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The map label for this gene is dxr [H]

Identifier: 222110432

GI number: 222110432

Start: 1290491

End: 1291663

Strand: Direct

Name: dxr [H]

Synonym: Dtpsy_1229

Alternate gene names: 222110432

Gene position: 1290491-1291663 (Clockwise)

Preceding gene: 222110431

Following gene: 222110433

Centisome position: 33.99

GC content: 67.95

Gene sequence:

>1173_bases
ATGAAACAACGTCTCACGGTGCTGGGTTCTACGGGATCCATCGGCACCAGCACCCTCGACGTGGTGGCACGCCACCCCGA
TCGCTACGAAGTCTTTGCGCTGAGCGCGGCCACGCAGGTGGACCTGATGCTGGCGCAGTGCGCGCAGTTCCGTCCGCGCT
ATGCGGTGATGGCCAGCAGTGCGCATGCGCGCCAGCTGGCAGACAAACTGCAGCAGAGCGGCTTGCCCACCGAGGTGCTG
CAAACACCCGATGCGCTGCAAGCCATTGCCTCGCACGAAGAGGTGGACGCGGTCATGGCGGCCATCGTGGGCGCGGCGGG
CCTGGCGCCGTGCCTGGCGGCCGCGCGTGCGGGCAAGCGCCTGCTGCTGGCCAACAAGGAGGCGCTGGTCGTCGGGGGCG
AGGTGTTCATGGCCGCGGTGCGCGAAGGCGGCGCCACGCTGCTGCCCATCGACAGCGAGCATTCCGCCATCTTCCAGAGC
CTGCCCGAAGACCCCGCCACCTGGCCGCGGCGCGTGGACCACGTGCTGCTCACCGCGTCGGGCGGGCCGTTTCGCACGCG
CGACCCGGCCACGCTGCGCGACGTGACGCCGGCGCAGGCCTGCGCGCATCCCAACTTCTCGATGGGCCGCAAGATTTCCA
TCGACTCGGCCACGATGATGAACAAGGCGCTGGAGGTGATCGAGGCGCGCTGGCTGTTCAACCTGGCGCCTGAGCAGATC
AAGGTGGTCATCCACCCGCAGCAGATCATCCACTCCATGGTGCAGTTTGTGGACGCGTCCATCATTGCCCAGTTGGGCAC
GCCCGATATGCGCGTGCCCATCGCCTGTGGCCTGGCCTGGCCCGAGCGGGTGGAAAGCGGCGCGGCGCCCCTGGATTTCA
CGCAACTGGCAGCGCTGACCTTCGAAGAAGCGGATGCCACGCGCTTTCCCGGGCTGCACCTGTCCTGGCAGGCGTTGCGC
GCGGCGCCCGGCACCACGGCCGTGCTCAATGCCGCCAACGAGGTGGCAGTGGCGGCTTTCCTGGAGCAGCGCATACGTTT
CGACCAGATCCATGCGCTCAACCTTGCAACTTTGGAAGCCGTCGAACCGTCCAACCCGGACTCGCTGGACGCACTGCTGG
CGCTGGATGCGCGCACGCGTGCGCGGTCCGCGGAGTTGATGGCGCGCTTGTGA

Upstream 100 bases:

>100_bases
GCAGCGGCCTGCTGCCTGGCCACGGCGGCGTACTGGACCGCATTGATGCGCTGCTGCCCACGCTGCCCTTGGCCATGATG
CTTTCTCATTTCGCATCCGC

Downstream 100 bases:

>100_bases
GGATGCTCTTAAAAGGTGAGCGTCTTGCGCTTGTCACATAAGGGTTACAGGTGCGTTTTATATTCAAACCATTGCTGGAT
AAGCGCAAGGCGCTCTGATT

Product: 1-deoxy-d-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase [H]

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MKQRLTVLGSTGSIGTSTLDVVARHPDRYEVFALSAATQVDLMLAQCAQFRPRYAVMASSAHARQLADKLQQSGLPTEVL
QTPDALQAIASHEEVDAVMAAIVGAAGLAPCLAAARAGKRLLLANKEALVVGGEVFMAAVREGGATLLPIDSEHSAIFQS
LPEDPATWPRRVDHVLLTASGGPFRTRDPATLRDVTPAQACAHPNFSMGRKISIDSATMMNKALEVIEARWLFNLAPEQI
KVVIHPQQIIHSMVQFVDASIIAQLGTPDMRVPIACGLAWPERVESGAAPLDFTQLAALTFEEADATRFPGLHLSWQALR
AAPGTTAVLNAANEVAVAAFLEQRIRFDQIHALNLATLEAVEPSNPDSLDALLALDARTRARSAELMARL

Sequences:

>Translated_390_residues
MKQRLTVLGSTGSIGTSTLDVVARHPDRYEVFALSAATQVDLMLAQCAQFRPRYAVMASSAHARQLADKLQQSGLPTEVL
QTPDALQAIASHEEVDAVMAAIVGAAGLAPCLAAARAGKRLLLANKEALVVGGEVFMAAVREGGATLLPIDSEHSAIFQS
LPEDPATWPRRVDHVLLTASGGPFRTRDPATLRDVTPAQACAHPNFSMGRKISIDSATMMNKALEVIEARWLFNLAPEQI
KVVIHPQQIIHSMVQFVDASIIAQLGTPDMRVPIACGLAWPERVESGAAPLDFTQLAALTFEEADATRFPGLHLSWQALR
AAPGTTAVLNAANEVAVAAFLEQRIRFDQIHALNLATLEAVEPSNPDSLDALLALDARTRARSAELMARL
>Mature_390_residues
MKQRLTVLGSTGSIGTSTLDVVARHPDRYEVFALSAATQVDLMLAQCAQFRPRYAVMASSAHARQLADKLQQSGLPTEVL
QTPDALQAIASHEEVDAVMAAIVGAAGLAPCLAAARAGKRLLLANKEALVVGGEVFMAAVREGGATLLPIDSEHSAIFQS
LPEDPATWPRRVDHVLLTASGGPFRTRDPATLRDVTPAQACAHPNFSMGRKISIDSATMMNKALEVIEARWLFNLAPEQI
KVVIHPQQIIHSMVQFVDASIIAQLGTPDMRVPIACGLAWPERVESGAAPLDFTQLAALTFEEADATRFPGLHLSWQALR
AAPGTTAVLNAANEVAVAAFLEQRIRFDQIHALNLATLEAVEPSNPDSLDALLALDARTRARSAELMARL

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) [H]

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family [H]

Homologues:

Organism=Escherichia coli, GI1786369, Length=400, Percent_Identity=55.5, Blast_Score=399, Evalue=1e-112,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom [H]

EC number: =1.1.1.267 [H]

Molecular weight: Translated: 41759; Mature: 41759

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQRLTVLGSTGSIGTSTLDVVARHPDRYEVFALSAATQVDLMLAQCAQFRPRYAVMASS
CCCEEEEEECCCCCCCHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHHCCCCEEEEECC
AHARQLADKLQQSGLPTEVLQTPDALQAIASHEEVDAVMAAIVGAAGLAPCLAAARAGKR
HHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
LLLANKEALVVGGEVFMAAVREGGATLLPIDSEHSAIFQSLPEDPATWPRRVDHVLLTAS
EEEECCCEEEECHHHHHHHHHCCCCEEEEECCCHHHHHHHCCCCCCHHHHHCCEEEEEEC
GGPFRTRDPATLRDVTPAQACAHPNFSMGRKISIDSATMMNKALEVIEARWLFNLAPEQI
CCCCCCCCCCHHHCCCHHHHHCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHCCCCCCE
KVVIHPQQIIHSMVQFVDASIIAQLGTPDMRVPIACGLAWPERVESGAAPLDFTQLAALT
EEEECHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHCCCCCCCHHHHHHHH
FEEADATRFPGLHLSWQALRAAPGTTAVLNAANEVAVAAFLEQRIRFDQIHALNLATLEA
HCCCCCCCCCCCCEEHHHHHCCCCCHHHHHCHHHHHHHHHHHHHHHHHHHEEECHHEEEC
VEPSNPDSLDALLALDARTRARSAELMARL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKQRLTVLGSTGSIGTSTLDVVARHPDRYEVFALSAATQVDLMLAQCAQFRPRYAVMASS
CCCEEEEEECCCCCCCHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHHCCCCEEEEECC
AHARQLADKLQQSGLPTEVLQTPDALQAIASHEEVDAVMAAIVGAAGLAPCLAAARAGKR
HHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
LLLANKEALVVGGEVFMAAVREGGATLLPIDSEHSAIFQSLPEDPATWPRRVDHVLLTAS
EEEECCCEEEECHHHHHHHHHCCCCEEEEECCCHHHHHHHCCCCCCHHHHHCCEEEEEEC
GGPFRTRDPATLRDVTPAQACAHPNFSMGRKISIDSATMMNKALEVIEARWLFNLAPEQI
CCCCCCCCCCHHHCCCHHHHHCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHCCCCCCE
KVVIHPQQIIHSMVQFVDASIIAQLGTPDMRVPIACGLAWPERVESGAAPLDFTQLAALT
EEEECHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCHHHHHCCCCCCCHHHHHHHH
FEEADATRFPGLHLSWQALRAAPGTTAVLNAANEVAVAAFLEQRIRFDQIHALNLATLEA
HCCCCCCCCCCCCEEHHHHHCCCCCHHHHHCHHHHHHHHHHHHHHHHHHHEEECHHEEEC
VEPSNPDSLDALLALDARTRARSAELMARL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA