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The map label for this gene is purC

Identifier: 222150939

GI number: 222150939

Start: 741524

End: 742225

Strand: Direct

Name: purC

Synonym: MCCL_0689

Alternate gene names: 222150939

Gene position: 741524-742225 (Clockwise)

Preceding gene: 222150938

Following gene: 222150940

Centisome position: 35.27

GC content: 42.17

Gene sequence:

>702_bases
ATGACCTTAGTTTATGAAGGAAAAGCAAAGCGTGTATACAGTACGGATGAGGACCATGTGTTCCGCATCGAATACAAGGA
TGAAGTAACAGCGGGCAACGGTGCAAAGAAAGATAATATGGCTGGTAAAGGTCGACTGAACAACTTGATTACAAGCTATT
TCTTCGAGCGCCTTGCACGACAAGGGCTGGAGTCTCACTTTATCAAGAAGTTAAGCGACACTGAACAGCTGGTTAAAGCA
GTTACGATTATTCCGCTTGAAGTTGTTGTCAGAAACTATGCTGCAGGTTCAATTGTCAAGCGTCTCGGTTTTGACAAAGG
TGTGCAGTTCAAATCACCGCTTGTAGAGTTCTATTATAAGGAAGATGCACTGAATGATCCAATTATTACAGATGACCACG
TGAAGTTACTCGGCATTGCAGATGATGACGACATCGCTGAACTGAAACGTCAGGCGTTAATCATCAATGACATGCTCGTG
AAGATGATGGATGAGATGAATTTGCAGCTGATCGATTTCAAGATTGAATTCGGTAAGGACCAGGACGGTAATATCCTGCT
TGCAGACGAAATTTCACCGGATACTTGCCGCATCTGGGATAAGGACACGAAAGAAAACTTTGATAAAGACGTATACAGAG
AAGACACAGGTTCACTGATTGATACTTATACTCAATTCTATAATAAGCTGGAGGCACTATAA

Upstream 100 bases:

>100_bases
GTAAAGAGGCAAGGAAAGAAAACAGGAAGATGGGACATATTACCCTTTTGTTAGACGATGACACGGATACTTATTATCCT
ATATATAAGGAGCTGATGAA

Downstream 100 bases:

>100_bases
AATGACTAAAATCGAATTACACATCACATTACAACCACAGGTATTAGACACACAAGGACAAACGTTAACACGTGCGGTAC
ATGATCTGGGCTACACTCAA

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase

Number of amino acids: Translated: 233; Mature: 232

Protein sequence:

>233_residues
MTLVYEGKAKRVYSTDEDHVFRIEYKDEVTAGNGAKKDNMAGKGRLNNLITSYFFERLARQGLESHFIKKLSDTEQLVKA
VTIIPLEVVVRNYAAGSIVKRLGFDKGVQFKSPLVEFYYKEDALNDPIITDDHVKLLGIADDDDIAELKRQALIINDMLV
KMMDEMNLQLIDFKIEFGKDQDGNILLADEISPDTCRIWDKDTKENFDKDVYREDTGSLIDTYTQFYNKLEAL

Sequences:

>Translated_233_residues
MTLVYEGKAKRVYSTDEDHVFRIEYKDEVTAGNGAKKDNMAGKGRLNNLITSYFFERLARQGLESHFIKKLSDTEQLVKA
VTIIPLEVVVRNYAAGSIVKRLGFDKGVQFKSPLVEFYYKEDALNDPIITDDHVKLLGIADDDDIAELKRQALIINDMLV
KMMDEMNLQLIDFKIEFGKDQDGNILLADEISPDTCRIWDKDTKENFDKDVYREDTGSLIDTYTQFYNKLEAL
>Mature_232_residues
TLVYEGKAKRVYSTDEDHVFRIEYKDEVTAGNGAKKDNMAGKGRLNNLITSYFFERLARQGLESHFIKKLSDTEQLVKAV
TIIPLEVVVRNYAAGSIVKRLGFDKGVQFKSPLVEFYYKEDALNDPIITDDHVKLLGIADDDDIAELKRQALIINDMLVK
MMDEMNLQLIDFKIEFGKDQDGNILLADEISPDTCRIWDKDTKENFDKDVYREDTGSLIDTYTQFYNKLEAL

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family

Homologues:

Organism=Homo sapiens, GI119220557, Length=223, Percent_Identity=35.8744394618834, Blast_Score=124, Evalue=7e-29,
Organism=Homo sapiens, GI5453539, Length=223, Percent_Identity=35.8744394618834, Blast_Score=124, Evalue=7e-29,
Organism=Homo sapiens, GI119220559, Length=230, Percent_Identity=34.3478260869565, Blast_Score=114, Evalue=1e-25,
Organism=Escherichia coli, GI1788820, Length=227, Percent_Identity=39.647577092511, Blast_Score=189, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17531275, Length=224, Percent_Identity=37.0535714285714, Blast_Score=129, Evalue=1e-30,
Organism=Drosophila melanogaster, GI18860083, Length=220, Percent_Identity=33.1818181818182, Blast_Score=124, Evalue=5e-29,
Organism=Drosophila melanogaster, GI24583917, Length=219, Percent_Identity=31.0502283105023, Blast_Score=109, Evalue=1e-24,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): PUR7_MACCJ (B9EAY5)

Other databases:

- EMBL:   AP009484
- RefSeq:   YP_002560092.1
- ProteinModelPortal:   B9EAY5
- GeneID:   7389886
- GenomeReviews:   AP009484_GR
- KEGG:   mcl:MCCL_0689
- OMA:   YKDDALG
- ProtClustDB:   PRK09362
- HAMAP:   MF_00137
- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236
- Gene3D:   G3DSA:3.30.470.20
- PANTHER:   PTHR11609
- TIGRFAMs:   TIGR00081

Pfam domain/function: PF01259 SAICAR_synt

EC number: =6.3.2.6

Molecular weight: Translated: 26755; Mature: 26624

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS01057 SAICAR_SYNTHETASE_1; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLVYEGKAKRVYSTDEDHVFRIEYKDEVTAGNGAKKDNMAGKGRLNNLITSYFFERLAR
CEEEECCCCCEEECCCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
QGLESHFIKKLSDTEQLVKAVTIIPLEVVVRNYAAGSIVKRLGFDKGVQFKSPLVEFYYK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
EDALNDPIITDDHVKLLGIADDDDIAELKRQALIINDMLVKMMDEMNLQLIDFKIEFGKD
HCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEECCC
QDGNILLADEISPDTCRIWDKDTKENFDKDVYREDTGSLIDTYTQFYNKLEAL
CCCCEEEEECCCCCEEEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TLVYEGKAKRVYSTDEDHVFRIEYKDEVTAGNGAKKDNMAGKGRLNNLITSYFFERLAR
EEEECCCCCEEECCCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
QGLESHFIKKLSDTEQLVKAVTIIPLEVVVRNYAAGSIVKRLGFDKGVQFKSPLVEFYYK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
EDALNDPIITDDHVKLLGIADDDDIAELKRQALIINDMLVKMMDEMNLQLIDFKIEFGKD
HCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEECCC
QDGNILLADEISPDTCRIWDKDTKENFDKDVYREDTGSLIDTYTQFYNKLEAL
CCCCEEEEECCCCCEEEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA