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The map label for this gene is moeB [H]

Identifier: 222150395

GI number: 222150395

Start: 150609

End: 151598

Strand: Direct

Name: moeB [H]

Synonym: MCCL_0145

Alternate gene names: 222150395

Gene position: 150609-151598 (Clockwise)

Preceding gene: 222150394

Following gene: 222150396

Centisome position: 7.16

GC content: 38.59

Gene sequence:

>990_bases
ATGCGATATGACAGACAAATAAAATTTTATGGTATCGGCCAGGAAGGTCAGGAGAAACTCTCTCGTAAGACTGTTGGTAT
TGTAGGATGTGGTGCATTAGGTACGCATCTTGCAGAATCCTTGGCAAGGTGCGGTGTAAGTAAAATTGTGGTTGTCGATC
GCGATTATGTTGAACTCTCAAATTTACAGCGACAATCACTTTTTAAGGAACAAGATGCGATTGATGCGACGCCTAAAGTG
ATTGCTTGTGAACGTGAAGTTAAAGCAATTCGAAGTGATATTCAAATTGAAACATATATCAATCATCTTGATGCGCCGCT
TTTAGAAGCGGCGTTTTTGCAATGTGATTGTATATTAGATGCAACAGATAACTTTGAAACGCGATTGTTAATTAACGATT
TCGCTTATAAATATAATATCCCATGGATTTATGGTGCATGTGTAGAATCAACTTACGTAGCATGCCCTTTTATTCCTGGT
GTAACGCCTTGCTTTAATTGTGTGATGGGTATGTTACCCGTAATGAATAGAACATGTGATACAGTAGGTATTATAGAACC
CGCTGTGAGTATGGCAACAAGCTTTCAGATGATGTACGCATTAAAACTGTTAACAGACACACCGTTCGATGCGAAATTAG
TATTCGGAGATGTATGGCAGATGGATCATACAGCACTGAAGTTTTCGCGAATGTTTAATGAAAGTTGTTCAACGTGCGCA
GCACATGCAACATATCCGGCACTTAGTCAGCAAACACATGAAACGATGTTATGTGGTAGAGATACAGTACAAATTGTGAC
AGCGTTCAGCGATGAAAATTTGTTGAAACATTTACAATCGTTGTCTATCATATTTCAGGAAACCCCTTACTTTATAAGGT
TTAATTTTGATAATCATCCGATTGTCTGGTTTAGAGGTGGTCGTATGCTTATTCATGAAGTTCAATCGATGGCGGAAGGC
AAGACAGTTTATCATCAACTATTTGGTTAG

Upstream 100 bases:

>100_bases
AATAAGCCAGCTTTTGCCTTCCTTTCAGTGTTTGGTATAATTGCATTAATAACAATGTTCTGGATGGACAAAAAAGAAGG
CAGAAATTAGGGGATGACAT

Downstream 100 bases:

>100_bases
GAGAGATAGTATTGGAACATTCAAATGACGTGCGTAAACAATTACTGGTTGGTGTGATTACAGTTAGTGATACGAGAGAT
TATGATACAGACAAAGGTGG

Product: molybdopterin biosynthesis protein MoeB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MRYDRQIKFYGIGQEGQEKLSRKTVGIVGCGALGTHLAESLARCGVSKIVVVDRDYVELSNLQRQSLFKEQDAIDATPKV
IACEREVKAIRSDIQIETYINHLDAPLLEAAFLQCDCILDATDNFETRLLINDFAYKYNIPWIYGACVESTYVACPFIPG
VTPCFNCVMGMLPVMNRTCDTVGIIEPAVSMATSFQMMYALKLLTDTPFDAKLVFGDVWQMDHTALKFSRMFNESCSTCA
AHATYPALSQQTHETMLCGRDTVQIVTAFSDENLLKHLQSLSIIFQETPYFIRFNFDNHPIVWFRGGRMLIHEVQSMAEG
KTVYHQLFG

Sequences:

>Translated_329_residues
MRYDRQIKFYGIGQEGQEKLSRKTVGIVGCGALGTHLAESLARCGVSKIVVVDRDYVELSNLQRQSLFKEQDAIDATPKV
IACEREVKAIRSDIQIETYINHLDAPLLEAAFLQCDCILDATDNFETRLLINDFAYKYNIPWIYGACVESTYVACPFIPG
VTPCFNCVMGMLPVMNRTCDTVGIIEPAVSMATSFQMMYALKLLTDTPFDAKLVFGDVWQMDHTALKFSRMFNESCSTCA
AHATYPALSQQTHETMLCGRDTVQIVTAFSDENLLKHLQSLSIIFQETPYFIRFNFDNHPIVWFRGGRMLIHEVQSMAEG
KTVYHQLFG
>Mature_329_residues
MRYDRQIKFYGIGQEGQEKLSRKTVGIVGCGALGTHLAESLARCGVSKIVVVDRDYVELSNLQRQSLFKEQDAIDATPKV
IACEREVKAIRSDIQIETYINHLDAPLLEAAFLQCDCILDATDNFETRLLINDFAYKYNIPWIYGACVESTYVACPFIPG
VTPCFNCVMGMLPVMNRTCDTVGIIEPAVSMATSFQMMYALKLLTDTPFDAKLVFGDVWQMDHTALKFSRMFNESCSTCA
AHATYPALSQQTHETMLCGRDTVQIVTAFSDENLLKHLQSLSIIFQETPYFIRFNFDNHPIVWFRGGRMLIHEVQSMAEG
KTVYHQLFG

Specific function: Catalyzes the adenylation by ATP of the carboxyl group of the C-terminal glycine of sulfur carrier protein ThiS [H]

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hesA/moeB/thiF family [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=173, Percent_Identity=30.635838150289, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI38045948, Length=171, Percent_Identity=32.1637426900585, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1787048, Length=244, Percent_Identity=32.3770491803279, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI87082356, Length=253, Percent_Identity=33.9920948616601, Blast_Score=105, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI17540406, Length=263, Percent_Identity=27.7566539923954, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6321903, Length=302, Percent_Identity=27.1523178807947, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320598, Length=163, Percent_Identity=28.8343558282209, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24582879, Length=264, Percent_Identity=25, Blast_Score=75, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR016040
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 37159; Mature: 37159

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
7.6 %Cys+Met (Translated Protein)
4.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
7.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYDRQIKFYGIGQEGQEKLSRKTVGIVGCGALGTHLAESLARCGVSKIVVVDRDYVELS
CCCCCEEEEEECCCHHHHHHHHHHCCEEECCHHHHHHHHHHHHCCCEEEEEEECCHHHHH
NLQRQSLFKEQDAIDATPKVIACEREVKAIRSDIQIETYINHLDAPLLEAAFLQCDCILD
HHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHEEEEE
ATDNFETRLLINDFAYKYNIPWIYGACVESTYVACPFIPGVTPCFNCVMGMLPVMNRTCD
CCCCCCEEEEEEEEEEEECCCEEEHHHHHCCEEECCCCCCCHHHHHHHHHHHHHHCCCCC
TVGIIEPAVSMATSFQMMYALKLLTDTPFDAKLVFGDVWQMDHTALKFSRMFNESCSTCA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHH
AHATYPALSQQTHETMLCGRDTVQIVTAFSDENLLKHLQSLSIIFQETPYFIRFNFDNHP
HHCCCCHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHEECCCEEEEEECCCCC
IVWFRGGRMLIHEVQSMAEGKTVYHQLFG
EEEEECCHHHHHHHHHHHCCHHHHHHHCC
>Mature Secondary Structure
MRYDRQIKFYGIGQEGQEKLSRKTVGIVGCGALGTHLAESLARCGVSKIVVVDRDYVELS
CCCCCEEEEEECCCHHHHHHHHHHCCEEECCHHHHHHHHHHHHCCCEEEEEEECCHHHHH
NLQRQSLFKEQDAIDATPKVIACEREVKAIRSDIQIETYINHLDAPLLEAAFLQCDCILD
HHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHEEEEE
ATDNFETRLLINDFAYKYNIPWIYGACVESTYVACPFIPGVTPCFNCVMGMLPVMNRTCD
CCCCCCEEEEEEEEEEEECCCEEEHHHHHCCEEECCCCCCCHHHHHHHHHHHHHHCCCCC
TVGIIEPAVSMATSFQMMYALKLLTDTPFDAKLVFGDVWQMDHTALKFSRMFNESCSTCA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHH
AHATYPALSQQTHETMLCGRDTVQIVTAFSDENLLKHLQSLSIIFQETPYFIRFNFDNHP
HHCCCCHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHEECCCEEEEEECCCCC
IVWFRGGRMLIHEVQSMAEGKTVYHQLFG
EEEEECCHHHHHHHHHHHCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]