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The map label for this gene is liaS [H]

Identifier: 222110966

GI number: 222110966

Start: 1887771

End: 1888604

Strand: Direct

Name: liaS [H]

Synonym: Dtpsy_1773

Alternate gene names: 222110966

Gene position: 1887771-1888604 (Clockwise)

Preceding gene: 222110965

Following gene: 222110968

Centisome position: 49.72

GC content: 66.79

Gene sequence:

>834_bases
ATGTTTCGCACCCGTCCGCCGGCCTTTGCAATCGCCTGCGTTGCTGTCTGGTTGCTTGCCATGTCCGTTGATACCCTGCT
GCTGGCCTCTGCGGAGCAACTGAGTCTGCAGGCGCAGTTGCGCTGGAAGCTCCTGGGCCTGGGGGCTCTGGTAGTGCTGG
GCATCTTGCTGATCGTGCAGTTGCCGCGCGCACTGCAGTGGCGCCCACGGCGCAGCATCCGGCCCAGCCCTGACGTGAAG
CGCGAGCGCGAACGCATTGCACGCAACCTCCACGACCAGGTGGGGTCCCAACTTGTCAACGCCATCGCCCTGGTGGACGA
GCGGGATCCCGAACACGGGACGCTGATGCAGTCGCTGGAGTTGTGCCTGCTCGACCTGCGCCTGTTGGTGGATTCGATGG
ACGGCGAGGACGATTCCCTGGCGGACCGGCTCGCGCGGCTGCGCCACCGCATCCAGCCTGCGCTGGACCGGCGCGGCATC
GCGCTGCACTGGGAGATTGCGCCACACGATGAACTGGCCCTGCCAGGAGGAAAGGTGGCGCGGGAGATAGCCGCCATCGT
CCAGGAAGCCGTGAGCAATGTGCTGCAGCATGCGGACGCCACGGCGCTCGTGATCCGCCTGCACTCCGTTCAAACGATGC
AGGGCAGGGCATGGCAGTTGCAGGTGGCAGACAACGGCGCAGGGCTGCCGAGCGGCGAGCCCACGTGCCACAGTCTGGGA
CGCGGCATTGACAGCATGCGCTCGCGTGCGGCGGCGTTGGCGGGCTGGCTGGAGCTGTTGCCGCAAGAAGGCCGCGGTCT
GTGTGTGCAACTCACGGTTCCGGCCGTGCAGTGA

Upstream 100 bases:

>100_bases
GGCCGTGCGCTTCGCGTCACTGCGCGGGCTGTTCTGAAAGAAGAGCCGCCTGGGCGCACAAACGTCCGTCGCACCTGCTG
CAGGGATCAGGGAGATTTCC

Downstream 100 bases:

>100_bases
GCACGACCAGTGCGTGCCCCAGGCCGCACACCCAGAAAACTATTAAAACAATAGCTGTTGGCGCTGTGTTGGCGAGCCTT
GTGGGCTGCTTTAACGTTGA

Product: signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 277; Mature: 277

Protein sequence:

>277_residues
MFRTRPPAFAIACVAVWLLAMSVDTLLLASAEQLSLQAQLRWKLLGLGALVVLGILLIVQLPRALQWRPRRSIRPSPDVK
RERERIARNLHDQVGSQLVNAIALVDERDPEHGTLMQSLELCLLDLRLLVDSMDGEDDSLADRLARLRHRIQPALDRRGI
ALHWEIAPHDELALPGGKVAREIAAIVQEAVSNVLQHADATALVIRLHSVQTMQGRAWQLQVADNGAGLPSGEPTCHSLG
RGIDSMRSRAAALAGWLELLPQEGRGLCVQLTVPAVQ

Sequences:

>Translated_277_residues
MFRTRPPAFAIACVAVWLLAMSVDTLLLASAEQLSLQAQLRWKLLGLGALVVLGILLIVQLPRALQWRPRRSIRPSPDVK
RERERIARNLHDQVGSQLVNAIALVDERDPEHGTLMQSLELCLLDLRLLVDSMDGEDDSLADRLARLRHRIQPALDRRGI
ALHWEIAPHDELALPGGKVAREIAAIVQEAVSNVLQHADATALVIRLHSVQTMQGRAWQLQVADNGAGLPSGEPTCHSLG
RGIDSMRSRAAALAGWLELLPQEGRGLCVQLTVPAVQ
>Mature_277_residues
MFRTRPPAFAIACVAVWLLAMSVDTLLLASAEQLSLQAQLRWKLLGLGALVVLGILLIVQLPRALQWRPRRSIRPSPDVK
RERERIARNLHDQVGSQLVNAIALVDERDPEHGTLMQSLELCLLDLRLLVDSMDGEDDSLADRLARLRHRIQPALDRRGI
ALHWEIAPHDELALPGGKVAREIAAIVQEAVSNVLQHADATALVIRLHSVQTMQGRAWQLQVADNGAGLPSGEPTCHSLG
RGIDSMRSRAAALAGWLELLPQEGRGLCVQLTVPAVQ

Specific function: Member of the two-component regulatory system liaS/liaR probably involved in response to a subset of cell wall-active antibiotics that interfere with the lipid II cycle in the cytoplasmic membrane (bacitracin, nisin, ramoplanin and vancomycin). Seems also

COG id: COG4585

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR011712
- InterPro:   IPR005467
- InterPro:   IPR017202 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 30429; Mature: 30429

Theoretical pI: Translated: 7.63; Mature: 7.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRTRPPAFAIACVAVWLLAMSVDTLLLASAEQLSLQAQLRWKLLGLGALVVLGILLIVQ
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LPRALQWRPRRSIRPSPDVKRERERIARNLHDQVGSQLVNAIALVDERDPEHGTLMQSLE
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
LCLLDLRLLVDSMDGEDDSLADRLARLRHRIQPALDRRGIALHWEIAPHDELALPGGKVA
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHH
REIAAIVQEAVSNVLQHADATALVIRLHSVQTMQGRAWQLQVADNGAGLPSGEPTCHSLG
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHH
RGIDSMRSRAAALAGWLELLPQEGRGLCVQLTVPAVQ
CCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCC
>Mature Secondary Structure
MFRTRPPAFAIACVAVWLLAMSVDTLLLASAEQLSLQAQLRWKLLGLGALVVLGILLIVQ
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LPRALQWRPRRSIRPSPDVKRERERIARNLHDQVGSQLVNAIALVDERDPEHGTLMQSLE
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
LCLLDLRLLVDSMDGEDDSLADRLARLRHRIQPALDRRGIALHWEIAPHDELALPGGKVA
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHH
REIAAIVQEAVSNVLQHADATALVIRLHSVQTMQGRAWQLQVADNGAGLPSGEPTCHSLG
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHH
RGIDSMRSRAAALAGWLELLPQEGRGLCVQLTVPAVQ
CCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377 [H]