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The map label for this gene is ydgK [H]

Identifier: 222150409

GI number: 222150409

Start: 162341

End: 163522

Strand: Direct

Name: ydgK [H]

Synonym: MCCL_0159

Alternate gene names: 222150409

Gene position: 162341-163522 (Clockwise)

Preceding gene: 222150404

Following gene: 222150411

Centisome position: 7.72

GC content: 37.73

Gene sequence:

>1182_bases
ATGAAGAAAGATAATAAGCTCATACTCATATTAACATTAGGATTACTAGCAGCTTTTGGACCATTATCATTAGATATGTA
TTTGCCTGCTTTACCGCGTGTAGCAGATGATCTTAGCACAGGCGCTTCCTTTGCTCAGCTCAGTCTGACTGCTTGTATGA
TAGGTTTAGCGGTGGGTCAGATCATAGTAGGACCCATCAGTGATGTCATAGGGAGAAAGAAACCGTTGTTTATCGTACTT
ATTGGATATGCTTTATTTTCTTACTTTGCTGCGCGTGCAGCTACGATAGAATGGCTTATTTTATTTAGATTTATTCAAGG
ATTTTGTGGTGGTGCAGGAGCTGTACTGTCACGAGCGATATCGAGCGATTTATATAAAGGGAAAGATCTGACAAAGTTTT
TAGCAGTGCTGATGCTTGTTAATGGACTTGCACCTGTGATTGCTCCCGTACTTGGTGGCGTTATATTGAGCATATCTACA
TGGCATACTGTTTTTTATATTTTATCGGTTTATGGTGTAGTGATGGTACTCTTATCACTTACTTTAGAGGAGAGTTTACC
GAAACCTAGCAGAAATGAAGGCGCATTGAAATCAATTTGGAAGGACTTTAAATCATTGCTAACAAATAAAGCGTTTGTGA
CGATGTTGATGCTCCAATCATTAACATATGGTATATTGTTCAGCTATATTTCAGGGTCTCCATTTATTACCCAGAAAATA
TATGATATGAATGCACAGCAATTCAGTTATCTATTTGCATTGAATGGTATAGGTTTAATTGGATTCAGTCAGTTAACCGC
TAAACTTGTAAATAAAATGGATGAACTTAAGATATTGAAGCTAGGACAAAATATTCAGCTCGTTGGCGTGATACTTACAG
TGATAGTATTGTTATTCCATCTTCCGGTATGGATGCTGTGTACCGCGTTCTTCTTGATGATTACTCCAGTTAGTATGATA
GGGACGACTGGATTTTCTGTCGCAATGCAAGTGCAGAATCAAGGTGCTGGCAGTGCATCGGCAATATTAGGATTAATGCA
GTTTTTAATTGGTGGTATACTATCACCCCTTGTTGGTGTAATGGGGGAAAATTCGATTATTCCATTTATCGTTATCATTA
TTACATGTACCGTTCTTGCGCAAAGTATTAGAGCTATTTCGGTGAAGAACATTGAAATTTAA

Upstream 100 bases:

>100_bases
TTATATCTATATCTACCCTTTTTATGGATGACTAAACAAATGATATGCTTACTGGATGAAATCTAGTATAGTAATTAATA
TTAAACATTGGAGGAAGTAT

Downstream 100 bases:

>100_bases
TGCAATGATCGACAGTAGATTGAATTAAATTAATATGATAAAAAGCCTGAACGATTCTCGCACATTTATGCATCGTTCAG
GCTTTTAAATGAAATCAAGA

Product: hypothetical protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 393; Mature: 393

Protein sequence:

>393_residues
MKKDNKLILILTLGLLAAFGPLSLDMYLPALPRVADDLSTGASFAQLSLTACMIGLAVGQIIVGPISDVIGRKKPLFIVL
IGYALFSYFAARAATIEWLILFRFIQGFCGGAGAVLSRAISSDLYKGKDLTKFLAVLMLVNGLAPVIAPVLGGVILSIST
WHTVFYILSVYGVVMVLLSLTLEESLPKPSRNEGALKSIWKDFKSLLTNKAFVTMLMLQSLTYGILFSYISGSPFITQKI
YDMNAQQFSYLFALNGIGLIGFSQLTAKLVNKMDELKILKLGQNIQLVGVILTVIVLLFHLPVWMLCTAFFLMITPVSMI
GTTGFSVAMQVQNQGAGSASAILGLMQFLIGGILSPLVGVMGENSIIPFIVIIITCTVLAQSIRAISVKNIEI

Sequences:

>Translated_393_residues
MKKDNKLILILTLGLLAAFGPLSLDMYLPALPRVADDLSTGASFAQLSLTACMIGLAVGQIIVGPISDVIGRKKPLFIVL
IGYALFSYFAARAATIEWLILFRFIQGFCGGAGAVLSRAISSDLYKGKDLTKFLAVLMLVNGLAPVIAPVLGGVILSIST
WHTVFYILSVYGVVMVLLSLTLEESLPKPSRNEGALKSIWKDFKSLLTNKAFVTMLMLQSLTYGILFSYISGSPFITQKI
YDMNAQQFSYLFALNGIGLIGFSQLTAKLVNKMDELKILKLGQNIQLVGVILTVIVLLFHLPVWMLCTAFFLMITPVSMI
GTTGFSVAMQVQNQGAGSASAILGLMQFLIGGILSPLVGVMGENSIIPFIVIIITCTVLAQSIRAISVKNIEI
>Mature_393_residues
MKKDNKLILILTLGLLAAFGPLSLDMYLPALPRVADDLSTGASFAQLSLTACMIGLAVGQIIVGPISDVIGRKKPLFIVL
IGYALFSYFAARAATIEWLILFRFIQGFCGGAGAVLSRAISSDLYKGKDLTKFLAVLMLVNGLAPVIAPVLGGVILSIST
WHTVFYILSVYGVVMVLLSLTLEESLPKPSRNEGALKSIWKDFKSLLTNKAFVTMLMLQSLTYGILFSYISGSPFITQKI
YDMNAQQFSYLFALNGIGLIGFSQLTAKLVNKMDELKILKLGQNIQLVGVILTVIVLLFHLPVWMLCTAFFLMITPVSMI
GTTGFSVAMQVQNQGAGSASAILGLMQFLIGGILSPLVGVMGENSIIPFIVIIITCTVLAQSIRAISVKNIEI

Specific function: Involved In Sulfonamide (Sulfathiazole) And Bicyclomycin Resistance. Probable Membrane Translocase. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI1788509, Length=379, Percent_Identity=29.5514511873351, Blast_Score=183, Evalue=2e-47,
Organism=Escherichia coli, GI48994889, Length=241, Percent_Identity=31.5352697095436, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1790146, Length=376, Percent_Identity=27.1276595744681, Blast_Score=105, Evalue=7e-24,
Organism=Escherichia coli, GI1790794, Length=289, Percent_Identity=25.6055363321799, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1787065, Length=339, Percent_Identity=23.0088495575221, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI87082312, Length=221, Percent_Identity=25.7918552036199, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323000, Length=157, Percent_Identity=28.0254777070064, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 42375; Mature: 42375

Theoretical pI: Translated: 9.71; Mature: 9.71

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure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HCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 9202461 [H]