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The map label for this gene is fabF [H]

Identifier: 222150854

GI number: 222150854

Start: 646735

End: 647967

Strand: Direct

Name: fabF [H]

Synonym: MCCL_0604

Alternate gene names: 222150854

Gene position: 646735-647967 (Clockwise)

Preceding gene: 222150853

Following gene: 222150855

Centisome position: 30.76

GC content: 45.42

Gene sequence:

>1233_bases
ATGAGAAGAGTTGTAATAACAGGTATGGGTGCTTTGACACCGATTGGTAACGATGTACAGACGACATTTAACAATGCATT
AAACGGTGTCAATGGTATCGATACGATTACGCGTATTGATACGAGTGATATGAATGTGAAAGTGGCTGGAGAACTGAAAG
ACTTCAATGTTGAAGACTATATCGATAAGAAAGAAGCACGTAGAATGGATCGCTTTACTCAATATGCGGTTGTCGCTGCA
AATGAAGCGCTTAAAGATTCCAAGCTGCAGATTGATGATGACAACAGCGATCGTGTTGGTGTCTGGATTGGTTCTGGAAT
TGGTGGGATGGAAACATTTGAGCTTGCACATACTGCGATGACAGAGAAAGGACCTAGACGTGTAAGCCCGTTCTTCGTTC
CGATGCTGATACCTGATATGGCAGCAGGACAGGTATCAATTGCACTTGGTGCTAAAGGGCCGAATGGCTGTACAGTGACA
GCATGTGCTACAGGAACAAACTCTATCGGTGATGCCATGCGTATTATACAGTATGGCGATGCGGATGTTATGTTTGCAGG
AGGTGCTGAAGCGCCCATTACACGTATGAGCTTAGCAGGATTCAGTGCGAATAAAGCATTAAGTACGAACGATGATCCAC
ATACAGCATGCAGGCCGTTCCAGGAAGGACGCGATGGCTTTATTATGGGTGAAGGCGCAGGTGTCGTTGTCCTGGAAGAA
CTGGAACACGCATTAGCACGTGGAGCACATATTTATGCAGAAGTCGTGGGCTACGGGAATAACGGTGATGCCCATCATAT
TACAGCACCAGCGCCAAACGGTGAAGGTGGCACACGTACGATGAACATGGCACTGAAAGACGCTGGAATAATACCGAGTG
ATGTGGGATACTTGAACGCCCATGGAACGAGTACACCCATCGGCGATTTATATGAGACGATGGCCATCAAAGCAACATTC
GGTGAATCAGCGAAAGATCTACTTGTATCATCAACTAAATCGATGACAGGTCATCTACTCGGCGCAACAGGCGCTGTTGA
GACGATTATTACAGCCCTCGCATTACAAACAGGTCAGATTCCTCCAACGATACATCAAGATACACCTGATGCGGAACTGA
ATCTCAATTATGTTCCAGAAAAAGCAGTGACAAAAGATATCGAATACGCCATGACAAACAGCCTTGGATTCGGTGGACAT
AACGCAGTACTAGTATTGAAGAAATATCAATAA

Upstream 100 bases:

>100_bases
ACGGTAAAATAAAAAATGGAGATCAACTCATATTAACCGGATTTGGTGGTGGCCTGACATTCGGCGCAATCGCATTGATA
TGGGGACAGGAGGAAAAAAG

Downstream 100 bases:

>100_bases
ATATAGAGCGAACCGGACATATAAGATATGTTCCGGTCGCTCTATATTATTGTCAATACAAGGGCTGAGTATAAGATTGA
TAGAAGAAACTATAATTACT

Product: 3-oxoacyl-[acyl-carrier-protein] synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 410; Mature: 410

Protein sequence:

>410_residues
MRRVVITGMGALTPIGNDVQTTFNNALNGVNGIDTITRIDTSDMNVKVAGELKDFNVEDYIDKKEARRMDRFTQYAVVAA
NEALKDSKLQIDDDNSDRVGVWIGSGIGGMETFELAHTAMTEKGPRRVSPFFVPMLIPDMAAGQVSIALGAKGPNGCTVT
ACATGTNSIGDAMRIIQYGDADVMFAGGAEAPITRMSLAGFSANKALSTNDDPHTACRPFQEGRDGFIMGEGAGVVVLEE
LEHALARGAHIYAEVVGYGNNGDAHHITAPAPNGEGGTRTMNMALKDAGIIPSDVGYLNAHGTSTPIGDLYETMAIKATF
GESAKDLLVSSTKSMTGHLLGATGAVETIITALALQTGQIPPTIHQDTPDAELNLNYVPEKAVTKDIEYAMTNSLGFGGH
NAVLVLKKYQ

Sequences:

>Translated_410_residues
MRRVVITGMGALTPIGNDVQTTFNNALNGVNGIDTITRIDTSDMNVKVAGELKDFNVEDYIDKKEARRMDRFTQYAVVAA
NEALKDSKLQIDDDNSDRVGVWIGSGIGGMETFELAHTAMTEKGPRRVSPFFVPMLIPDMAAGQVSIALGAKGPNGCTVT
ACATGTNSIGDAMRIIQYGDADVMFAGGAEAPITRMSLAGFSANKALSTNDDPHTACRPFQEGRDGFIMGEGAGVVVLEE
LEHALARGAHIYAEVVGYGNNGDAHHITAPAPNGEGGTRTMNMALKDAGIIPSDVGYLNAHGTSTPIGDLYETMAIKATF
GESAKDLLVSSTKSMTGHLLGATGAVETIITALALQTGQIPPTIHQDTPDAELNLNYVPEKAVTKDIEYAMTNSLGFGGH
NAVLVLKKYQ
>Mature_410_residues
MRRVVITGMGALTPIGNDVQTTFNNALNGVNGIDTITRIDTSDMNVKVAGELKDFNVEDYIDKKEARRMDRFTQYAVVAA
NEALKDSKLQIDDDNSDRVGVWIGSGIGGMETFELAHTAMTEKGPRRVSPFFVPMLIPDMAAGQVSIALGAKGPNGCTVT
ACATGTNSIGDAMRIIQYGDADVMFAGGAEAPITRMSLAGFSANKALSTNDDPHTACRPFQEGRDGFIMGEGAGVVVLEE
LEHALARGAHIYAEVVGYGNNGDAHHITAPAPNGEGGTRTMNMALKDAGIIPSDVGYLNAHGTSTPIGDLYETMAIKATF
GESAKDLLVSSTKSMTGHLLGATGAVETIITALALQTGQIPPTIHQDTPDAELNLNYVPEKAVTKDIEYAMTNSLGFGGH
NAVLVLKKYQ

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=416, Percent_Identity=48.3173076923077, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI223972627, Length=166, Percent_Identity=50.6024096385542, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI41872631, Length=421, Percent_Identity=25.8907363420428, Blast_Score=117, Evalue=3e-26,
Organism=Escherichia coli, GI1787337, Length=409, Percent_Identity=53.3007334963325, Blast_Score=402, Evalue=1e-113,
Organism=Escherichia coli, GI1788663, Length=417, Percent_Identity=40.0479616306954, Blast_Score=258, Evalue=6e-70,
Organism=Caenorhabditis elegans, GI71983541, Length=416, Percent_Identity=38.7019230769231, Blast_Score=271, Evalue=3e-73,
Organism=Caenorhabditis elegans, GI71983535, Length=257, Percent_Identity=43.1906614785992, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI212642053, Length=379, Percent_Identity=28.4960422163588, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17550940, Length=365, Percent_Identity=25.4794520547945, Blast_Score=96, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6320904, Length=444, Percent_Identity=38.5135135135135, Blast_Score=281, Evalue=2e-76,
Organism=Drosophila melanogaster, GI24644341, Length=420, Percent_Identity=44.2857142857143, Blast_Score=342, Evalue=2e-94,
Organism=Drosophila melanogaster, GI19920632, Length=421, Percent_Identity=26.603325415677, Blast_Score=115, Evalue=6e-26,
Organism=Drosophila melanogaster, GI221330659, Length=421, Percent_Identity=26.603325415677, Blast_Score=115, Evalue=7e-26,
Organism=Drosophila melanogaster, GI24581345, Length=423, Percent_Identity=24.3498817966903, Blast_Score=105, Evalue=7e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43282; Mature: 43282

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS00606 B_KETOACYL_SYNTHASE ; PS00107 PROTEIN_KINASE_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRVVITGMGALTPIGNDVQTTFNNALNGVNGIDTITRIDTSDMNVKVAGELKDFNVEDY
CCEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEECCCCCEEEEECCCCCCCHHHH
IDKKEARRMDRFTQYAVVAANEALKDSKLQIDDDNSDRVGVWIGSGIGGMETFELAHTAM
HCHHHHHHHHHHHHEEEEECCHHHCCCCEEECCCCCCEEEEEEECCCCCCHHHHHHHHHH
TEKGPRRVSPFFVPMLIPDMAAGQVSIALGAKGPNGCTVTACATGTNSIGDAMRIIQYGD
HCCCCCCCCCEEEEECCCCCCCCEEEEEEECCCCCCCEEEEEECCCCCHHHHHHHEEECC
ADVMFAGGAEAPITRMSLAGFSANKALSTNDDPHTACRPFQEGRDGFIMGEGAGVVVLEE
CCEEEECCCCCCEEEEEECCCCCCCCCCCCCCCCHHHCCHHCCCCCEEEECCCCEEEHHH
LEHALARGAHIYAEVVGYGNNGDAHHITAPAPNGEGGTRTMNMALKDAGIIPSDVGYLNA
HHHHHHCCCEEEEEEEEECCCCCCCEEECCCCCCCCCCEEEEEEECCCCCCCCCCCEEEC
HGTSTPIGDLYETMAIKATFGESAKDLLVSSTKSMTGHLLGATGAVETIITALALQTGQI
CCCCCCHHHHHHHHEEEEECCCCHHHHHHHCCHHHCCEEEECCHHHHHHHHHHHHHCCCC
PPTIHQDTPDAELNLNYVPEKAVTKDIEYAMTNSLGFGGHNAVLVLKKYQ
CCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCCCCCCCCEEEEEEECC
>Mature Secondary Structure
MRRVVITGMGALTPIGNDVQTTFNNALNGVNGIDTITRIDTSDMNVKVAGELKDFNVEDY
CCEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEECCCCCEEEEECCCCCCCHHHH
IDKKEARRMDRFTQYAVVAANEALKDSKLQIDDDNSDRVGVWIGSGIGGMETFELAHTAM
HCHHHHHHHHHHHHEEEEECCHHHCCCCEEECCCCCCEEEEEEECCCCCCHHHHHHHHHH
TEKGPRRVSPFFVPMLIPDMAAGQVSIALGAKGPNGCTVTACATGTNSIGDAMRIIQYGD
HCCCCCCCCCEEEEECCCCCCCCEEEEEEECCCCCCCEEEEEECCCCCHHHHHHHEEECC
ADVMFAGGAEAPITRMSLAGFSANKALSTNDDPHTACRPFQEGRDGFIMGEGAGVVVLEE
CCEEEECCCCCCEEEEEECCCCCCCCCCCCCCCCHHHCCHHCCCCCEEEECCCCEEEHHH
LEHALARGAHIYAEVVGYGNNGDAHHITAPAPNGEGGTRTMNMALKDAGIIPSDVGYLNA
HHHHHHCCCEEEEEEEEECCCCCCCEEECCCCCCCCCCEEEEEEECCCCCCCCCCCEEEC
HGTSTPIGDLYETMAIKATFGESAKDLLVSSTKSMTGHLLGATGAVETIITALALQTGQI
CCCCCCHHHHHHHHEEEEECCCCHHHHHHHCCHHHCCEEEECCHHHHHHHHHHHHHCCCC
PPTIHQDTPDAELNLNYVPEKAVTKDIEYAMTNSLGFGGHNAVLVLKKYQ
CCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA