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The map label for this gene is cobB [H]

Identifier: 222110883

GI number: 222110883

Start: 1792315

End: 1793199

Strand: Direct

Name: cobB [H]

Synonym: Dtpsy_1690

Alternate gene names: 222110883

Gene position: 1792315-1793199 (Clockwise)

Preceding gene: 222110882

Following gene: 222110884

Centisome position: 47.21

GC content: 70.62

Gene sequence:

>885_bases
ATGCAAGCTGCCGCCAACGTTGATGCGCTGCTTGACTTCGTGCGCCGCCATCCGCGCCTGTTCGTCATCACGGGCGCGGG
CTGCAGTACGGAGGTGGGCATTCCCGACTACCGCGACCACAACGGTGAATGGAAGCGCCCCCAGCCCGTCACCTTCCAGG
CCTTCATGGGCGATGAAGCCACGCGCCGGCGCTACTGGGCGCGCAGCCTGCTGGGCTGGCGGGTGATGGGCCGCGCCCAG
CCCGGTTCGGCGCACCGTGCGCTGGCTGCGCTGGAAGCGGCGGGCCGTATCGAACTGCTGTTGACCCAGAACGTGGACGG
CCTGCACAGCGCAGCGGGCAGCCAGCGCACGCTGGACCTGCACGGGCGCATCGACACCGTGCTGTGCATGGACTGCGGCA
TGCGTGCGCCGCGTACCGCGTTGCAACACGAACTGGAGCGGCGCAACCCCGGATGGGTGGCGCTGCAGGCCAGCGCTGCG
CCCGATGGGGACGCCGATCTGGAGGGGCTGGATTTCGGCGGCTTCGATGTGCCTTCCTGCGCACATTGCGGCAACGGCCT
GCTCAAGCCCGACGTGGTGTTCTTTGGCGAGAGCGTGCCGCGCGAGCGTGTGGAGGCCGCGCGCGCGGCGCTGGCACGCT
CGCAAGCGGTGCTCGTCGTGGGCTCGTCGCTCATGGTGTATTCGGGCTTTCGGTTCGTGCAGGCGGCGGCCGATGCGGGC
CTGCCGGTGGCAGCGGTCAACCAGGGGCGTACACGGGCCGACGGGCTGCTGGCGCTCAAGCTCGAGCAGGACGCAGGCAC
TGCCCTGCAGGCGTTGGCCCACGCGTGGGCGCAGCCCCATGCCAGCGTGCCCGCCGCGGTTGCTGGGCTCGTCAGCGGCC
GTTGA

Upstream 100 bases:

>100_bases
CGCTGGGTGCCGAGGCCGATGACGAACGCACCGAGGCCATCCTCGGTGCGGTGTACGACTACGCCGAGAGCATCGCGCCC
GGCATGGACTGAGGGCTGTG

Downstream 100 bases:

>100_bases
TGCTATCGTCCGGTCCCAAAGCGCCGCCTGGCCGCGTGCCGTGCAGCGCATAGCTTGCATAGGAGACACCATGCACCGCA
CCGCAACGCCCGGCGCGCAT

Product: silent information regulator protein sir2

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog [H]

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MQAAANVDALLDFVRRHPRLFVITGAGCSTEVGIPDYRDHNGEWKRPQPVTFQAFMGDEATRRRYWARSLLGWRVMGRAQ
PGSAHRALAALEAAGRIELLLTQNVDGLHSAAGSQRTLDLHGRIDTVLCMDCGMRAPRTALQHELERRNPGWVALQASAA
PDGDADLEGLDFGGFDVPSCAHCGNGLLKPDVVFFGESVPRERVEAARAALARSQAVLVVGSSLMVYSGFRFVQAAADAG
LPVAAVNQGRTRADGLLALKLEQDAGTALQALAHAWAQPHASVPAAVAGLVSGR

Sequences:

>Translated_294_residues
MQAAANVDALLDFVRRHPRLFVITGAGCSTEVGIPDYRDHNGEWKRPQPVTFQAFMGDEATRRRYWARSLLGWRVMGRAQ
PGSAHRALAALEAAGRIELLLTQNVDGLHSAAGSQRTLDLHGRIDTVLCMDCGMRAPRTALQHELERRNPGWVALQASAA
PDGDADLEGLDFGGFDVPSCAHCGNGLLKPDVVFFGESVPRERVEAARAALARSQAVLVVGSSLMVYSGFRFVQAAADAG
LPVAAVNQGRTRADGLLALKLEQDAGTALQALAHAWAQPHASVPAAVAGLVSGR
>Mature_294_residues
MQAAANVDALLDFVRRHPRLFVITGAGCSTEVGIPDYRDHNGEWKRPQPVTFQAFMGDEATRRRYWARSLLGWRVMGRAQ
PGSAHRALAALEAAGRIELLLTQNVDGLHSAAGSQRTLDLHGRIDTVLCMDCGMRAPRTALQHELERRNPGWVALQASAA
PDGDADLEGLDFGGFDVPSCAHCGNGLLKPDVVFFGESVPRERVEAARAALARSQAVLVVGSSLMVYSGFRFVQAAADAG
LPVAAVNQGRTRADGLLALKLEQDAGTALQALAHAWAQPHASVPAAVAGLVSGR

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI6912662, Length=267, Percent_Identity=45.3183520599251, Blast_Score=228, Evalue=5e-60,
Organism=Homo sapiens, GI6912664, Length=269, Percent_Identity=31.5985130111524, Blast_Score=118, Evalue=7e-27,
Organism=Homo sapiens, GI13787215, Length=248, Percent_Identity=31.8548387096774, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI300795542, Length=267, Percent_Identity=30.3370786516854, Blast_Score=110, Evalue=2e-24,
Organism=Escherichia coli, GI308199517, Length=247, Percent_Identity=29.1497975708502, Blast_Score=68, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71990482, Length=260, Percent_Identity=40.7692307692308, Blast_Score=193, Evalue=7e-50,
Organism=Caenorhabditis elegans, GI71990487, Length=262, Percent_Identity=40.4580152671756, Blast_Score=188, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17567771, Length=260, Percent_Identity=38.4615384615385, Blast_Score=182, Evalue=2e-46,
Organism=Drosophila melanogaster, GI28571445, Length=270, Percent_Identity=41.1111111111111, Blast_Score=194, Evalue=6e-50,
Organism=Drosophila melanogaster, GI28571443, Length=218, Percent_Identity=40.8256880733945, Blast_Score=161, Evalue=6e-40,
Organism=Drosophila melanogaster, GI28571441, Length=218, Percent_Identity=40.8256880733945, Blast_Score=161, Evalue=6e-40,
Organism=Drosophila melanogaster, GI17137536, Length=237, Percent_Identity=29.535864978903, Blast_Score=99, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 31329; Mature: 31329

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQAAANVDALLDFVRRHPRLFVITGAGCSTEVGIPDYRDHNGEWKRPQPVTFQAFMGDEA
CCCCCCHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCHH
TRRRYWARSLLGWRVMGRAQPGSAHRALAALEAAGRIELLLTQNVDGLHSAAGSQRTLDL
HHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHCCCEEEEEECCCCHHHHCCCCCEEEEE
HGRIDTVLCMDCGMRAPRTALQHELERRNPGWVALQASAAPDGDADLEGLDFGGFDVPSC
CCCCCEEEEECCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCH
AHCGNGLLKPDVVFFGESVPRERVEAARAALARSQAVLVVGSSLMVYSGFRFVQAAADAG
HHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCEEEEECCCCHHHCCHHHHHHHHCCC
LPVAAVNQGRTRADGLLALKLEQDAGTALQALAHAWAQPHASVPAAVAGLVSGR
CCEEECCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCHHHHHHHHCCC
>Mature Secondary Structure
MQAAANVDALLDFVRRHPRLFVITGAGCSTEVGIPDYRDHNGEWKRPQPVTFQAFMGDEA
CCCCCCHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCHH
TRRRYWARSLLGWRVMGRAQPGSAHRALAALEAAGRIELLLTQNVDGLHSAAGSQRTLDL
HHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHCCCEEEEEECCCCHHHHCCCCCEEEEE
HGRIDTVLCMDCGMRAPRTALQHELERRNPGWVALQASAAPDGDADLEGLDFGGFDVPSC
CCCCCEEEEECCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCH
AHCGNGLLKPDVVFFGESVPRERVEAARAALARSQAVLVVGSSLMVYSGFRFVQAAADAG
HHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCEEEEECCCCHHHCCHHHHHHHHCCC
LPVAAVNQGRTRADGLLALKLEQDAGTALQALAHAWAQPHASVPAAVAGLVSGR
CCEEECCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA