTTTAACCT
TGTGAAGTGCGTTCAATATACTTCTAATGGCTTATTACAAGGGAATAATGGTAGAATTATTGTAATTAGTTCTATATGGG
GTGAAACAGGGAGTAGCATGGAAAGCATCTATAGTGGTTTCAAAGCGGCACAAATCGGCTTTATAAAGTCCATCGCTAAA
GAATATGCGCAAACAAATATTACTGCAAATATTATTGCACCGGGCCTCGTTACCGGAAGAATGACGGATGCACTTGAAGA
TGATGTTGAAAGTATCATTGAACAGATCCCTCAAAAAAAATGTGTCCAGCCAGTAGAAATCAGCCATTTTGTACGTGCTC
TGTTACACCAGTATAGCCATACCACAACAGGCACTGTAATACGTATTAATGGTGGCTGGTATATATAG

Upstream 100 bases:

>100_bases
TTATTACCAATACTCAATCAGCTACAACTCGAGGACTGTATATCAACGTATAGGACAGCGATAGCATCAGCCTCAATTAC
AGATAGCAGGATGCTACCGA

Downstream 100 bases:

>100_bases
GAGGAAACGAATGGAACAAACTTTAAAGAAGGAATGGTACCTTGAATATGAGATAGTGATTAATCGTGCGGGACTTCTAG
GTGATGTATCAAGTCTACTA

Product: hypothetical protein

Products: 3-oxoacyl-[acyl-carrier protein]; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 235; Mature: 234

Protein sequence:

>235_residues
MGKYMVIGASGDIGSQITRDLLLDGHEVIAQYFSADIRGLKEQFSGQAISFLHLDLSVPLQKNPFETWMTAHLDGLIYVA
GKSYFSELRDVTDDKIHEQYAIHFFNLVKCVQYTSNGLLQGNNGRIIVISSIWGETGSSMESIYSGFKAAQIGFIKSIAK
EYAQTNITANIIAPGLVTGRMTDALEDDVESIIEQIPQKKCVQPVEISHFVRALLHQYSHTTTGTVIRINGGWYI

Sequences:

>Translated_235_residues
MGKYMVIGASGDIGSQITRDLLLDGHEVIAQYFSADIRGLKEQFSGQAISFLHLDLSVPLQKNPFETWMTAHLDGLIYVA
GKSYFSELRDVTDDKIHEQYAIHFFNLVKCVQYTSNGLLQGNNGRIIVISSIWGETGSSMESIYSGFKAAQIGFIKSIAK
EYAQTNITANIIAPGLVTGRMTDALEDDVESIIEQIPQKKCVQPVEISHFVRALLHQYSHTTTGTVIRINGGWYI
>Mature_234_residues
GKYMVIGASGDIGSQITRDLLLDGHEVIAQYFSADIRGLKEQFSGQAISFLHLDLSVPLQKNPFETWMTAHLDGLIYVAG
KSYFSELRDVTDDKIHEQYAIHFFNLVKCVQYTSNGLLQGNNGRIIVISSIWGETGSSMESIYSGFKAAQIGFIKSIAKE
YAQTNITANIIAPGLVTGRMTDALEDDVESIIEQIPQKKCVQPVEISHFVRALLHQYSHTTTGTVIRINGGWYI

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI40254992, Length=192, Percent_Identity=28.125, Blast_Score=73, Evalue=2e-13,
Organism=Escherichia coli, GI1787335, Length=235, Percent_Identity=28.5106382978723, Blast_Score=91, Evalue=5e-20,
Organism=Escherichia coli, GI87082100, Length=254, Percent_Identity=26.7716535433071, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1789378, Length=251, Percent_Identity=27.0916334661355, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17555706, Length=234, Percent_Identity=23.5042735042735, Blast_Score=70, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI25147288, Length=111, Percent_Identity=35.1351351351351, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100

Molecular weight: Translated: 26080; Mature: 25949

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKYMVIGASGDIGSQITRDLLLDGHEVIAQYFSADIRGLKEQFSGQAISFLHLDLSVPL
CCCEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCC
QKNPFETWMTAHLDGLIYVAGKSYFSELRDVTDDKIHEQYAIHFFNLVKCVQYTSNGLLQ
CCCCHHHHHHHHHCCEEEEECHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEE
GNNGRIIVISSIWGETGSSMESIYSGFKAAQIGFIKSIAKEYAQTNITANIIAPGLVTGR
CCCCCEEEEEECCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHH
MTDALEDDVESIIEQIPQKKCVQPVEISHFVRALLHQYSHTTTGTVIRINGGWYI
HHHHHHHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCC
>Mature Secondary Structure 
GKYMVIGASGDIGSQITRDLLLDGHEVIAQYFSADIRGLKEQFSGQAISFLHLDLSVPL
CCEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCC
QKNPFETWMTAHLDGLIYVAGKSYFSELRDVTDDKIHEQYAIHFFNLVKCVQYTSNGLLQ
CCCCHHHHHHHHHCCEEEEECHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCEE
GNNGRIIVISSIWGETGSSMESIYSGFKAAQIGFIKSIAKEYAQTNITANIIAPGLVTGR
CCCCCEEEEEECCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHH
MTDALEDDVESIIEQIPQKKCVQPVEISHFVRALLHQYSHTTTGTVIRINGGWYI
HHHHHHHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (3R)-3-hydroxyacyl-[acyl-carrier protein]; NADP+

Specific reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]