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The map label for this gene is rnr [H]

Identifier: 222150778

GI number: 222150778

Start: 560538

End: 562859

Strand: Direct

Name: rnr [H]

Synonym: MCCL_0528

Alternate gene names: 222150778

Gene position: 560538-562859 (Clockwise)

Preceding gene: 222150777

Following gene: 222150779

Centisome position: 26.66

GC content: 39.71

Gene sequence:

>2322_bases
ATGCATCTGTATGAACATGAAGTAATTGCATATTTAAAATCATTAAAGGGTAGTGCAGTTACGATAGAAGCAATAGAAGC
GCATCTAAATCTTGAGAGTGCAGATGCATTTAAAGATTTAGTTAAAACGCTTGTACATTTAGAACAAACAGGAAAGTTGA
GTCGCACGAAAAACGATAAGTACTTTATTGCATTTGATGGCAGTAAAGCGCTCGTAAAAGGGACACTTAGTCAGCATAAG
AAAGGTTTTGCATTCGTAAGAGCAGAGGACGAAACAGTAGATGATGTATTTATTCCACCGAATAAGATTAATCGTGCCAT
GGATGGAGATACGGTACTTGTGAGCGTATCAAAGGCGCGAGATGGTCGTAATGAAGGTGAAGTAAAGGCAATTGAAAAGC
GTGCGATCACTCAAGTTGTCGGCACCTATACTGAAGCGAAACATTTTGGTTTTGTATTACCGGATGACTCAAGAATTACA
CAAGATATCTTTATTCCAAAAGGTAAAAATTTAGGGGCAGTTGAAGGTCATAAAGTGCTTGTAGAACTGACGGAATATGC
TGATGGCACGAATAACCCTGAAGGCATGGTGAAAGCCATTCTTGGTCATAAAAATGACCCTGGTGTGGATATATTATCGA
TTATTTATCAGCATGGTATTAACATTGAGTTTAATCCGGCGACGATTGAAGAAGCAAATAATGTTCCGGATGAAATAAGT
GCATCTGAAATCTCCGGACGCACGGACTTACGTGATGTGCTGACGATTACGATTGACGGAGCTGACGCAAAGGACCTTGA
TGATGCGATCAGTGTTGAGAAACTGGATAACGGGAATTACCGTTTAATCGTCTCTATTGCAGATGTCAGCCACTATGTAA
CAGAAGGATCTAGTCTTGATGCAGATGCGTATGAACGTGGTACGAGTGTGTATCTAGTAGACCGCGTAATCCCGATGATT
CCACATCGACTTAGTAATGGTATATGCTCGCTTAATCCACACGCTGATCGATTGACACTCAGCTGTGAAATGGAGATTAC
GCCGAATGGTCATACAGTCAATCATAGAATTTATGAAAGTGTTATACATTCGGACGAACGTATGACCTATGATGATGTGA
ATGCCATATTAGAAGATAACGATCAGGCACTCATTCAAAAGTATACACACATTCATGAAATGCTCCTGCATGCAAAAGAA
CTTGCTGCAATACTTAAACGCATGCGTGAAGCACGTGGAGAGATTGATTTTGATTTAAAAGAAGCGAAGATATTGGTAGA
TACAGACGGTGTACCGAGAGAAGTTGTAATACGTGACAGAGGATTAGGTGAACGTTTAATCGAGTCATTTATGCTCGCAG
CAAATGAAACGGTTGCTGAACACTTTGCGAAGATGAAAGTACCGTTTCTCTATCGCGTACATGAAGAACCGAAAGCGGAC
CGCTTAAAACGATTCTTCGAGTTTATTACGAATTTCGGTATTTTAGTTAAAGGTGGTACGGAGAATATTCATCCGAAAAC
TTTACAGAATATCGGTAAGGAAATTCATGGTAAACCAGAGGAACTCGTAATATCTACGTTAATGCTGCGCTCGATGCAGC
AGGCGAAATACGCTGAAGAAAATTTAGGTCATTTCGGACTATCAGCAGAATATTATACGCACTTTACATCGCCGATACGA
CGTTACCCGGATTTAATCGTACACAGACTGATTCGTAAATATTTGATTGAGAAATCAATGGATGATAAAGCACAGGATTA
CTGGGCAGAAAAACTTGTTGAAATAAGCGACCATACATCTAAACGAGAACGCCGTGCAATCGATGCAGAGCGTGATACGG
ATGATCTGAAAAAAGCAGAATATATGGTACAGCATATCGGTGAAGAATTTGATGGTATCATTAGTAGTGTTGCGAACTTC
GGAATGTTTGTCGAACTTGAGAATACGATTGAAGGTATGGTTCATAACTCAAATATGACAGACGATTACTATAACTTCGA
TGAACGCCACATGGCTATGATTGGTGAACGTCACGGTAAAGTTTTCCGAATTGGACAGAAAGTGCGTGTAAAAGTCGTTA
ACGTAAATGTTGATGAACGCATGATCGACTTTGCGATTGTCGGAATGGATATGAAAAAGATTGAAGACAAAATTCGCGAA
GTGAAAATTAAAGCGAAGCGCAATACGAAATCAACAAATGAAAAACCACGTAAAAAAGGGCGCGGAAAAGCACGCGGTGC
TGAGAAGAGTAAAAACAAAAATAAAAAACCATTCTATAAATCTAAAGCAGTGAAAAATTCAGGACGCAGAAAGAAGAAGT
AG

Upstream 100 bases:

>100_bases
TGGTCACGTTATAACAATAGATAAAGAAAAAGAACAGTTATTTGAAGATTATTATCAGTTTTTAGAACAATTAGACTGGT
CAAATTAAAGGAGGAATTAT

Downstream 100 bases:

>100_bases
AGGTGGCGTTATGCCTAAAGGAACAGGAAAAGTATTAGCACAGAACAGAAAAGCAAGTCATGACTATATAATTGAAGAGA
CGATTGAAGCGGGGATTGAA

Product: VacB/RNase II family exoribonuclease

Products: NA

Alternate protein names: RNase R; VacB protein homolog [H]

Number of amino acids: Translated: 773; Mature: 773

Protein sequence:

>773_residues
MHLYEHEVIAYLKSLKGSAVTIEAIEAHLNLESADAFKDLVKTLVHLEQTGKLSRTKNDKYFIAFDGSKALVKGTLSQHK
KGFAFVRAEDETVDDVFIPPNKINRAMDGDTVLVSVSKARDGRNEGEVKAIEKRAITQVVGTYTEAKHFGFVLPDDSRIT
QDIFIPKGKNLGAVEGHKVLVELTEYADGTNNPEGMVKAILGHKNDPGVDILSIIYQHGINIEFNPATIEEANNVPDEIS
ASEISGRTDLRDVLTITIDGADAKDLDDAISVEKLDNGNYRLIVSIADVSHYVTEGSSLDADAYERGTSVYLVDRVIPMI
PHRLSNGICSLNPHADRLTLSCEMEITPNGHTVNHRIYESVIHSDERMTYDDVNAILEDNDQALIQKYTHIHEMLLHAKE
LAAILKRMREARGEIDFDLKEAKILVDTDGVPREVVIRDRGLGERLIESFMLAANETVAEHFAKMKVPFLYRVHEEPKAD
RLKRFFEFITNFGILVKGGTENIHPKTLQNIGKEIHGKPEELVISTLMLRSMQQAKYAEENLGHFGLSAEYYTHFTSPIR
RYPDLIVHRLIRKYLIEKSMDDKAQDYWAEKLVEISDHTSKRERRAIDAERDTDDLKKAEYMVQHIGEEFDGIISSVANF
GMFVELENTIEGMVHNSNMTDDYYNFDERHMAMIGERHGKVFRIGQKVRVKVVNVNVDERMIDFAIVGMDMKKIEDKIRE
VKIKAKRNTKSTNEKPRKKGRGKARGAEKSKNKNKKPFYKSKAVKNSGRRKKK

Sequences:

>Translated_773_residues
MHLYEHEVIAYLKSLKGSAVTIEAIEAHLNLESADAFKDLVKTLVHLEQTGKLSRTKNDKYFIAFDGSKALVKGTLSQHK
KGFAFVRAEDETVDDVFIPPNKINRAMDGDTVLVSVSKARDGRNEGEVKAIEKRAITQVVGTYTEAKHFGFVLPDDSRIT
QDIFIPKGKNLGAVEGHKVLVELTEYADGTNNPEGMVKAILGHKNDPGVDILSIIYQHGINIEFNPATIEEANNVPDEIS
ASEISGRTDLRDVLTITIDGADAKDLDDAISVEKLDNGNYRLIVSIADVSHYVTEGSSLDADAYERGTSVYLVDRVIPMI
PHRLSNGICSLNPHADRLTLSCEMEITPNGHTVNHRIYESVIHSDERMTYDDVNAILEDNDQALIQKYTHIHEMLLHAKE
LAAILKRMREARGEIDFDLKEAKILVDTDGVPREVVIRDRGLGERLIESFMLAANETVAEHFAKMKVPFLYRVHEEPKAD
RLKRFFEFITNFGILVKGGTENIHPKTLQNIGKEIHGKPEELVISTLMLRSMQQAKYAEENLGHFGLSAEYYTHFTSPIR
RYPDLIVHRLIRKYLIEKSMDDKAQDYWAEKLVEISDHTSKRERRAIDAERDTDDLKKAEYMVQHIGEEFDGIISSVANF
GMFVELENTIEGMVHNSNMTDDYYNFDERHMAMIGERHGKVFRIGQKVRVKVVNVNVDERMIDFAIVGMDMKKIEDKIRE
VKIKAKRNTKSTNEKPRKKGRGKARGAEKSKNKNKKPFYKSKAVKNSGRRKKK
>Mature_773_residues
MHLYEHEVIAYLKSLKGSAVTIEAIEAHLNLESADAFKDLVKTLVHLEQTGKLSRTKNDKYFIAFDGSKALVKGTLSQHK
KGFAFVRAEDETVDDVFIPPNKINRAMDGDTVLVSVSKARDGRNEGEVKAIEKRAITQVVGTYTEAKHFGFVLPDDSRIT
QDIFIPKGKNLGAVEGHKVLVELTEYADGTNNPEGMVKAILGHKNDPGVDILSIIYQHGINIEFNPATIEEANNVPDEIS
ASEISGRTDLRDVLTITIDGADAKDLDDAISVEKLDNGNYRLIVSIADVSHYVTEGSSLDADAYERGTSVYLVDRVIPMI
PHRLSNGICSLNPHADRLTLSCEMEITPNGHTVNHRIYESVIHSDERMTYDDVNAILEDNDQALIQKYTHIHEMLLHAKE
LAAILKRMREARGEIDFDLKEAKILVDTDGVPREVVIRDRGLGERLIESFMLAANETVAEHFAKMKVPFLYRVHEEPKAD
RLKRFFEFITNFGILVKGGTENIHPKTLQNIGKEIHGKPEELVISTLMLRSMQQAKYAEENLGHFGLSAEYYTHFTSPIR
RYPDLIVHRLIRKYLIEKSMDDKAQDYWAEKLVEISDHTSKRERRAIDAERDTDDLKKAEYMVQHIGEEFDGIISSVANF
GMFVELENTIEGMVHNSNMTDDYYNFDERHMAMIGERHGKVFRIGQKVRVKVVNVNVDERMIDFAIVGMDMKKIEDKIRE
VKIKAKRNTKSTNEKPRKKGRGKARGAEKSKNKNKKPFYKSKAVKNSGRRKKK

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI134288890, Length=446, Percent_Identity=31.8385650224215, Blast_Score=209, Evalue=6e-54,
Organism=Homo sapiens, GI190014623, Length=473, Percent_Identity=29.5983086680761, Blast_Score=178, Evalue=1e-44,
Organism=Homo sapiens, GI190014625, Length=473, Percent_Identity=29.5983086680761, Blast_Score=178, Evalue=2e-44,
Organism=Homo sapiens, GI19115966, Length=532, Percent_Identity=26.5037593984962, Blast_Score=152, Evalue=1e-36,
Organism=Homo sapiens, GI219521928, Length=532, Percent_Identity=26.5037593984962, Blast_Score=152, Evalue=1e-36,
Organism=Homo sapiens, GI156105695, Length=340, Percent_Identity=27.0588235294118, Blast_Score=79, Evalue=2e-14,
Organism=Homo sapiens, GI156105693, Length=342, Percent_Identity=27.1929824561404, Blast_Score=76, Evalue=1e-13,
Organism=Escherichia coli, GI87082383, Length=693, Percent_Identity=37.2294372294372, Blast_Score=464, Evalue=1e-131,
Organism=Escherichia coli, GI1787542, Length=588, Percent_Identity=25.8503401360544, Blast_Score=150, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI17553506, Length=417, Percent_Identity=33.8129496402878, Blast_Score=188, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI212645896, Length=420, Percent_Identity=30, Blast_Score=155, Evalue=7e-38,
Organism=Saccharomyces cerevisiae, GI6324552, Length=597, Percent_Identity=27.6381909547739, Blast_Score=172, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6323943, Length=367, Percent_Identity=24.5231607629428, Blast_Score=85, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6320499, Length=400, Percent_Identity=24.75, Blast_Score=84, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24649634, Length=469, Percent_Identity=31.1300639658849, Blast_Score=199, Evalue=7e-51,
Organism=Drosophila melanogaster, GI19922976, Length=525, Percent_Identity=28.1904761904762, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24654597, Length=525, Percent_Identity=28.1904761904762, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24654592, Length=525, Percent_Identity=28.1904761904762, Blast_Score=160, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805 [H]

Pfam domain/function: PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 87630; Mature: 87630

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: PS50126 S1 ; PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHLYEHEVIAYLKSLKGSAVTIEAIEAHLNLESADAFKDLVKTLVHLEQTGKLSRTKNDK
CCCHHHHHHHHHHHCCCCEEEEEEHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCC
YFIAFDGSKALVKGTLSQHKKGFAFVRAEDETVDDVFIPPNKINRAMDGDTVLVSVSKAR
EEEEECCCHHHHHHHHHHCCCCEEEEEECCCCCCCEECCHHHHHHCCCCCEEEEEECCCC
DGRNEGEVKAIEKRAITQVVGTYTEAKHFGFVLPDDSRITQDIFIPKGKNLGAVEGHKVL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCEEECCCCCCCCCEEECCCCCCCCCCCCCCEE
VELTEYADGTNNPEGMVKAILGHKNDPGVDILSIIYQHGINIEFNPATIEEANNVPDEIS
EEEHHHCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEECCCHHHHCCCCCCCCC
ASEISGRTDLRDVLTITIDGADAKDLDDAISVEKLDNGNYRLIVSIADVSHYVTEGSSLD
HHHCCCCCCCCEEEEEEECCCCCCCCHHHHHHEEECCCCEEEEEEEECHHHHHCCCCCCC
ADAYERGTSVYLVDRVIPMIPHRLSNGICSLNPHADRLTLSCEMEITPNGHTVNHRIYES
CHHHHCCCEEEEHHHHHHHHHHHHCCCCEECCCCCCEEEEEEEEEECCCCCEEHHHHHHH
VIHSDERMTYDDVNAILEDNDQALIQKYTHIHEMLLHAKELAAILKRMREARGEIDFDLK
HHCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHC
EAKILVDTDGVPREVVIRDRGLGERLIESFMLAANETVAEHFAKMKVPFLYRVHEEPKAD
CCEEEEECCCCCCEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEECCCCCHH
RLKRFFEFITNFGILVKGGTENIHPKTLQNIGKEIHGKPEELVISTLMLRSMQQAKYAEE
HHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
NLGHFGLSAEYYTHFTSPIRRYPDLIVHRLIRKYLIEKSMDDKAQDYWAEKLVEISDHTS
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCH
KRERRAIDAERDTDDLKKAEYMVQHIGEEFDGIISSVANFGMFVELENTIEGMVHNSNMT
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHEECCCCC
DDYYNFDERHMAMIGERHGKVFRIGQKVRVKVVNVNVDERMIDFAIVGMDMKKIEDKIRE
CHHCCCCHHHHHHHHHHCCCEEEECCEEEEEEEEECCHHHHEEHHEECCCHHHHHHHHHH
VKIKAKRNTKSTNEKPRKKGRGKARGAEKSKNKNKKPFYKSKAVKNSGRRKKK
EEEEECCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCC
>Mature Secondary Structure
MHLYEHEVIAYLKSLKGSAVTIEAIEAHLNLESADAFKDLVKTLVHLEQTGKLSRTKNDK
CCCHHHHHHHHHHHCCCCEEEEEEHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCC
YFIAFDGSKALVKGTLSQHKKGFAFVRAEDETVDDVFIPPNKINRAMDGDTVLVSVSKAR
EEEEECCCHHHHHHHHHHCCCCEEEEEECCCCCCCEECCHHHHHHCCCCCEEEEEECCCC
DGRNEGEVKAIEKRAITQVVGTYTEAKHFGFVLPDDSRITQDIFIPKGKNLGAVEGHKVL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCEEECCCCCCCCCEEECCCCCCCCCCCCCCEE
VELTEYADGTNNPEGMVKAILGHKNDPGVDILSIIYQHGINIEFNPATIEEANNVPDEIS
EEEHHHCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEECCCHHHHCCCCCCCCC
ASEISGRTDLRDVLTITIDGADAKDLDDAISVEKLDNGNYRLIVSIADVSHYVTEGSSLD
HHHCCCCCCCCEEEEEEECCCCCCCCHHHHHHEEECCCCEEEEEEEECHHHHHCCCCCCC
ADAYERGTSVYLVDRVIPMIPHRLSNGICSLNPHADRLTLSCEMEITPNGHTVNHRIYES
CHHHHCCCEEEEHHHHHHHHHHHHCCCCEECCCCCCEEEEEEEEEECCCCCEEHHHHHHH
VIHSDERMTYDDVNAILEDNDQALIQKYTHIHEMLLHAKELAAILKRMREARGEIDFDLK
HHCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHC
EAKILVDTDGVPREVVIRDRGLGERLIESFMLAANETVAEHFAKMKVPFLYRVHEEPKAD
CCEEEEECCCCCCEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHCCCCEEEEECCCCCHH
RLKRFFEFITNFGILVKGGTENIHPKTLQNIGKEIHGKPEELVISTLMLRSMQQAKYAEE
HHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
NLGHFGLSAEYYTHFTSPIRRYPDLIVHRLIRKYLIEKSMDDKAQDYWAEKLVEISDHTS
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCH
KRERRAIDAERDTDDLKKAEYMVQHIGEEFDGIISSVANFGMFVELENTIEGMVHNSNMT
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHEECCCCC
DDYYNFDERHMAMIGERHGKVFRIGQKVRVKVVNVNVDERMIDFAIVGMDMKKIEDKIRE
CHHCCCCHHHHHHHHHHCCCEEEECCEEEEEEEEECCHHHHEEHHEECCCHHHHHHHHHH
VKIKAKRNTKSTNEKPRKKGRGKARGAEKSKNKNKKPFYKSKAVKNSGRRKKK
EEEEECCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]