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The map label for this gene is ndh [H]

Identifier: 222110953

GI number: 222110953

Start: 1871731

End: 1873011

Strand: Direct

Name: ndh [H]

Synonym: Dtpsy_1760

Alternate gene names: 222110953

Gene position: 1871731-1873011 (Clockwise)

Preceding gene: 222110949

Following gene: 222110955

Centisome position: 49.3

GC content: 70.1

Gene sequence:

>1281_bases
ATGCATTACGACATCGTGATCGTGGGGGGTGGGGCCGGCGGCCTGGAACTGGCTGCGCGCCTGGGCCGCGCGCTGGGGCC
GCGCCAAGGGCGTGAGCGGGTGCTGCTGGTGGACCGCTTTGCGTTCCACATCTGGAAGCCCACGCTGCACGAAGTCGCGG
CCGGGACGCTAGACGCCCATCAGGAGGGTCTGTCGTACCCCGTGCTCGCACGGCGCAACCATTTCAGCTTCACCATGGGC
GAACTGGCCGGGCTGGACGCCGCGCGCAAGACCATCGCCCTGGCCCCTCAGCGCAATGCACATGGCGAGGAGGTGGTGCC
CGCGCGCACGCTGAGCTTCACGCGTTTGGTGCTGGCGCTGGGCAGCGGCTCCAACGCCTTTGGCACGCCGGGCATCGAAC
ACGCCTATCTGCTGGAAAACGTGCGCGATGCGCAGCGCTTTCATGCCGACTGGCTGAGCGCCTGCGCGCGGGCATCGTTC
ACGGACAAGCGCGCCCTGTCCATCGCCATCGTGGGCGCGGGCGCCACGGGGGTGGAGCTGTCCGCCGAGCTGCTGGAAGC
CCATGCCGAACTGCTGGAGAGCCTGGGCAGCAGCCAGCGTTTTCGGCTGGACGTGACGCTGGTGGAGGCGGGCGACCGCA
TTCTGGGCGGCCTGCCCGAGCGCATCTCTGCCCAGGCCGCCGTGGCCCTGCGCCGCAAGCAGGTGCGGGTGATGACGGGC
ACACGTGTGCTGGAGCTGCGTCCGGGCGTGCTGGTCACCTCGGCCGGAGAGATCGCGGCCGAGATGATGGTCTGGGCCGC
GGGCATCAAGGCCGCGGACGCCAACGCCGCGCTGGGCCTGGAAGTGAACCGGCTCAACCAGTTCGTGGTGGACGAGCGGC
TGCGCACCTCGGCCCCTGACGTGCTGGCCCTGGGCGACTGCGCGGCCTGCGTGTGGGAGGGCGGGCGCATGGTGCCGGCA
CGCGCGCAGGCCGCGCACCAGCAGGCCGACTACCTGGCGCGCGTGCTGCTGGCGCTGCTGCGCGAGCGCGAGGTGACGCA
GCCCTTCGTCTACCGCGACTTCGGCTCACTCGTGTCGCTGGGCGAGAACAAGGGCGTGGGCAACCTGATGGGCGGCCTGG
CGGGGCGCAACTTCTTCGTGGAAGGGCTGATCGCCAAGTGGATGTACATGTCGCTGCACTTGATGCACCACCGCGCCATC
CTGGGTCTAGGCAAGACGGCGGTGCTGGCGCTGGCGCGGCTGCTGCAGCAACGCGTGTCGGGGCGGCTCAAACTGCACTG
A

Upstream 100 bases:

>100_bases
CTATTTAAAGGGCAAGCCAAAACCCATTGAATTTCCGCAACGCGGCAATAGGCGCAGGCTTGCCTACACTGTAGAGCGGT
AACCTGGAAGAAGGTTTGAC

Downstream 100 bases:

>100_bases
CCGGCGCGACGGCGGCTTCAAAAACCATAGCTGGCAGCGCTTGCTGCGATTGGATTTCAGGCAATAAACGCCTTGAACTG
CTTGATTAGCAAGCGCCAAC

Product: fad-dependent pyridine nucleotide-disulfide oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MHYDIVIVGGGAGGLELAARLGRALGPRQGRERVLLVDRFAFHIWKPTLHEVAAGTLDAHQEGLSYPVLARRNHFSFTMG
ELAGLDAARKTIALAPQRNAHGEEVVPARTLSFTRLVLALGSGSNAFGTPGIEHAYLLENVRDAQRFHADWLSACARASF
TDKRALSIAIVGAGATGVELSAELLEAHAELLESLGSSQRFRLDVTLVEAGDRILGGLPERISAQAAVALRRKQVRVMTG
TRVLELRPGVLVTSAGEIAAEMMVWAAGIKAADANAALGLEVNRLNQFVVDERLRTSAPDVLALGDCAACVWEGGRMVPA
RAQAAHQQADYLARVLLALLREREVTQPFVYRDFGSLVSLGENKGVGNLMGGLAGRNFFVEGLIAKWMYMSLHLMHHRAI
LGLGKTAVLALARLLQQRVSGRLKLH

Sequences:

>Translated_426_residues
MHYDIVIVGGGAGGLELAARLGRALGPRQGRERVLLVDRFAFHIWKPTLHEVAAGTLDAHQEGLSYPVLARRNHFSFTMG
ELAGLDAARKTIALAPQRNAHGEEVVPARTLSFTRLVLALGSGSNAFGTPGIEHAYLLENVRDAQRFHADWLSACARASF
TDKRALSIAIVGAGATGVELSAELLEAHAELLESLGSSQRFRLDVTLVEAGDRILGGLPERISAQAAVALRRKQVRVMTG
TRVLELRPGVLVTSAGEIAAEMMVWAAGIKAADANAALGLEVNRLNQFVVDERLRTSAPDVLALGDCAACVWEGGRMVPA
RAQAAHQQADYLARVLLALLREREVTQPFVYRDFGSLVSLGENKGVGNLMGGLAGRNFFVEGLIAKWMYMSLHLMHHRAI
LGLGKTAVLALARLLQQRVSGRLKLH
>Mature_426_residues
MHYDIVIVGGGAGGLELAARLGRALGPRQGRERVLLVDRFAFHIWKPTLHEVAAGTLDAHQEGLSYPVLARRNHFSFTMG
ELAGLDAARKTIALAPQRNAHGEEVVPARTLSFTRLVLALGSGSNAFGTPGIEHAYLLENVRDAQRFHADWLSACARASF
TDKRALSIAIVGAGATGVELSAELLEAHAELLESLGSSQRFRLDVTLVEAGDRILGGLPERISAQAAVALRRKQVRVMTG
TRVLELRPGVLVTSAGEIAAEMMVWAAGIKAADANAALGLEVNRLNQFVVDERLRTSAPDVLALGDCAACVWEGGRMVPA
RAQAAHQQADYLARVLLALLREREVTQPFVYRDFGSLVSLGENKGVGNLMGGLAGRNFFVEGLIAKWMYMSLHLMHHRAI
LGLGKTAVLALARLLQQRVSGRLKLH

Specific function: Transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Does not couple the redox reaction to proton translocation [H]

COG id: COG1252

COG function: function code C; NADH dehydrogenase, FAD-containing subunit

Gene ontology:

Cell location: Cell membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NADH dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1787352, Length=430, Percent_Identity=46.7441860465116, Blast_Score=313, Evalue=1e-86,
Organism=Saccharomyces cerevisiae, GI6320118, Length=460, Percent_Identity=25.4347826086956, Blast_Score=93, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6323794, Length=462, Percent_Identity=24.4588744588745, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323515, Length=447, Percent_Identity=22.5950782997763, Blast_Score=83, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013027
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: =1.6.99.3 [H]

Molecular weight: Translated: 45909; Mature: 45909

Theoretical pI: Translated: 9.86; Mature: 9.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHYDIVIVGGGAGGLELAARLGRALGPRQGRERVLLVDRFAFHIWKPTLHEVAAGTLDAH
CCEEEEEEECCCCHHHHHHHHHHHCCCCCCCCEEEEEEHHHHHHCCHHHHHHHHCCHHHH
QEGLSYPVLARRNHFSFTMGELAGLDAARKTIALAPQRNAHGEEVVPARTLSFTRLVLAL
HCCCCCCEEECCCCCEEEHHHHHCCHHHHHHEEECCCCCCCCCCCCCHHHHHHHHHHHHC
GSGSNAFGTPGIEHAYLLENVRDAQRFHADWLSACARASFTDKRALSIAIVGAGATGVEL
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCHHH
SAELLEAHAELLESLGSSQRFRLDVTLVEAGDRILGGLPERISAQAAVALRRKQVRVMTG
HHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCHHHCCCCHHHHHHHHHHHHHHHEEEEEC
TRVLELRPGVLVTSAGEIAAEMMVWAAGIKAADANAALGLEVNRLNQFVVDERLRTSAPD
CEEEEECCCEEEECCHHHHHHHHHHHHCCCCCCCCCEECEEHHHHHHHHHHHHHHCCCCC
VLALGDCAACVWEGGRMVPARAQAAHQQADYLARVLLALLREREVTQPFVYRDFGSLVSL
EEECCHHHHHHHCCCEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHC
GENKGVGNLMGGLAGRNFFVEGLIAKWMYMSLHLMHHRAILGLGKTAVLALARLLQQRVS
CCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHC
GRLKLH
CCCCCC
>Mature Secondary Structure
MHYDIVIVGGGAGGLELAARLGRALGPRQGRERVLLVDRFAFHIWKPTLHEVAAGTLDAH
CCEEEEEEECCCCHHHHHHHHHHHCCCCCCCCEEEEEEHHHHHHCCHHHHHHHHCCHHHH
QEGLSYPVLARRNHFSFTMGELAGLDAARKTIALAPQRNAHGEEVVPARTLSFTRLVLAL
HCCCCCCEEECCCCCEEEHHHHHCCHHHHHHEEECCCCCCCCCCCCCHHHHHHHHHHHHC
GSGSNAFGTPGIEHAYLLENVRDAQRFHADWLSACARASFTDKRALSIAIVGAGATGVEL
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCHHH
SAELLEAHAELLESLGSSQRFRLDVTLVEAGDRILGGLPERISAQAAVALRRKQVRVMTG
HHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCHHHCCCCHHHHHHHHHHHHHHHEEEEEC
TRVLELRPGVLVTSAGEIAAEMMVWAAGIKAADANAALGLEVNRLNQFVVDERLRTSAPD
CEEEEECCCEEEECCHHHHHHHHHHHHCCCCCCCCCEECEEHHHHHHHHHHHHHHCCCCC
VLALGDCAACVWEGGRMVPARAQAAHQQADYLARVLLALLREREVTQPFVYRDFGSLVSL
EEECCHHHHHHHCCCEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHC
GENKGVGNLMGGLAGRNFFVEGLIAKWMYMSLHLMHHRAILGLGKTAVLALARLLQQRVS
CCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHC
GRLKLH
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6265208; 8905232; 9278503 [H]