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The map label for this gene is moeA [H]

Identifier: 222150398

GI number: 222150398

Start: 152651

End: 153895

Strand: Direct

Name: moeA [H]

Synonym: MCCL_0148

Alternate gene names: 222150398

Gene position: 152651-153895 (Clockwise)

Preceding gene: 222150396

Following gene: 222150399

Centisome position: 7.26

GC content: 40.88

Gene sequence:

>1245_bases
ATGCTTGAAAAACGTACACCAATTCCTGTAACAGAAGCGATAGATAAGTGTTTAGAACATGCTAAAAATAAATCAGTAAT
CAAGAAATATTATACAGATAGTTTAGGCTATACATTAGCTGAAGATATTATTGCAACATATGATATACCTATGTTTGACA
AGTCACCATATGACGGCTTTGCGATTGTAAGTGAAGCATCAGAAGGCGCAAGTGGTGATGATAGAAAATCGTTTAAAGTT
ATCGATCACATCGGCGCCGGACATGTAAGTGACGCACAACTAAAAGCCAACGAGGCAGTACGTATTATGACGGGCGCACC
AATTCCAGAAGGTGCTGATGCTGTCGTAATGCTTGAACAAACGACGCCAATAGAAGATGGATTTAGGCTTAGAAAAACCT
TTGCACCAGGTGAAAATATTTCAAGGCAGGGTGAAGAATGTAAGCGAGGTGAAGTTGTTATTCCGAAAGGAACGCAAATT
ACTGCAGGGGTAATCGCAGTACTGGCGACGTTTTCGTATGAGTACGTGAACGTTTATCGTAAGCCAACTGTTGCACTCAT
CGCTACTGGTTCAGAACTTGTGGAAATTAATGAACCACTTGCACCGGGGAAAATTAGAAATTCGAATGGACCGATGATTG
CATCACTTTGTAAAGCAATGGATGTTGAAGTGAAAGACTATCGTGTCCATGGTGACGACTTCGATGCGCTATACGAAGTC
GTCCGTAATGCACTGGATGCACACGACATCGTAATTACTACGGGCGGTGTGAGTGTTGGTGACTTCGATTTCATGCCTGA
AATTTATAATAAGCTTTCAGCAGAAGTATTATTCAACAAAATTGCGATGCGACCAGGTAGCGTAACAACTGTTGCAGTAA
GTGATGATAAATTTCTATTCGGATTATCCGGAAACCCAAGCGCTTGTTACACAGGGTTTGAGCTATATACGAAACCTGTA
CTGCGTAAAATGATGGGGCAAAGCGATGTATATCCAACAGTGATTAAAGCAACGCTTGCAGAAGACTTGGCGAAAGCAAA
TCCATTTACTAGGTTTATAAGAGCGGATTTAGATTACCGTAATATGATGGTAGCACCGAGTGGATTTAATAAGAGTAATG
CAGTAATTGCCATTGCCAAAAGTAACAGCATGATTGTTTTACCTGGAGGAACGAGAGGATTTAAACAAGGCGATACGGTA
GATGTCCTGTTAACAGATCTTTCTTGTCAGGATTCATCATGGTAA

Upstream 100 bases:

>100_bases
CACGCCCTTGTTCGTTAAAGTGTGTTAATTGATTCATCATTTCACTTCCTTTTTTATATACTATAACTATCATACTACAT
TTATAGAAAGTAGGATAACG

Downstream 100 bases:

>100_bases
AAGTATTGCAAGTCGTCGGATATAAAAAGTCTGGAAAAACAACGACGATGAATCGGATTATTAAGCAATTAAAAGCAATG
GATTATGAAGTATCTGTTAT

Product: molybdopterin biosynthesis protein MoeA

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MLEKRTPIPVTEAIDKCLEHAKNKSVIKKYYTDSLGYTLAEDIIATYDIPMFDKSPYDGFAIVSEASEGASGDDRKSFKV
IDHIGAGHVSDAQLKANEAVRIMTGAPIPEGADAVVMLEQTTPIEDGFRLRKTFAPGENISRQGEECKRGEVVIPKGTQI
TAGVIAVLATFSYEYVNVYRKPTVALIATGSELVEINEPLAPGKIRNSNGPMIASLCKAMDVEVKDYRVHGDDFDALYEV
VRNALDAHDIVITTGGVSVGDFDFMPEIYNKLSAEVLFNKIAMRPGSVTTVAVSDDKFLFGLSGNPSACYTGFELYTKPV
LRKMMGQSDVYPTVIKATLAEDLAKANPFTRFIRADLDYRNMMVAPSGFNKSNAVIAIAKSNSMIVLPGGTRGFKQGDTV
DVLLTDLSCQDSSW

Sequences:

>Translated_414_residues
MLEKRTPIPVTEAIDKCLEHAKNKSVIKKYYTDSLGYTLAEDIIATYDIPMFDKSPYDGFAIVSEASEGASGDDRKSFKV
IDHIGAGHVSDAQLKANEAVRIMTGAPIPEGADAVVMLEQTTPIEDGFRLRKTFAPGENISRQGEECKRGEVVIPKGTQI
TAGVIAVLATFSYEYVNVYRKPTVALIATGSELVEINEPLAPGKIRNSNGPMIASLCKAMDVEVKDYRVHGDDFDALYEV
VRNALDAHDIVITTGGVSVGDFDFMPEIYNKLSAEVLFNKIAMRPGSVTTVAVSDDKFLFGLSGNPSACYTGFELYTKPV
LRKMMGQSDVYPTVIKATLAEDLAKANPFTRFIRADLDYRNMMVAPSGFNKSNAVIAIAKSNSMIVLPGGTRGFKQGDTV
DVLLTDLSCQDSSW
>Mature_414_residues
MLEKRTPIPVTEAIDKCLEHAKNKSVIKKYYTDSLGYTLAEDIIATYDIPMFDKSPYDGFAIVSEASEGASGDDRKSFKV
IDHIGAGHVSDAQLKANEAVRIMTGAPIPEGADAVVMLEQTTPIEDGFRLRKTFAPGENISRQGEECKRGEVVIPKGTQI
TAGVIAVLATFSYEYVNVYRKPTVALIATGSELVEINEPLAPGKIRNSNGPMIASLCKAMDVEVKDYRVHGDDFDALYEV
VRNALDAHDIVITTGGVSVGDFDFMPEIYNKLSAEVLFNKIAMRPGSVTTVAVSDDKFLFGLSGNPSACYTGFELYTKPV
LRKMMGQSDVYPTVIKATLAEDLAKANPFTRFIRADLDYRNMMVAPSGFNKSNAVIAIAKSNSMIVLPGGTRGFKQGDTV
DVLLTDLSCQDSSW

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=394, Percent_Identity=33.248730964467, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI10880983, Length=394, Percent_Identity=33.248730964467, Blast_Score=194, Evalue=1e-49,
Organism=Escherichia coli, GI1787049, Length=358, Percent_Identity=33.5195530726257, Blast_Score=175, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI25147659, Length=336, Percent_Identity=30.952380952381, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17562606, Length=375, Percent_Identity=28, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI17136978, Length=359, Percent_Identity=28.133704735376, Blast_Score=122, Evalue=6e-28,
Organism=Drosophila melanogaster, GI24638841, Length=359, Percent_Identity=28.133704735376, Blast_Score=122, Evalue=6e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 45032; Mature: 45032

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEKRTPIPVTEAIDKCLEHAKNKSVIKKYYTDSLGYTLAEDIIATYDIPMFDKSPYDGF
CCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCE
AIVSEASEGASGDDRKSFKVIDHIGAGHVSDAQLKANEAVRIMTGAPIPEGADAVVMLEQ
EEEECCCCCCCCCCCCHHHHHHHCCCCCCCCCEECCCCEEEEEECCCCCCCCCEEEEEEC
TTPIEDGFRLRKTFAPGENISRQGEECKRGEVVIPKGTQITAGVIAVLATFSYEYVNVYR
CCCCCCCCEEEEECCCCCCCHHCCCHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHEEC
KPTVALIATGSELVEINEPLAPGKIRNSNGPMIASLCKAMDVEVKDYRVHGDDFDALYEV
CCEEEEEECCCEEEEECCCCCCCEEECCCCCHHHHHHHHHCCCEEEEEECCCCHHHHHHH
VRNALDAHDIVITTGGVSVGDFDFMPEIYNKLSAEVLFNKIAMRPGSVTTVAVSDDKFLF
HHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEE
GLSGNPSACYTGFELYTKPVLRKMMGQSDVYPTVIKATLAEDLAKANPFTRFIRADLDYR
EECCCCCCEECCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCC
NMMVAPSGFNKSNAVIAIAKSNSMIVLPGGTRGFKQGDTVDVLLTDLSCQDSSW
EEEEECCCCCCCCCEEEEEECCCEEEECCCCCCCCCCCEEEEEEEECCCCCCCC
>Mature Secondary Structure
MLEKRTPIPVTEAIDKCLEHAKNKSVIKKYYTDSLGYTLAEDIIATYDIPMFDKSPYDGF
CCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCE
AIVSEASEGASGDDRKSFKVIDHIGAGHVSDAQLKANEAVRIMTGAPIPEGADAVVMLEQ
EEEECCCCCCCCCCCCHHHHHHHCCCCCCCCCEECCCCEEEEEECCCCCCCCCEEEEEEC
TTPIEDGFRLRKTFAPGENISRQGEECKRGEVVIPKGTQITAGVIAVLATFSYEYVNVYR
CCCCCCCCEEEEECCCCCCCHHCCCHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHEEC
KPTVALIATGSELVEINEPLAPGKIRNSNGPMIASLCKAMDVEVKDYRVHGDDFDALYEV
CCEEEEEECCCEEEEECCCCCCCEEECCCCCHHHHHHHHHCCCEEEEEECCCCHHHHHHH
VRNALDAHDIVITTGGVSVGDFDFMPEIYNKLSAEVLFNKIAMRPGSVTTVAVSDDKFLF
HHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEE
GLSGNPSACYTGFELYTKPVLRKMMGQSDVYPTVIKATLAEDLAKANPFTRFIRADLDYR
EECCCCCCEECCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCC
NMMVAPSGFNKSNAVIAIAKSNSMIVLPGGTRGFKQGDTVDVLLTDLSCQDSSW
EEEEECCCCCCCCCEEEEEECCCEEEECCCCCCCCCCCEEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA