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The map label for this gene is malR [H]

Identifier: 222150606

GI number: 222150606

Start: 373068

End: 374078

Strand: Direct

Name: malR [H]

Synonym: MCCL_0356

Alternate gene names: 222150606

Gene position: 373068-374078 (Clockwise)

Preceding gene: 222150605

Following gene: 222150607

Centisome position: 17.75

GC content: 33.33

Gene sequence:

>1011_bases
TTGGTAACAATCAAGGATGTAGCTAAAAGAGCGAGTGTATCACCTTCAACTGTATCGCGTGTGATTAGTAACCATAGCGG
TATCAGTAGTGAGACAAAGAAGAAAGTACAGAAAGTGATGGACGAAATAGGTTATACACCAAATTTATCTGCACGTTATC
TTGTAACGAAACAAACGAAAACAATATTACTTGTGTTAAAGACTGCTTCGATTGAAATGAGACAGAACCCCTTTTTCACT
GACGTATTAATCAGTGTTTCAAAGGTCTGTAAAGGGAATGGATATTCAACGATTACGACAACAAGTATCGATGAACAAGC
CCTATTTAAAGAAGTTAAGAATTATATAGATAGTCGTATGATTGACGGTGTTATTTTACTATACTCAAAACAAGACAAAG
TAACAGATTATCTGAAGGCAAAATCTTTTCCGTTTGTAGTGATCGGTAAAGCACTTGATGACAATTATCCAGTTATGTAT
ATCGATAATGATAACGTAAAGGCAAGCGAACAGTTAACTGAATATATGGTAGATCTTGGTCACAAAAATCTACTATTTAT
TCGTGAACAAGGTGATTATGAAGTAAGTAAAGATAGAGAATTGGGATTCATCAATGTTTGCAGAAAACACGGTATTGATT
ATGAAGTACTAGAAGGCACGCTTGAATTAAAAGAAGCTCAATCCATATTGAAAGAAATTAATATTGAAAGATTTAGTGGT
TTGATTACATCAGACAGTATGATGAACTTGTTAGTATTAAATATACTTTATCAGATGAAGATTAATGTGCCTGAAACAAT
ACAGACCGCAACATTTAATGACTCATTTCTAAGTGAAACTGCATGTCCATCACAAACTGTCGTCAATATTTATCCAGAAT
CACTAGGCAAAGTAGCAGCAACGAATTTAATTGAACTATTATCAGATAAAGCATTTCCAATATATAACGTGATTATTCCT
ACAACAATAATTGAAAGAAACTCAACACAAATGATTGGAGCGAGAAGATGA

Upstream 100 bases:

>100_bases
TTTAGCAGGATTAACATTATCTATTATACCGGTTGTTATTGGTTACTTCTTTGCACAAAAACACATTATTAAAGGTGTAT
CGGATGGGGCTGTGAAATAG

Downstream 100 bases:

>100_bases
ATATTACAGTATGGAATGAATATAGACACGAAAAAGAATCAGAAAAAGTGAGACTTCATTATCCAGAAGGCATTCATAAA
GTTATTGCAGACTTTCTGGA

Product: hypothetical protein

Products: NA

Alternate protein names: Maltose operon transcriptional repressor [H]

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MVTIKDVAKRASVSPSTVSRVISNHSGISSETKKKVQKVMDEIGYTPNLSARYLVTKQTKTILLVLKTASIEMRQNPFFT
DVLISVSKVCKGNGYSTITTTSIDEQALFKEVKNYIDSRMIDGVILLYSKQDKVTDYLKAKSFPFVVIGKALDDNYPVMY
IDNDNVKASEQLTEYMVDLGHKNLLFIREQGDYEVSKDRELGFINVCRKHGIDYEVLEGTLELKEAQSILKEINIERFSG
LITSDSMMNLLVLNILYQMKINVPETIQTATFNDSFLSETACPSQTVVNIYPESLGKVAATNLIELLSDKAFPIYNVIIP
TTIIERNSTQMIGARR

Sequences:

>Translated_336_residues
MVTIKDVAKRASVSPSTVSRVISNHSGISSETKKKVQKVMDEIGYTPNLSARYLVTKQTKTILLVLKTASIEMRQNPFFT
DVLISVSKVCKGNGYSTITTTSIDEQALFKEVKNYIDSRMIDGVILLYSKQDKVTDYLKAKSFPFVVIGKALDDNYPVMY
IDNDNVKASEQLTEYMVDLGHKNLLFIREQGDYEVSKDRELGFINVCRKHGIDYEVLEGTLELKEAQSILKEINIERFSG
LITSDSMMNLLVLNILYQMKINVPETIQTATFNDSFLSETACPSQTVVNIYPESLGKVAATNLIELLSDKAFPIYNVIIP
TTIIERNSTQMIGARR
>Mature_336_residues
MVTIKDVAKRASVSPSTVSRVISNHSGISSETKKKVQKVMDEIGYTPNLSARYLVTKQTKTILLVLKTASIEMRQNPFFT
DVLISVSKVCKGNGYSTITTTSIDEQALFKEVKNYIDSRMIDGVILLYSKQDKVTDYLKAKSFPFVVIGKALDDNYPVMY
IDNDNVKASEQLTEYMVDLGHKNLLFIREQGDYEVSKDRELGFINVCRKHGIDYEVLEGTLELKEAQSILKEINIERFSG
LITSDSMMNLLVLNILYQMKINVPETIQTATFNDSFLSETACPSQTVVNIYPESLGKVAATNLIELLSDKAFPIYNVIIP
TTIIERNSTQMIGARR

Specific function: Transcriptional repressor of the malA gene for maltase [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787580, Length=319, Percent_Identity=28.5266457680251, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1790194, Length=337, Percent_Identity=27.0029673590504, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1789068, Length=298, Percent_Identity=27.1812080536913, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1787948, Length=340, Percent_Identity=24.1176470588235, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1790689, Length=323, Percent_Identity=24.4582043343653, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI1790369, Length=336, Percent_Identity=21.1309523809524, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1789202, Length=343, Percent_Identity=25.3644314868805, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1787906, Length=232, Percent_Identity=25.8620689655172, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788474, Length=346, Percent_Identity=22.2543352601156, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI48994940, Length=307, Percent_Identity=21.4983713355049, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1790715, Length=321, Percent_Identity=24.2990654205607, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1786540, Length=340, Percent_Identity=21.7647058823529, Blast_Score=68, Evalue=9e-13,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 37774; Mature: 37774

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTIKDVAKRASVSPSTVSRVISNHSGISSETKKKVQKVMDEIGYTPNLSARYLVTKQTK
CCCHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEECCC
TILLVLKTASIEMRQNPFFTDVLISVSKVCKGNGYSTITTTSIDEQALFKEVKNYIDSRM
EEEEEEEECCEEECCCCCHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHHH
IDGVILLYSKQDKVTDYLKAKSFPFVVIGKALDDNYPVMYIDNDNVKASEQLTEYMVDLG
HCCEEEEEECCHHHHHHHHHCCCCEEEEEEECCCCCCEEEEECCCCCHHHHHHHHHHHCC
HKNLLFIREQGDYEVSKDRELGFINVCRKHGIDYEVLEGTLELKEAQSILKEINIERFSG
CCCEEEEEECCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCHHHHHC
LITSDSMMNLLVLNILYQMKINVPETIQTATFNDSFLSETACPSQTVVNIYPESLGKVAA
CCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHCCCCCCCEEEECHHHHHHHHH
TNLIELLSDKAFPIYNVIIPTTIIERNSTQMIGARR
HHHHHHHCCCCCCEEEEEECCEEECCCCCCCCCCCC
>Mature Secondary Structure
MVTIKDVAKRASVSPSTVSRVISNHSGISSETKKKVQKVMDEIGYTPNLSARYLVTKQTK
CCCHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEEEECCC
TILLVLKTASIEMRQNPFFTDVLISVSKVCKGNGYSTITTTSIDEQALFKEVKNYIDSRM
EEEEEEEECCEEECCCCCHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHHH
IDGVILLYSKQDKVTDYLKAKSFPFVVIGKALDDNYPVMYIDNDNVKASEQLTEYMVDLG
HCCEEEEEECCHHHHHHHHHCCCCEEEEEEECCCCCCEEEEECCCCCHHHHHHHHHHHCC
HKNLLFIREQGDYEVSKDRELGFINVCRKHGIDYEVLEGTLELKEAQSILKEINIERFSG
CCCEEEEEECCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCHHHHHC
LITSDSMMNLLVLNILYQMKINVPETIQTATFNDSFLSETACPSQTVVNIYPESLGKVAA
CCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHCCCCCCCEEEECHHHHHHHHH
TNLIELLSDKAFPIYNVIIPTTIIERNSTQMIGARR
HHHHHHHCCCCCCEEEEEECCEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7730272 [H]