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The map label for this gene is cueR [H]

Identifier: 222110364

GI number: 222110364

Start: 1218478

End: 1218864

Strand: Direct

Name: cueR [H]

Synonym: Dtpsy_1155

Alternate gene names: 222110364

Gene position: 1218478-1218864 (Clockwise)

Preceding gene: 222110363

Following gene: 222110365

Centisome position: 32.09

GC content: 62.79

Gene sequence:

>387_bases
ATGAGGATCGGTGAACTTGCGCGCTTGACGGGCACCCCCCCGGAGAACATTCGGTTCTACGAGCGGGAGGGCCTGTTGCA
AGCCCCGGAGCGGTCACGCAACAACTATCGGCGCTATGGCCCGGCCCATGTCGAACGGCTTCACCTGATTCGCAACTACC
GTGCCTCGGGAATCGGCCTGGATGACGTGCGCCGCCTACTGGGTTGGGCACATGAGGGGTTCCTGGAACCTGAGCTGCTA
AGGCAGGCTGTCCAAGGCCATCTCGCCTGTGTTGAGGAACGCATGGAGCAACTGATCCAGGTGAAAGAGCACCTGCTCGC
ATTGGCCCTGCACGGTGCTGCTTCCGCCGGGGCTTCCGAGGATGGACCGGCTCGCGATGGTTCGTGA

Upstream 100 bases:

>100_bases
ACGGTGCAATCGGGCGCCACCGGGCAACCATCCGCCCGGTCGCCGGGATAAGGGCTATGCGCAACGGCGGCGTTCCCCAT
CGTTGCGCACGGAGAACCGG

Downstream 100 bases:

>100_bases
GCATCGCATGTCCATATAACTGAATATATATTCATGCGTGTAATATTTCCGGCCAGACAAACGAATAAGAAAGACGCCCA
TGACCGACCAGAGCATCACG

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: Copper efflux regulator; Copper export regulator [H]

Number of amino acids: Translated: 128; Mature: 128

Protein sequence:

>128_residues
MRIGELARLTGTPPENIRFYEREGLLQAPERSRNNYRRYGPAHVERLHLIRNYRASGIGLDDVRRLLGWAHEGFLEPELL
RQAVQGHLACVEERMEQLIQVKEHLLALALHGAASAGASEDGPARDGS

Sequences:

>Translated_128_residues
MRIGELARLTGTPPENIRFYEREGLLQAPERSRNNYRRYGPAHVERLHLIRNYRASGIGLDDVRRLLGWAHEGFLEPELL
RQAVQGHLACVEERMEQLIQVKEHLLALALHGAASAGASEDGPARDGS
>Mature_128_residues
MRIGELARLTGTPPENIRFYEREGLLQAPERSRNNYRRYGPAHVERLHLIRNYRASGIGLDDVRRLLGWAHEGFLEPELL
RQAVQGHLACVEERMEQLIQVKEHLLALALHGAASAGASEDGPARDGS

Specific function: Regulates the transcription of the copA and cueO genes. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations [H]

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786695, Length=123, Percent_Identity=32.520325203252, Blast_Score=67, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011789
- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 14388; Mature: 14388

Theoretical pI: Translated: 7.16; Mature: 7.16

Prosite motif: PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIGELARLTGTPPENIRFYEREGLLQAPERSRNNYRRYGPAHVERLHLIRNYRASGIGL
CCCCCHHHHCCCCCCCCEECCCCCCCCCCHHHHHCCHHCCHHHHHHHHHHHHHCCCCCCH
DDVRRLLGWAHEGFLEPELLRQAVQGHLACVEERMEQLIQVKEHLLALALHGAASAGASE
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DGPARDGS
CCCCCCCC
>Mature Secondary Structure
MRIGELARLTGTPPENIRFYEREGLLQAPERSRNNYRRYGPAHVERLHLIRNYRASGIGL
CCCCCHHHHCCCCCCCCEECCCCCCCCCCHHHHHCCHHCCHHHHHHHHHHHHHCCCCCCH
DDVRRLLGWAHEGFLEPELLRQAVQGHLACVEERMEQLIQVKEHLLALALHGAASAGASE
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DGPARDGS
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]