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The map label for this gene is uvrA [H]

Identifier: 222150290

GI number: 222150290

Start: 43179

End: 45440

Strand: Direct

Name: uvrA [H]

Synonym: MCCL_0040

Alternate gene names: 222150290

Gene position: 43179-45440 (Clockwise)

Preceding gene: 222150289

Following gene: 222150292

Centisome position: 2.05

GC content: 34.66

Gene sequence:

>2262_bases
ATGAAACCAATCAAGATTATTGGAGCAAAGCAGAATAATTTAAAAGATATCTCACTGGAGATACCGAAACATCAGTTGAC
TGTCTTTACAGGGCGTTCGGGTTCTGGGAAGTCATCGCTAGTGTTTAATACGATTGCCGCGGAGAGTGAGCGGCTATTGA
ATGAAACATATAGTACTTATATACAGAATCAACTTAATCATTATGATAAACCTGTTGTCGACCGTATTGAGAATTTGCCT
GTATCAATGGTCATTGGACAAGATAGAATTGGTGGAAACTCAAGGTCGACGGTAGGAACAATTTCAGATATCTATTCTGG
TGTGAGATTATTGTGGTCACGTATTGGACAGCCATTTGTAGGATATTCTATGGATTTTTCTTTTAACAATACGAATGGCA
TGTGCAAAACATGTGATGGATTAGGCTATGTAGAAGATATTGACTTAAATGAGTTATTACATTTCGATCGTTCATTAAAT
GAAGATGCGATCAAATTCCCATCTTTTGCTCCAAATACGTGGCGTGGTAAACGGTATTTAAATACCGGATTATTTGACAA
TGATAAGAAATTGAAAGATTACTCTAAAGCAGAGATGGATACATTTTTGTATCAAGAACCTATCAAATTAAAGAATCCTC
CATCAAACTGGCCAAAGACGGCTAAATACGAAGGATTAATTTATCGATTTAGAAGGTCTTTCCTAATCAATGATACATAT
GAAAAGAAAAAATTTATTAAAGACGTGAATCGTATCGTTACAAAACAAGTATGTCCAGATTGCCATGGTCAACGTCTGAA
TGACAAGATATTAAGTTGTAAAATAGATGGATTAAATATTGCTGAATTTTGTAATCTAACAGTAGATGATGAGATTAAGT
TTTTGAATAAAATTAATGATGATAAAGCACAGTATATTATTGAATCTCTAGTCAAACAATTAGAAGCATTAAAACGAATT
GGCTTAGGTTATTTGACTTTAAGTCGAGAAACGACAACTTTATCAGGGGGAGAGTCTCAAAGGATTAAGTTGATTCGTCA
TTTAAATAGTCCGCTTACAGATTTAGTCTATATTATTGACGAACCAAGTGTTGGTCTACACCCTGAAGATATAGAAAATA
TTAATCAAATCATGCTTTCAATTCGAGATAAAGGTAATACAGTGCTTGTTGTTGAGCATGATCCTGATGTAATTAAGATT
GCTGATTATTGTGTTGATATAGGTCCGGGAAGTGGAAAGCATGGAGGAGAGATTATATTTACTGGGAAATATCACGAATT
ACTTAAGGGTAACAGTCCCACAGGTAAGGCGCTATCACAACCACATGTTTTTAAAAAGGAAGTGAGAGTACCAAATGATT
ATATAGCACTAAAAAACATTACGAAGAATAACTTGAAGGATGTATCGGTTAATATTCCTGAACATGTGTTAACTGCTGTA
ACAGGTGTTGCAGGATCAGGTAAAAGTACATTAATACAAACTGGCCTGAGTGAAAGAGAAGATGTAGTTTATATCGATCA
GAAACCTGTTCATGCGACGAATCGTTCAAATCTACTGACCTATCTTGATGTCTTTGATGATATTAGAGCATACTATAGCA
AAGAGACTGGTCTCAAAAAAGGGATGTTCAGCTACAACTCGGAAGGTGCATGTCCAAACTGCAATGGAAAAGGTGTAATA
AAAACGGAGCTTGCATTTATGTCTGACTTTGTTCAACAATGTGAAGTATGTCATGGTAAACGTTATCGATTAGAAGTGTT
AGAAGCAAAAATAAAAGGATACTCTATCGCAGACATACTTGAGCTCTCTGTAGAAGAAGCGATCGATTTCTTTCCGATAG
AAAGTGTTAATGAAGTGTTGAAGAGTGTAAAACGTACAGGGCTTGATTATATGACCTTAGGACAGTCATTAGATACTTTA
TCAGGTGGGGAAAGTCAGCGGGTTAAACTTAGCAGATATATCAACGAAGGTGTGAAAGATAAGATATTTATTTTTGATGA
ACCTACAACAGGTTTACATGAAGCAGATATAGATAATTTAAAACGCATCTTTGATTATTTAATTGATGAGGATAATACGG
TGATTGTGATAGAACATAATTTAACAATGATGACTTATGCAGATTGGATTATAGACATTGGACCTCGTGCAGGATTAAGT
GGAGGAAAAGTACTCTATAGTGGTGTTCCAGAAGAAATTATCCACAAAAAAACATCATTAACAGGAAAACATTTATTGAG
ATATGTTGATGATAGCAATTAA

Upstream 100 bases:

>100_bases
TTAGGTCATACTTTCTATTTATGCATAGTTCATCTAATGATTAAACATGCTTATAGTTAGAGTGAAATAGGGTATATTAA
CAGAAGTGAGGAGTGATTCA

Downstream 100 bases:

>100_bases
AGCATATTGCACATAGACAGTAGATTTAAAATATAAAAGAGGATATGGAACAATATAAAACAGGCATTGTATAAATAATA
CAATGCCTGTTTCTACATTT

Product: daunorubicin resistance protein

Products: NA

Alternate protein names: UvrA protein; Excinuclease ABC subunit A [H]

Number of amino acids: Translated: 753; Mature: 753

Protein sequence:

>753_residues
MKPIKIIGAKQNNLKDISLEIPKHQLTVFTGRSGSGKSSLVFNTIAAESERLLNETYSTYIQNQLNHYDKPVVDRIENLP
VSMVIGQDRIGGNSRSTVGTISDIYSGVRLLWSRIGQPFVGYSMDFSFNNTNGMCKTCDGLGYVEDIDLNELLHFDRSLN
EDAIKFPSFAPNTWRGKRYLNTGLFDNDKKLKDYSKAEMDTFLYQEPIKLKNPPSNWPKTAKYEGLIYRFRRSFLINDTY
EKKKFIKDVNRIVTKQVCPDCHGQRLNDKILSCKIDGLNIAEFCNLTVDDEIKFLNKINDDKAQYIIESLVKQLEALKRI
GLGYLTLSRETTTLSGGESQRIKLIRHLNSPLTDLVYIIDEPSVGLHPEDIENINQIMLSIRDKGNTVLVVEHDPDVIKI
ADYCVDIGPGSGKHGGEIIFTGKYHELLKGNSPTGKALSQPHVFKKEVRVPNDYIALKNITKNNLKDVSVNIPEHVLTAV
TGVAGSGKSTLIQTGLSEREDVVYIDQKPVHATNRSNLLTYLDVFDDIRAYYSKETGLKKGMFSYNSEGACPNCNGKGVI
KTELAFMSDFVQQCEVCHGKRYRLEVLEAKIKGYSIADILELSVEEAIDFFPIESVNEVLKSVKRTGLDYMTLGQSLDTL
SGGESQRVKLSRYINEGVKDKIFIFDEPTTGLHEADIDNLKRIFDYLIDEDNTVIVIEHNLTMMTYADWIIDIGPRAGLS
GGKVLYSGVPEEIIHKKTSLTGKHLLRYVDDSN

Sequences:

>Translated_753_residues
MKPIKIIGAKQNNLKDISLEIPKHQLTVFTGRSGSGKSSLVFNTIAAESERLLNETYSTYIQNQLNHYDKPVVDRIENLP
VSMVIGQDRIGGNSRSTVGTISDIYSGVRLLWSRIGQPFVGYSMDFSFNNTNGMCKTCDGLGYVEDIDLNELLHFDRSLN
EDAIKFPSFAPNTWRGKRYLNTGLFDNDKKLKDYSKAEMDTFLYQEPIKLKNPPSNWPKTAKYEGLIYRFRRSFLINDTY
EKKKFIKDVNRIVTKQVCPDCHGQRLNDKILSCKIDGLNIAEFCNLTVDDEIKFLNKINDDKAQYIIESLVKQLEALKRI
GLGYLTLSRETTTLSGGESQRIKLIRHLNSPLTDLVYIIDEPSVGLHPEDIENINQIMLSIRDKGNTVLVVEHDPDVIKI
ADYCVDIGPGSGKHGGEIIFTGKYHELLKGNSPTGKALSQPHVFKKEVRVPNDYIALKNITKNNLKDVSVNIPEHVLTAV
TGVAGSGKSTLIQTGLSEREDVVYIDQKPVHATNRSNLLTYLDVFDDIRAYYSKETGLKKGMFSYNSEGACPNCNGKGVI
KTELAFMSDFVQQCEVCHGKRYRLEVLEAKIKGYSIADILELSVEEAIDFFPIESVNEVLKSVKRTGLDYMTLGQSLDTL
SGGESQRVKLSRYINEGVKDKIFIFDEPTTGLHEADIDNLKRIFDYLIDEDNTVIVIEHNLTMMTYADWIIDIGPRAGLS
GGKVLYSGVPEEIIHKKTSLTGKHLLRYVDDSN
>Mature_753_residues
MKPIKIIGAKQNNLKDISLEIPKHQLTVFTGRSGSGKSSLVFNTIAAESERLLNETYSTYIQNQLNHYDKPVVDRIENLP
VSMVIGQDRIGGNSRSTVGTISDIYSGVRLLWSRIGQPFVGYSMDFSFNNTNGMCKTCDGLGYVEDIDLNELLHFDRSLN
EDAIKFPSFAPNTWRGKRYLNTGLFDNDKKLKDYSKAEMDTFLYQEPIKLKNPPSNWPKTAKYEGLIYRFRRSFLINDTY
EKKKFIKDVNRIVTKQVCPDCHGQRLNDKILSCKIDGLNIAEFCNLTVDDEIKFLNKINDDKAQYIIESLVKQLEALKRI
GLGYLTLSRETTTLSGGESQRIKLIRHLNSPLTDLVYIIDEPSVGLHPEDIENINQIMLSIRDKGNTVLVVEHDPDVIKI
ADYCVDIGPGSGKHGGEIIFTGKYHELLKGNSPTGKALSQPHVFKKEVRVPNDYIALKNITKNNLKDVSVNIPEHVLTAV
TGVAGSGKSTLIQTGLSEREDVVYIDQKPVHATNRSNLLTYLDVFDDIRAYYSKETGLKKGMFSYNSEGACPNCNGKGVI
KTELAFMSDFVQQCEVCHGKRYRLEVLEAKIKGYSIADILELSVEEAIDFFPIESVNEVLKSVKRTGLDYMTLGQSLDTL
SGGESQRVKLSRYINEGVKDKIFIFDEPTTGLHEADIDNLKRIFDYLIDEDNTVIVIEHNLTMMTYADWIIDIGPRAGLS
GGKVLYSGVPEEIIHKKTSLTGKHLLRYVDDSN

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion h

COG id: COG0178

COG function: function code L; Excinuclease ATPase subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ABC transporter domains [H]

Homologues:

Organism=Escherichia coli, GI2367343, Length=760, Percent_Identity=34.8684210526316, Blast_Score=390, Evalue=1e-109,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR013815
- InterPro:   IPR003593
- InterPro:   IPR004602 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 84769; Mature: 84769

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPIKIIGAKQNNLKDISLEIPKHQLTVFTGRSGSGKSSLVFNTIAAESERLLNETYSTY
CCCEEEEECCCCCCEEEEEECCCEEEEEEECCCCCCCCCEEEEHHHHHHHHHHHHHHHHH
IQNQLNHYDKPVVDRIENLPVSMVIGQDRIGGNSRSTVGTISDIYSGVRLLWSRIGQPFV
HHHHHHHCCCHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
GYSMDFSFNNTNGMCKTCDGLGYVEDIDLNELLHFDRSLNEDAIKFPSFAPNTWRGKRYL
CEEEEEEECCCCCCEECCCCCCCEECCCHHHHHHHHCCCCCCCEECCCCCCCCCCCCHHE
NTGLFDNDKKLKDYSKAEMDTFLYQEPIKLKNPPSNWPKTAKYEGLIYRFRRSFLINDTY
ECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHH
EKKKFIKDVNRIVTKQVCPDCHGQRLNDKILSCKIDGLNIAEFCNLTVDDEIKFLNKIND
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCHHHHHCCCCCHHHHHHHHCCC
DKAQYIIESLVKQLEALKRIGLGYLTLSRETTTLSGGESQRIKLIRHLNSPLTDLVYIID
HHHHHHHHHHHHHHHHHHHCCCCEEEECCCCEEECCCCHHHHHHHHHHCCCHHHEEEEEC
EPSVGLHPEDIENINQIMLSIRDKGNTVLVVEHDPDVIKIADYCVDIGPGSGKHGGEIIF
CCCCCCCHHHHHHHHHHHHHEECCCCEEEEEECCCCEEEEEHHHEECCCCCCCCCCEEEE
TGKYHELLKGNSPTGKALSQPHVFKKEVRVPNDYIALKNITKNNLKDVSVNIPEHVLTAV
ECCHHHHHCCCCCCCCCCCCCCHHHHHHCCCCCEEEEECCCCCCCCEEEECCHHHHHHHH
TGVAGSGKSTLIQTGLSEREDVVYIDQKPVHATNRSNLLTYLDVFDDIRAYYSKETGLKK
HCCCCCCCHHHHHCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHH
GMFSYNSEGACPNCNGKGVIKTELAFMSDFVQQCEVCHGKRYRLEVLEAKIKGYSIADIL
CCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHCCCCHHHHH
ELSVEEAIDFFPIESVNEVLKSVKRTGLDYMTLGQSLDTLSGGESQRVKLSRYINEGVKD
HHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHCCCHHHCCCCCCHHHHHHHHHCCCCCC
KIFIFDEPTTGLHEADIDNLKRIFDYLIDEDNTVIVIEHNLTMMTYADWIIDIGPRAGLS
EEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCEEEEEECHHEECCCCCCCC
GGKVLYSGVPEEIIHKKTSLTGKHLLRYVDDSN
CCEEEECCCCHHHHHHHHCCCHHHHHHHHCCCC
>Mature Secondary Structure
MKPIKIIGAKQNNLKDISLEIPKHQLTVFTGRSGSGKSSLVFNTIAAESERLLNETYSTY
CCCEEEEECCCCCCEEEEEECCCEEEEEEECCCCCCCCCEEEEHHHHHHHHHHHHHHHHH
IQNQLNHYDKPVVDRIENLPVSMVIGQDRIGGNSRSTVGTISDIYSGVRLLWSRIGQPFV
HHHHHHHCCCHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCC
GYSMDFSFNNTNGMCKTCDGLGYVEDIDLNELLHFDRSLNEDAIKFPSFAPNTWRGKRYL
CEEEEEEECCCCCCEECCCCCCCEECCCHHHHHHHHCCCCCCCEECCCCCCCCCCCCHHE
NTGLFDNDKKLKDYSKAEMDTFLYQEPIKLKNPPSNWPKTAKYEGLIYRFRRSFLINDTY
ECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHH
EKKKFIKDVNRIVTKQVCPDCHGQRLNDKILSCKIDGLNIAEFCNLTVDDEIKFLNKIND
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCHHHHHCCCCCHHHHHHHHCCC
DKAQYIIESLVKQLEALKRIGLGYLTLSRETTTLSGGESQRIKLIRHLNSPLTDLVYIID
HHHHHHHHHHHHHHHHHHHCCCCEEEECCCCEEECCCCHHHHHHHHHHCCCHHHEEEEEC
EPSVGLHPEDIENINQIMLSIRDKGNTVLVVEHDPDVIKIADYCVDIGPGSGKHGGEIIF
CCCCCCCHHHHHHHHHHHHHEECCCCEEEEEECCCCEEEEEHHHEECCCCCCCCCCEEEE
TGKYHELLKGNSPTGKALSQPHVFKKEVRVPNDYIALKNITKNNLKDVSVNIPEHVLTAV
ECCHHHHHCCCCCCCCCCCCCCHHHHHHCCCCCEEEEECCCCCCCCEEEECCHHHHHHHH
TGVAGSGKSTLIQTGLSEREDVVYIDQKPVHATNRSNLLTYLDVFDDIRAYYSKETGLKK
HCCCCCCCHHHHHCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHH
GMFSYNSEGACPNCNGKGVIKTELAFMSDFVQQCEVCHGKRYRLEVLEAKIKGYSIADIL
CCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHCCCCHHHHH
ELSVEEAIDFFPIESVNEVLKSVKRTGLDYMTLGQSLDTLSGGESQRVKLSRYINEGVKD
HHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHCCCHHHCCCCCCHHHHHHHHHCCCCCC
KIFIFDEPTTGLHEADIDNLKRIFDYLIDEDNTVIVIEHNLTMMTYADWIIDIGPRAGLS
EEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCEEEEEECHHEECCCCCCCC
GGKVLYSGVPEEIIHKKTSLTGKHLLRYVDDSN
CCEEEECCCCHHHHHHHHCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11792842 [H]