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The map label for this gene is hppA [H]

Identifier: 222111157

GI number: 222111157

Start: 2101239

End: 2103323

Strand: Direct

Name: hppA [H]

Synonym: Dtpsy_1965

Alternate gene names: 222111157

Gene position: 2101239-2103323 (Clockwise)

Preceding gene: 222111154

Following gene: 222111158

Centisome position: 55.35

GC content: 68.82

Gene sequence:

>2085_bases
ATGGCTGGTTCCACCTCGGCGCTGACTGCCCCTCTCATCCTGGCTCTGGTTTGCGGACTGATTGCTGTGGCCTACGGACT
GTGGGCACGCAGCTGGATCCTTTCCAAGGACGCGGGCAACGCCCGCATGCAGGAGATCGCCGGCGCCATCCAGATGGGCG
CGGCGGCCTACCTCGCACGGCAATACAAGACCATCGCCTTCGTCGGCATCGTGCTGGCCATCCTCATTGCGGCGTTCTTG
GACGGCACCACCGCCGTGGGCTTCGTCATCGGCGCGGTACTCTCCGGCGCCTGCGGCTTCATCGGCATGAACGTCTCGGT
GCGCGCCAACGTGCGCACGGCCCAGGCCGCCACGCAGGGCATGGGCCCGGCGCTGCAGGTTGCCTTCCGCGGCGGGGCCA
TCACGGGCATGCTGGTGGTGGGCCTGGGCCTGCTGGGCGTGACCGCCTTCGCGTGGTTCTTGGTTGGCAATGGCCGGCTC
ACCCCCACGGCCAGCCTGCCGGCGCTGCTCAACCCGCTGATCGGCTTTGCGTTCGGCTCGTCGCTGATTTCCATCTTTGC
CCGCTTGGGCGGGGGCATCTTCACCAAGGGTGCCGACGTGGGCGCGGACCTGGTCGGCAAGGTGGAGGCCGGCATCCCCG
AGGACGACCCCCGCAACCCCGCCGTGATCGCCGACAACGTGGGCGACAACGTCGGCGACTGCGCCGGTATGGCGGCCGAC
CTGTTCGAGACCTATGCCGTCACCCTCATCGCCACCATGGTGCTGGGCGCACTGCTGGTGGGTGCTGCGCCCGTCGCGGC
CGTGACCTACCCACTGGCGCTGGGGGCCGTCTCCATCATCGCCTCCATCATCGGCTGCTTCTTCGTGCAGGCCGGCCCGG
GCATGCGCAACGTGATGCCCGCGCTGTACCGGGGGCTGGCCATCGCGGGCGTGTTGTCGCTCGTCGCCTTCTGGTTCGTC
ACGGCCTGGGTCATCCCCGACAACGCGCTGGGCGGCACGGGCGCGCAGATGCGGCTGTTCGGCGCCTGCGCCACCGGCCT
GGTGCTGACGGCGGCGCTGGTGTGGATCACGGAGTTCTACACCGGCACGCAATATTCGCCCGTGCGCCACATCGCGCAGG
CGTCCACCACGGGCCACGGCACCAACATCATTGCGGGTCTGGGCGTATCCATGCGCTCCACGGCCTGGCCGGTGATCTTC
GTGTGCGCGGCCATCATCGTGTCGTACACGCTGGCGGGCCTGTACGGCGTGGCCGTGGCCGCCATGTCCATGCTCAGCAT
GGCGGGCATCGTGGTGGCGCTGGACGCCTACGGCCCCATCACCGACAACGCCGGCGGCATTGCCGAGATGGCCGAGCTGC
CCAGCAGCGTGCGCGACATCACCGACCCGCTGGACGCCGTGGGCAACACCACCAAGGCCGTGACCAAGGGCTACGCCATC
GGCTCGGCGGGCCTGGCAGCACTGGTGCTGTTCGCCGACTACACGCACAAGCTGGAGAGCTTCGGCCAGGCGATCCGCTT
CGACCTGAGCGACCCGATGGTCATCGTGGGCCTGTTCATCGGCGGGCTCATTCCCTACCTGTTCGGCGCCATGGCCATGG
AGGCCGTGGGCCGCGCCGCCGGCAGCGTGGTGGTGGAGGTGCGCCGCCAGTTCAGCGAGATCGCCGGCATCATGGAAGGC
ACGGCCAAGCCCGAGTACGGCCGCGCGGTGGACATGCTGACCAGCGCCGCCATCAAGGAGATGATCATTCCCAGCCTGCT
CCCCGTGGCAGTGCCCATCATCGTGGGCCTGGCGCTGGGGCCGAAGGCGCTGGGCGGGCTGCTCATGGGCACCATCGTCA
CGGGCCTGTTCGTGGCCATCAGCATGTGCACCGGCGGCGGCGCCTGGGACAACGCCAAAAAGTTCATCGAGGACGGCCAC
CACGGCGGCAAGGGCAGCGACGCGCACAAGGCCGCCGTCACCGGCGACACCGTGGGAGACCCCTACAAGGACACGGCCGG
CCCGGCGGTCAACCCGCTCATCAAGATCATCAATATCGTGGCGCTGCTCATCGTGCCGCTGGTGGTGAAGTTCCACGCCG
GCTGA

Upstream 100 bases:

>100_bases
CGTCTCCGCCACCGGGGCACGAGGAAGCAACGCAGCGGAAGCACTTCCCCATGCGTTGCGCTTCCCCCTCCGTGCAACTG
ACAACCGATGGAGATAACGA

Downstream 100 bases:

>100_bases
CCCGGCACTATCAAAAAAGAAGCTGCCAGCGCCCGTCCCTTGGGCGCTGGACGGCATTCCGGCTCGTAGCCCAGCACGCT
GCGCGCGCCTGCCGCACAAT

Product: membrane-bound proton-translocating pyrophosphatase

Products: NA

Alternate protein names: Membrane-bound proton-translocating pyrophosphatase; Pyrophosphate-energized inorganic pyrophosphatase; H(+)-PPase [H]

Number of amino acids: Translated: 694; Mature: 693

Protein sequence:

>694_residues
MAGSTSALTAPLILALVCGLIAVAYGLWARSWILSKDAGNARMQEIAGAIQMGAAAYLARQYKTIAFVGIVLAILIAAFL
DGTTAVGFVIGAVLSGACGFIGMNVSVRANVRTAQAATQGMGPALQVAFRGGAITGMLVVGLGLLGVTAFAWFLVGNGRL
TPTASLPALLNPLIGFAFGSSLISIFARLGGGIFTKGADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDCAGMAAD
LFETYAVTLIATMVLGALLVGAAPVAAVTYPLALGAVSIIASIIGCFFVQAGPGMRNVMPALYRGLAIAGVLSLVAFWFV
TAWVIPDNALGGTGAQMRLFGACATGLVLTAALVWITEFYTGTQYSPVRHIAQASTTGHGTNIIAGLGVSMRSTAWPVIF
VCAAIIVSYTLAGLYGVAVAAMSMLSMAGIVVALDAYGPITDNAGGIAEMAELPSSVRDITDPLDAVGNTTKAVTKGYAI
GSAGLAALVLFADYTHKLESFGQAIRFDLSDPMVIVGLFIGGLIPYLFGAMAMEAVGRAAGSVVVEVRRQFSEIAGIMEG
TAKPEYGRAVDMLTSAAIKEMIIPSLLPVAVPIIVGLALGPKALGGLLMGTIVTGLFVAISMCTGGGAWDNAKKFIEDGH
HGGKGSDAHKAAVTGDTVGDPYKDTAGPAVNPLIKIINIVALLIVPLVVKFHAG

Sequences:

>Translated_694_residues
MAGSTSALTAPLILALVCGLIAVAYGLWARSWILSKDAGNARMQEIAGAIQMGAAAYLARQYKTIAFVGIVLAILIAAFL
DGTTAVGFVIGAVLSGACGFIGMNVSVRANVRTAQAATQGMGPALQVAFRGGAITGMLVVGLGLLGVTAFAWFLVGNGRL
TPTASLPALLNPLIGFAFGSSLISIFARLGGGIFTKGADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDCAGMAAD
LFETYAVTLIATMVLGALLVGAAPVAAVTYPLALGAVSIIASIIGCFFVQAGPGMRNVMPALYRGLAIAGVLSLVAFWFV
TAWVIPDNALGGTGAQMRLFGACATGLVLTAALVWITEFYTGTQYSPVRHIAQASTTGHGTNIIAGLGVSMRSTAWPVIF
VCAAIIVSYTLAGLYGVAVAAMSMLSMAGIVVALDAYGPITDNAGGIAEMAELPSSVRDITDPLDAVGNTTKAVTKGYAI
GSAGLAALVLFADYTHKLESFGQAIRFDLSDPMVIVGLFIGGLIPYLFGAMAMEAVGRAAGSVVVEVRRQFSEIAGIMEG
TAKPEYGRAVDMLTSAAIKEMIIPSLLPVAVPIIVGLALGPKALGGLLMGTIVTGLFVAISMCTGGGAWDNAKKFIEDGH
HGGKGSDAHKAAVTGDTVGDPYKDTAGPAVNPLIKIINIVALLIVPLVVKFHAG
>Mature_693_residues
AGSTSALTAPLILALVCGLIAVAYGLWARSWILSKDAGNARMQEIAGAIQMGAAAYLARQYKTIAFVGIVLAILIAAFLD
GTTAVGFVIGAVLSGACGFIGMNVSVRANVRTAQAATQGMGPALQVAFRGGAITGMLVVGLGLLGVTAFAWFLVGNGRLT
PTASLPALLNPLIGFAFGSSLISIFARLGGGIFTKGADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDCAGMAADL
FETYAVTLIATMVLGALLVGAAPVAAVTYPLALGAVSIIASIIGCFFVQAGPGMRNVMPALYRGLAIAGVLSLVAFWFVT
AWVIPDNALGGTGAQMRLFGACATGLVLTAALVWITEFYTGTQYSPVRHIAQASTTGHGTNIIAGLGVSMRSTAWPVIFV
CAAIIVSYTLAGLYGVAVAAMSMLSMAGIVVALDAYGPITDNAGGIAEMAELPSSVRDITDPLDAVGNTTKAVTKGYAIG
SAGLAALVLFADYTHKLESFGQAIRFDLSDPMVIVGLFIGGLIPYLFGAMAMEAVGRAAGSVVVEVRRQFSEIAGIMEGT
AKPEYGRAVDMLTSAAIKEMIIPSLLPVAVPIIVGLALGPKALGGLLMGTIVTGLFVAISMCTGGGAWDNAKKFIEDGHH
GGKGSDAHKAAVTGDTVGDPYKDTAGPAVNPLIKIINIVALLIVPLVVKFHAG

Specific function: Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force [H]

COG id: COG3808

COG function: function code C; Inorganic pyrophosphatase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004131 [H]

Pfam domain/function: PF03030 H_PPase [H]

EC number: =3.6.1.1 [H]

Molecular weight: Translated: 70523; Mature: 70392

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGSTSALTAPLILALVCGLIAVAYGLWARSWILSKDAGNARMQEIAGAIQMGAAAYLAR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
QYKTIAFVGIVLAILIAAFLDGTTAVGFVIGAVLSGACGFIGMNVSVRANVRTAQAATQG
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHEECCEEEEECCHHHHHHHHC
MGPALQVAFRGGAITGMLVVGLGLLGVTAFAWFLVGNGRLTPTASLPALLNPLIGFAFGS
CCHHHEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
SLISIFARLGGGIFTKGADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDCAGMAAD
HHHHHHHHHCCCEEECCCCCCHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHH
LFETYAVTLIATMVLGALLVGAAPVAAVTYPLALGAVSIIASIIGCFFVQAGPGMRNVMP
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
ALYRGLAIAGVLSLVAFWFVTAWVIPDNALGGTGAQMRLFGACATGLVLTAALVWITEFY
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
TGTQYSPVRHIAQASTTGHGTNIIAGLGVSMRSTAWPVIFVCAAIIVSYTLAGLYGVAVA
CCCCCHHHHHHHHHCCCCCCCCHHEECCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHH
AMSMLSMAGIVVALDAYGPITDNAGGIAEMAELPSSVRDITDPLDAVGNTTKAVTKGYAI
HHHHHHHHHHHEEEECCCCCCCCCCCHHHHHHCHHHHHHHHHHHHHHCCCHHHHHHCCCC
GSAGLAALVLFADYTHKLESFGQAIRFDLSDPMVIVGLFIGGLIPYLFGAMAMEAVGRAA
CHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GSVVVEVRRQFSEIAGIMEGTAKPEYGRAVDMLTSAAIKEMIIPSLLPVAVPIIVGLALG
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PKALGGLLMGTIVTGLFVAISMCTGGGAWDNAKKFIEDGHHGGKGSDAHKAAVTGDTVGD
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCCEECCCCCCC
PYKDTAGPAVNPLIKIINIVALLIVPLVVKFHAG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AGSTSALTAPLILALVCGLIAVAYGLWARSWILSKDAGNARMQEIAGAIQMGAAAYLAR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
QYKTIAFVGIVLAILIAAFLDGTTAVGFVIGAVLSGACGFIGMNVSVRANVRTAQAATQG
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHEECCEEEEECCHHHHHHHHC
MGPALQVAFRGGAITGMLVVGLGLLGVTAFAWFLVGNGRLTPTASLPALLNPLIGFAFGS
CCHHHEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
SLISIFARLGGGIFTKGADVGADLVGKVEAGIPEDDPRNPAVIADNVGDNVGDCAGMAAD
HHHHHHHHHCCCEEECCCCCCHHHHHHHHCCCCCCCCCCCEEEECCCCCCHHHHHHHHHH
LFETYAVTLIATMVLGALLVGAAPVAAVTYPLALGAVSIIASIIGCFFVQAGPGMRNVMP
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
ALYRGLAIAGVLSLVAFWFVTAWVIPDNALGGTGAQMRLFGACATGLVLTAALVWITEFY
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
TGTQYSPVRHIAQASTTGHGTNIIAGLGVSMRSTAWPVIFVCAAIIVSYTLAGLYGVAVA
CCCCCHHHHHHHHHCCCCCCCCHHEECCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHH
AMSMLSMAGIVVALDAYGPITDNAGGIAEMAELPSSVRDITDPLDAVGNTTKAVTKGYAI
HHHHHHHHHHHEEEECCCCCCCCCCCHHHHHHCHHHHHHHHHHHHHHCCCHHHHHHCCCC
GSAGLAALVLFADYTHKLESFGQAIRFDLSDPMVIVGLFIGGLIPYLFGAMAMEAVGRAA
CHHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GSVVVEVRRQFSEIAGIMEGTAKPEYGRAVDMLTSAAIKEMIIPSLLPVAVPIIVGLALG
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PKALGGLLMGTIVTGLFVAISMCTGGGAWDNAKKFIEDGHHGGKGSDAHKAAVTGDTVGD
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCCEECCCCCCC
PYKDTAGPAVNPLIKIINIVALLIVPLVVKFHAG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA