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The map label for this gene is degU [H]

Identifier: 222110965

GI number: 222110965

Start: 1886919

End: 1887707

Strand: Direct

Name: degU [H]

Synonym: Dtpsy_1772

Alternate gene names: 222110965

Gene position: 1886919-1887707 (Clockwise)

Preceding gene: 222110960

Following gene: 222110966

Centisome position: 49.7

GC content: 64.77

Gene sequence:

>789_bases
ATGCTGCCCGTCAACGATCCTCCTGGTGCAATGGCCGCTCCGCGGGGGGCGTCTGTCACCCCAGGCCAATTCGCCATGCA
CCAGAATCCGCCCTCCATCTGGCCGGACTTTCTGGCGGGGCAGCTAGAAAAGCCTGTGCGCGTTTTGCTGGTGGATGACG
ATGCGCACATGCGGCGCGTCATCGCGCAAGAGTTGATGAGCGACCAGCGTACGCTGCTGGTGGCGCAGGCCACCAGCGTG
CGCGAGGGCCGCAAGGCCATCAAGCAGCATGAGTTCGATGTGATGCTCGTGGACCTGAACCTCGGCGATGGCGAGGGCTT
CATGCTGATCGACTACATGAAGTCGGTGCGCCCCACGGCCGAGGCCATCGTCATCTCCATCATGCAGAACGATGAGCAGG
TGCTGCACGCCTTCGAGCTGGGTGCCACGGGCTATCTCGTCAAGAACTCATGGTTCGGCAGCTATCCGCAGGCGGTACTG
CAGGTAGCCAACGGCGGTGCTTCCATCACCCCCAACCTTGCGCGCCGCCTGCTGCAGCGGTTTGACCCGAGCGGCGCCGC
CGCCCCGCACGCCCAGCGGCGCGTGGAGCAGGAAACCGAGCGCCTGTCCCAGCGCGAGAAAGAAGTGCTGCGCATGGTGG
CCAGCGGTTACACCAGCGCCGAGATCGGCAACCGGCTGTTCATCAGCAGCCTGACCGTGAACACGCACATCAAGAACATC
TACCGCAAGCTGCAGGTGCGCACGCGGGCGCAGGCCGTGCGCTTCGCGTCACTGCGCGGGCTGTTCTGA

Upstream 100 bases:

>100_bases
TGTGAGGAAAGCACCCAAAGCGTTGGGATGATCTTTCCGTGGTTACGGTGTGCAAACGCTGAGGGGCCGCCAACAGGCGC
CCCCGTCTGGAGACTTCTTT

Downstream 100 bases:

>100_bases
AAGAAGAGCCGCCTGGGCGCACAAACGTCCGTCGCACCTGCTGCAGGGATCAGGGAGATTTCCATGTTTCGCACCCGTCC
GCCGGCCTTTGCAATCGCCT

Product: two component LuxR family transcriptional regulator

Products: NA

Alternate protein names: Protease production enhancer protein [H]

Number of amino acids: Translated: 262; Mature: 262

Protein sequence:

>262_residues
MLPVNDPPGAMAAPRGASVTPGQFAMHQNPPSIWPDFLAGQLEKPVRVLLVDDDAHMRRVIAQELMSDQRTLLVAQATSV
REGRKAIKQHEFDVMLVDLNLGDGEGFMLIDYMKSVRPTAEAIVISIMQNDEQVLHAFELGATGYLVKNSWFGSYPQAVL
QVANGGASITPNLARRLLQRFDPSGAAAPHAQRRVEQETERLSQREKEVLRMVASGYTSAEIGNRLFISSLTVNTHIKNI
YRKLQVRTRAQAVRFASLRGLF

Sequences:

>Translated_262_residues
MLPVNDPPGAMAAPRGASVTPGQFAMHQNPPSIWPDFLAGQLEKPVRVLLVDDDAHMRRVIAQELMSDQRTLLVAQATSV
REGRKAIKQHEFDVMLVDLNLGDGEGFMLIDYMKSVRPTAEAIVISIMQNDEQVLHAFELGATGYLVKNSWFGSYPQAVL
QVANGGASITPNLARRLLQRFDPSGAAAPHAQRRVEQETERLSQREKEVLRMVASGYTSAEIGNRLFISSLTVNTHIKNI
YRKLQVRTRAQAVRFASLRGLF
>Mature_262_residues
MLPVNDPPGAMAAPRGASVTPGQFAMHQNPPSIWPDFLAGQLEKPVRVLLVDDDAHMRRVIAQELMSDQRTLLVAQATSV
REGRKAIKQHEFDVMLVDLNLGDGEGFMLIDYMKSVRPTAEAIVISIMQNDEQVLHAFELGATGYLVKNSWFGSYPQAVL
QVANGGASITPNLARRLLQRFDPSGAAAPHAQRRVEQETERLSQREKEVLRMVASGYTSAEIGNRLFISSLTVNTHIKNI
YRKLQVRTRAQAVRFASLRGLF

Specific function: Regulating factor for the production of extracellular proteases. The N-terminal region acts as an inhibitor, whereas the C-terminal region carries enhancing activity [H]

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788521, Length=217, Percent_Identity=29.9539170506912, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1790102, Length=210, Percent_Identity=28.0952380952381, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1787473, Length=221, Percent_Identity=25.7918552036199, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1786747, Length=218, Percent_Identity=23.8532110091743, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788222, Length=220, Percent_Identity=26.8181818181818, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 29089; Mature: 29089

Theoretical pI: Translated: 9.93; Mature: 9.93

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLPVNDPPGAMAAPRGASVTPGQFAMHQNPPSIWPDFLAGQLEKPVRVLLVDDDAHMRRV
CCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCHHHHHHHCCCCEEEEEECCCHHHHHH
IAQELMSDQRTLLVAQATSVREGRKAIKQHEFDVMLVDLNLGDGEGFMLIDYMKSVRPTA
HHHHHHCCCCEEEEEHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCEEHHHHHHHCCCHH
EAIVISIMQNDEQVLHAFELGATGYLVKNSWFGSYPQAVLQVANGGASITPNLARRLLQR
HHHHHHHHHCCHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHH
FDPSGAAAPHAQRRVEQETERLSQREKEVLRMVASGYTSAEIGNRLFISSLTVNTHIKNI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCEEEEEEEHHHHHHHHH
YRKLQVRTRAQAVRFASLRGLF
HHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLPVNDPPGAMAAPRGASVTPGQFAMHQNPPSIWPDFLAGQLEKPVRVLLVDDDAHMRRV
CCCCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCHHHHHHHCCCCEEEEEECCCHHHHHH
IAQELMSDQRTLLVAQATSVREGRKAIKQHEFDVMLVDLNLGDGEGFMLIDYMKSVRPTA
HHHHHHCCCCEEEEEHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCEEHHHHHHHCCCHH
EAIVISIMQNDEQVLHAFELGATGYLVKNSWFGSYPQAVLQVANGGASITPNLARRLLQR
HHHHHHHHHCCHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHH
FDPSGAAAPHAQRRVEQETERLSQREKEVLRMVASGYTSAEIGNRLFISSLTVNTHIKNI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCEEEEEEEHHHHHHHHH
YRKLQVRTRAQAVRFASLRGLF
HHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3136143; 3141378; 3141377; 9384377 [H]