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The map label for this gene is lpsI [H]

Identifier: 222110955

GI number: 222110955

Start: 1873759

End: 1874466

Strand: Direct

Name: lpsI [H]

Synonym: Dtpsy_1762

Alternate gene names: 222110955

Gene position: 1873759-1874466 (Clockwise)

Preceding gene: 222110953

Following gene: 222110956

Centisome position: 49.35

GC content: 65.96

Gene sequence:

>708_bases
GTGAACAAGCTTTACCCCTCGGCGGCCGAAGCGCTCAAGGGCGTCGTGGCCGATGGCCAGCTGATGGCCGTTGGCGGTTT
CGGCCTGTGCGGCATTCCAGAGGCCTTGATCGATGCGCTGCAGGCCAGCGGCGTGAAGGACCTCACGGTGATTTCCAACA
ACGCGGGCGTTGACGGCTTCGGCCTGGGCAAGCTGCTGGAGACGCGCCAGATCAAGAAGATGATCAGCTCCTACGTGGGC
GAGAACAAGGAGTTCGAGCGCCAGTACCTCGCGGGCGAGCTGGAGCTGGAGTTCACCCCGCAGGGCACGCTGGCCGAGAA
GCTGCGCGCCGGCGGCGCGGGCATCCCGGCCTTCTTCACCAAAACCGGTGTGGGCACCATCGTGGCCGAGGGCAAGGAGC
TGCGCGAGTTCGACGGCGAGACCTACGTGATGGAACGCTCGCTGGTGCCGCAGGTTTCGCTGGTCAAGGCGCAGCGGGCC
GACAAGTCGGGCAATCTGCAGTTCCGCCTGACGGCACGCAACTTCAACCCGGCCGCCGCCATGGCGGGCAAGCTGTGCAT
CGTCGAGGTGGAGGAGGTGGTGGAGACGGGCGCCCTGGACCCCGACCAGATCCACCTGCCCGGCATCTACGTGCACCGCA
TCGTGCACAACCCGAACCCCGAGAAGCGCATCGAGAAGCGCACCATCACCGAGAAAGCAGGAGCCTGA

Upstream 100 bases:

>100_bases
GTAGTCGGCAACATTCATAGTGGTGCAAGTCTTTAGGGAAAACTACTTAAAAAACTACGTAGTATCGTAGCGTATCCACC
CAGCAAACCAGGAGACTGTA

Downstream 100 bases:

>100_bases
ACCATGCCGTGGACCCAAGACCAGATGGCGGCCCGCGCCGCGCAAGAACTCGAAGACGGCTTCTACGTCAACTTAGGGAT
AGGCATTCCCACGCTGGTGG

Product: 3-oxoacid CoA-transferase subunit A

Products: NA

Alternate protein names: Succinyl CoA:3-oxoacid CoA-transferase; OXCT A [H]

Number of amino acids: Translated: 235; Mature: 235

Protein sequence:

>235_residues
MNKLYPSAAEALKGVVADGQLMAVGGFGLCGIPEALIDALQASGVKDLTVISNNAGVDGFGLGKLLETRQIKKMISSYVG
ENKEFERQYLAGELELEFTPQGTLAEKLRAGGAGIPAFFTKTGVGTIVAEGKELREFDGETYVMERSLVPQVSLVKAQRA
DKSGNLQFRLTARNFNPAAAMAGKLCIVEVEEVVETGALDPDQIHLPGIYVHRIVHNPNPEKRIEKRTITEKAGA

Sequences:

>Translated_235_residues
MNKLYPSAAEALKGVVADGQLMAVGGFGLCGIPEALIDALQASGVKDLTVISNNAGVDGFGLGKLLETRQIKKMISSYVG
ENKEFERQYLAGELELEFTPQGTLAEKLRAGGAGIPAFFTKTGVGTIVAEGKELREFDGETYVMERSLVPQVSLVKAQRA
DKSGNLQFRLTARNFNPAAAMAGKLCIVEVEEVVETGALDPDQIHLPGIYVHRIVHNPNPEKRIEKRTITEKAGA
>Mature_235_residues
MNKLYPSAAEALKGVVADGQLMAVGGFGLCGIPEALIDALQASGVKDLTVISNNAGVDGFGLGKLLETRQIKKMISSYVG
ENKEFERQYLAGELELEFTPQGTLAEKLRAGGAGIPAFFTKTGVGTIVAEGKELREFDGETYVMERSLVPQVSLVKAQRA
DKSGNLQFRLTARNFNPAAAMAGKLCIVEVEEVVETGALDPDQIHLPGIYVHRIVHNPNPEKRIEKRTITEKAGA

Specific function: SHORT-CHAIN FATTY ACIDS METABOLISM. [C]

COG id: COG1788

COG function: function code I; Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-oxoacid CoA-transferase subunit A family [H]

Homologues:

Organism=Homo sapiens, GI4557817, Length=246, Percent_Identity=54.4715447154472, Blast_Score=272, Evalue=2e-73,
Organism=Homo sapiens, GI11545841, Length=245, Percent_Identity=51.0204081632653, Blast_Score=231, Evalue=3e-61,
Organism=Escherichia coli, GI1788551, Length=202, Percent_Identity=44.5544554455446, Blast_Score=189, Evalue=2e-49,
Organism=Escherichia coli, GI1787985, Length=241, Percent_Identity=24.896265560166, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17531517, Length=244, Percent_Identity=55.327868852459, Blast_Score=261, Evalue=1e-70,
Organism=Drosophila melanogaster, GI21358325, Length=247, Percent_Identity=52.2267206477733, Blast_Score=251, Evalue=2e-67,
Organism=Drosophila melanogaster, GI24655794, Length=247, Percent_Identity=52.2267206477733, Blast_Score=251, Evalue=2e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012792
- InterPro:   IPR004165
- InterPro:   IPR004163 [H]

Pfam domain/function: PF01144 CoA_trans [H]

EC number: =2.8.3.5 [H]

Molecular weight: Translated: 25241; Mature: 25241

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS01273 COA_TRANSF_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKLYPSAAEALKGVVADGQLMAVGGFGLCGIPEALIDALQASGVKDLTVISNNAGVDGF
CCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCC
GLGKLLETRQIKKMISSYVGENKEFERQYLAGELELEFTPQGTLAEKLRAGGAGIPAFFT
CHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCEEEEEECCCCHHHHHHHCCCCCCCHHHH
KTGVGTIVAEGKELREFDGETYVMERSLVPQVSLVKAQRADKSGNLQFRLTARNFNPAAA
HCCCEEEEECCHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCCCEEEEEEECCCCHHHH
MAGKLCIVEVEEVVETGALDPDQIHLPGIYVHRIVHNPNPEKRIEKRTITEKAGA
HHCCEEEEEHHHHHHHCCCCCCCEECCCEEEEEECCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNKLYPSAAEALKGVVADGQLMAVGGFGLCGIPEALIDALQASGVKDLTVISNNAGVDGF
CCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCC
GLGKLLETRQIKKMISSYVGENKEFERQYLAGELELEFTPQGTLAEKLRAGGAGIPAFFT
CHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCEEEEEECCCCHHHHHHHCCCCCCCHHHH
KTGVGTIVAEGKELREFDGETYVMERSLVPQVSLVKAQRADKSGNLQFRLTARNFNPAAA
HCCCEEEEECCHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCCCEEEEEEECCCCHHHH
MAGKLCIVEVEEVVETGALDPDQIHLPGIYVHRIVHNPNPEKRIEKRTITEKAGA
HHCCEEEEEHHHHHHHCCCCCCCEECCCEEEEEECCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9385134; 11589581 [H]