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The map label for this gene is cysG [H]

Identifier: 222110911

GI number: 222110911

Start: 1823798

End: 1824742

Strand: Direct

Name: cysG [H]

Synonym: Dtpsy_1718

Alternate gene names: 222110911

Gene position: 1823798-1824742 (Clockwise)

Preceding gene: 222110901

Following gene: 222110912

Centisome position: 48.04

GC content: 68.68

Gene sequence:

>945_bases
ATGCGAGTGGGAGCATCGTCGCAGCGGGTGTTGCCGCTGTCCTTGAACTGGTTCAAGGACGCAAACGGTGCAGCCTTTGA
ACAATGGAGCCACCCCATGATCCGCAAAGGAGAGGCCCATATGAGCTTCATTGAAGATGCGCGCTGGTTCACCGTGGCAC
CCGCAGCAGGAGAGTCCGGACAGCCCCCGAAGCCTGGACACGTGACGCTGGTGGGCGCAGGCCCGGGCGACCCTGAGTTG
CTCACGCTGCGCGCCGTCAAGGCCCTGCGCGGCGCGCGCCTGGTGCTCTACGATCACCTGGTCGGCAAGGAGGTGCTGCG
CTACGTGGCCGAGGATGCCGACCTGATCTACGTGGGCAAGCAGTCTTCGCACCATACGCTGCCGCAGGAATCGATCATTG
ACCTCATGGTGCGCCTGGCGCGCAGCGGGCGCAGCCTGGTGCGCCTGAAGGGCGGCGATGGCTTCATCTTCGGCCGTGGC
GGCGAAGAGGTGCAGGCGCTGGCCGAGGCCGGTATCGCGTTCGACGTGGTGCCGGGCATCACGGCCGCGCAGGGTGCGGG
CGCCTGCGCCGGCATCCCGCTCACGCACCGCGACCACTCCGCGACCCTGGTGTTTGCCACCGGCCACCTGCGCGGCGACA
ACGAAGTGGCGCTGGACTGGGAGGCGCTGGCGCGCCCGCGCCAGACCGTGGTGATTTACATGGGGATGGGCACGCTGCCG
ATCATCTGCCGCGAACTGGTGCGCCACGGCCTGCCGGACAGCACGCCCGCAGCGCTGGTGGAGCAAGCCTCGCTGCCCGG
GCAGCGCTGCATCACCGGCACGCTGCAGGACCTGCCCGCGCTGGCGCAGCAGCACCGCGTGCGTCCCCCTGCGCTCATCA
TCGTGGGCGACGTGGTGGCGCTGCAGCCGCAACTCATGCAGGGCATGCTGGCGACGATGGTGTGA

Upstream 100 bases:

>100_bases
TTGCTGTCATTGTGGGTCCTCTGCGTCACGGATCAGCGCTTGGGTGGGCCCTGGCGGCTGCCACGGCCACTCTCGCGAGG
TCGCTGTCCATCCCCTCTTC

Downstream 100 bases:

>100_bases
CGGGCGCCGGCCGCCGGTAGGGCGGCGGGCAGCGCTGGTTCTGAGGCATCATGGGCGCCTCATCTGGCAAAAGCCCATGC
AACAAGACATCCTCATCAAC

Product: uroporphyrin-iii c-methyltransferase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MRVGASSQRVLPLSLNWFKDANGAAFEQWSHPMIRKGEAHMSFIEDARWFTVAPAAGESGQPPKPGHVTLVGAGPGDPEL
LTLRAVKALRGARLVLYDHLVGKEVLRYVAEDADLIYVGKQSSHHTLPQESIIDLMVRLARSGRSLVRLKGGDGFIFGRG
GEEVQALAEAGIAFDVVPGITAAQGAGACAGIPLTHRDHSATLVFATGHLRGDNEVALDWEALARPRQTVVIYMGMGTLP
IICRELVRHGLPDSTPAALVEQASLPGQRCITGTLQDLPALAQQHRVRPPALIIVGDVVALQPQLMQGMLATMV

Sequences:

>Translated_314_residues
MRVGASSQRVLPLSLNWFKDANGAAFEQWSHPMIRKGEAHMSFIEDARWFTVAPAAGESGQPPKPGHVTLVGAGPGDPEL
LTLRAVKALRGARLVLYDHLVGKEVLRYVAEDADLIYVGKQSSHHTLPQESIIDLMVRLARSGRSLVRLKGGDGFIFGRG
GEEVQALAEAGIAFDVVPGITAAQGAGACAGIPLTHRDHSATLVFATGHLRGDNEVALDWEALARPRQTVVIYMGMGTLP
IICRELVRHGLPDSTPAALVEQASLPGQRCITGTLQDLPALAQQHRVRPPALIIVGDVVALQPQLMQGMLATMV
>Mature_314_residues
MRVGASSQRVLPLSLNWFKDANGAAFEQWSHPMIRKGEAHMSFIEDARWFTVAPAAGESGQPPKPGHVTLVGAGPGDPEL
LTLRAVKALRGARLVLYDHLVGKEVLRYVAEDADLIYVGKQSSHHTLPQESIIDLMVRLARSGRSLVRLKGGDGFIFGRG
GEEVQALAEAGIAFDVVPGITAAQGAGACAGIPLTHRDHSATLVFATGHLRGDNEVALDWEALARPRQTVVIYMGMGTLP
IICRELVRHGLPDSTPAALVEQASLPGQRCITGTLQDLPALAQQHRVRPPALIIVGDVVALQPQLMQGMLATMV

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=240, Percent_Identity=50, Blast_Score=235, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6322922, Length=295, Percent_Identity=28.4745762711864, Blast_Score=117, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043 [H]

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]

Molecular weight: Translated: 33589; Mature: 33589

Theoretical pI: Translated: 7.38; Mature: 7.38

Prosite motif: PS00732 RIBOSOMAL_S16 ; PS00839 SUMT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVGASSQRVLPLSLNWFKDANGAAFEQWSHPMIRKGEAHMSFIEDARWFTVAPAAGESG
CCCCCCCCEEEEEEEEEECCCCCCHHHHHCCCHHHCCCHHHHHHHCCCEEEEECCCCCCC
QPPKPGHVTLVGAGPGDPELLTLRAVKALRGARLVLYDHLVGKEVLRYVAEDADLIYVGK
CCCCCCEEEEEECCCCCCCEEHHHHHHHHHCCEEEEHHHHHHHHHHHHHHCCCCEEEEEC
QSSHHTLPQESIIDLMVRLARSGRSLVRLKGGDGFIFGRGGEEVQALAEAGIAFDVVPGI
CCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCEEEECCCCHHHHHHHHCCCEEEECCCC
TAAQGAGACAGIPLTHRDHSATLVFATGHLRGDNEVALDWEALARPRQTVVIYMGMGTLP
CCCCCCCCCCCCCEECCCCCEEEEEEECEECCCCCEEEEHHHHCCCCEEEEEEECCCCHH
IICRELVRHGLPDSTPAALVEQASLPGQRCITGTLQDLPALAQQHRVRPPALIIVGDVVA
HHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHH
LQPQLMQGMLATMV
CCHHHHHHHHHHCC
>Mature Secondary Structure
MRVGASSQRVLPLSLNWFKDANGAAFEQWSHPMIRKGEAHMSFIEDARWFTVAPAAGESG
CCCCCCCCEEEEEEEEEECCCCCCHHHHHCCCHHHCCCHHHHHHHCCCEEEEECCCCCCC
QPPKPGHVTLVGAGPGDPELLTLRAVKALRGARLVLYDHLVGKEVLRYVAEDADLIYVGK
CCCCCCEEEEEECCCCCCCEEHHHHHHHHHCCEEEEHHHHHHHHHHHHHHCCCCEEEEEC
QSSHHTLPQESIIDLMVRLARSGRSLVRLKGGDGFIFGRGGEEVQALAEAGIAFDVVPGI
CCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCEEEECCCCHHHHHHHHCCCEEEECCCC
TAAQGAGACAGIPLTHRDHSATLVFATGHLRGDNEVALDWEALARPRQTVVIYMGMGTLP
CCCCCCCCCCCCCEECCCCCEEEEEEECEECCCCCEEEEHHHHCCCCEEEEEEECCCCHH
IICRELVRHGLPDSTPAALVEQASLPGQRCITGTLQDLPALAQQHRVRPPALIIVGDVVA
HHHHHHHHCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHH
LQPQLMQGMLATMV
CCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA