BacMap

Definition	Macrococcus caseolyticus JCSC5402, complete genome.
Accession	NC_011999
Length	2,102,324

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The map label for this gene is gmk [H]

Identifier: 222151043

GI number: 222151043

Start: 861362

End: 861982

Strand: Direct

Name: gmk [H]

Synonym: MCCL_0794

Alternate gene names: 222151043

Gene position: 861362-861982 (Clockwise)

Preceding gene: 222151041

Following gene: 222151044

Centisome position: 40.97

GC content: 39.29

Gene sequence:

>621_bases
ATGGATATAGAAAAAGGTTTATTAATTGTATTATCTGGTCCCTCTGGAGTTGGTAAGGGAACTGTGCGTCGTGCGATATT
TGAGGATCCGGATACTGATTTCGAATACTCAATTTCAATGACGACTAGAAACAAACGTGAAGGCGAAGTAGATGGTGTAG
ATTATTTCTTTAAGTCACGTGAAGAATTTGAAGCACTGATCGAGCAAGATGCATTTATCGAATATGCTGAATATGTCGGG
AACTACTACGGGACCCCTGTACAGTATGTTAAGGATACTATGGAACGTGGTAAGGATGTATTTTTAGAGATTGAAGTTGA
AGGTGCAAAGCAAGTCAGAAAGAAATTTCCTGAAGCGCTATTTATCTTCTTAGCGCCACCAACACTTGAGCATCTAGAGG
AACGACTTATCGGTCGTGGCACTGAAAGTCAGGAAGTCATCAATCATAGAATAAGTGAAGCACGTAAAGAAGTGGAGATG
ATGAATCTCTATGATTACGTAGTGATCAATGATGAAGTGATGGATGCAAAGGAAAAGGTTCAGATGATTGTTGAGGCTGA
ACATTTAAAACGTGAACGTGTAGAAGCACGATTCAGAAAAATGATACTGGAGGCAAAATAA

Upstream 100 bases:

>100_bases
AACATGAAATAACAATTTCACAAGGCGAATGTTTCATCTATATTTTTATCCATTTATATGATAAATTTAATTTATATCAT
TTTTATGAAAGGTCGTAGAC

Downstream 100 bases:

>100_bases
TGTTAAACCCACCATTAGATAAATTAAAAGAAAAAGTGAATTCTAAATATTTAATCGTAACCCTTGCAGCGAAACGTGCA
CGTGAAATGCAGGACCATCC

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 206; Mature: 206

Protein sequence:

>206_residues
MDIEKGLLIVLSGPSGVGKGTVRRAIFEDPDTDFEYSISMTTRNKREGEVDGVDYFFKSREEFEALIEQDAFIEYAEYVG
NYYGTPVQYVKDTMERGKDVFLEIEVEGAKQVRKKFPEALFIFLAPPTLEHLEERLIGRGTESQEVINHRISEARKEVEM
MNLYDYVVINDEVMDAKEKVQMIVEAEHLKRERVEARFRKMILEAK

Sequences:

>Translated_206_residues
MDIEKGLLIVLSGPSGVGKGTVRRAIFEDPDTDFEYSISMTTRNKREGEVDGVDYFFKSREEFEALIEQDAFIEYAEYVG
NYYGTPVQYVKDTMERGKDVFLEIEVEGAKQVRKKFPEALFIFLAPPTLEHLEERLIGRGTESQEVINHRISEARKEVEM
MNLYDYVVINDEVMDAKEKVQMIVEAEHLKRERVEARFRKMILEAK
>Mature_206_residues
MDIEKGLLIVLSGPSGVGKGTVRRAIFEDPDTDFEYSISMTTRNKREGEVDGVDYFFKSREEFEALIEQDAFIEYAEYVG
NYYGTPVQYVKDTMERGKDVFLEIEVEGAKQVRKKFPEALFIFLAPPTLEHLEERLIGRGTESQEVINHRISEARKEVEM
MNLYDYVVINDEVMDAKEKVQMIVEAEHLKRERVEARFRKMILEAK

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874831, Length=191, Percent_Identity=34.5549738219895, Blast_Score=120, Evalue=6e-28,
Organism=Homo sapiens, GI226874833, Length=191, Percent_Identity=34.5549738219895, Blast_Score=120, Evalue=7e-28,
Organism=Homo sapiens, GI4504221, Length=191, Percent_Identity=34.5549738219895, Blast_Score=120, Evalue=7e-28,
Organism=Homo sapiens, GI38570142, Length=167, Percent_Identity=31.7365269461078, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI14780902, Length=183, Percent_Identity=29.5081967213115, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI21361598, Length=199, Percent_Identity=28.643216080402, Blast_Score=84, Evalue=9e-17,
Organism=Homo sapiens, GI111154074, Length=158, Percent_Identity=29.746835443038, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI262118259, Length=174, Percent_Identity=29.3103448275862, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI4505237, Length=174, Percent_Identity=29.3103448275862, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI262118255, Length=174, Percent_Identity=29.3103448275862, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI262118263, Length=174, Percent_Identity=29.3103448275862, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI4557529, Length=200, Percent_Identity=31.5, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI192447426, Length=200, Percent_Identity=31.5, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI119943106, Length=156, Percent_Identity=31.4102564102564, Blast_Score=74, Evalue=7e-14,
Organism=Homo sapiens, GI148539578, Length=173, Percent_Identity=33.5260115606936, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI148539628, Length=173, Percent_Identity=33.5260115606936, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI218156270, Length=165, Percent_Identity=36.3636363636364, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI218156340, Length=173, Percent_Identity=35.2601156069364, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI218156338, Length=163, Percent_Identity=36.8098159509202, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI91199538, Length=163, Percent_Identity=36.8098159509202, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI21536464, Length=123, Percent_Identity=30.0813008130081, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI119943108, Length=154, Percent_Identity=32.4675324675325, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI261862237, Length=154, Percent_Identity=32.4675324675325, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI52630447, Length=154, Percent_Identity=29.2207792207792, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI186700627, Length=187, Percent_Identity=24.0641711229947, Blast_Score=64, Evalue=9e-11,
Organism=Escherichia coli, GI1790080, Length=201, Percent_Identity=40.7960199004975, Blast_Score=164, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI17508835, Length=181, Percent_Identity=37.5690607734807, Blast_Score=123, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI193203132, Length=181, Percent_Identity=37.5690607734807, Blast_Score=122, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI71988048, Length=183, Percent_Identity=25.1366120218579, Blast_Score=84, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI71988041, Length=183, Percent_Identity=25.1366120218579, Blast_Score=82, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17556244, Length=117, Percent_Identity=35.8974358974359, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17557440, Length=121, Percent_Identity=32.2314049586777, Blast_Score=74, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6320662, Length=183, Percent_Identity=43.7158469945355, Blast_Score=155, Evalue=5e-39,
Organism=Drosophila melanogaster, GI21356141, Length=151, Percent_Identity=41.7218543046358, Blast_Score=124, Evalue=5e-29,
Organism=Drosophila melanogaster, GI161077626, Length=186, Percent_Identity=32.258064516129, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24640542, Length=186, Percent_Identity=32.258064516129, Blast_Score=100, Evalue=5e-22,
Organism=Drosophila melanogaster, GI45554489, Length=186, Percent_Identity=32.258064516129, Blast_Score=100, Evalue=5e-22,
Organism=Drosophila melanogaster, GI45554481, Length=186, Percent_Identity=32.258064516129, Blast_Score=100, Evalue=7e-22,
Organism=Drosophila melanogaster, GI85724806, Length=186, Percent_Identity=32.258064516129, Blast_Score=100, Evalue=9e-22,
Organism=Drosophila melanogaster, GI116007136, Length=186, Percent_Identity=32.258064516129, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI221330164, Length=202, Percent_Identity=32.1782178217822, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI221330166, Length=202, Percent_Identity=32.1782178217822, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI221330162, Length=202, Percent_Identity=32.1782178217822, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI85816106, Length=126, Percent_Identity=34.9206349206349, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI45551002, Length=126, Percent_Identity=34.9206349206349, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI85816281, Length=126, Percent_Identity=34.9206349206349, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI45554804, Length=165, Percent_Identity=34.5454545454545, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24641280, Length=165, Percent_Identity=34.5454545454545, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI281360700, Length=165, Percent_Identity=34.5454545454545, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24641282, Length=165, Percent_Identity=34.5454545454545, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI45554818, Length=165, Percent_Identity=34.5454545454545, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI161077752, Length=165, Percent_Identity=34.5454545454545, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI45554813, Length=100, Percent_Identity=44, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI45554791, Length=100, Percent_Identity=44, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI161077754, Length=100, Percent_Identity=44, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI281362230, Length=185, Percent_Identity=22.1621621621622, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI161078487, Length=195, Percent_Identity=21.5384615384615, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24648808, Length=195, Percent_Identity=21.5384615384615, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI161078485, Length=195, Percent_Identity=21.5384615384615, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24648810, Length=195, Percent_Identity=21.5384615384615, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI281362232, Length=195, Percent_Identity=21.5384615384615, Blast_Score=64, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 23962; Mature: 23962

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIEKGLLIVLSGPSGVGKGTVRRAIFEDPDTDFEYSISMTTRNKREGEVDGVDYFFKSR
CCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCCCCHHHHHHCH
EEFEALIEQDAFIEYAEYVGNYYGTPVQYVKDTMERGKDVFLEIEVEGAKQVRKKFPEAL
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEEEEECCHHHHHHHCCCEE
FIFLAPPTLEHLEERLIGRGTESQEVINHRISEARKEVEMMNLYDYVVINDEVMDAKEKV
EEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEECHHHHHHHHHH
QMIVEAEHLKRERVEARFRKMILEAK
HHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDIEKGLLIVLSGPSGVGKGTVRRAIFEDPDTDFEYSISMTTRNKREGEVDGVDYFFKSR
CCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCEEEEEEEEECCCCCCCCCCHHHHHHCH
EEFEALIEQDAFIEYAEYVGNYYGTPVQYVKDTMERGKDVFLEIEVEGAKQVRKKFPEAL
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEEEEECCHHHHHHHCCCEE
FIFLAPPTLEHLEERLIGRGTESQEVINHRISEARKEVEMMNLYDYVVINDEVMDAKEKV
EEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHEEEEECHHHHHHHHHH
QMIVEAEHLKRERVEARFRKMILEAK
HHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA