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The map label for this gene is coaBC [H]

Identifier: 222151044

GI number: 222151044

Start: 862247

End: 863425

Strand: Direct

Name: coaBC [H]

Synonym: MCCL_0795

Alternate gene names: 222151044

Gene position: 862247-863425 (Clockwise)

Preceding gene: 222151043

Following gene: 222151045

Centisome position: 41.01

GC content: 40.63

Gene sequence:

>1179_bases
ATGAAGATTGTATTAGGCGTTACTGGTGGGATTGCGGTATATAAAGCGATAGATTTAACAAGTAAGCTCGTACAGAATGG
CCATGAAGTGCGTGTCATCATGACGGAGAGTGCAGAGCAGTTTGTGACGCCACTTGCATTTCAGGCGTTAAGCAGAAATC
CTGTATACACAGATATCTTCGTGGAACAGAACCCGGCTGAAATTCAGCATATTGCCCTTGGAGACTGGGCCGACATCATG
ATCATTGCGCCATTAACAGCATCAACGCTCGGTAAGATTGCACATGGTATCAGTGATAATATGCTGACTGCAACTGTACT
TGCGTTTACGAAGACGATTTATCTAGCACCTGCGATGAACAGTAATATGTACAATAATCCAGCAGTAATAGATAACATTC
AAACGTTACTGAAGCGCGGATTCAAGTTCATAGAACCAGGAGAAGGTTTCCTGGCCTGTGGCTATATAGCAAAAGGACGT
ATGAGCGAGCCGCTAGAAATCATGAAATTTATTGCTGAAGATAATATAGAAAAAGATTTGCAAGGCAAGAAAGTATTGAT
TACAGCAGGACCTACAATTGAAACGATAGATCCAGTGCGCTATTTGACGAATCGTTCGTCGGGTAAGATGGGGTATAGTT
TAGCTGAAGCAGCAAACTTAAGAGGAGCAGACGTAACATTAGTATCGGCAGATGTAGGAATACCTGTGCCGAATGGTGTA
CGTCATATTAAGACTGAAAGTGCACAGGATATGTTCAATGCAGTAAGAGACAATATGGAACAGGATCTGATTATTAAAGC
AGCAGCAGTAGCAGACTATACACCAGTTGAAACATATGATCAGAAATTAAAGAAACAAGAAGGAGATCTGACGATTAGAT
TTAAACGTACAGAGGATATACTGAAATATATTGGTGAGCATAAGACGACACAATTTGTTGTAGGCTTTGCAGCAGAGACA
GAACACGTCGAAAAGTATGCACGCGGTAAACTCATCAGGAAAAATGCGGATGTTATTGTTGCAAATAATGTGGGTGATAA
ATCTATCGGATTTAAATCGAATGACAACGCTGTAACGATGTATTTCAAAGACGGAACGCACATCGATATTCCGAAACAGT
CTAAGCTGAACATCGCACATGAAATATTATCATACGTAAAAGAGAAGGGATTTAAGTGA

Upstream 100 bases:

>100_bases
GCTGCAGGTAAGATTCATATTACAAGCGCACACCCTGAGGAATAGTATAAACTGACAAATGTAATGTTTGTCAGTTTTTT
TATAGGAGGAATTTAGACTT

Downstream 100 bases:

>100_bases
TTGCAAAAGTTATCGTAGACGTTAATAGTAAACGTGTTGATAAGTTATTTGATTATTATATTCCGGAACATCTAAAAAGC
GATATCGTACCAGGCCAGAG

Product: phosphopantothenoylcysteine decarboxylase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MKIVLGVTGGIAVYKAIDLTSKLVQNGHEVRVIMTESAEQFVTPLAFQALSRNPVYTDIFVEQNPAEIQHIALGDWADIM
IIAPLTASTLGKIAHGISDNMLTATVLAFTKTIYLAPAMNSNMYNNPAVIDNIQTLLKRGFKFIEPGEGFLACGYIAKGR
MSEPLEIMKFIAEDNIEKDLQGKKVLITAGPTIETIDPVRYLTNRSSGKMGYSLAEAANLRGADVTLVSADVGIPVPNGV
RHIKTESAQDMFNAVRDNMEQDLIIKAAAVADYTPVETYDQKLKKQEGDLTIRFKRTEDILKYIGEHKTTQFVVGFAAET
EHVEKYARGKLIRKNADVIVANNVGDKSIGFKSNDNAVTMYFKDGTHIDIPKQSKLNIAHEILSYVKEKGFK

Sequences:

>Translated_392_residues
MKIVLGVTGGIAVYKAIDLTSKLVQNGHEVRVIMTESAEQFVTPLAFQALSRNPVYTDIFVEQNPAEIQHIALGDWADIM
IIAPLTASTLGKIAHGISDNMLTATVLAFTKTIYLAPAMNSNMYNNPAVIDNIQTLLKRGFKFIEPGEGFLACGYIAKGR
MSEPLEIMKFIAEDNIEKDLQGKKVLITAGPTIETIDPVRYLTNRSSGKMGYSLAEAANLRGADVTLVSADVGIPVPNGV
RHIKTESAQDMFNAVRDNMEQDLIIKAAAVADYTPVETYDQKLKKQEGDLTIRFKRTEDILKYIGEHKTTQFVVGFAAET
EHVEKYARGKLIRKNADVIVANNVGDKSIGFKSNDNAVTMYFKDGTHIDIPKQSKLNIAHEILSYVKEKGFK
>Mature_392_residues
MKIVLGVTGGIAVYKAIDLTSKLVQNGHEVRVIMTESAEQFVTPLAFQALSRNPVYTDIFVEQNPAEIQHIALGDWADIM
IIAPLTASTLGKIAHGISDNMLTATVLAFTKTIYLAPAMNSNMYNNPAVIDNIQTLLKRGFKFIEPGEGFLACGYIAKGR
MSEPLEIMKFIAEDNIEKDLQGKKVLITAGPTIETIDPVRYLTNRSSGKMGYSLAEAANLRGADVTLVSADVGIPVPNGV
RHIKTESAQDMFNAVRDNMEQDLIIKAAAVADYTPVETYDQKLKKQEGDLTIRFKRTEDILKYIGEHKTTQFVVGFAAET
EHVEKYARGKLIRKNADVIVANNVGDKSIGFKSNDNAVTMYFKDGTHIDIPKQSKLNIAHEILSYVKEKGFK

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=168, Percent_Identity=35.1190476190476, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI87082301, Length=380, Percent_Identity=43.1578947368421, Blast_Score=285, Evalue=4e-78,
Organism=Caenorhabditis elegans, GI17560194, Length=184, Percent_Identity=35.3260869565217, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6322762, Length=193, Percent_Identity=32.1243523316062, Blast_Score=87, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6322925, Length=222, Percent_Identity=26.1261261261261, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324629, Length=80, Percent_Identity=42.5, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24657262, Length=172, Percent_Identity=33.1395348837209, Blast_Score=92, Evalue=9e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 43202; Mature: 43202

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIVLGVTGGIAVYKAIDLTSKLVQNGHEVRVIMTESAEQFVTPLAFQALSRNPVYTDIF
CEEEEEECCCCHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHCCCCCEEEEE
VEQNPAEIQHIALGDWADIMIIAPLTASTLGKIAHGISDNMLTATVLAFTKTIYLAPAMN
EECCCCCEEEEEECCCCCEEEEECCCHHHHHHHHHCCCCCHHHHHHHHHHHHEEEEECCC
SNMYNNPAVIDNIQTLLKRGFKFIEPGEGFLACGYIAKGRMSEPLEIMKFIAEDNIEKDL
CCCCCCCHHHHHHHHHHHCCCEEECCCCCEEEECEECCCCCCCHHHHHHHHHHCCCCCCC
QGKKVLITAGPTIETIDPVRYLTNRSSGKMGYSLAEAANLRGADVTLVSADVGIPVPNGV
CCCEEEEEECCCCCCCCHHHHHHCCCCCCCCCHHHHHCCCCCCEEEEEEECCCCCCCCCC
RHIKTESAQDMFNAVRDNMEQDLIIKAAAVADYTPVETYDQKLKKQEGDLTIRFKRTEDI
HHHCCHHHHHHHHHHHCCCCHHHEEEEHHHCCCCCHHHHHHHHHHCCCCEEEEEECHHHH
LKYIGEHKTTQFVVGFAAETEHVEKYARGKLIRKNADVIVANNVGDKSIGFKSNDNAVTM
HHHHCCCCCEEEEEEECCCHHHHHHHHCCCEEECCCCEEEECCCCCCCCCCCCCCCEEEE
YFKDGTHIDIPKQSKLNIAHEILSYVKEKGFK
EEECCCEECCCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKIVLGVTGGIAVYKAIDLTSKLVQNGHEVRVIMTESAEQFVTPLAFQALSRNPVYTDIF
CEEEEEECCCCHHHHHHHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHCCCCCEEEEE
VEQNPAEIQHIALGDWADIMIIAPLTASTLGKIAHGISDNMLTATVLAFTKTIYLAPAMN
EECCCCCEEEEEECCCCCEEEEECCCHHHHHHHHHCCCCCHHHHHHHHHHHHEEEEECCC
SNMYNNPAVIDNIQTLLKRGFKFIEPGEGFLACGYIAKGRMSEPLEIMKFIAEDNIEKDL
CCCCCCCHHHHHHHHHHHCCCEEECCCCCEEEECEECCCCCCCHHHHHHHHHHCCCCCCC
QGKKVLITAGPTIETIDPVRYLTNRSSGKMGYSLAEAANLRGADVTLVSADVGIPVPNGV
CCCEEEEEECCCCCCCCHHHHHHCCCCCCCCCHHHHHCCCCCCEEEEEEECCCCCCCCCC
RHIKTESAQDMFNAVRDNMEQDLIIKAAAVADYTPVETYDQKLKKQEGDLTIRFKRTEDI
HHHCCHHHHHHHHHHHCCCCHHHEEEEHHHCCCCCHHHHHHHHHHCCCCEEEEEECHHHH
LKYIGEHKTTQFVVGFAAETEHVEKYARGKLIRKNADVIVANNVGDKSIGFKSNDNAVTM
HHHHCCCCCEEEEEEECCCHHHHHHHHCCCEEECCCCEEEECCCCCCCCCCCCCCCEEEE
YFKDGTHIDIPKQSKLNIAHEILSYVKEKGFK
EEECCCEECCCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9534248; 9384377 [H]