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The map label for this gene is pgm [H]

Identifier: 222111023

GI number: 222111023

Start: 1947399

End: 1948787

Strand: Direct

Name: pgm [H]

Synonym: Dtpsy_1830

Alternate gene names: 222111023

Gene position: 1947399-1948787 (Clockwise)

Preceding gene: 222111018

Following gene: 222111024

Centisome position: 51.29

GC content: 68.47

Gene sequence:

>1389_bases
GTGCAGCTTTCTCCCGCGATCTTCAAGGCCTACGACATCCGCGGCATCGTGCCCAGCACGCTCAACGACGACGTGGCCCG
CGCCCTCGGCCGGGCCTTTGGCACCGCCGCACTCGCGCAAGGCGAGCGTACGGTGGCTGTGGGACGCGACGGGCGCCTGT
CGGGCCCCGCGCTCTCGGCCGCGCTGATCCAGGGCCTGGTGGACGCGGGCGTCGAGGTCATCGACATCGGCATGAGCACC
ACGCCCCTGCTGTACTTCGCGGCCAGCACGCTGTGCGCCAGCGGCATCCAGGTCACGGGCAGCCACAACCCCAAGGACTA
CAACGGCTTCAAGATGGTGCTGGCCGGCCGCGCGATCTACGGAGAGGAAATCCAGCAGCTACGCCGCACCATGGAGCAGC
AGAGCTGGCAACTGCGCGAAGGGGGCCACGTGCGCCATGAGGACGTGCTGCCCGCCTACGTGCAACGCATCGTGGGCGAC
GTGAAGCTCGCGCGGCCCATGAAAATCGTGGTGGACAGCGGCAACGGCATCGCCGGCGCGTCGGCGCCCGGCATCTTCCG
TGCACTGGGCTGCGAGGTGATTGAGCTGTTCTCCGAGGTGGACGGCAACTTCCCCAACCACCACCCCGACCCCAGCAAGC
CCGACAACCTGCGCGACGTGATCGAGGCCTTGAAGACCAGCGACGCCGAACTGGGCCTGGCCTTCGACGGCGACGGCGAC
CGCCTGGGCATCGTGACCAAGGACGGTCAGAACATCTTCCCCGACCGGCAGATGATGCTGTTCGCCCAGGATGTGCTCTC
GCGCGTGCCGGGCGCACCCATCCTGTTCGACGTGAAGTGCACGCAGCGCCTGGCGCCCGCCATCGAGGCCGCGGGCGGCC
AGCCGCAGATGTACAAGACCGGCCATTCGCTCATCAAGGCACGCATGAAAGAACTGGACGCACCCCTGGGCGGCGAGATG
AGCGGCCACATCTTCTTCAAGGAACGCTGGTTCGGTTTTGACGACGGCACGTATGCAGGCTGCCGCCTGCTGGAGATCCT
GAGCCACCATGCCGACCCCAGCGCCGTGCTGAACGCCCTGCCCACGAGCCATTCCACGCCCGAACTCAACGTGCATTGCG
AGGAGGGCGAGCCCCATCGCCTGACGGCCGAGTTGCAGGCGCTGGCGGCCGACGCGTTTGCGGCGCCGGCCCGCATCAGC
ACCATCGACGGCCTGCGCGTGGACTGGCCCGATGGCTTTGGCCTGATCCGCGCCAGCAACACCACGCCTGTGCTGGTGCT
GCGCTTCGAGGGCCACACCGACGCCGCGCTGCAGCGCATCGAAGCCGCCATGCTGGCGCTGCTGGAACGCGTGAAGCCCG
GCGCCCAGGTGGGCGGCGCCGCGCACTGA

Upstream 100 bases:

>100_bases
GGACCGGGCCTACAATTCCGACCTTTCTGCCGGCCTTCCTGCCGGCCTTGCCTGGACGGCGGACCTCCCGGTCCAGCCCC
TTATCTCCAAGGAATCCCCT

Downstream 100 bases:

>100_bases
GGGCAGCGCGGGCGGCATGCACCAGCTCATCCTGTGGCTCTACAGCCTGGCCGTGTGGCTGGCCACGCCGCTGCTGCTGC
GCAAGCTGCGCCGCCGCGCG

Product: phosphomannomutase

Products: NA

Alternate protein names: PGM; Glucose phosphomutase [H]

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MQLSPAIFKAYDIRGIVPSTLNDDVARALGRAFGTAALAQGERTVAVGRDGRLSGPALSAALIQGLVDAGVEVIDIGMST
TPLLYFAASTLCASGIQVTGSHNPKDYNGFKMVLAGRAIYGEEIQQLRRTMEQQSWQLREGGHVRHEDVLPAYVQRIVGD
VKLARPMKIVVDSGNGIAGASAPGIFRALGCEVIELFSEVDGNFPNHHPDPSKPDNLRDVIEALKTSDAELGLAFDGDGD
RLGIVTKDGQNIFPDRQMMLFAQDVLSRVPGAPILFDVKCTQRLAPAIEAAGGQPQMYKTGHSLIKARMKELDAPLGGEM
SGHIFFKERWFGFDDGTYAGCRLLEILSHHADPSAVLNALPTSHSTPELNVHCEEGEPHRLTAELQALAADAFAAPARIS
TIDGLRVDWPDGFGLIRASNTTPVLVLRFEGHTDAALQRIEAAMLALLERVKPGAQVGGAAH

Sequences:

>Translated_462_residues
MQLSPAIFKAYDIRGIVPSTLNDDVARALGRAFGTAALAQGERTVAVGRDGRLSGPALSAALIQGLVDAGVEVIDIGMST
TPLLYFAASTLCASGIQVTGSHNPKDYNGFKMVLAGRAIYGEEIQQLRRTMEQQSWQLREGGHVRHEDVLPAYVQRIVGD
VKLARPMKIVVDSGNGIAGASAPGIFRALGCEVIELFSEVDGNFPNHHPDPSKPDNLRDVIEALKTSDAELGLAFDGDGD
RLGIVTKDGQNIFPDRQMMLFAQDVLSRVPGAPILFDVKCTQRLAPAIEAAGGQPQMYKTGHSLIKARMKELDAPLGGEM
SGHIFFKERWFGFDDGTYAGCRLLEILSHHADPSAVLNALPTSHSTPELNVHCEEGEPHRLTAELQALAADAFAAPARIS
TIDGLRVDWPDGFGLIRASNTTPVLVLRFEGHTDAALQRIEAAMLALLERVKPGAQVGGAAH
>Mature_462_residues
MQLSPAIFKAYDIRGIVPSTLNDDVARALGRAFGTAALAQGERTVAVGRDGRLSGPALSAALIQGLVDAGVEVIDIGMST
TPLLYFAASTLCASGIQVTGSHNPKDYNGFKMVLAGRAIYGEEIQQLRRTMEQQSWQLREGGHVRHEDVLPAYVQRIVGD
VKLARPMKIVVDSGNGIAGASAPGIFRALGCEVIELFSEVDGNFPNHHPDPSKPDNLRDVIEALKTSDAELGLAFDGDGD
RLGIVTKDGQNIFPDRQMMLFAQDVLSRVPGAPILFDVKCTQRLAPAIEAAGGQPQMYKTGHSLIKARMKELDAPLGGEM
SGHIFFKERWFGFDDGTYAGCRLLEILSHHADPSAVLNALPTSHSTPELNVHCEEGEPHRLTAELQALAADAFAAPARIS
TIDGLRVDWPDGFGLIRASNTTPVLVLRFEGHTDAALQRIEAAMLALLERVKPGAQVGGAAH

Specific function: This enzyme participates in both the breakdown and synthesis of glucose [H]

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Escherichia coli, GI1788361, Length=458, Percent_Identity=36.0262008733624, Blast_Score=227, Evalue=1e-60,
Organism=Escherichia coli, GI1789566, Length=446, Percent_Identity=28.0269058295964, Blast_Score=87, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2 [H]

Molecular weight: Translated: 49503; Mature: 49503

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLSPAIFKAYDIRGIVPSTLNDDVARALGRAFGTAALAQGERTVAVGRDGRLSGPALSA
CCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHH
ALIQGLVDAGVEVIDIGMSTTPLLYFAASTLCASGIQVTGSHNPKDYNGFKMVLAGRAIY
HHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHCCCEEECCCCCCCCCCEEEEEECCHHH
GEEIQQLRRTMEQQSWQLREGGHVRHEDVLPAYVQRIVGDVKLARPMKIVVDSGNGIAGA
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCC
SAPGIFRALGCEVIELFSEVDGNFPNHHPDPSKPDNLRDVIEALKTSDAELGLAFDGDGD
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCC
RLGIVTKDGQNIFPDRQMMLFAQDVLSRVPGAPILFDVKCTQRLAPAIEAAGGQPQMYKT
EEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHCCCCCHHHHH
GHSLIKARMKELDAPLGGEMSGHIFFKERWFGFDDGTYAGCRLLEILSHHADPSAVLNAL
HHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHCCCHHHHHHHC
PTSHSTPELNVHCEEGEPHRLTAELQALAADAFAAPARISTIDGLRVDWPDGFGLIRASN
CCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCEEECCCCCEEEEECC
TTPVLVLRFEGHTDAALQRIEAAMLALLERVKPGAQVGGAAH
CCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MQLSPAIFKAYDIRGIVPSTLNDDVARALGRAFGTAALAQGERTVAVGRDGRLSGPALSA
CCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHH
ALIQGLVDAGVEVIDIGMSTTPLLYFAASTLCASGIQVTGSHNPKDYNGFKMVLAGRAIY
HHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHCCCEEECCCCCCCCCCEEEEEECCHHH
GEEIQQLRRTMEQQSWQLREGGHVRHEDVLPAYVQRIVGDVKLARPMKIVVDSGNGIAGA
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCC
SAPGIFRALGCEVIELFSEVDGNFPNHHPDPSKPDNLRDVIEALKTSDAELGLAFDGDGD
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCC
RLGIVTKDGQNIFPDRQMMLFAQDVLSRVPGAPILFDVKCTQRLAPAIEAAGGQPQMYKT
EEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHCCCCCHHHHH
GHSLIKARMKELDAPLGGEMSGHIFFKERWFGFDDGTYAGCRLLEILSHHADPSAVLNAL
HHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHCCCHHHHHHHC
PTSHSTPELNVHCEEGEPHRLTAELQALAADAFAAPARISTIDGLRVDWPDGFGLIRASN
CCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCEEECCCCCEEEEECC
TTPVLVLRFEGHTDAALQRIEAAMLALLERVKPGAQVGGAAH
CCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8157643; 8188595 [H]