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The map label for this gene is hemF [H]

Identifier: 222110898

GI number: 222110898

Start: 1811516

End: 1812535

Strand: Direct

Name: hemF [H]

Synonym: Dtpsy_1705

Alternate gene names: 222110898

Gene position: 1811516-1812535 (Clockwise)

Preceding gene: 222110897

Following gene: 222110899

Centisome position: 47.71

GC content: 68.73

Gene sequence:

>1020_bases
ATGACCACACAAAAACCCACCTTCAACACGGCGGACACCGTGGCCCGCGTGCGCGGCTATCTGGAGGGCCTGCAGGCGCG
CATCACCAGCGCGCTGGAGGACATCGAGGGGCCGCAAAGCCACGGCGGGGCGCGCTTTCGGTCCGATGCCTGGCGGCGCG
AAAGCGGCTCTGCACTGCAGGGCGACGGCATCACGCGCATCCTGGAAGGTGGGCGCGTGTTCGAGCGCGCGGGCTGCGGC
TTCTCGCATGTGAGCGGGCCGCGTCTGCCGCCCTCGGCCACGCAGCACCGGCCGGAGCTGGCGGGTGCGCCGTTCGAGGC
CATGGGCGTGTCGCTGGTGTTTCACCCGCGCAACCCCTATGTGCCCACGGTGCACATGAACGTGCGCATGATCGCAGCCG
GCACAGGTGCGGCCGGCACAGGTGCGGCCGGCACAGGTGCGGCCGGCACAGAAGCGGCAGGTCAGGCAGGCCAGGGCCCC
ATCTGCTGGTTCGGCGGCGGCATGGACCTCACGCCGTACTACGGTTTCGACGAGGATGCGGTGCACTTTCACCGTGCCTG
CCGCGATGCGCTCGCACCCTTCGGCGAAGGCCTGTACCCGCGCTTCAAGACCTGGTGCGACGAGTACTTCTACCTTAAGC
ACCGCAATGAGCAGCGCGGCGTGGGCGGCATCTTCTTTGACGACTTCGCGGAGCTGGGCTTCGAGCAGAGCCTGGCCATG
ACGCAGAGCGTGGGCGATGCCTTCCTGGGCGCTTACCTGCCCATCGTGCAGCGGCGCATGCACATGGACCATGGCGAGCG
CGAACGCGAGTTCCAGCTCTACCGGCGTGGCCGCTATGTGGAGTTCAACCTGGTGTGGGACCGCGGCACGCACTTCGGCC
TGCAGTCGGGTGGGCGCACGGAATCCATCCTGCTGTCCATGCCGCCGCTGGCGGCCTGGTCCTACCAGCGCGAGCCGCAG
CCGGGCTCGCCCGAGGCGCTGTTGACCGAGCGCTTTCTGCAGCGCCGCGACTGGATCTGA

Upstream 100 bases:

>100_bases
AGCAGGCACAGCAGCGCGTGTATGACGTGGCGCGCGGCATTCACTTTGACGGCGCGCAGTACCGCCACGACATTGGCCAC
CGCGCGGTGAAGGCCAACGG

Downstream 100 bases:

>100_bases
GTGTGTGAGCGCGGGTAACTATAATTTCAATAGCTGCCTGCGCTTGATCATCAAGCGCCAGACCCGTTTTTGATATCTGA
AACATGCCCTGACAACCGCT

Product: coproporphyrinogen iii oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MTTQKPTFNTADTVARVRGYLEGLQARITSALEDIEGPQSHGGARFRSDAWRRESGSALQGDGITRILEGGRVFERAGCG
FSHVSGPRLPPSATQHRPELAGAPFEAMGVSLVFHPRNPYVPTVHMNVRMIAAGTGAAGTGAAGTGAAGTEAAGQAGQGP
ICWFGGGMDLTPYYGFDEDAVHFHRACRDALAPFGEGLYPRFKTWCDEYFYLKHRNEQRGVGGIFFDDFAELGFEQSLAM
TQSVGDAFLGAYLPIVQRRMHMDHGEREREFQLYRRGRYVEFNLVWDRGTHFGLQSGGRTESILLSMPPLAAWSYQREPQ
PGSPEALLTERFLQRRDWI

Sequences:

>Translated_339_residues
MTTQKPTFNTADTVARVRGYLEGLQARITSALEDIEGPQSHGGARFRSDAWRRESGSALQGDGITRILEGGRVFERAGCG
FSHVSGPRLPPSATQHRPELAGAPFEAMGVSLVFHPRNPYVPTVHMNVRMIAAGTGAAGTGAAGTGAAGTEAAGQAGQGP
ICWFGGGMDLTPYYGFDEDAVHFHRACRDALAPFGEGLYPRFKTWCDEYFYLKHRNEQRGVGGIFFDDFAELGFEQSLAM
TQSVGDAFLGAYLPIVQRRMHMDHGEREREFQLYRRGRYVEFNLVWDRGTHFGLQSGGRTESILLSMPPLAAWSYQREPQ
PGSPEALLTERFLQRRDWI
>Mature_338_residues
TTQKPTFNTADTVARVRGYLEGLQARITSALEDIEGPQSHGGARFRSDAWRRESGSALQGDGITRILEGGRVFERAGCGF
SHVSGPRLPPSATQHRPELAGAPFEAMGVSLVFHPRNPYVPTVHMNVRMIAAGTGAAGTGAAGTGAAGTEAAGQAGQGPI
CWFGGGMDLTPYYGFDEDAVHFHRACRDALAPFGEGLYPRFKTWCDEYFYLKHRNEQRGVGGIFFDDFAELGFEQSLAMT
QSVGDAFLGAYLPIVQRRMHMDHGEREREFQLYRRGRYVEFNLVWDRGTHFGLQSGGRTESILLSMPPLAAWSYQREPQP
GSPEALLTERFLQRRDWI

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=323, Percent_Identity=41.7956656346749, Blast_Score=238, Evalue=8e-63,
Organism=Escherichia coli, GI1788777, Length=324, Percent_Identity=56.7901234567901, Blast_Score=366, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6320249, Length=344, Percent_Identity=40.9883720930233, Blast_Score=248, Evalue=7e-67,
Organism=Drosophila melanogaster, GI17864388, Length=332, Percent_Identity=42.4698795180723, Blast_Score=253, Evalue=1e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 37453; Mature: 37322

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: PS01021 COPROGEN_OXIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTQKPTFNTADTVARVRGYLEGLQARITSALEDIEGPQSHGGARFRSDAWRRESGSALQ
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCC
GDGITRILEGGRVFERAGCGFSHVSGPRLPPSATQHRPELAGAPFEAMGVSLVFHPRNPY
CCCHHHHHHCCCHHHHCCCCCCCCCCCCCCCCCHHCCCCCCCCCHHHHCEEEEEECCCCC
VPTVHMNVRMIAAGTGAAGTGAAGTGAAGTEAAGQAGQGPICWFGGGMDLTPYYGFDEDA
CCEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCHHH
VHFHRACRDALAPFGEGLYPRFKTWCDEYFYLKHRNEQRGVGGIFFDDFAELGFEQSLAM
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHEECCCCCCCCCCCHHHHHHHCCHHHHHHH
TQSVGDAFLGAYLPIVQRRMHMDHGEREREFQLYRRGRYVEFNLVWDRGTHFGLQSGGRT
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCC
ESILLSMPPLAAWSYQREPQPGSPEALLTERFLQRRDWI
CEEEEECCCHHHCCCCCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TTQKPTFNTADTVARVRGYLEGLQARITSALEDIEGPQSHGGARFRSDAWRRESGSALQ
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCCC
GDGITRILEGGRVFERAGCGFSHVSGPRLPPSATQHRPELAGAPFEAMGVSLVFHPRNPY
CCCHHHHHHCCCHHHHCCCCCCCCCCCCCCCCCHHCCCCCCCCCHHHHCEEEEEECCCCC
VPTVHMNVRMIAAGTGAAGTGAAGTGAAGTEAAGQAGQGPICWFGGGMDLTPYYGFDEDA
CCEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCHHH
VHFHRACRDALAPFGEGLYPRFKTWCDEYFYLKHRNEQRGVGGIFFDDFAELGFEQSLAM
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHEECCCCCCCCCCCHHHHHHHCCHHHHHHH
TQSVGDAFLGAYLPIVQRRMHMDHGEREREFQLYRRGRYVEFNLVWDRGTHFGLQSGGRT
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCC
ESILLSMPPLAAWSYQREPQPGSPEALLTERFLQRRDWI
CEEEEECCCHHHCCCCCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA