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The map label for this gene is glyA [H]

Identifier: 222111236

GI number: 222111236

Start: 2188545

End: 2189789

Strand: Direct

Name: glyA [H]

Synonym: Dtpsy_2044

Alternate gene names: 222111236

Gene position: 2188545-2189789 (Clockwise)

Preceding gene: 222111235

Following gene: 222111237

Centisome position: 57.65

GC content: 64.1

Gene sequence:

>1245_bases
ATGTACCAACGCAATATTCTTGTCGAACAAACCGATCCCGAGGTGTGGGCCGCCATCCAGGCCGAAGACCGCCGCCAGGA
AGAGCACATCGAGCTGATCGCCAGCGAGAACTACGCCTCGCCCGCCGTGATGGCCGCTCAGGGCTCGCAGCTCACCAACA
AGTACGCCGAAGGCTACCCTGGCAAGCGCTACTACGGCGGCTGCGAGAACGTGGACGTGATCGAGCAGTTGGCCATCGAC
CGCATCAAGCAACTCTTCGGCGCTGAAGCGGCCAATGTGCAGCCCAACTCGGGTTCGCAGGCCAACCAGGCTGTGCTGAT
GGCCTTCCTGAAGCCCGGCGACACCATTCTGGGCATGAGCCTGGCCGAGGGCGGCCACCTCACGCACGGCATGCCGCTGA
ACATGAGCGGCAAGTGGTTCAACGTAGTCTCCTACGGACTGAACGACAAGGAAGAGATCGACTACGACGCGCTGGAAGCC
AAGGCCCGCGAGCACAAGCCCAAGCTGATCATCGCCGGCGCCTCCGCCTACGCCCTGCGCATCGACTTCGAGCGCTTCGC
GAAGATCGCCAAGGAAGTCGGCGCCATCTTCTGGGTGGACATTGCCCACTATGCCGGCCTGGTCGTCGCGGGCGAGTACC
CCAACCCGGTGCCGTTTGCGGACGTGGTGACCTCCACCACGCACAAGAGCCTGCGCGGCCCGCGCGGCGGCATCATTCTG
ATGAAGGCGGAGCACGAGAAGGCCATCAACAGCGCCATCTTCCCCGGCCTGCAGGGCGGCCCGCTGGAGCACGTCATCGC
CGCCAAGGCCGTGGCCTTCAAGGAAGCCCTGTCGCCCGAGTTCAAGCAGTATCAGCAGCAGGTGACCAAGAACGCCAAGG
TGTTTGCGGAAACGCTGATCCAGCGCGGACTGCGCATCGTGAGCGGTCGCACCGAAAGCCACGTGATGCTGGTGGACCTT
CGCGCCAAGGGCATCACCGGCAAGGAGGCCGAGGCAGCCCTGGGCAAGGCCCATATCACGATCAACAAGAACGCGATCCC
CAACGATCCCGAAAAGCCGATGGTCACCAGCGGCATTCGCGTGGGCACGCCCGCCATCACGACACGGGGTTTCAAGGAAG
AGGAAACGCGCCTCACGGCCAACCTGGTGGCCGACGTGCTGGACAACCCGCATGACGAGGCGAACCTGGAAGCCGTGCGC
GCCAAGGTGCACGCGCTGACCAGCCGCTTCCCGGTCTATCGCTGA

Upstream 100 bases:

>100_bases
CTGGGGAGCGTGCCGCGCGGCAGGCACAAGCCCCGCAGCGATCCGTCGTTCGCCTGGGCAGCCCTTGATTGCCAAGGGAC
ACTTAGTTCATCGGACTGCC

Downstream 100 bases:

>100_bases
TCGACCGCTGCGATGAAGTGCCCCTTTTGCAGCCATCAGGAGACGCAGGTCGTCGAAACCCGCGTCTCCGAGGACGGGGA
CTTCATCCGCCGCAGGCGCC

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase [H]

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MYQRNILVEQTDPEVWAAIQAEDRRQEEHIELIASENYASPAVMAAQGSQLTNKYAEGYPGKRYYGGCENVDVIEQLAID
RIKQLFGAEAANVQPNSGSQANQAVLMAFLKPGDTILGMSLAEGGHLTHGMPLNMSGKWFNVVSYGLNDKEEIDYDALEA
KAREHKPKLIIAGASAYALRIDFERFAKIAKEVGAIFWVDIAHYAGLVVAGEYPNPVPFADVVTSTTHKSLRGPRGGIIL
MKAEHEKAINSAIFPGLQGGPLEHVIAAKAVAFKEALSPEFKQYQQQVTKNAKVFAETLIQRGLRIVSGRTESHVMLVDL
RAKGITGKEAEAALGKAHITINKNAIPNDPEKPMVTSGIRVGTPAITTRGFKEEETRLTANLVADVLDNPHDEANLEAVR
AKVHALTSRFPVYR

Sequences:

>Translated_414_residues
MYQRNILVEQTDPEVWAAIQAEDRRQEEHIELIASENYASPAVMAAQGSQLTNKYAEGYPGKRYYGGCENVDVIEQLAID
RIKQLFGAEAANVQPNSGSQANQAVLMAFLKPGDTILGMSLAEGGHLTHGMPLNMSGKWFNVVSYGLNDKEEIDYDALEA
KAREHKPKLIIAGASAYALRIDFERFAKIAKEVGAIFWVDIAHYAGLVVAGEYPNPVPFADVVTSTTHKSLRGPRGGIIL
MKAEHEKAINSAIFPGLQGGPLEHVIAAKAVAFKEALSPEFKQYQQQVTKNAKVFAETLIQRGLRIVSGRTESHVMLVDL
RAKGITGKEAEAALGKAHITINKNAIPNDPEKPMVTSGIRVGTPAITTRGFKEEETRLTANLVADVLDNPHDEANLEAVR
AKVHALTSRFPVYR
>Mature_414_residues
MYQRNILVEQTDPEVWAAIQAEDRRQEEHIELIASENYASPAVMAAQGSQLTNKYAEGYPGKRYYGGCENVDVIEQLAID
RIKQLFGAEAANVQPNSGSQANQAVLMAFLKPGDTILGMSLAEGGHLTHGMPLNMSGKWFNVVSYGLNDKEEIDYDALEA
KAREHKPKLIIAGASAYALRIDFERFAKIAKEVGAIFWVDIAHYAGLVVAGEYPNPVPFADVVTSTTHKSLRGPRGGIIL
MKAEHEKAINSAIFPGLQGGPLEHVIAAKAVAFKEALSPEFKQYQQQVTKNAKVFAETLIQRGLRIVSGRTESHVMLVDL
RAKGITGKEAEAALGKAHITINKNAIPNDPEKPMVTSGIRVGTPAITTRGFKEEETRLTANLVADVLDNPHDEANLEAVR
AKVHALTSRFPVYR

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI19923315, Length=401, Percent_Identity=45.8852867830424, Blast_Score=340, Evalue=2e-93,
Organism=Homo sapiens, GI261862352, Length=401, Percent_Identity=45.8852867830424, Blast_Score=339, Evalue=2e-93,
Organism=Homo sapiens, GI261862350, Length=401, Percent_Identity=45.8852867830424, Blast_Score=339, Evalue=2e-93,
Organism=Homo sapiens, GI261862348, Length=401, Percent_Identity=45.8852867830424, Blast_Score=339, Evalue=2e-93,
Organism=Homo sapiens, GI261862346, Length=400, Percent_Identity=45, Blast_Score=330, Evalue=2e-90,
Organism=Homo sapiens, GI22547186, Length=401, Percent_Identity=44.6384039900249, Blast_Score=310, Evalue=1e-84,
Organism=Homo sapiens, GI22547189, Length=386, Percent_Identity=42.4870466321244, Blast_Score=275, Evalue=5e-74,
Organism=Escherichia coli, GI1788902, Length=416, Percent_Identity=62.9807692307692, Blast_Score=527, Evalue=1e-151,
Organism=Caenorhabditis elegans, GI25144732, Length=406, Percent_Identity=46.3054187192118, Blast_Score=347, Evalue=8e-96,
Organism=Caenorhabditis elegans, GI25144729, Length=406, Percent_Identity=46.3054187192118, Blast_Score=346, Evalue=1e-95,
Organism=Saccharomyces cerevisiae, GI6319739, Length=415, Percent_Identity=42.8915662650602, Blast_Score=336, Evalue=5e-93,
Organism=Saccharomyces cerevisiae, GI6323087, Length=426, Percent_Identity=42.4882629107981, Blast_Score=326, Evalue=3e-90,
Organism=Drosophila melanogaster, GI24640005, Length=390, Percent_Identity=46.6666666666667, Blast_Score=347, Evalue=1e-95,
Organism=Drosophila melanogaster, GI221329721, Length=390, Percent_Identity=46.6666666666667, Blast_Score=345, Evalue=2e-95,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 45233; Mature: 45233

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYQRNILVEQTDPEVWAAIQAEDRRQEEHIELIASENYASPAVMAAQGSQLTNKYAEGYP
CCCCCEEEECCCCCCEEEECCHHHHHHHHHEEEECCCCCCCEEEECCCCHHHHHHHCCCC
GKRYYGGCENVDVIEQLAIDRIKQLFGAEAANVQPNSGSQANQAVLMAFLKPGDTILGMS
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHEEEEECCCCEEEEEE
LAEGGHLTHGMPLNMSGKWFNVVSYGLNDKEEIDYDALEAKAREHKPKLIIAGASAYALR
ECCCCCCCCCCCCCCCCCEEEEEEECCCCHHHCCHHHHHHHHHHCCCCEEEECCCEEEEE
IDFERFAKIAKEVGAIFWVDIAHYAGLVVAGEYPNPVPFADVVTSTTHKSLRGPRGGIIL
ECHHHHHHHHHHHCCEEEEEHHHHCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCEEE
MKAEHEKAINSAIFPGLQGGPLEHVIAAKAVAFKEALSPEFKQYQQQVTKNAKVFAETLI
EECCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
QRGLRIVSGRTESHVMLVDLRAKGITGKEAEAALGKAHITINKNAIPNDPEKPMVTSGIR
HCCCEEECCCCCCEEEEEEEECCCCCCCHHHHHHCEEEEEECCCCCCCCCCCCCEECCEE
VGTPAITTRGFKEEETRLTANLVADVLDNPHDEANLEAVRAKVHALTSRFPVYR
ECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MYQRNILVEQTDPEVWAAIQAEDRRQEEHIELIASENYASPAVMAAQGSQLTNKYAEGYP
CCCCCEEEECCCCCCEEEECCHHHHHHHHHEEEECCCCCCCEEEECCCCHHHHHHHCCCC
GKRYYGGCENVDVIEQLAIDRIKQLFGAEAANVQPNSGSQANQAVLMAFLKPGDTILGMS
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHEEEEECCCCEEEEEE
LAEGGHLTHGMPLNMSGKWFNVVSYGLNDKEEIDYDALEAKAREHKPKLIIAGASAYALR
ECCCCCCCCCCCCCCCCCEEEEEEECCCCHHHCCHHHHHHHHHHCCCCEEEECCCEEEEE
IDFERFAKIAKEVGAIFWVDIAHYAGLVVAGEYPNPVPFADVVTSTTHKSLRGPRGGIIL
ECHHHHHHHHHHHCCEEEEEHHHHCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCEEE
MKAEHEKAINSAIFPGLQGGPLEHVIAAKAVAFKEALSPEFKQYQQQVTKNAKVFAETLI
EECCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
QRGLRIVSGRTESHVMLVDLRAKGITGKEAEAALGKAHITINKNAIPNDPEKPMVTSGIR
HCCCEEECCCCCCEEEEEEEECCCCCCCHHHHHHCEEEEEECCCCCCCCCCCCCEECCEE
VGTPAITTRGFKEEETRLTANLVADVLDNPHDEANLEAVRAKVHALTSRFPVYR
ECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA