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The map label for this gene is hslU [H]

Identifier: 222151087

GI number: 222151087

Start: 914495

End: 915868

Strand: Direct

Name: hslU [H]

Synonym: MCCL_0838

Alternate gene names: 222151087

Gene position: 914495-915868 (Clockwise)

Preceding gene: 222151086

Following gene: 222151088

Centisome position: 43.5

GC content: 39.16

Gene sequence:

>1374_bases
ATGAAGTCAGCGAACTTAACGCCAAGACAAATCGTTAGTCATCTCGATGAACATATTATCGGTCAGCAGGATGCAAAGAG
GAAGGTGGCGGTAAGCTTGAGAAATCGTTACCGTCGTATGGCACTAGATGATGAGATTCAAAAGGAAGTTATTCCTAAGA
ATATATTGATGATCGGGCCGACGGGTGTCGGTAAAACAGAGATAGCGAGACGAATGGCAAAGCTGGTTGGCGCCCCTTTT
GTGAAAGTAGAAGCAACTAAATATACAGAAGTCGGTTATGTAGGTCGAGATGTTGAAAGTATGATCAGGGATCTTACGGA
AAATGGTGTCAGGTTAATTAAAGAGAAGAAAAAACAGGAAGTTCTAGAAGAAGCTAAACGAAATGCAGAAGAACGCCTTG
TTAAATTGCTCGTTCCAGCGATGAAGAAAAAAGAAAATAAAGCTGGAAATCCATTTGAAATGCTGTTCAATCAAACCATC
CAAGAAGAAGAAGACGCACCTGATGAGCAAGTAAAATTAAAACGTAAAGATATTCAAGCTCAACTGAAAGCAGGAAAATT
AGAGGATGAAACTGTCAAGATTAAAGTAGAGCAGGAATTTAAAGGATTGAATATGTTCGGTATGGATATGCAGAACAATC
AAATGCAGGATATGTTCAGTCAGATGATGCCTAAGAAGAAGGTTGAACGTACGTTAAAGGTTTCAGATGCAAGGGAAGTT
CTGATTGATGAAGAAGCAACAAAGCTGATTGATGAAGAATCAATGCATAGTGAAGCTGTAGCCTTAACTGAGCAGTTAGG
AATCGTATTTATCGATGAAATAGATAAGATAGCTGGGGGTAATCAAGGCCCGGATGTTTCAAGGCAAGGTGTTCAGCGAG
ATATATTACCGATTGTCGAAGGTAGTGTGGTTCAGACGAAATATGGAGCGGTTAATACGGAGCATATCCTATTCATAGGT
GCCGGGGCTTTCCATGTATCCAAGCCAAGTGACCTGATTCCTGAATTACAAGGAAGATTTCCGATTCGTGTGGAGCTTGA
TAAGCTATCGGTCGATGATTTCAAAAGAATATTAAAAGAACCGAAACTATCACTGTTAAAACAGTATGAAAGCTTACTGG
CGACAGAAGATGTTACTATCAATTTTACGGATGAAGCAATTGACAGGCTCGCGGAGATGTCCTATGAAGTGAATCAGGAA
ACTGACAACATTGGTGCAAGACGCCTACATACAATTTTAGAAAAGATGCTTGAAGATCTGCTGTTTGAAGCTTCGGAAAT
GCCGAATGCACACGTAGATATTACTGCACAATATGTGGATGCTAAATTAGGAAATATTACAAAAAATAAAAATTTAAGTG
AATTTATACTTTAA

Upstream 100 bases:

>100_bases
AGCGCGCGTGATATTGCACAGGCTTCTTTAGAAACAGCAGCTGATATATGTGTATTCACAAATCATAATATTATTATTGA
AGAAATTTAGGAGGCATATC

Downstream 100 bases:

>100_bases
AGGAGTGCCTTTTAATAATGGAATTATTACAAAGAACGAGAAAGATTAATAAACTTTTACAGGAACATAAAGGGATTGCA
GTTGACTTCAAAGAAATGGC

Product: ATP-dependent protease ATP-binding subunit HslU

Products: NA

Alternate protein names: Unfoldase HslU [H]

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MKSANLTPRQIVSHLDEHIIGQQDAKRKVAVSLRNRYRRMALDDEIQKEVIPKNILMIGPTGVGKTEIARRMAKLVGAPF
VKVEATKYTEVGYVGRDVESMIRDLTENGVRLIKEKKKQEVLEEAKRNAEERLVKLLVPAMKKKENKAGNPFEMLFNQTI
QEEEDAPDEQVKLKRKDIQAQLKAGKLEDETVKIKVEQEFKGLNMFGMDMQNNQMQDMFSQMMPKKKVERTLKVSDAREV
LIDEEATKLIDEESMHSEAVALTEQLGIVFIDEIDKIAGGNQGPDVSRQGVQRDILPIVEGSVVQTKYGAVNTEHILFIG
AGAFHVSKPSDLIPELQGRFPIRVELDKLSVDDFKRILKEPKLSLLKQYESLLATEDVTINFTDEAIDRLAEMSYEVNQE
TDNIGARRLHTILEKMLEDLLFEASEMPNAHVDITAQYVDAKLGNITKNKNLSEFIL

Sequences:

>Translated_457_residues
MKSANLTPRQIVSHLDEHIIGQQDAKRKVAVSLRNRYRRMALDDEIQKEVIPKNILMIGPTGVGKTEIARRMAKLVGAPF
VKVEATKYTEVGYVGRDVESMIRDLTENGVRLIKEKKKQEVLEEAKRNAEERLVKLLVPAMKKKENKAGNPFEMLFNQTI
QEEEDAPDEQVKLKRKDIQAQLKAGKLEDETVKIKVEQEFKGLNMFGMDMQNNQMQDMFSQMMPKKKVERTLKVSDAREV
LIDEEATKLIDEESMHSEAVALTEQLGIVFIDEIDKIAGGNQGPDVSRQGVQRDILPIVEGSVVQTKYGAVNTEHILFIG
AGAFHVSKPSDLIPELQGRFPIRVELDKLSVDDFKRILKEPKLSLLKQYESLLATEDVTINFTDEAIDRLAEMSYEVNQE
TDNIGARRLHTILEKMLEDLLFEASEMPNAHVDITAQYVDAKLGNITKNKNLSEFIL
>Mature_457_residues
MKSANLTPRQIVSHLDEHIIGQQDAKRKVAVSLRNRYRRMALDDEIQKEVIPKNILMIGPTGVGKTEIARRMAKLVGAPF
VKVEATKYTEVGYVGRDVESMIRDLTENGVRLIKEKKKQEVLEEAKRNAEERLVKLLVPAMKKKENKAGNPFEMLFNQTI
QEEEDAPDEQVKLKRKDIQAQLKAGKLEDETVKIKVEQEFKGLNMFGMDMQNNQMQDMFSQMMPKKKVERTLKVSDAREV
LIDEEATKLIDEESMHSEAVALTEQLGIVFIDEIDKIAGGNQGPDVSRQGVQRDILPIVEGSVVQTKYGAVNTEHILFIG
AGAFHVSKPSDLIPELQGRFPIRVELDKLSVDDFKRILKEPKLSLLKQYESLLATEDVTINFTDEAIDRLAEMSYEVNQE
TDNIGARRLHTILEKMLEDLLFEASEMPNAHVDITAQYVDAKLGNITKNKNLSEFIL

Specific function: ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N

COG id: COG1220

COG function: function code O; ATP-dependent protease HslVU (ClpYQ), ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family. HslU subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790366, Length=459, Percent_Identity=49.8910675381264, Blast_Score=460, Evalue=1e-131,
Organism=Escherichia coli, GI1786642, Length=105, Percent_Identity=46.6666666666667, Blast_Score=98, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24648291, Length=245, Percent_Identity=29.7959183673469, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24648289, Length=245, Percent_Identity=29.7959183673469, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR019489
- InterPro:   IPR004491 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 51856; Mature: 51856

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSANLTPRQIVSHLDEHIIGQQDAKRKVAVSLRNRYRRMALDDEIQKEVIPKNILMIGP
CCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCEEEECC
TGVGKTEIARRMAKLVGAPFVKVEATKYTEVGYVGRDVESMIRDLTENGVRLIKEKKKQE
CCCCHHHHHHHHHHHHCCCCEEEECCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VLEEAKRNAEERLVKLLVPAMKKKENKAGNPFEMLFNQTIQEEEDAPDEQVKLKRKDIQA
HHHHHHHCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
QLKAGKLEDETVKIKVEQEFKGLNMFGMDMQNNQMQDMFSQMMPKKKVERTLKVSDAREV
HHHCCCCCCCEEEEEEECCCCCCCEECCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHH
LIDEEATKLIDEESMHSEAVALTEQLGIVFIDEIDKIAGGNQGPDVSRQGVQRDILPIVE
HHCHHHHHHHHHHHHHHHHHHHHHHCCEEEEHHHHHHCCCCCCCCCCHHCHHHHHHHHHC
GSVVQTKYGAVNTEHILFIGAGAFHVSKPSDLIPELQGRFPIRVELDKLSVDDFKRILKE
CCEEEEECCCCCCCEEEEEECCEEECCCCHHHHHHHCCCCCEEEEECCCCHHHHHHHHHC
PKLSLLKQYESLLATEDVTINFTDEAIDRLAEMSYEVNQETDNIGARRLHTILEKMLEDL
HHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
LFEASEMPNAHVDITAQYVDAKLGNITKNKNLSEFIL
HHHHHHCCCCCEEEEHHHHHHHHCCCCCCCCHHHHCC
>Mature Secondary Structure
MKSANLTPRQIVSHLDEHIIGQQDAKRKVAVSLRNRYRRMALDDEIQKEVIPKNILMIGP
CCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCEEEECC
TGVGKTEIARRMAKLVGAPFVKVEATKYTEVGYVGRDVESMIRDLTENGVRLIKEKKKQE
CCCCHHHHHHHHHHHHCCCCEEEECCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VLEEAKRNAEERLVKLLVPAMKKKENKAGNPFEMLFNQTIQEEEDAPDEQVKLKRKDIQA
HHHHHHHCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
QLKAGKLEDETVKIKVEQEFKGLNMFGMDMQNNQMQDMFSQMMPKKKVERTLKVSDAREV
HHHCCCCCCCEEEEEEECCCCCCCEECCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHH
LIDEEATKLIDEESMHSEAVALTEQLGIVFIDEIDKIAGGNQGPDVSRQGVQRDILPIVE
HHCHHHHHHHHHHHHHHHHHHHHHHCCEEEEHHHHHHCCCCCCCCCCHHCHHHHHHHHHC
GSVVQTKYGAVNTEHILFIGAGAFHVSKPSDLIPELQGRFPIRVELDKLSVDDFKRILKE
CCEEEEECCCCCCCEEEEEECCEEECCCCHHHHHHHCCCCCEEEEECCCCHHHHHHHHHC
PKLSLLKQYESLLATEDVTINFTDEAIDRLAEMSYEVNQETDNIGARRLHTILEKMLEDL
HHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
LFEASEMPNAHVDITAQYVDAKLGNITKNKNLSEFIL
HHHHHHCCCCCEEEEHHHHHHHHCCCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA