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The map label for this gene is fhuB [H]

Identifier: 222150417

GI number: 222150417

Start: 172308

End: 173303

Strand: Direct

Name: fhuB [H]

Synonym: MCCL_0167

Alternate gene names: 222150417

Gene position: 172308-173303 (Clockwise)

Preceding gene: 222150416

Following gene: 222150418

Centisome position: 8.2

GC content: 40.26

Gene sequence:

>996_bases
ATGAATAGAACTTACCTCTTCAAAAATTATTTTTACTCAGGGCTTTTATTATCCATGATTTTTTTAGTGATTACGCTGCT
ACTTTCTTTTATGTTAGGTTCAGAAAATTATAGCCTCTACGAAGTCGTTCAAGCTGTGCTTCATTATAATAATAGTGAGG
TCCATAACATCATTCGTGAAATTCGAATGCCACGTGAAGTAGCAGCGATGCTTGTTGGTATGAGCCTTGCTTGTAGTGGT
GCAGTAATGCAAGGAATAACGAGAAATCCACTCGCAGATCCAGCGCTTATCGGTCTGAATGCGGGGGCATTGTTATTTAT
CAGTATTATGTTTGCGATTGTACCGGGTGCGAACTTTATGATGATTATGTTATCAGGATTTATCGGTGCGATTATCGGTG
GGACAATTGTACTTATGCTGGGAAATTCAAAGCGTGGAGGATTTAACGCGATGAAAATTATTTTAGCGGGAGCAGCGGTA
AGTACATTGATGACCGCACTTGCACAGGGAGTTTCGATATATTTTAAGACGAACCAAAGCAATTTATTATGGTCAAGCGG
AGGTGTAACAGGAACAACGTGGCAACATATATTTTATGCAGCACCGGTGATTCTGATTACGCTGTTGCTATTATTTATAT
TCAGTAGACAGCTTACAATTTTAAGTGTAGGAGATGAAATGGCTGCAGGATTAGGCGTAAATACATCAAAGACGAGAGTG
TTATTCTCAGTGCTCACAATGATACTTGCAGGTGTAGCTGTTGCTTTAGTAGGATCCCTTGCATTTGTAGGGTTAATGGT
GCCTCATATCGCTAGGATGCTTGTAGGTATTGATTATAGAAAGTTGTTGCCATTTACAACGATACTCGGTGGAATCTTCG
TAGTTTGGGCAGATATTATTGCACGTCAGACGGGCGAGGCACCTATTGGAGCGATTGTATCGATTATCGGTGTTCCGTTC
TTCATATATCTTGTTAGAAAGGATGGGACGATGTGA

Upstream 100 bases:

>100_bases
ATTGATGCGGAGCTATCTAATGATCCACGTAACGGTAAACCGATGCTTGTGACTTATGATTTATTATGCAGACATTATAT
GAAAGATGTAGTTGAAGATT

Downstream 100 bases:

>100_bases
ACATAAATAAGATAACAAGGCAGTGGTTCGTGATGGTTGCGCTTATAATATTATTGTTTATGGTGATTATCATCAGTATG
ACAACAGGAGACTTTAAAAT

Product: ferrichrome transport permease

Products: ADP; phosphate; iron dicitrate [Cytoplasm] [C]

Alternate protein names: Ferric hydroxamate uptake protein B; Ferrichrome transport system permease protein fhuB; Iron(III)-hydroxamate import system permease protein fhuB [H]

Number of amino acids: Translated: 331; Mature: 331

Protein sequence:

>331_residues
MNRTYLFKNYFYSGLLLSMIFLVITLLLSFMLGSENYSLYEVVQAVLHYNNSEVHNIIREIRMPREVAAMLVGMSLACSG
AVMQGITRNPLADPALIGLNAGALLFISIMFAIVPGANFMMIMLSGFIGAIIGGTIVLMLGNSKRGGFNAMKIILAGAAV
STLMTALAQGVSIYFKTNQSNLLWSSGGVTGTTWQHIFYAAPVILITLLLLFIFSRQLTILSVGDEMAAGLGVNTSKTRV
LFSVLTMILAGVAVALVGSLAFVGLMVPHIARMLVGIDYRKLLPFTTILGGIFVVWADIIARQTGEAPIGAIVSIIGVPF
FIYLVRKDGTM

Sequences:

>Translated_331_residues
MNRTYLFKNYFYSGLLLSMIFLVITLLLSFMLGSENYSLYEVVQAVLHYNNSEVHNIIREIRMPREVAAMLVGMSLACSG
AVMQGITRNPLADPALIGLNAGALLFISIMFAIVPGANFMMIMLSGFIGAIIGGTIVLMLGNSKRGGFNAMKIILAGAAV
STLMTALAQGVSIYFKTNQSNLLWSSGGVTGTTWQHIFYAAPVILITLLLLFIFSRQLTILSVGDEMAAGLGVNTSKTRV
LFSVLTMILAGVAVALVGSLAFVGLMVPHIARMLVGIDYRKLLPFTTILGGIFVVWADIIARQTGEAPIGAIVSIIGVPF
FIYLVRKDGTM
>Mature_331_residues
MNRTYLFKNYFYSGLLLSMIFLVITLLLSFMLGSENYSLYEVVQAVLHYNNSEVHNIIREIRMPREVAAMLVGMSLACSG
AVMQGITRNPLADPALIGLNAGALLFISIMFAIVPGANFMMIMLSGFIGAIIGGTIVLMLGNSKRGGFNAMKIILAGAAV
STLMTALAQGVSIYFKTNQSNLLWSSGGVTGTTWQHIFYAAPVILITLLLLFIFSRQLTILSVGDEMAAGLGVNTSKTRV
LFSVLTMILAGVAVALVGSLAFVGLMVPHIARMLVGIDYRKLLPFTTILGGIFVVWADIIARQTGEAPIGAIVSIIGVPF
FIYLVRKDGTM

Specific function: Part of the ABC transporter complex fhuBGCD involved in iron(3+)-hydroxamate import. Responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790741, Length=283, Percent_Identity=33.9222614840989, Blast_Score=155, Evalue=4e-39,
Organism=Escherichia coli, GI1790740, Length=279, Percent_Identity=33.3333333333333, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1786347, Length=274, Percent_Identity=33.5766423357664, Blast_Score=137, Evalue=8e-34,
Organism=Escherichia coli, GI1786805, Length=303, Percent_Identity=32.3432343234323, Blast_Score=134, Evalue=6e-33,
Organism=Escherichia coli, GI1788004, Length=281, Percent_Identity=34.1637010676157, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1786804, Length=247, Percent_Identity=29.9595141700405, Blast_Score=114, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 35619; Mature: 35619

Theoretical pI: Translated: 9.95; Mature: 9.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
5.7 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
5.7 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRTYLFKNYFYSGLLLSMIFLVITLLLSFMLGSENYSLYEVVQAVLHYNNSEVHNIIRE
CCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHH
IRMPREVAAMLVGMSLACSGAVMQGITRNPLADPALIGLNAGALLFISIMFAIVPGANFM
HCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCHHHHHHHHHHHHHCCCHHH
MIMLSGFIGAIIGGTIVLMLGNSKRGGFNAMKIILAGAAVSTLMTALAQGVSIYFKTNQS
HHHHHHHHHHHHHHEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCC
NLLWSSGGVTGTTWQHIFYAAPVILITLLLLFIFSRQLTILSVGDEMAAGLGVNTSKTRV
CEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHCCCCCCHHHHH
LFSVLTMILAGVAVALVGSLAFVGLMVPHIARMLVGIDYRKLLPFTTILGGIFVVWADII
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
ARQTGEAPIGAIVSIIGVPFFIYLVRKDGTM
HHCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MNRTYLFKNYFYSGLLLSMIFLVITLLLSFMLGSENYSLYEVVQAVLHYNNSEVHNIIRE
CCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHH
IRMPREVAAMLVGMSLACSGAVMQGITRNPLADPALIGLNAGALLFISIMFAIVPGANFM
HCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCHHHHHHHHHHHHHCCCHHH
MIMLSGFIGAIIGGTIVLMLGNSKRGGFNAMKIILAGAAVSTLMTALAQGVSIYFKTNQS
HHHHHHHHHHHHHHEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCC
NLLWSSGGVTGTTWQHIFYAAPVILITLLLLFIFSRQLTILSVGDEMAAGLGVNTSKTRV
CEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHCCCCCCHHHHH
LFSVLTMILAGVAVALVGSLAFVGLMVPHIARMLVGIDYRKLLPFTTILGGIFVVWADII
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
ARQTGEAPIGAIVSIIGVPFFIYLVRKDGTM
HHCCCCCHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron dicitrate [Periplasm]; H2O [C]

Specific reaction: ATP + iron dicitrate [Periplasm] + H2O = ADP + phosphate + iron dicitrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377; 8388528 [H]