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The map label for this gene is rocD

Identifier: 222150833

GI number: 222150833

Start: 618210

End: 619403

Strand: Direct

Name: rocD

Synonym: MCCL_0583

Alternate gene names: 222150833

Gene position: 618210-619403 (Clockwise)

Preceding gene: 222150832

Following gene: 222150834

Centisome position: 29.41

GC content: 40.28

Gene sequence:

>1194_bases
ATGACGAAATCTCAAGATATTATCGAAATTACAAATCATTACGGAGCGCCAAACTATCACCCACTACCAATCGTGATCTC
AGAAGCTGAAGGGGTATGGGTAAAGGACCCGGAAGGCAACAAATATATGGATATGTTATCAGCGTACTCAGCAGTAAACC
AAGGACACCGTCATCCAAAGATTATTCAAGCATTGAAAGAACAGGCTGACCGTGTGACATTAACTTCACGTGCTTTCCAT
AGTGACCAATTAGGTCCCTGGTATGAAAAGATCTGTAAACTTGCAGGTAAAGAAATGGTATTGCCGATGAATACAGGTGC
GGAAGCAGTTGAAACTGCAATTAAAGCAGCGCGACGCTGGGCATATGATGTTAAAGGTGTAGCGAAAGACCAGGCAGAAA
TCATTGCAATGAAAGGGAACTTCCATGGTCGTACGCTGGCTGCTGTATCATTATCAAGCGAAGCAGAATACCAACGTGGC
TATGGTCCATTATTGGGAGGCTTTAAACTTGTTGAGTTTGGTGATATCGAACAGATTAAATCGGCTATAACACCGAACAC
TGCTGCGGTATTACTTGAGCCAATCCAAGGTGAAGCAGGAATCAATATTCCTGAAGATGGATTTTTAAAACAAGTACGTG
ATGTATGTACTGAGAACAATGTATTATTTATTGCTGATGAGATACAGGCAGGTCTTGGTCGCTCAGGTAAGATGTTTGCT
ACAGATTGGGATAATGTAGTTCCTGATATGTATATTTTAGGTAAAGCATTAGGTGGTGGAGTATTCCCAATCTCATGTGT
GCTAGCTGATAAAGAAATTTTAGAAGTATTCAATGCAGGTAGCCATGGTTCAACATTCGGTGGGAATCCATTAGCGTGTG
CGGTGTCAAACGCAGCGTTGGATGTATTGGTTGATGAGAAGTTAGCAGAACGTTCTTTAGAACTAGGAGAATATTTCCAA
TCTAAATTGAAAGAAATTGACAACCCTGTTATTAAAGAAGTTCGTGGTAAAGGATTATTTATTGGTGTTGAATTAAATGA
AGCAGCACGTCCATACTGCGAACAACTTAAAGAACTAGGCTTACTATGTAAAGAAACACATGATACTGTAATCCGCTTTG
CACCCCCTTTAATCATCTCTCAAGAAGATCTAGACTGGGCGATTGACAAAGTAAAGCAAGTATTTTCAAAATAG

Upstream 100 bases:

>100_bases
ACTGCACATGCAAGGTCGTACAACTTCTGAAATGTTTTAATCTATATAAAATCTAAACAGTAGTGCACCGCACTACTGTT
TTTAAAAAAGGGGAATAATA

Downstream 100 bases:

>100_bases
TTGGTAGCGTTTTCAATTTTGGACTTTTAAAAGTTTTTTAATATGTTACAATTAACAATGTAGAATTATAGAATAAAAAA
AGAGGCGAATAAAATGTCAG

Product: ornithine aminotransferase

Products: NA

Alternate protein names: OAT; Ornithine--oxo-acid aminotransferase

Number of amino acids: Translated: 397; Mature: 396

Protein sequence:

>397_residues
MTKSQDIIEITNHYGAPNYHPLPIVISEAEGVWVKDPEGNKYMDMLSAYSAVNQGHRHPKIIQALKEQADRVTLTSRAFH
SDQLGPWYEKICKLAGKEMVLPMNTGAEAVETAIKAARRWAYDVKGVAKDQAEIIAMKGNFHGRTLAAVSLSSEAEYQRG
YGPLLGGFKLVEFGDIEQIKSAITPNTAAVLLEPIQGEAGINIPEDGFLKQVRDVCTENNVLFIADEIQAGLGRSGKMFA
TDWDNVVPDMYILGKALGGGVFPISCVLADKEILEVFNAGSHGSTFGGNPLACAVSNAALDVLVDEKLAERSLELGEYFQ
SKLKEIDNPVIKEVRGKGLFIGVELNEAARPYCEQLKELGLLCKETHDTVIRFAPPLIISQEDLDWAIDKVKQVFSK

Sequences:

>Translated_397_residues
MTKSQDIIEITNHYGAPNYHPLPIVISEAEGVWVKDPEGNKYMDMLSAYSAVNQGHRHPKIIQALKEQADRVTLTSRAFH
SDQLGPWYEKICKLAGKEMVLPMNTGAEAVETAIKAARRWAYDVKGVAKDQAEIIAMKGNFHGRTLAAVSLSSEAEYQRG
YGPLLGGFKLVEFGDIEQIKSAITPNTAAVLLEPIQGEAGINIPEDGFLKQVRDVCTENNVLFIADEIQAGLGRSGKMFA
TDWDNVVPDMYILGKALGGGVFPISCVLADKEILEVFNAGSHGSTFGGNPLACAVSNAALDVLVDEKLAERSLELGEYFQ
SKLKEIDNPVIKEVRGKGLFIGVELNEAARPYCEQLKELGLLCKETHDTVIRFAPPLIISQEDLDWAIDKVKQVFSK
>Mature_396_residues
TKSQDIIEITNHYGAPNYHPLPIVISEAEGVWVKDPEGNKYMDMLSAYSAVNQGHRHPKIIQALKEQADRVTLTSRAFHS
DQLGPWYEKICKLAGKEMVLPMNTGAEAVETAIKAARRWAYDVKGVAKDQAEIIAMKGNFHGRTLAAVSLSSEAEYQRGY
GPLLGGFKLVEFGDIEQIKSAITPNTAAVLLEPIQGEAGINIPEDGFLKQVRDVCTENNVLFIADEIQAGLGRSGKMFAT
DWDNVVPDMYILGKALGGGVFPISCVLADKEILEVFNAGSHGSTFGGNPLACAVSNAALDVLVDEKLAERSLELGEYFQS
KLKEIDNPVIKEVRGKGLFIGVELNEAARPYCEQLKELGLLCKETHDTVIRFAPPLIISQEDLDWAIDKVKQVFSK

Specific function: Catalyzes the interconversion of ornithine to glutamate semialdehyde

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. OAT subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=396, Percent_Identity=48.989898989899, Blast_Score=396, Evalue=1e-110,
Organism=Homo sapiens, GI284507298, Length=298, Percent_Identity=46.6442953020134, Blast_Score=283, Evalue=3e-76,
Organism=Homo sapiens, GI13994255, Length=451, Percent_Identity=27.7161862527716, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI24119277, Length=417, Percent_Identity=27.3381294964029, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI37574042, Length=421, Percent_Identity=26.1282660332542, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI226442709, Length=389, Percent_Identity=25.9640102827763, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI226442705, Length=421, Percent_Identity=25.41567695962, Blast_Score=134, Evalue=2e-31,
Organism=Escherichia coli, GI1789759, Length=387, Percent_Identity=35.6589147286822, Blast_Score=240, Evalue=9e-65,
Organism=Escherichia coli, GI1788044, Length=380, Percent_Identity=34.2105263157895, Blast_Score=232, Evalue=3e-62,
Organism=Escherichia coli, GI145693181, Length=383, Percent_Identity=33.6814621409922, Blast_Score=224, Evalue=8e-60,
Organism=Escherichia coli, GI1787560, Length=407, Percent_Identity=33.1695331695332, Blast_Score=187, Evalue=7e-49,
Organism=Escherichia coli, GI1789016, Length=412, Percent_Identity=29.8543689320388, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI1786991, Length=298, Percent_Identity=31.2080536912752, Blast_Score=131, Evalue=8e-32,
Organism=Escherichia coli, GI1786349, Length=418, Percent_Identity=25.8373205741627, Blast_Score=104, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI25144271, Length=389, Percent_Identity=50.1285347043702, Blast_Score=398, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI25144274, Length=263, Percent_Identity=47.5285171102662, Blast_Score=251, Evalue=4e-67,
Organism=Caenorhabditis elegans, GI32564660, Length=433, Percent_Identity=32.3325635103926, Blast_Score=191, Evalue=8e-49,
Organism=Caenorhabditis elegans, GI71981843, Length=178, Percent_Identity=47.752808988764, Blast_Score=184, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI71992977, Length=433, Percent_Identity=26.7898383371824, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17541228, Length=415, Percent_Identity=25.5421686746988, Blast_Score=114, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6323470, Length=412, Percent_Identity=47.8155339805825, Blast_Score=373, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6324432, Length=372, Percent_Identity=32.7956989247312, Blast_Score=204, Evalue=3e-53,
Organism=Saccharomyces cerevisiae, GI6324386, Length=418, Percent_Identity=26.0765550239234, Blast_Score=103, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6321456, Length=371, Percent_Identity=25.8760107816712, Blast_Score=97, Evalue=3e-21,
Organism=Drosophila melanogaster, GI21357415, Length=396, Percent_Identity=48.989898989899, Blast_Score=405, Evalue=1e-113,
Organism=Drosophila melanogaster, GI161085790, Length=451, Percent_Identity=28.3813747228381, Blast_Score=175, Evalue=6e-44,
Organism=Drosophila melanogaster, GI28574759, Length=445, Percent_Identity=28.7640449438202, Blast_Score=172, Evalue=3e-43,
Organism=Drosophila melanogaster, GI21356575, Length=433, Percent_Identity=25.635103926097, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI281366494, Length=421, Percent_Identity=23.7529691211401, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24667139, Length=421, Percent_Identity=23.7529691211401, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24667143, Length=421, Percent_Identity=23.7529691211401, Blast_Score=93, Evalue=3e-19,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): OAT_MACCJ (B9EAM9)

Other databases:

- EMBL:   AP009484
- RefSeq:   YP_002559986.1
- ProteinModelPortal:   B9EAM9
- GeneID:   7390211
- GenomeReviews:   AP009484_GR
- KEGG:   mcl:MCCL_0583
- OMA:   RHPKIIE
- GO:   GO:0005737
- HAMAP:   MF_01689
- InterPro:   IPR005814
- InterPro:   IPR010164
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- PANTHER:   PTHR11986:SF18
- TIGRFAMs:   TIGR01885

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.13

Molecular weight: Translated: 43490; Mature: 43359

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKSQDIIEITNHYGAPNYHPLPIVISEAEGVWVKDPEGNKYMDMLSAYSAVNQGHRHPK
CCCCCCHHHHHHCCCCCCCCCCEEEEECCCCEEEECCCCCHHHHHHHHHHHHHCCCCCHH
IIQALKEQADRVTLTSRAFHSDQLGPWYEKICKLAGKEMVLPMNTGAEAVETAIKAARRW
HHHHHHHHHHEEEEHHHHHCCCCCCHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHH
AYDVKGVAKDQAEIIAMKGNFHGRTLAAVSLSSEAEYQRGYGPLLGGFKLVEFGDIEQIK
HHHHCCCCCCCEEEEEEECCCCCCEEEEEECCCCHHHHCCCCCHHCCEEEEECCCHHHHH
SAITPNTAAVLLEPIQGEAGINIPEDGFLKQVRDVCTENNVLFIADEIQAGLGRSGKMFA
HHCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEHHHHCCCCCCCEEE
TDWDNVVPDMYILGKALGGGVFPISCVLADKEILEVFNAGSHGSTFGGNPLACAVSNAAL
CCHHHHCCHHHHHHHHHCCCCCEEEEEECCHHHHHHHCCCCCCCCCCCCCEEEEECCCHH
DVLVDEKLAERSLELGEYFQSKLKEIDNPVIKEVRGKGLFIGVELNEAARPYCEQLKELG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHH
LLCKETHDTVIRFAPPLIISQEDLDWAIDKVKQVFSK
HHHHHHHCCCEEECCCEEEECCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
TKSQDIIEITNHYGAPNYHPLPIVISEAEGVWVKDPEGNKYMDMLSAYSAVNQGHRHPK
CCCCCHHHHHHCCCCCCCCCCEEEEECCCCEEEECCCCCHHHHHHHHHHHHHCCCCCHH
IIQALKEQADRVTLTSRAFHSDQLGPWYEKICKLAGKEMVLPMNTGAEAVETAIKAARRW
HHHHHHHHHHEEEEHHHHHCCCCCCHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHH
AYDVKGVAKDQAEIIAMKGNFHGRTLAAVSLSSEAEYQRGYGPLLGGFKLVEFGDIEQIK
HHHHCCCCCCCEEEEEEECCCCCCEEEEEECCCCHHHHCCCCCHHCCEEEEECCCHHHHH
SAITPNTAAVLLEPIQGEAGINIPEDGFLKQVRDVCTENNVLFIADEIQAGLGRSGKMFA
HHCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEHHHHCCCCCCCEEE
TDWDNVVPDMYILGKALGGGVFPISCVLADKEILEVFNAGSHGSTFGGNPLACAVSNAAL
CCHHHHCCHHHHHHHHHCCCCCEEEEEECCHHHHHHHCCCCCCCCCCCCCEEEEECCCHH
DVLVDEKLAERSLELGEYFQSKLKEIDNPVIKEVRGKGLFIGVELNEAARPYCEQLKELG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHH
LLCKETHDTVIRFAPPLIISQEDLDWAIDKVKQVFSK
HHHHHHHCCCEEECCCEEEECCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA