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The map label for this gene is merA [H]

Identifier: 222110367

GI number: 222110367

Start: 1220984

End: 1222438

Strand: Direct

Name: merA [H]

Synonym: Dtpsy_1158

Alternate gene names: 222110367

Gene position: 1220984-1222438 (Clockwise)

Preceding gene: 222110365

Following gene: 222110370

Centisome position: 32.16

GC content: 54.91

Gene sequence:

>1455_bases
ATGAACACGACAACAGCGGCTTCCGCACAACAGCCCTCCGTCATCTATGATCTAGTCACGATAGGTTCCGGTTCGGCGGC
TAGAGCCGCAGCGAACGAAGCACGTAGGCTCGACAAAACAGTCGCCATGATCGAACAGGGGTTGGCAGGAGGGACCTGTC
TCAATGTAGGATGCGTTCCTTCAAAGACGTTGCTTGCGGCGGCTTCTGCTCGCATGTCTGCTGCGCATGGGAAGTTCCCA
GGTATAGCGACCTCGGCCGGGCCTGTCGACTTGTCTTTGCTTGTCAGAGATAAAGATCAAATGATCGGGCACTTCCGGCA
GTCTTTCCATGTACAAGCACCCAAGGATGCAGGTATTGCGGTATTTCGCGGCAAGGCGACCTTTGTAGCGTCAGATGAGC
CAGATATCGTAGCGCTCGTCGTCGCGGACTCAGACGGAAACACAAACCTGGTGTACGCCAAGCAGGTACTGATCGCCAGT
GGGGCAGCGCCATTCATTCCTTCCATTCCTGGCCTCAGTGAGGTGGACTTTCTCACTTCCGGCTCGGCCATGTCCCTTGA
GCAGGTGCCTGAGTCCATGCTGGTCGTCGGCGGCAATGCGATCGGTCTGGAGCAAGGTCAATTGTTCGCTCGACTGGGCA
GCAAGGTTGAAGTGGTCGAGATAGCTCCTCGAATTGCACCGTTCGAGGATCCCGCGATTTCTGCGGCACTGGAGCAGGCG
CTGTCAGCGGAGGGCATCATGTTCCATACTGGCGCCAATCTGACAAACGTCGTACCACACGAGAGCGGGGTGCTTGCAAC
TGTCGTCGCCGAAGGACGTACTCAGCAAATTTTCGCCCATAAGATTCTCATAGCGACGGGGCGCCGTCCGGCAACTGAAG
GACTCAACTTGGATGCTGTCAATGTGTCCAGGGGCGATCGAGGCGAAATAATTGTGGACGAACATCTGCGAACCTCAAAT
CCTCGCATCTGGGCAGCGGGCGATGTCACTGGTATGGCTCAATTAGTGTATGTCGCTAGTGCGCAGGGGACCGTGGCCGC
GAGCAATGCTCTGGGCAACGAGCCTCGGTCCCTAGACTACACCGCCTTGCCCCGCGTCATTTTCACGTCGCCCGAGATGG
CTGCTGTCGGCATGACTCCTATGCAGGCTGAGGCGGCCCAAATTGCCTATGATGTTCGTGAAATTCCGGTTTCCTTTGTT
CTACGTGCTATTGTAAGTCGTCACGACAAAGGGATAATCAAGATGATATCCGAGCGTGAGACAGGAAGGATTCTGGGTAT
TCATATGGTAGGCGAATCTGCTGGAGAGGTTATTGCAGCTGCAACCTATATTATCTCCGCAGGACTTACGGTTGACCAAC
TTGCAAAACAGTGGTCTCCGTACTTCACTATGGCGGAGTCGCTTAAAAACGTAGCAAGCAGTGCGCCAACTTTGGAAGAT
TCGGCTAATGGCTAA

Upstream 100 bases:

>100_bases
ATTCATACGCGACATGTTGACACAAGGAGACAGGGTTGTCTACAATCCCTCAAGGAGACCGATCTGTCTCTTTCTTTGCA
ATTTCCTTGAGGCTTCTTTT

Downstream 100 bases:

>100_bases
ATCTTATTATTACTATGCGCTTAAATTTCAAGGGATCGTTTCAGGGTAAAGTTTCCTGATGTGAGCATGTTTGAGTTTTT
TGCTATGGCGGGATCGCTCA

Product: mercuric reductase

Products: NA

Alternate protein names: Hg(II) reductase [H]

Number of amino acids: Translated: 484; Mature: 484

Protein sequence:

>484_residues
MNTTTAASAQQPSVIYDLVTIGSGSAARAAANEARRLDKTVAMIEQGLAGGTCLNVGCVPSKTLLAAASARMSAAHGKFP
GIATSAGPVDLSLLVRDKDQMIGHFRQSFHVQAPKDAGIAVFRGKATFVASDEPDIVALVVADSDGNTNLVYAKQVLIAS
GAAPFIPSIPGLSEVDFLTSGSAMSLEQVPESMLVVGGNAIGLEQGQLFARLGSKVEVVEIAPRIAPFEDPAISAALEQA
LSAEGIMFHTGANLTNVVPHESGVLATVVAEGRTQQIFAHKILIATGRRPATEGLNLDAVNVSRGDRGEIIVDEHLRTSN
PRIWAAGDVTGMAQLVYVASAQGTVAASNALGNEPRSLDYTALPRVIFTSPEMAAVGMTPMQAEAAQIAYDVREIPVSFV
LRAIVSRHDKGIIKMISERETGRILGIHMVGESAGEVIAAATYIISAGLTVDQLAKQWSPYFTMAESLKNVASSAPTLED
SANG

Sequences:

>Translated_484_residues
MNTTTAASAQQPSVIYDLVTIGSGSAARAAANEARRLDKTVAMIEQGLAGGTCLNVGCVPSKTLLAAASARMSAAHGKFP
GIATSAGPVDLSLLVRDKDQMIGHFRQSFHVQAPKDAGIAVFRGKATFVASDEPDIVALVVADSDGNTNLVYAKQVLIAS
GAAPFIPSIPGLSEVDFLTSGSAMSLEQVPESMLVVGGNAIGLEQGQLFARLGSKVEVVEIAPRIAPFEDPAISAALEQA
LSAEGIMFHTGANLTNVVPHESGVLATVVAEGRTQQIFAHKILIATGRRPATEGLNLDAVNVSRGDRGEIIVDEHLRTSN
PRIWAAGDVTGMAQLVYVASAQGTVAASNALGNEPRSLDYTALPRVIFTSPEMAAVGMTPMQAEAAQIAYDVREIPVSFV
LRAIVSRHDKGIIKMISERETGRILGIHMVGESAGEVIAAATYIISAGLTVDQLAKQWSPYFTMAESLKNVASSAPTLED
SANG
>Mature_484_residues
MNTTTAASAQQPSVIYDLVTIGSGSAARAAANEARRLDKTVAMIEQGLAGGTCLNVGCVPSKTLLAAASARMSAAHGKFP
GIATSAGPVDLSLLVRDKDQMIGHFRQSFHVQAPKDAGIAVFRGKATFVASDEPDIVALVVADSDGNTNLVYAKQVLIAS
GAAPFIPSIPGLSEVDFLTSGSAMSLEQVPESMLVVGGNAIGLEQGQLFARLGSKVEVVEIAPRIAPFEDPAISAALEQA
LSAEGIMFHTGANLTNVVPHESGVLATVVAEGRTQQIFAHKILIATGRRPATEGLNLDAVNVSRGDRGEIIVDEHLRTSN
PRIWAAGDVTGMAQLVYVASAQGTVAASNALGNEPRSLDYTALPRVIFTSPEMAAVGMTPMQAEAAQIAYDVREIPVSFV
LRAIVSRHDKGIIKMISERETGRILGIHMVGESAGEVIAAATYIISAGLTVDQLAKQWSPYFTMAESLKNVASSAPTLED
SANG

Specific function: Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0) [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=488, Percent_Identity=31.1475409836066, Blast_Score=199, Evalue=7e-51,
Organism=Homo sapiens, GI50301238, Length=448, Percent_Identity=28.7946428571429, Blast_Score=152, Evalue=5e-37,
Organism=Homo sapiens, GI22035672, Length=466, Percent_Identity=27.8969957081545, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI33519430, Length=419, Percent_Identity=25.2983293556086, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI33519428, Length=419, Percent_Identity=25.2983293556086, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI33519426, Length=419, Percent_Identity=25.2983293556086, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI148277071, Length=419, Percent_Identity=25.2983293556086, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI148277065, Length=419, Percent_Identity=25.2983293556086, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI291045266, Length=460, Percent_Identity=24.7826086956522, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI87081717, Length=463, Percent_Identity=29.8056155507559, Blast_Score=184, Evalue=9e-48,
Organism=Escherichia coli, GI1786307, Length=461, Percent_Identity=30.3687635574837, Blast_Score=179, Evalue=4e-46,
Organism=Escherichia coli, GI1789915, Length=461, Percent_Identity=29.9349240780911, Blast_Score=167, Evalue=2e-42,
Organism=Escherichia coli, GI87082354, Length=464, Percent_Identity=26.7241379310345, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI1789065, Length=346, Percent_Identity=26.878612716763, Blast_Score=76, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI32565766, Length=467, Percent_Identity=32.5481798715203, Blast_Score=221, Evalue=6e-58,
Organism=Caenorhabditis elegans, GI71983429, Length=464, Percent_Identity=27.801724137931, Blast_Score=138, Evalue=8e-33,
Organism=Caenorhabditis elegans, GI71983419, Length=464, Percent_Identity=27.801724137931, Blast_Score=138, Evalue=8e-33,
Organism=Caenorhabditis elegans, GI17557007, Length=461, Percent_Identity=26.6811279826464, Blast_Score=135, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI71982272, Length=455, Percent_Identity=25.9340659340659, Blast_Score=104, Evalue=9e-23,
Organism=Saccharomyces cerevisiae, GI6321091, Length=466, Percent_Identity=29.3991416309013, Blast_Score=193, Evalue=4e-50,
Organism=Saccharomyces cerevisiae, GI6325166, Length=450, Percent_Identity=26.6666666666667, Blast_Score=129, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6325240, Length=477, Percent_Identity=25.1572327044025, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI21358499, Length=473, Percent_Identity=32.5581395348837, Blast_Score=215, Evalue=6e-56,
Organism=Drosophila melanogaster, GI17737741, Length=489, Percent_Identity=29.2433537832311, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24640549, Length=487, Percent_Identity=27.9260780287474, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24640553, Length=493, Percent_Identity=27.5862068965517, Blast_Score=123, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24640551, Length=490, Percent_Identity=27.7551020408163, Blast_Score=122, Evalue=4e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR021179
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.16.1.1 [H]

Molecular weight: Translated: 50450; Mature: 50450

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTTTAASAQQPSVIYDLVTIGSGSAARAAANEARRLDKTVAMIEQGLAGGTCLNVGCVP
CCCCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCC
SKTLLAAASARMSAAHGKFPGIATSAGPVDLSLLVRDKDQMIGHFRQSFHVQAPKDAGIA
CHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECHHHHHHHHHHHCCCCCCCCCCEE
VFRGKATFVASDEPDIVALVVADSDGNTNLVYAKQVLIASGAAPFIPSIPGLSEVDFLTS
EEECCEEEEECCCCCEEEEEEECCCCCCEEEEEEEEEEECCCCCCCCCCCCCCCEEEECC
GSAMSLEQVPESMLVVGGNAIGLEQGQLFARLGSKVEVVEIAPRIAPFEDPAISAALEQA
CCCCCHHHCCCEEEEECCCEECCCCCHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHH
LSAEGIMFHTGANLTNVVPHESGVLATVVAEGRTQQIFAHKILIATGRRPATEGLNLDAV
HCCCCEEEECCCCCCCCCCCCCCEEEEEEECCCCHHHHHEEEEEEECCCCCCCCCCEEEE
NVSRGDRGEIIVDEHLRTSNPRIWAAGDVTGMAQLVYVASAQGTVAASNALGNEPRSLDY
ECCCCCCCCEEEECCCCCCCCEEEEECCHHHHEEEEEEECCCCCEEECCCCCCCCCCCCH
TALPRVIFTSPEMAAVGMTPMQAEAAQIAYDVREIPVSFVLRAIVSRHDKGIIKMISERE
HHCCEEEECCCCHHEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHCCC
TGRILGIHMVGESAGEVIAAATYIISAGLTVDQLAKQWSPYFTMAESLKNVASSAPTLED
CCCEEEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHCCCCCCC
SANG
CCCC
>Mature Secondary Structure
MNTTTAASAQQPSVIYDLVTIGSGSAARAAANEARRLDKTVAMIEQGLAGGTCLNVGCVP
CCCCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCC
SKTLLAAASARMSAAHGKFPGIATSAGPVDLSLLVRDKDQMIGHFRQSFHVQAPKDAGIA
CHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECHHHHHHHHHHHCCCCCCCCCCEE
VFRGKATFVASDEPDIVALVVADSDGNTNLVYAKQVLIASGAAPFIPSIPGLSEVDFLTS
EEECCEEEEECCCCCEEEEEEECCCCCCEEEEEEEEEEECCCCCCCCCCCCCCCEEEECC
GSAMSLEQVPESMLVVGGNAIGLEQGQLFARLGSKVEVVEIAPRIAPFEDPAISAALEQA
CCCCCHHHCCCEEEEECCCEECCCCCHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHHHH
LSAEGIMFHTGANLTNVVPHESGVLATVVAEGRTQQIFAHKILIATGRRPATEGLNLDAV
HCCCCEEEECCCCCCCCCCCCCCEEEEEEECCCCHHHHHEEEEEEECCCCCCCCCCEEEE
NVSRGDRGEIIVDEHLRTSNPRIWAAGDVTGMAQLVYVASAQGTVAASNALGNEPRSLDY
ECCCCCCCCEEEECCCCCCCCEEEEECCHHHHEEEEEEECCCCCEEECCCCCCCCCCCCH
TALPRVIFTSPEMAAVGMTPMQAEAAQIAYDVREIPVSFVLRAIVSRHDKGIIKMISERE
HHCCEEEECCCCHHEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHCCC
TGRILGIHMVGESAGEVIAAATYIISAGLTVDQLAKQWSPYFTMAESLKNVASSAPTLED
CCCEEEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHHHHHHCCCCCCC
SANG
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1494353 [H]