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The map label for this gene is moaA [H]

Identifier: 222150403

GI number: 222150403

Start: 155626

End: 156636

Strand: Direct

Name: moaA [H]

Synonym: MCCL_0153

Alternate gene names: 222150403

Gene position: 155626-156636 (Clockwise)

Preceding gene: 222150402

Following gene: 222150404

Centisome position: 7.4

GC content: 36.5

Gene sequence:

>1011_bases
ATGGAACAAATAACAGATAAATTAGGGCGCCCGATTAGAGATTTGCGTATTTCTGTAACAGATCGCTGTAACTTCCGTTG
TACATATTGCATGCCGAAAGAAATATTTGGCGATGACTATGTTTTTCTGCCGAAAGATGAACTGCTTTCCTTTGAAGAGT
TAACACGTATTGCAAAAGTATATGCACAGCTCGGTGTTAAGAAAGTAAGGATTACAGGTGGAGAACCGTTATTGCGTAGA
GATTTACCGGACTTGATACGGGAAATCCATGCGATAGAAGGTATAGAAGATATCGGTTTAACGACCAATGGTTTGTTGCT
GAAAAAACACGGACAAGCATTATACGATGCAGGTTTACGTCGCATAAATGTGAGTTTAGATGCCCTGGATGCAACATTTG
AAGCGGTCAATGGACGTGGTATAAAAGCAGAACAAATATTAGAACAAATTGATTACGCTGTTTCTATCGGTTTACAAGTT
AAAGTGAACATGGTCATACAAAAAGGTATGAATGACCACCAGATGATTCCGATGGTGAAGTATTTCAAAGATAAAAAAAT
AACATTGCGCTTTATTGAATTTATGGATGTCGGTAACGATAATGGCTGGAATTTTGATAAAGTTATTACAAAACAGGAAA
TGATAACGCATATTTCAGAGCATTTTAATATTAAACGTGAACAACCTAAATACTTTGGTGAAGTTGCGAAATATTATGTT
CATGATAATGGTGCGAAACTCGGATTTATTACTAGTGTTTCAGAATCATTTTGTTCATCGTGTACAAGAACACGCTTAAG
TTCAGATGGTAAACTGTTCGGTTGTTTATTTGCAACAGATGGCTATGACTTGAAAACATTCATTAGAAGTGGTGTGACAG
ATCAGGCGTTGAAAGAAAAGTTAATTGCGCTATGGTCTGTGCGTCAGGATCGTTATTCTGATGAACGTACTGTCGAAACT
GTGAGACAAAGAAAGAAAAATAAAATTAATATGAACTATATCGGCGGATAA

Upstream 100 bases:

>100_bases
GAGGCACAGTTTATTCCCGTTTCAGAAGTAAGCGACGAAAGCGAATGGTATGCTAATATTAATACAAAGAATGATTTACA
GAGCGTAAGGAGGGTGACAA

Downstream 100 bases:

>100_bases
AATTAATTATTTTAATATAGCAATTTTATTAGATATTAACTGCATTTAAGAATATATAAACTCGTATAACAATTTCAATA
TAGTATGTCATCATTTTTTT

Product: molybdenum cofactor biosynthesis protein MoaA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MEQITDKLGRPIRDLRISVTDRCNFRCTYCMPKEIFGDDYVFLPKDELLSFEELTRIAKVYAQLGVKKVRITGGEPLLRR
DLPDLIREIHAIEGIEDIGLTTNGLLLKKHGQALYDAGLRRINVSLDALDATFEAVNGRGIKAEQILEQIDYAVSIGLQV
KVNMVIQKGMNDHQMIPMVKYFKDKKITLRFIEFMDVGNDNGWNFDKVITKQEMITHISEHFNIKREQPKYFGEVAKYYV
HDNGAKLGFITSVSESFCSSCTRTRLSSDGKLFGCLFATDGYDLKTFIRSGVTDQALKEKLIALWSVRQDRYSDERTVET
VRQRKKNKINMNYIGG

Sequences:

>Translated_336_residues
MEQITDKLGRPIRDLRISVTDRCNFRCTYCMPKEIFGDDYVFLPKDELLSFEELTRIAKVYAQLGVKKVRITGGEPLLRR
DLPDLIREIHAIEGIEDIGLTTNGLLLKKHGQALYDAGLRRINVSLDALDATFEAVNGRGIKAEQILEQIDYAVSIGLQV
KVNMVIQKGMNDHQMIPMVKYFKDKKITLRFIEFMDVGNDNGWNFDKVITKQEMITHISEHFNIKREQPKYFGEVAKYYV
HDNGAKLGFITSVSESFCSSCTRTRLSSDGKLFGCLFATDGYDLKTFIRSGVTDQALKEKLIALWSVRQDRYSDERTVET
VRQRKKNKINMNYIGG
>Mature_336_residues
MEQITDKLGRPIRDLRISVTDRCNFRCTYCMPKEIFGDDYVFLPKDELLSFEELTRIAKVYAQLGVKKVRITGGEPLLRR
DLPDLIREIHAIEGIEDIGLTTNGLLLKKHGQALYDAGLRRINVSLDALDATFEAVNGRGIKAEQILEQIDYAVSIGLQV
KVNMVIQKGMNDHQMIPMVKYFKDKKITLRFIEFMDVGNDNGWNFDKVITKQEMITHISEHFNIKREQPKYFGEVAKYYV
HDNGAKLGFITSVSESFCSSCTRTRLSSDGKLFGCLFATDGYDLKTFIRSGVTDQALKEKLIALWSVRQDRYSDERTVET
VRQRKKNKINMNYIGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=337, Percent_Identity=34.1246290801187, Blast_Score=202, Evalue=3e-52,
Organism=Homo sapiens, GI22027536, Length=337, Percent_Identity=34.1246290801187, Blast_Score=202, Evalue=4e-52,
Organism=Escherichia coli, GI1786999, Length=336, Percent_Identity=34.2261904761905, Blast_Score=193, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI32566329, Length=324, Percent_Identity=35.1851851851852, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI32566331, Length=301, Percent_Identity=36.2126245847176, Blast_Score=194, Evalue=4e-50,
Organism=Caenorhabditis elegans, GI17561210, Length=324, Percent_Identity=34.8765432098765, Blast_Score=191, Evalue=5e-49,
Organism=Drosophila melanogaster, GI28574490, Length=314, Percent_Identity=34.7133757961783, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI28574488, Length=299, Percent_Identity=35.7859531772575, Blast_Score=194, Evalue=6e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 38517; Mature: 38517

Theoretical pI: Translated: 8.72; Mature: 8.72

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQITDKLGRPIRDLRISVTDRCNFRCTYCMPKEIFGDDYVFLPKDELLSFEELTRIAKV
CCCHHHHHCCCHHHEEEEEECCCCCEEEEECCHHHCCCCEEEECHHHHCCHHHHHHHHHH
YAQLGVKKVRITGGEPLLRRDLPDLIREIHAIEGIEDIGLTTNGLLLKKHGQALYDAGLR
HHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHCCHHHCCCCCCCEEEECCCCHHHHCCHH
RINVSLDALDATFEAVNGRGIKAEQILEQIDYAVSIGLQVKVNMVIQKGMNDHQMIPMVK
EEEEEHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEEEEHHHHCCCCCCHHHHHHH
YFKDKKITLRFIEFMDVGNDNGWNFDKVITKQEMITHISEHFNIKREQPKYFGEVAKYYV
HHCCCCCEEEEEEHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHE
HDNGAKLGFITSVSESFCSSCTRTRLSSDGKLFGCLFATDGYDLKTFIRSGVTDQALKEK
ECCCCEEEEEHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHCCCCHHHHHHH
LIALWSVRQDRYSDERTVETVRQRKKNKINMNYIGG
HHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEECCC
>Mature Secondary Structure
MEQITDKLGRPIRDLRISVTDRCNFRCTYCMPKEIFGDDYVFLPKDELLSFEELTRIAKV
CCCHHHHHCCCHHHEEEEEECCCCCEEEEECCHHHCCCCEEEECHHHHCCHHHHHHHHHH
YAQLGVKKVRITGGEPLLRRDLPDLIREIHAIEGIEDIGLTTNGLLLKKHGQALYDAGLR
HHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHCCHHHCCCCCCCEEEECCCCHHHHCCHH
RINVSLDALDATFEAVNGRGIKAEQILEQIDYAVSIGLQVKVNMVIQKGMNDHQMIPMVK
EEEEEHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEEEEHHHHCCCCCCHHHHHHH
YFKDKKITLRFIEFMDVGNDNGWNFDKVITKQEMITHISEHFNIKREQPKYFGEVAKYYV
HHCCCCCEEEEEEHHCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHE
HDNGAKLGFITSVSESFCSSCTRTRLSSDGKLFGCLFATDGYDLKTFIRSGVTDQALKEK
ECCCCEEEEEHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHCCCCHHHHHHH
LIALWSVRQDRYSDERTVETVRQRKKNKINMNYIGG
HHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA