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The map label for this gene is lctP [H]

Identifier: 222150412

GI number: 222150412

Start: 166668

End: 168263

Strand: Direct

Name: lctP [H]

Synonym: MCCL_0162

Alternate gene names: 222150412

Gene position: 166668-168263 (Clockwise)

Preceding gene: 222150411

Following gene: 222150413

Centisome position: 7.93

GC content: 38.53

Gene sequence:

>1596_bases
ATGTTCGTCAGTTCGTTTGATCCATTTAGTAACTTAGCAATATCAGCTATCGTTGCAGCAGTACCGATTATTTTGTTTTT
ATTATGTTTAACCGCCTTTAAAATGAAGGGGATAAATGCAGCACTGATTACGCTTGTAGTTACAGCAATTATTGCTTTAT
TCGTTTTCAAATTACCAGGAGCAGTCGCTGTAGGTGGTGTAACTGAAGGTGTTGTACAAGGATTGTTCCCGATTGGTTAC
ATCATTATTATGGCAGTCTGGCTGTATAAAGTTTCAGTAGAAAGTGGTAAGTTTAAGGTCATCCAAGATTCTATTTCAGG
AATTTCACCTGATCAGCGCATTCAGTTATTGCTGATAGGATTTTGTTTTAATGCTTTTCTGGAAGGTGCAGCTGGGTTTG
GAGTACCAATCGCAATTTGTGCCGTGTTACTTGTACAACTTGGATTTAAGCCACTTCAAGCTGCGATGTTTTGTTTGATT
GCTAATGCCGCTTCTGGAGCTTTTGGAGCAATCGGCATCCCAGTAGGAATTGTAAATACACTAGGCTTAAAAGGTGGCGT
TACGGCAATGGATGTGTCACAGATGACCGTGTATACACTACCTATAACTAATATTGTTATTCCATTTGTGCTTGTATTTG
TATTAAATGGTATGAAAGGGATTAAAGAAACTTTACCGGCAATTTTAGTTTCAGGTTTAACTTATGCAGTTACACAAGTA
TTGATTACACTCTTTATGGGACCTGAACTCGCAGATATTATTCCGTCTTTACTTGCAATGGCAGCATTGGCGATATTCTG
TAACAAATGGCAGCCGAAGAATATATTCCGATTATCAGATGATCAAGTTGAAACAGTACATCATCCAATTAAGGAGATTA
TCTCAGCCTGGAGCCCGTTCATCTTCTTGACTGGACTAGTACTTTTATGGAGCTTACCTGCATTTAAAGCACTGTTTGCA
GAAGGTGGCATATTACAGAAATCGATTCTAACGTTCCAAATGCCAGGAACGTTCAATGAAACATTGCAAAAAGGTGTAAT
GCTGAAACTTGATCTAATTGGAGCGACAGGGACAGCAATCTTACTTGCAGTTCTGATTACGATCATCACTTCACCTAAAA
TCAATTTTGGTAAAGCATTTCAATTACTCGGTTTGACAATTAAAGAACTATGGATACCAGTTATCACAATTTGTGCAATT
TTAGCGATTGCGAAGTTAACAACTTATGGTGGTTTAACTGTAGCGATGGGTCAAGCCATTGCCAAAACAGGGTCAATATT
CCCGCTACTTTCACCTGTACTTGGTTGGATTGGGGTATTTATGACAGGCTCTGTTGTAAATAACAATGTTCTATTTGCTT
CTATCCAGGCAACAGCAGGTCATACGATTGGCACAAATCCAGCACTGCTTGTTGCAGCAAATACAGCAGGTGGTGTTATG
GCGAAGCTGATTTCTCCTCAATCTATAGCGATTGCTACTGCAGCTGTTGGTGAAGTTGGTCAAGAATCGAAGTTATTAAG
TATGACATTGAAATATAGTATTGCATTACTTGTATTTGTTTGTATTTGGACATTCGCACTTAGTTTAATACTCTAA

Upstream 100 bases:

>100_bases
GTAGTATTATAAAGCTGTGCTAAGAAATATTTAAATAAAATGCAACAGTTTATTTCATGATATTATGATTATTTTATATA
AAAGAAGAGGAGAATGTCTT

Downstream 100 bases:

>100_bases
TCAATTATTATTAAAGGAGAGATAAAGATGGAAAAATTTAAAGGCAATAAAGTAGTTCTTGTAGGTAATGGTGCAGTAGG
ATCTAGTTATGCATTTGCGA

Product: L-lactate permease 1

Products: Proton [Cytoplasm]; lactate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 531; Mature: 531

Protein sequence:

>531_residues
MFVSSFDPFSNLAISAIVAAVPIILFLLCLTAFKMKGINAALITLVVTAIIALFVFKLPGAVAVGGVTEGVVQGLFPIGY
IIIMAVWLYKVSVESGKFKVIQDSISGISPDQRIQLLLIGFCFNAFLEGAAGFGVPIAICAVLLVQLGFKPLQAAMFCLI
ANAASGAFGAIGIPVGIVNTLGLKGGVTAMDVSQMTVYTLPITNIVIPFVLVFVLNGMKGIKETLPAILVSGLTYAVTQV
LITLFMGPELADIIPSLLAMAALAIFCNKWQPKNIFRLSDDQVETVHHPIKEIISAWSPFIFLTGLVLLWSLPAFKALFA
EGGILQKSILTFQMPGTFNETLQKGVMLKLDLIGATGTAILLAVLITIITSPKINFGKAFQLLGLTIKELWIPVITICAI
LAIAKLTTYGGLTVAMGQAIAKTGSIFPLLSPVLGWIGVFMTGSVVNNNVLFASIQATAGHTIGTNPALLVAANTAGGVM
AKLISPQSIAIATAAVGEVGQESKLLSMTLKYSIALLVFVCIWTFALSLIL

Sequences:

>Translated_531_residues
MFVSSFDPFSNLAISAIVAAVPIILFLLCLTAFKMKGINAALITLVVTAIIALFVFKLPGAVAVGGVTEGVVQGLFPIGY
IIIMAVWLYKVSVESGKFKVIQDSISGISPDQRIQLLLIGFCFNAFLEGAAGFGVPIAICAVLLVQLGFKPLQAAMFCLI
ANAASGAFGAIGIPVGIVNTLGLKGGVTAMDVSQMTVYTLPITNIVIPFVLVFVLNGMKGIKETLPAILVSGLTYAVTQV
LITLFMGPELADIIPSLLAMAALAIFCNKWQPKNIFRLSDDQVETVHHPIKEIISAWSPFIFLTGLVLLWSLPAFKALFA
EGGILQKSILTFQMPGTFNETLQKGVMLKLDLIGATGTAILLAVLITIITSPKINFGKAFQLLGLTIKELWIPVITICAI
LAIAKLTTYGGLTVAMGQAIAKTGSIFPLLSPVLGWIGVFMTGSVVNNNVLFASIQATAGHTIGTNPALLVAANTAGGVM
AKLISPQSIAIATAAVGEVGQESKLLSMTLKYSIALLVFVCIWTFALSLIL
>Mature_531_residues
MFVSSFDPFSNLAISAIVAAVPIILFLLCLTAFKMKGINAALITLVVTAIIALFVFKLPGAVAVGGVTEGVVQGLFPIGY
IIIMAVWLYKVSVESGKFKVIQDSISGISPDQRIQLLLIGFCFNAFLEGAAGFGVPIAICAVLLVQLGFKPLQAAMFCLI
ANAASGAFGAIGIPVGIVNTLGLKGGVTAMDVSQMTVYTLPITNIVIPFVLVFVLNGMKGIKETLPAILVSGLTYAVTQV
LITLFMGPELADIIPSLLAMAALAIFCNKWQPKNIFRLSDDQVETVHHPIKEIISAWSPFIFLTGLVLLWSLPAFKALFA
EGGILQKSILTFQMPGTFNETLQKGVMLKLDLIGATGTAILLAVLITIITSPKINFGKAFQLLGLTIKELWIPVITICAI
LAIAKLTTYGGLTVAMGQAIAKTGSIFPLLSPVLGWIGVFMTGSVVNNNVLFASIQATAGHTIGTNPALLVAANTAGGVM
AKLISPQSIAIATAAVGEVGQESKLLSMTLKYSIALLVFVCIWTFALSLIL

Specific function: May play a role in L-lactate transport [H]

COG id: COG1620

COG function: function code C; L-lactate permease

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lactate permease family [H]

Homologues:

Organism=Escherichia coli, GI1790031, Length=539, Percent_Identity=45.4545454545455, Blast_Score=432, Evalue=1e-122,
Organism=Escherichia coli, GI1789347, Length=534, Percent_Identity=42.1348314606742, Blast_Score=391, Evalue=1e-110,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003804 [H]

Pfam domain/function: PF02652 Lactate_perm [H]

EC number: NA

Molecular weight: Translated: 55889; Mature: 55889

Theoretical pI: Translated: 9.03; Mature: 9.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFVSSFDPFSNLAISAIVAAVPIILFLLCLTAFKMKGINAALITLVVTAIIALFVFKLPG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCC
AVAVGGVTEGVVQGLFPIGYIIIMAVWLYKVSVESGKFKVIQDSISGISPDQRIQLLLIG
CEEECCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEEHHHHCCCCCCHHHHHHHHH
FCFNAFLEGAAGFGVPIAICAVLLVQLGFKPLQAAMFCLIANAASGAFGAIGIPVGIVNT
HHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
LGLKGGVTAMDVSQMTVYTLPITNIVIPFVLVFVLNGMKGIKETLPAILVSGLTYAVTQV
CCCCCCCCEEECCCEEEEECCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
LITLFMGPELADIIPSLLAMAALAIFCNKWQPKNIFRLSDDQVETVHHPIKEIISAWSPF
HHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCHHHHHHHHHHHHHHHHHCHH
IFLTGLVLLWSLPAFKALFAEGGILQKSILTFQMPGTFNETLQKGVMLKLDLIGATGTAI
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHEEEECCCCHHHHHHCCCEEEEEEECCCHHHH
LLAVLITIITSPKINFGKAFQLLGLTIKELWIPVITICAILAIAKLTTYGGLTVAMGQAI
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
AKTGSIFPLLSPVLGWIGVFMTGSVVNNNVLFASIQATAGHTIGTNPALLVAANTAGGVM
HHCCCHHHHHHHHHHHHHHHHCCCEECCCEEEEEEECCCCCCCCCCCEEEEEECCCCHHH
AKLISPQSIAIATAAVGEVGQESKLLSMTLKYSIALLVFVCIWTFALSLIL
HHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MFVSSFDPFSNLAISAIVAAVPIILFLLCLTAFKMKGINAALITLVVTAIIALFVFKLPG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCC
AVAVGGVTEGVVQGLFPIGYIIIMAVWLYKVSVESGKFKVIQDSISGISPDQRIQLLLIG
CEEECCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEEHHHHCCCCCCHHHHHHHHH
FCFNAFLEGAAGFGVPIAICAVLLVQLGFKPLQAAMFCLIANAASGAFGAIGIPVGIVNT
HHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
LGLKGGVTAMDVSQMTVYTLPITNIVIPFVLVFVLNGMKGIKETLPAILVSGLTYAVTQV
CCCCCCCCEEECCCEEEEECCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
LITLFMGPELADIIPSLLAMAALAIFCNKWQPKNIFRLSDDQVETVHHPIKEIISAWSPF
HHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCHHHHHHHHHHHHHHHHHCHH
IFLTGLVLLWSLPAFKALFAEGGILQKSILTFQMPGTFNETLQKGVMLKLDLIGATGTAI
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHEEEECCCCHHHHHHCCCEEEEEEECCCHHHH
LLAVLITIITSPKINFGKAFQLLGLTIKELWIPVITICAILAIAKLTTYGGLTVAMGQAI
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
AKTGSIFPLLSPVLGWIGVFMTGSVVNNNVLFASIQATAGHTIGTNPALLVAANTAGGVM
HHCCCHHHHHHHHHHHHHHHHCCCEECCCEEEEEEECCCCCCCCCCCEEEEEECCCCHHH
AKLISPQSIAIATAAVGEVGQESKLLSMTLKYSIALLVFVCIWTFALSLIL
HHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; lactate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + lactate [Periplasm] = Proton [Cytoplasm] + lactate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]