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The map label for this gene is ldh2 [H]

Identifier: 222150505

GI number: 222150505

Start: 257128

End: 258039

Strand: Direct

Name: ldh2 [H]

Synonym: MCCL_0255

Alternate gene names: 222150505

Gene position: 257128-258039 (Clockwise)

Preceding gene: 222150504

Following gene: 222150506

Centisome position: 12.23

GC content: 38.27

Gene sequence:

>912_bases
ATGAAGCTAGGAATCATTGGTGTTGGACGTGTGGGCAGTCAGGTGTTGACTGACGTACAGTATTTGAACGTATTTAACGA
GATTGTCTTGATTGATAGTGATGAAAATGTTGCGACTGGAGAGGCAATGGATCATTTGCACAGTCAAGGTATTGGTGTCA
CGAATCATATCAATATTTATGCGGGAACATATAAGGATTTAAAGGATGCGGATGTTATCGTTATAGCGGCCAGTACAAAG
ACAGATACATCAATTCCAGATCGCACTGCGCTAGCAAAGGCGAATACAGTGATTATTAAAGAAATCACTACACGTATCGG
TGAAGTAACGACCGATGCCTTGCTTGTTATTATTTCCAATCCTGTCGATGCGATGACGTACATCGCTTCAAAGTATTATC
CGGAGAGTAAAGTGATAGGTACTGGTACGTTATTAGAAACTTCACGTTTTAAAACTTTAATTGCAAATCATTACAACATT
GACCCTAAAAGTGTTGAAGGGTTTGTTATAGGAGAGCATGGAGCGCATGCTGTACCGCTCTGGAGTAAAACGAGTATTCA
TGGTATAGCGTTAGAGGAATATGAACAGCTTAGTGGTCACCACAAGATAGATAAAAAGGAGATAACTGAGGCGATTGATA
GCGTGTCATTTGATGTATTCCATCAAAAAGGATGGACCAATGCAGCGATATCAAAAATCACTGTATTGCTTATCAAATCT
CTTGTGCTCAATGAACGTTCAATTTTCCCATTATCAACGAGGAATGAGGAGTTAGCATATAGCTTACCCGTGCTTGTAGG
AAAGGAAGGTATCATCCAGAGATTAGATATTTCAATAGATAATCAAGAAGCACAGGATTTAAAAAGAGCTAAACAATTTA
TTAGAAATACAATAGAACAGCATTATAATTAA

Upstream 100 bases:

>100_bases
GAAGTTTCAGGATTTGATTGAAGTGCTTCAGTCTCAAGATATGAAAGATTATATTAATAAGGAATTTAACAAAGATGTCA
TTCCATATGGAGGGAAGTAG

Downstream 100 bases:

>100_bases
GACCTTGTAAAATTACAGGGTCTTTTTGTATGTATCAGGATTAATGATAAAATAATAGGGAGGCCGAGTATATAAGAAGG
GGTGAGAGAATGGCGAATAT

Product: lactate dehydrogenase

Products: NA

Alternate protein names: L-LDH 2 [H]

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MKLGIIGVGRVGSQVLTDVQYLNVFNEIVLIDSDENVATGEAMDHLHSQGIGVTNHINIYAGTYKDLKDADVIVIAASTK
TDTSIPDRTALAKANTVIIKEITTRIGEVTTDALLVIISNPVDAMTYIASKYYPESKVIGTGTLLETSRFKTLIANHYNI
DPKSVEGFVIGEHGAHAVPLWSKTSIHGIALEEYEQLSGHHKIDKKEITEAIDSVSFDVFHQKGWTNAAISKITVLLIKS
LVLNERSIFPLSTRNEELAYSLPVLVGKEGIIQRLDISIDNQEAQDLKRAKQFIRNTIEQHYN

Sequences:

>Translated_303_residues
MKLGIIGVGRVGSQVLTDVQYLNVFNEIVLIDSDENVATGEAMDHLHSQGIGVTNHINIYAGTYKDLKDADVIVIAASTK
TDTSIPDRTALAKANTVIIKEITTRIGEVTTDALLVIISNPVDAMTYIASKYYPESKVIGTGTLLETSRFKTLIANHYNI
DPKSVEGFVIGEHGAHAVPLWSKTSIHGIALEEYEQLSGHHKIDKKEITEAIDSVSFDVFHQKGWTNAAISKITVLLIKS
LVLNERSIFPLSTRNEELAYSLPVLVGKEGIIQRLDISIDNQEAQDLKRAKQFIRNTIEQHYN
>Mature_303_residues
MKLGIIGVGRVGSQVLTDVQYLNVFNEIVLIDSDENVATGEAMDHLHSQGIGVTNHINIYAGTYKDLKDADVIVIAASTK
TDTSIPDRTALAKANTVIIKEITTRIGEVTTDALLVIISNPVDAMTYIASKYYPESKVIGTGTLLETSRFKTLIANHYNI
DPKSVEGFVIGEHGAHAVPLWSKTSIHGIALEEYEQLSGHHKIDKKEITEAIDSVSFDVFHQKGWTNAAISKITVLLIKS
LVLNERSIFPLSTRNEELAYSLPVLVGKEGIIQRLDISIDNQEAQDLKRAKQFIRNTIEQHYN

Specific function: Catalyzes The Reversible Oxidation Of Malate To Oxaloacetate. [C]

COG id: COG0039

COG function: function code C; Malate/lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH/MDH superfamily. LDH family [H]

Homologues:

Organism=Homo sapiens, GI15082234, Length=303, Percent_Identity=30.3630363036304, Blast_Score=144, Evalue=7e-35,
Organism=Homo sapiens, GI9257228, Length=307, Percent_Identity=28.9902280130293, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI4504973, Length=307, Percent_Identity=28.9902280130293, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI5031857, Length=301, Percent_Identity=28.9036544850498, Blast_Score=135, Evalue=4e-32,
Organism=Homo sapiens, GI260099723, Length=301, Percent_Identity=28.9036544850498, Blast_Score=135, Evalue=4e-32,
Organism=Homo sapiens, GI291575128, Length=300, Percent_Identity=28.3333333333333, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI4557032, Length=300, Percent_Identity=28.3333333333333, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI47059044, Length=302, Percent_Identity=27.8145695364238, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI221136809, Length=302, Percent_Identity=27.8145695364238, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI260099727, Length=221, Percent_Identity=30.7692307692308, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI260099725, Length=212, Percent_Identity=30.6603773584906, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI207028494, Length=186, Percent_Identity=31.1827956989247, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17535107, Length=279, Percent_Identity=30.1075268817204, Blast_Score=130, Evalue=6e-31,
Organism=Drosophila melanogaster, GI17136226, Length=307, Percent_Identity=29.3159609120521, Blast_Score=138, Evalue=4e-33,
Organism=Drosophila melanogaster, GI45550422, Length=297, Percent_Identity=28.956228956229, Blast_Score=136, Evalue=1e-32,

Paralogues:

None

Copy number: 2640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 260 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2380 Molecules/Cell In: Stationary-Phase, Rich-Media (Based on E. coli). 260 Molecules/Cell In: Stationary Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001557
- InterPro:   IPR011304
- InterPro:   IPR022383
- InterPro:   IPR001236
- InterPro:   IPR015955
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02866 Ldh_1_C; PF00056 Ldh_1_N [H]

EC number: =1.1.1.27 [H]

Molecular weight: Translated: 33436; Mature: 33436

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLGIIGVGRVGSQVLTDVQYLNVFNEIVLIDSDENVATGEAMDHLHSQGIGVTNHINIY
CEEEEEECCCCCHHHHHHHHHHHHHCEEEEEECCCCCCCHHHHHHHHHCCCCEEEEEEEE
AGTYKDLKDADVIVIAASTKTDTSIPDRTALAKANTVIIKEITTRIGEVTTDALLVIISN
ECCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHCCEEHHHHHHHHHHHHCCCEEEEEECC
PVDAMTYIASKYYPESKVIGTGTLLETSRFKTLIANHYNIDPKSVEGFVIGEHGAHAVPL
CHHHHHHHHHHCCCCCCEEECCCEEEHHHHHHHHHHCCCCCCCCCCEEEEECCCCEEEEC
WSKTSIHGIALEEYEQLSGHHKIDKKEITEAIDSVSFDVFHQKGWTNAAISKITVLLIKS
CCCCCCCEEEHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHHHH
LVLNERSIFPLSTRNEELAYSLPVLVGKEGIIQRLDISIDNQEAQDLKRAKQFIRNTIEQ
HHHCCCCCCCCCCCCCCEEEECCEEECCCCHHEEECEEECCHHHHHHHHHHHHHHHHHHH
HYN
HCC
>Mature Secondary Structure
MKLGIIGVGRVGSQVLTDVQYLNVFNEIVLIDSDENVATGEAMDHLHSQGIGVTNHINIY
CEEEEEECCCCCHHHHHHHHHHHHHCEEEEEECCCCCCCHHHHHHHHHCCCCEEEEEEEE
AGTYKDLKDADVIVIAASTKTDTSIPDRTALAKANTVIIKEITTRIGEVTTDALLVIISN
ECCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHCCEEHHHHHHHHHHHHCCCEEEEEECC
PVDAMTYIASKYYPESKVIGTGTLLETSRFKTLIANHYNIDPKSVEGFVIGEHGAHAVPL
CHHHHHHHHHHCCCCCCEEECCCEEEHHHHHHHHHHCCCCCCCCCCEEEEECCCCEEEEC
WSKTSIHGIALEEYEQLSGHHKIDKKEITEAIDSVSFDVFHQKGWTNAAISKITVLLIKS
CCCCCCCEEEHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHCCCCCHHHHHHHHHHHHHH
LVLNERSIFPLSTRNEELAYSLPVLVGKEGIIQRLDISIDNQEAQDLKRAKQFIRNTIEQ
HHHCCCCCCCCCCCCCCEEEECCEEECCCCHHEEECEEECCHHHHHHHHHHHHHHHHHHH
HYN
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]